Breaking a species barrier by enabling hybrid recombination

SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination

Myung, K., Datta, A., Chen, C., & Kolodner, R. D. (2001) · Nature Genetics · doi:10.1038/83673 · Cited by 316 · see citing works

Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase

Zakharyevich, K., Tang, S.-M., Ma, Y.-M., & Hunter, N. (2012) · Cell · doi:10.1016/j.cell.2012.03.023 · Cited by 309 · see citing works

The mismatch repair system contributes to meiotic sterility in an interspecific yeast hybrid.

Hunter, N., Chambers, S. R., Louis, E. J., & Borts, R. H. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00518.x · Cited by 305 · see citing works

Sequence Diversity, Reproductive Isolation and Species Concepts in Saccharomyces

Liti, G., Barton, D. B. H., & Louis, E. J. (2006) · Genetics · doi:10.1534/genetics.106.062166 · Cited by 301 · see citing works

Differential function and expression of Saccharomyces cerevisiae B-type cyclins in mitosis and meiosis.

Grandin, N., & Reed, S. I. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.4.2113 · Cited by 168 · see citing works

A role for the mismatch repair system during incipient speciation in Saccharomyces

Greig, D., Travisano, M., Louis, E. J., & Borts, R. H. (2003) · Journal of Evolutionary Biology · doi:10.1046/j.1420-9101.2003.00546.x · Cited by 104 · see citing works

Chromosomal variation segregates within incipient species and correlates with reproductive isolation

Charron, G., Leducq, J., & Landry, C. R. (2014) · Molecular Ecology · doi:10.1111/mec.12864 · Cited by 97 · see citing works

Understanding how mismatch repair proteins participate in the repair/anti-recombination decision

Chakraborty, U., & Alani, E. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow071 · Cited by 90 · see citing works

A Genome-Wide Analysis Reveals No Nuclear Dobzhansky-Muller Pairs of Determinants of Speciation between S. cerevisiae and S. paradoxus, but Suggests More Complex Incompatibilities

Kao, K. C., Schwartz, K., & Sherlock, G. J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001038 · Cited by 83 · see citing works

The genomic consequences of hybridization

Moran, B. M., Payne, C. Y., Langdon, Q. K., Powell, D. L., Brandvain, Y. J., & Schumer, M. E. (2021) · eLife · doi:10.7554/elife.69016 · Cited by 326 · see citing works

Meiosis: Dances Between Homologs

Zickler, D., & Kleckner, N. E. (2023) · Annual Review of Genetics · doi:10.1146/annurev-genet-061323-044915 · Cited by 175 · see citing works

The evolving species concepts used for yeasts: from phenotypes and genomes to speciation networks

Boekhout, T., Aime, M. C., Begerow, D., Gabaldón, T., Heitman, J., Kemler, M., Khayhan, K., Lachance, M., Louis, E. J., Sun, S., et al. (2021) · Fungal Diversity · doi:10.1007/s13225-021-00475-9 · Cited by 73 · see citing works

Saccharomyces yeast hybrids on the rise

Bendixsen, D. P., Frazão, J. G. F. L., & Stelkens, R. B. (2021) · Yeast · doi:10.1002/yea.3684 · Cited by 35 · see citing works

Mechanisms of Intrinsic Postzygotic Isolation: From Traditional Genic and Chromosomal Views to Genomic and Epigenetic PerspectivesPreprint

Reifová, R., Ament‐Velásquez, S. L., Bourgeois, Y., Coughlan, J. M., Kulmuni, J., Lipinska, A. P., Okude, G., Stevison, L. S., Yoshida, K., & Kitano, J. (2023) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041607 · Cited by 34 · see citing works

The evolutionary and ecological potential of yeast hybrids

Stelkens, R. B., & Bendixsen, D. P. (2022) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2022.101958 · Cited by 24 · see citing works

Sugar‐seeking insects as a source of diverse bread‐making yeasts with enhanced attributes

