Cited by 142Microtubule and mitosis dynamicsDNA Repair MechanismsGenomic variations and chromosomal abnormalities

The mitotic origin of chromosomal instability

Open access
Bakhoum, Samuel F., Silkworth, William T., Nardi, Isaac K., Nicholson, Joshua M., Compton, Duane A., Cimini, Daniela·2014·Current Biology

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.cub.2014.01.019

Cites

11 of 11 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Overexpression of Kif2b or MCAK directly suppresses CIN in otherwise chromosomally unstable cells.

    “Destabilization of microtubule attachments to chromosomes at the kinetochores, through overexpression of the non-motile microtubule depolymerizing kinesin-13 proteins, Kif2b or MCAK/Kif2c, directly suppresses CIN in otherwise chromosomally unstable cells5–7.”

    From Chromosomal instability drives metastasis through a cytosolic DNA response (2018) · cites this paper as [5]

    In the main text (page unavailable), GFP–Kif2b overexpression reduced karyotypic heterogeneity in two CIN+ cell lines, supporting suppression of CIN. The paper also reports earlier results for kinesin-13 overexpression in two other CIN+ lines, but our copy does not identify MCAK/Kif2c or establish its effect separately. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Bakhoum, S. F., Silkworth, W. T., Nardi, I. K., Nicholson, J. M., Compton, D. A., & Cimini, D.
Affiliations
  • Dartmouth College (US)
  • University of California, Los Angeles (US)
  • University of Virginia Medical Center (US)
  • Virginia Tech (US)
Corresponding author
  • Compton, Duane A.
  • Cimini, Daniela
Venue
Current Biology
Publisher
Elsevier BV
Published
2014-02
Volume
24
Issue
4
Pages
R148-R149
ISSN
0960-9822 (ISSN-L)
OpenAlex
W2129124130
Cited by
142
References
11
Citations by year
2026: 4 · 2025: 9 · 2024: 16 · 2023: 9 · 2022: 14 · 2021: 14 · 2020: 7 · 2019: 21 · 2018: 8 · 2017: 12 · 2016: 14 · 2015: 11 · 2014: 3
FWCI
6.64
Type
journal article
Language
en
Open access
Locations
  • Current Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Science Foundation
  • National Institutes of Health
  • National Cancer Institute (P30CA023108)
  • National Institute of General Medical Sciences (GM51542, R37GM051542)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
Keywords
chromosomal instability, mitosis, chromosome missegregation, lagging chromosomes, merotelic attachment, spindle assembly checkpoint, sister chromatid cohesion, kinetochore-microtubule attachment, centrosome number, replication stress, chromatin bridges, acentric fragments, anaphase, cancer
MeSH terms
DNA, DNA Replication, Humans, Mitosis, Chromosomal Instability

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review