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Tracing the Evolutionary Origin of Desmosomes
Open accessAbstract
Cadherin-based cell-cell junctions help metazoans form polarized sheets of cells, which are necessary for the development of organs and the compartmentalization of functions. The components of the protein complexes that generate cadherin-based junctions have ancient origins, with conserved elements shared between animals as diverse as sponges and vertebrates. In invertebrates, the formation and function of epithelial sheets depends on classical cadherin-containing adherens junctions, which link actin to the plasma membrane through α-, β- and p120 catenins. Vertebrates also have a new type of cadherin-based intercellular junction called the desmosome, which allowed for the creation of more complex and effective tissue barriers against environmental stress. While desmosomes have a molecular blueprint that is similar to that of adherens junctions, desmosomal cadherins - called desmogleins and desmocollins - link intermediate filaments (IFs) rather than actin to the plasma membrane through protein complexes comprising relatives of β-catenin (plakoglobin) and p120 catenin (plakophilins). In turn, desmosomal catenins interact with members of the IF-binding plakin family to create the desmosome-IF linking complex. In this Minireview, we discuss when and how desmosomal components evolved, and how their ability to anchor the highly elastic and tough IF cytoskeleton endowed vertebrates with robust tissues capable of not only resisting but also properly responding to environmental stress.
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Desmosomes are an evolutionary innovation of vertebrates and share a conserved role in maintaining epidermal integrity to mechanical stress, including in amphibians.
“Desmosomes are an evolutionary innovation of vertebrates (Green et al., 2020) and share a conserved role in maintaining epidermal integrity to mechanical stress including in amphibians (Bharathan and Dickinson, 2019).”
From Genomic and physiological mechanisms underlying skin plasticity during water to air transition in an amphibious fish (2020) · cites this paper as Green et al., 2020
Desmocollin and desmoglein genes have expanded in the tetrapods, and desmosome genes are subject to selection during re-invasion of aquatic environments in mammals.
“Desmocollin and desmoglein genes have expanded in the tetrapods (Green et al., 2020) and desmosome genes are subject to selection during re-invasion of aquatic environments in mammals (Chikina et al., 2016)”
From Genomic and physiological mechanisms underlying skin plasticity during water to air transition in an amphibious fish (2020) · cites this paper as Green et al., 2020
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- Dong, 2019, Life out of water: genomic and physiological mechanisms underlying skin phenotypic plasticity, bioRxiv
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Dong, Y.-W., Blanchard, T. S., Noll, A., Vasquez, P., Schmitz, J., Kelly, S. P., Wright, P. A., & Whitehead, A. (2020) · Journal of Experimental Biology · doi:10.1242/jeb.235515 · Cited by 18
Metadata
- Authors
- Green, K. J., Roth-Carter, Q., Niessen, C. M., & Nichols, S. A.
- Affiliations
- Northwestern University (US)
- University of Cologne (DE)
- University of Denver (US)
- Corresponding author
- Green, Kathleen J.
- Nichols, Scott A.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 30
- Issue
- 10
- Pages
- R535-R543
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC7310670
- OpenAlex
- W3025035007
- Cited by
- 56
- References
- 50
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 13 · 2023: 9 · 2022: 9 · 2021: 11 · 2020: 4
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 386 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Aeronautics and Space Administration (16-EXO16_2-0041, T32 CA070085)
- Alexander von Humboldt-Stiftung
- Deutsche Forschungsgemeinschaft (73111208 - SFB 829 A1, EXC 2030 – 390661388, NI1234/6-2 – SPP1782)
- National Institutes of Health
- Universität zu Köln
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR041836, R37 AR43380)
- National Cancer Institute (R01 CA228196)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
- Keywords
- desmosomes, desmoglein, desmocollin, intermediate filaments, plakoglobin, plakophilin, adherens junctions, tissue mechanical properties
- MeSH terms
- Animals, Desmosomes, Biological Evolution, Gene Expression Regulation, Membrane Proteins
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