Madden, A. A., Lahue, C., Gordy, C. L., Little, J. L., Nichols, L. M., Calvert, M. D., Dunn, R. R., & Heil, C. S. (2021) · Yeast · doi:10.1002/yea.3676 · Cited by 24 · see citing works

MSH2 stimulates interfering and inhibits non-interfering crossovers in response to genetic polymorphism

Dluzewska, J., Dzięgielewski, W., Szymańska-Lejman, M., Gazecka, M., Henderson, I. R., Higgins, J. D., & Ziółkowski, P. A. (2023) · Nature Communications · doi:10.1038/s41467-023-42511-z · Cited by 23 · see citing works

Lager Yeast Design Through Meiotic Segregation of a Saccharomyces cerevisiae × Saccharomyces eubayanus Hybrid

Krogerus, K., Magalhães, F., Castillo, S., Gopalacharyulu, P. V., Vidgren, V., Chiara, M. D., Yue, J., Liti, G., & Gibson, B. R. (2021) · Frontiers in Fungal Biology · doi:10.3389/ffunb.2021.733655 · Cited by 22 · see citing works

Meiotic Recognition of Evolutionarily Diverged Homologs: Chromosomal Hybrid Sterility Revisited

Forejt, J., & Jansa, P. (2023) · Molecular Biology and Evolution · doi:10.1093/molbev/msad083 · Cited by 22 · see citing works

Mismatch repair disturbs meiotic crossover control in S. cerevisiae

Harper, J. A., Cooper, T. J., Crawford, M. R., Hunt, L. J., Allison, R. M., Marsolier‐Kergoat, M., Llorente, B., & Neale, M. J. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf1136 · Cited by 21 · see citing works

Genome-scale patterns in the loss of heterozygosity incidence in Saccharomyces cerevisiae

Tutaj, H., Pirog, A., Tomala, K., & Korona, R. (2022) · Genetics · doi:10.1093/genetics/iyac032 · Cited by 20 · see citing works

Evolution and molecular bases of reproductive isolation

Bozdag, G. O., & Ono, J. (2022) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2022.101952 · Cited by 19 · see citing works

Neutralism versus selectionism: Chargaff's second parity rule, revisited

Forsdyke, D. R. (2021) · Genetica · doi:10.1007/s10709-021-00119-5 · Cited by 17 · see citing works

The molecular evolutionary basis of species formation revisited

Frayer, M. E., Robles, N. V., Rodríguez-Barrera, M. J., Coughlan, J. M., & Schumer, M. E. (2025) · Trends in Genetics · doi:10.1016/j.tig.2025.07.003 · Cited by 16 · see citing works

Meiosis in allopolyploid Arabidopsis suecica

Nibau, C., Gonzalo, A., Evans, A., Sweet‐Jones, W., Phillips, D. W., & Lloyd, A. H. (2022) · The Plant Journal · doi:10.1111/tpj.15879 · Cited by 16 · see citing works

Patterns of Genomic Instability in Interspecific Yeast Hybrids With Diverse Ancestries

Bendixsen, D. P., Peris, D., & Stelkens, R. B. (2021) · Frontiers in Fungal Biology · doi:10.3389/ffunb.2021.742894 · Cited by 14 · see citing works

Meiosis through three centuries

Jones, G., Kleckner, N. E., & Zickler, D. (2024) · Chromosoma · doi:10.1007/s00412-024-00822-0 · Cited by 13 · see citing works

Causative genes of intrinsic hybrid incompatibility in animals and plants: what we have learned about speciation from the molecular perspective

Kitano, J., & Okude, G. (2024) · Evolutionary Journal of the Linnean Society · doi:10.1093/evolinnean/kzae022 · Cited by 12 · see citing works

Enforcement of Postzygotic Species Boundaries in the Fungal Kingdom

Chou, J., Hsu, P., & Leu, J. (2022) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00098-22 · Cited by 8 · see citing works

