The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Integrin adhesion complexes
Open accessAbstract
Tissue architecture and function are orchestrated by an intricate repertoire of cellular adhesion and signalling receptors, and by the surrounding extracellular matrix (ECM). The essential role of cell-tissue interactions in guiding organogenesis was identified in experimental embryology studies over a century ago, and in 1954 Grobstein laid down the fundamental concept of ECM being the ultimate integrator of cellular systems. Long before the main cell adhesion receptors were identified, Abercrombie and colleagues proposed in 1971 that cell attachment to the ECM substratum was mediated through electron-dense plaques containing longitudinal cytoplasmic filaments that localise to areas of the ventral cell membrane that lie close to the substratum. In 1982, Bissell and co-workers proposed "the minimum required unit for expression of tissue specific functions", a model depicting a structure in which the nucleus links to the ECM via cytoskeletal filament bundles that connect to a hypothetical transmembrane ECM adhesion receptor.
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Cellular adhesion strength is often modulated by integrin binding to ECM ligands, which is mediated by actin-talin coupling and focal adhesions.
“Cellular adhesion strength is often modulated by integrin binding to ECM ligands, which is mediated by actin-talin coupling and focal adhesions [60, 61].”
Citations
Cites
Every step of the way: integrins in cancer progression and metastasis
Hamidi, H., & Ivaska, J. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0038-z · Cited by 1,493
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Research works printed but not linked: 15
- Chastney, 2020, Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation, J. Cell Biol., 219, e202003038, 10.1083/jcb.202003038 · DOI
- Conway, 2019, Cell matrix adhesion in cell migration, Essays Biochem, 63, 535, 10.1042/EBC20190012 · DOI
- Couchman, 2003, Syndecans: proteoglycan regulators of cell-surface microdomains?, Nat. Rev. Mol. Cell Biol., 4, 926, 10.1038/nrm1257 · DOI
- Ezratty, 2005, Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase, Nat. Cell Biol., 7, 581, 10.1038/ncb1262 · DOI
- Green, 2019, Integrin intracellular machinery in action, Exp. Cell Res., 378, 226, 10.1016/j.yexcr.2019.03.011 · DOI
- Hoffmann, 2014, Symmetric exchange of multi-protein building blocks between stationary focal adhesions and the cytosol, eLife, 3, e02257, 10.7554/eLife.02257 · DOI
- Horton, 2015, Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly, Nat. Cell Biol., 17, 1577, 10.1038/ncb3257 · DOI
- Kanchanawong, 2010, Nanoscale architecture of integrin-based cell adhesions, Nature, 468, 580, 10.1038/nature09621 · DOI
- Kechagia, 2019, Integrins as biomechanical sensors of the microenvironment, Nat. Rev. Mol. Cell Biol., 20, 457, 10.1038/s41580-019-0134-2 · DOI · Paper page
- Lock, 2019, Clathrin-containing adhesion complexes, J. Cell Biol., 218, 2086, 10.1083/jcb.201811160 · DOI
- López-Ceballos, 2016, In vivo regulation of integrin turnover by outside-in activation, J. Cell Sci., 129, 2912, 10.1242/jcs.190256 · DOI
- Michael, 2020, New perspectives on integrin-dependent adhesions, Curr. Opin. Cell Biol., 63, 31, 10.1016/j.ceb.2019.12.008 · DOI
- Moreno-Layseca, 2019, Integrin trafficking in cells and tissues, Nat. Cell Biol., 21, 122, 10.1038/s41556-018-0223-z · DOI
- Schiller, 2013, β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments, Nat. Cell Biol., 15, 625, 10.1038/ncb2747 · DOI
- Spiess, 2018, Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions, J. Cell Biol., 217, 1929, 10.1083/jcb.201707075 · DOI
Cited by
Sorted by citations
Park, J., Soh, H., Jang, Y.-K., Lee, Y. S., Lee, M.-K., Kim, H., Kim, T.-H., Alkhelaifi, K., Kim, T.-J., & Lee, J. K. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04760-1 · Cited by 3
Trusting the forces of our cell lines
Moro-López, M., Farré, R., Otero, J., & Sunyer, R. (2024) · Cells & Development · doi:10.1016/j.cdev.2024.203931 · Cited by 2
Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling
Sipilä, T., Ponna, S. K., Venkatesha Murthy, A., Pink, A., Enkavi, G., Bohra, S. K., Lewna, K., Ganesh, K., Liu, Q., Korhonen, M., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci190552
“Whereas active ECM-bound β 1 -integrins are well characterized for their signaling via adhesion complexes on the basolateral cell surface, the localization of inactive β 1 -integrins in ECs remains less well understood (33).”
Self-citation
Metadata
- Authors
- Chastney, M. R., Conway, J. R. W., & Ivaska, J.
- Affiliations
- Åbo Akademi University (FI)
- Corresponding author
- Ivaska, Johanna
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 31
- Issue
- 10
- Pages
- R536-R542
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W3164962028
- Cited by
- 159
- References
- 1
- Citations by year
- 2026: 43 · 2025: 42 · 2024: 33 · 2023: 26 · 2022: 12 · 2021: 3
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 391 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Academy of Finland
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- integrin adhesion complexes, cell adhesion, extracellular matrix, cell-matrix interactions, cell attachment, cytoskeletal filaments, cell adhesion receptors, tissue structure, organogenesis, integrin signaling
- MeSH terms
- Carrier Proteins, Cell Adhesion, Cell Membrane, Cytoskeleton, Extracellular Matrix, Humans, Integrins
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