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Cited by 75Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanismsEvolution and Paleontology Studies

Evolution of the Chordate Telencephalon

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Briscoe, Steven D., Ragsdale, Clifton W.·2019·Current Biology
DOI 10.1016/j.cub.2019.05.026PMC PMC11073819
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Abstract

The dramatic evolutionary expansion of the neocortex, together with a proliferation of specialized cortical areas, is believed to underlie the emergence of human cognitive abilities. In a broader phylogenetic context, however, neocortex evolution in mammals, including humans, is remarkably conservative, characterized largely by size variations on a shared six-layered neuronal architecture. By contrast, the telencephalon in non-mammalian vertebrates, including reptiles, amphibians, bony and cartilaginous fishes, and cyclostomes, features a great variety of very different tissue structures. Our understanding of the evolutionary relationships of these telencephalic structures, especially those of basally branching vertebrates and invertebrate chordates, remains fragmentary and is impeded by conceptual obstacles. To make sense of highly divergent anatomies requires a hierarchical view of biological organization, one that permits the recognition of homologies at multiple levels beyond neuroanatomical structure. Here we review the origin and diversification of the telencephalon with a focus on key evolutionary innovations shaping the neocortex at multiple levels of organization.

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  • The telencephalon contains putative analogues to components of the mammalian limbic system (for example, hippocampus).

    “a brain region that contains putative analogues to components of the mammalian limbic system (for example, hippocampus)2–4”

    From A population code for spatial representation in the zebrafish telencephalon (2024) · cites this paper as [2]

  • In teleost fish, the location or even existence of the hippocampus is an area of active debate.

    “In teleost fish, which shared a common ancestor with mammals around 450 million years ago18, the location or even existence of the hippocampus is an area of active debate2,19”

    From A population code for spatial representation in the zebrafish telencephalon (2024) · cites this paper as [2]

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Authors
Briscoe, S. D., & Ragsdale, C. W.
Affiliations
  • Max Planck Institute of Molecular Cell Biology and Genetics (DE)
  • University of Chicago (US)
Corresponding author
Briscoe, Steven D.
ORCID
Venue
Current Biology
Publisher
Elsevier BV
Published
2019-07
Volume
29
Issue
13
Pages
R647-R662
ISSN
0960-9822 (ISSN-L)
DOI
10.1016/j.cub.2019.05.026
PMC
PMC11073819
OpenAlex
W2956452028
Cited by
75
References
204
Citations by year
2026: 5 · 2025: 8 · 2024: 13 · 2023: 12 · 2022: 12 · 2021: 16 · 2020: 6 · 2019: 3
FWCI
0.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • Alexander von Humboldt-Stiftung
  • European Molecular Biology Organization (ALTF 1014-2018)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Physical Sciences › Earth and Planetary Sciences › Paleontology › Evolution and Paleontology Studies
Keywords
neocortex evolution, chordate phylogeny, non-mammalian vertebrates, reptiles, amphibians, Chondrichthyes, cyclostomes, invertebrate chordates, homology, cortical organization, evolutionary innovation, human cognition
MeSH terms
Animals, Biological Evolution, Telencephalon, Chordata

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