Finding Hybrid Incompatibilities Using Genome Sequences from Hybrid Populations

Blanckaert, A., & Payseur, B. A. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab168 · Cited by 7 · see citing works

Complementary Oligonucleotides Rendered Discordant by Single Base Mutations May Drive Speciation

Forsdyke, D. R. (2021) · Biological Theory · doi:10.1007/s13752-021-00380-z · Cited by 7 · see citing works

A microbial perspective on speciation

Stelkens, R. B. (2024) · Evolutionary Journal of the Linnean Society · doi:10.1093/evolinnean/kzae023 · Cited by 7 · see citing works

Synthetic two-species allodiploid and three-species allotetraploid Saccharomyces hybrids with euploid (complete) parental subgenomes

Antunovics, Z., Szabó, A. M., Heistinger, L., Mattanovich, D., & Sipiczki, M. (2023) · Scientific Reports · doi:10.1038/s41598-023-27693-2 · Cited by 5 · see citing works

Reproductive Isolation due to Divergent Ecological Selection Is Accompanied by Vast Genomic Instability in Experimentally Evolved Yeast Populations

Bendixsen, D. P., Gilchrist, C., Haberkorn, C., Persson, K. O., Geijer, C., Warringer, J., & Stelkens, R. B. (2025) · Molecular Ecology · doi:10.1111/mec.70110 · Cited by 3 · see citing works

Agent-based modeling of nuclear chromosome ensembles identifies determinants of homolog pairing during meiosis

Chriss, A., Börner, G. V., & Ryan, S. D. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011416 · Cited by 3 · see citing works

Does the Pachytene Checkpoint, a Feature of Meiosis, Filter Out Mistakes in Double-Strand DNA Break Repair and as a side-Effect Strongly Promote Adaptive Speciation?

Foe, V. E. (2022) · Integrative Organismal Biology · doi:10.1093/iob/obac008 · Cited by 3 · see citing works

Enhanced flavour profiles through radicicol induced genomic variation in the lager yeasts, Saccharomyces pastorianus

de la Cerda, R., Thompson, G., Zhang, P., Hokamp, K., Roche, F. M., Carlin, S., Vrhovšek, U., & Bond, U. (2022) · Yeast · doi:10.1002/yea.3815 · Cited by 3 · see citing works

Genomic and chromosomal architectures underlying fertility maintenance in the testes of intergeneric homoploid hybrids

Ren, L., Zeng, Y., Liu, Q., Tu, X., Chen, F., Wu, H., Wang, C., Wu, C., Luo, M., Tai, Y., et al. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2868-y · Cited by 2 · see citing works

Homologous recombination counteracts mismatch repair to promote fertility and genetic diversity

Wang, T., & Liao, J.-L. (2025) · Trends in Genetics · doi:10.1016/j.tig.2025.10.009 · Cited by 2 · see citing works

Pervasive weak incompatibilities shape phenotypic variation and genome evolution in yeast hybrids

Martínez, A. A., & Lang, G. I. (2026) · Nature Communications · doi:10.1038/s41467-026-77469-1 · Cited by 2 · see citing works

Recruiting Distant Hybridization for Reshaping Meiotic Recombination

Rabbani, M. T., & Nayak, G. (2023) · Plant Breeding and Biotechnology · doi:10.9787/pbb.2023.11.3.168 · Cited by 2 · see citing works

The recombination landscape of introgression in yeast

Schwarzkopf, E. J., Brandt, N. J., & Heil, C. S. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011585 · Cited by 2 · see citing works

Rad51, Rad54, and ZMM proteins antagonize the mismatch repair system to promote fertility of budding yeast intraspecies hybrid zygotes

Hung, Y.-L., Chuang, C.-N., Kim, H.-X., Liu, H.-C., Yao, J.-S., Jovanska, L., Hsueh, Y., Chen, R.-S., & Wang, T. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf847 · Cited by 2 · see citing works

