The mitotic origin of chromosomal instability
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Overexpression of Kif2b or MCAK directly suppresses CIN in otherwise chromosomally unstable cells.
“Destabilization of microtubule attachments to chromosomes at the kinetochores, through overexpression of the non-motile microtubule depolymerizing kinesin-13 proteins, Kif2b or MCAK/Kif2c, directly suppresses CIN in otherwise chromosomally unstable cells5–7.”
From Chromosomal instability drives metastasis through a cytosolic DNA response (2018) · cites this paper as [5]
In the main text (page unavailable), GFP–Kif2b overexpression reduced karyotypic heterogeneity in two CIN+ cell lines, supporting suppression of CIN. The paper also reports earlier results for kinesin-13 overexpression in two other CIN+ lines, but our copy does not identify MCAK/Kif2c or establish its effect separately. (LLM, conf=0.88)
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- Authors
- Bakhoum, S. F., Silkworth, W. T., Nardi, I. K., Nicholson, J. M., Compton, D. A., & Cimini, D.
- Affiliations
- Dartmouth College (US)
- University of California, Los Angeles (US)
- University of Virginia Medical Center (US)
- Virginia Tech (US)
- Corresponding author
- Compton, Duane A.
- Cimini, Daniela
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 24
- Issue
- 4
- Pages
- R148-R149
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC3970164
- OpenAlex
- W2129124130
- Cited by
- 142
- References
- 11
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 16 · 2023: 9 · 2022: 14 · 2021: 14 · 2020: 7 · 2019: 21 · 2018: 8 · 2017: 12 · 2016: 14 · 2015: 11 · 2014: 3
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- National Institutes of Health
- National Cancer Institute (P30CA023108)
- National Institute of General Medical Sciences (GM51542, R37GM051542)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- chromosomal instability, mitosis, chromosome missegregation, lagging chromosomes, merotelic attachment, spindle assembly checkpoint, sister chromatid cohesion, kinetochore-microtubule attachment, centrosome number, replication stress, chromatin bridges, acentric fragments, anaphase, cancer
- MeSH terms
- DNA, DNA Replication, Humans, Mitosis, Chromosomal Instability
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