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Cited by 44Neurobiology and Insect Physiology ResearchVisual perception and processing mechanismsNeuroscience and Neuropharmacology Research

Object-Displacement-Sensitive Visual Neurons Drive Freezing in Drosophila

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Tanaka, Ryosuke, Clark, Damon A.·2020·Current Biology
DOI 10.1016/j.cub.2020.04.068PMC PMC8716191
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Abstract

Visual systems are often equipped with neurons that detect small moving objects, which may represent prey, predators, or conspecifics. Although the processing properties of those neurons have been studied in diverse organisms, links between the proposed algorithms and animal behaviors or circuit mechanisms remain elusive. Here, we have investigated behavioral function, computational algorithm, and neurochemical mechanisms of an object-selective neuron, LC11, in Drosophila. With genetic silencing and optogenetic activation, we show that LC11 is necessary for a visual object-induced stopping behavior in walking flies, a form of short-term freezing, and its activity can promote stopping. We propose a new quantitative model for small object selectivity based on the physiology and anatomy of LC11 and its inputs. The model accurately reproduces LC11 responses by pooling fast-adapting, tightly size-tuned inputs. Direct visualization of neurotransmitter inputs to LC11 confirmed the model conjectures about upstream processing. Our results demonstrate how adaptation can enhance selectivity for behaviorally relevant, dynamic visual features.

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  • The results were consistent with previous studies, such as LC11 encoding the position of a small moving spot and LPLC2 encoding loom.

    “Our results were consistent with previous studies, such as LC11 encoding the position of a small moving spot27,28 (Fig. 3g, LC11 has highest R2 for ‘position’ in ‘vary female position’ than in other stimulus sequences) and LPLC2 encoding loom24 (Fig. 3g, LPLC2 has highest R2 for ‘size’ in ‘vary female size’).”

    From Mapping model units to visual neurons reveals population code for social behaviour (2024) · cites this paper as [27]

  • LC11 neurons respond to small, moving spots and contribute to freezing behaviour.

    “LC11 neurons respond to small, moving spots and contribute to freezing behaviour27,28.”

    From Mapping model units to visual neurons reveals population code for social behaviour (2024) · cites this paper as [27]

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Authors
Tanaka, R., & Clark, D. A.
Affiliations
Yale University (US)
Corresponding author
Clark, Damon A.
ORCID
Venue
Current Biology
Publisher
Elsevier BV
Published
2020-07
Volume
30
Issue
13
Pages
2532-2550.e8
ISSN
0960-9822 (ISSN-L)
DOI
10.1016/j.cub.2020.04.068
PMC
PMC8716191
OpenAlex
W3027334868
Cited by
44
References
13
Citations by year
2026: 7 · 2025: 8 · 2024: 9 · 2023: 8 · 2022: 7 · 2021: 4 · 2020: 1
FWCI
2.27
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Alfred P. Sloan Foundation
  • Gruber Foundation
  • National Institutes of Health (R01EY026555, P30EY026878)
  • Richard and Susan Smith Family Foundation
  • E. Matilda Ziegler Foundation for the Blind
  • National Science Foundation (IOS1558103)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
small object detection, Drosophila, visual adaptation, stopping behavior, optogenetic stimulation
MeSH terms
Animals, Drosophila melanogaster, Female, Male, Motion Perception, Neurons, Visual Pathways

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