Adaptive benefits of hybridization in Saccharomyces yeast are constrained by genomic background and depend on temperature

Haberkorn, C., Gettle, N., Elsen, J., Medina-Chávez, N. O., Sivigny, J., Baselga‐Cervera, B., Greig, D., Travisano, M., Saxer, G., & Stelkens, R. B. (2026) · Evolution · doi:10.1093/evolut/qpag108 · Cited by 1 · see citing works

Improved genotype inference reveals cis- and trans-driven variation in the loss-of-heterozygosity rates in yeast

Overton, M. S., & Kryazhimskiy, S. (2025) · Genetics · doi:10.1093/genetics/iyaf274 · Cited by 1 · see citing works

Mapping Species Birth Across the Recombination Landscapes of Marine Snails

Giles, E. C., Laso‐Jadart, R., Ortíz-Barrientos, D., Carimán, P., Delrieu‐Trottin, E., Guillemin, M., Mona, S., Pochon, X., & Saenz‐Agudelo, P. (2025) · Molecular Ecology · doi:10.1111/mec.70108 · Cited by 1 · see citing works

Bateson’s Residue: Oligonucleotide Disharmony May Drive Speciation

Cock, A. G., & Forsdyke, D. R. (2022) · Springer eBooks · doi:10.1007/978-3-030-92099-9_29

Reviewer #2 (Public Review): The recombination landscape of introgression in yeast

(2024) · eLife · doi:10.7554/elife.96184.1.sa1

Reviewer #3 (Public review): The recombination landscape of introgression in yeast

(2024) · eLife · doi:10.7554/elife.96184.2.sa1

The role of mitotype variation and positive epistasis in trait differences between Saccharomyces species

Wang, J.-T. J., Ng, P. L. P., Powers, M. E., Rha, C. H., & Brem, R. B. (2025) · Genetics · doi:10.1093/genetics/iyaf233

Simulations reveal hybridization in Caribbean Acropora restoration poses low risk of genetic swamping but limited potential for adaptive introgressionPreprint

LaPolice, T. M., Howe, C. N., Locatelli, N. S., & Huber, C. D. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.26.708281

Interspecific hybrid and backcross between two crucian carp causing expression imbalances of SINE allelic genes

Zhu, Y., Wang, Y., Zeng, Y., Wang, J., Zhou, Y., Wang, C., & Liu, D. (2026) · Aquaculture · doi:10.1016/j.aquaculture.2026.743969

The Role of the Msh2 Mismatch Repair Gene in the Prdm9-Driven Hybrid Male Sterility in the House Mouse

Fusek, K., Jansa, P., & Forejt, J. (2026) · Genes · doi:10.3390/genes17070795

Engineering recombination between diverged yeast species reveals genetic incompatibilitiesPreprint

Bozdag, G. O., Ono, J., Denton, J. A., Karakoç, E., Hunter, N., Leu, J., & Greig, D. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/755165 · Cited by 11 · see citing works

Spore-autonomous fluorescent protein expression identifies meiotic chromosome mis-segregation as the principal cause of hybrid sterility in yeast

Rogers, D. W., McConnell, E., Ono, J., & Greig, D. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005066 · Cited by 46 · see citing works

A Saccharomyces paradox: chromosomes from different species are incompatible because of anti-recombination, not because of differences in number or arrangement

Ono, J., & Greig, D. (2019) · Current Genetics · doi:10.1007/s00294-019-01038-x · Cited by 11 · see citing works

Reproductive isolation in Saccharomyces

Greig, D. (2008) · Heredity · doi:10.1038/hdy.2008.73 · Cited by 113 · see citing works

Meiotic null MSH2 and SGS1 alleles in S. cerevisiae x S. uvarum hybrids result in near-haploid offspring with mixed parental chromosomal inheritancePreprint

Wang, T., & Dunham, M. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.02.657486