The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability
Open accessAbstract
SUMMARY The persistent mal-attachment of microtubules to chromosomes at kinetochores is a major mechanism of chromosomal instability (CIN) [1, 2]. In normal diploid cells, mal-attachments arise spontaneously and are efficiently corrected to preserve genomic stability [3]. However, it is unknown if cancer cells with CIN possess the ability to efficiently correct attachment errors. Here we show that kinetochore-microtubule attachments in cancer cells with CIN are inherently more stable than those in normal diploid RPE-1 cells. The observed differences in attachment stability account for the persistence of mal-attachments into anaphase, where they cause chromosome mis-segregation. Furthermore, increasing the stability of kinetochore-microtubule attachments in normal diploid RPE-1 cells, either by depleting the tumor suppressor protein, APC, or the kinesin-13 protein, MCAK, is sufficient to promote chromosome segregation defects to levels comparable to those in cancer cells with CIN. Collectively, these data identify that cancer cells have a diminished capacity to correct erroneous kinetochore-microtubule attachments and accounts for the widespread occurrence of CIN in tumors [4].
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Nowell, P. C. (1976) · Science · doi:10.1126/science.959840 · Cited by 6,471
Genetic instabilities in human cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168 · cited 3×
“Yet, these data provide a compelling account for the widespread occurrence of CIN in tumors regardless of the number of centrosomes present [4,5] and explains why promoting kinetochore-microtubule dynamics leads to the suppression of CIN in four independent cancer cell lines that were derived from three different type…”
Mack, G. J., & Compton, D. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261371298 · Cited by 157
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Cited by
The causes and consequences of genetic heterogeneity in cancer evolution
Burrell, R. A., McGranahan, N., Bartek, J., & Swanton, C. (2013) · Nature · doi:10.1038/nature12625 · Cited by 2,262
Fenech, M., Kirsch-Volders, M., Natarajan, A. T., Surralles, J., Crott, J. W., Parry, J., Norppa, H., Eastmond, D. A., Tucker, J. D., & Thomas, P. (2011) · Mutagenesis · doi:10.1093/mutage/geq052 · Cited by 1,244
The mitotic origin of chromosomal instability
Bakhoum, S. F., Silkworth, W. T., Nardi, I. K., Nicholson, J. M., Compton, D. A., & Cimini, D. (2014) · Current Biology · doi:10.1016/j.cub.2014.01.019 · Cited by 142
Self-citationKif18B interacts with EB1 and controls astral microtubule length during mitosis
Stout, J. R., Yount, A. L., Powers, J. A., LeBlanc, C., Ems-McClung, S. C., & Walczak, C. E. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-04-0363 · Cited by 111
Numerical chromosomal instability mediates susceptibility to radiation treatment
Bakhoum, S. F., Kabeche, L., Wood, M. D., Laucius, C. D., Qu, D., Laughney, A. M., Reynolds, G. E., Louie, R. J., Phillips, J., Chan, D. A., et al. (2015) · Nature Communications · doi:10.1038/ncomms6990 · Cited by 95
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Metadata
- Authors
- Bakhoum, S. F., Genovese, G., & Compton, D. A.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 19
- Issue
- 22
- Pages
- 1937-1942
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2050953095
- Cited by
- 348
- References
- 3
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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