Cited by 238Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesMemory and Neural Mechanisms

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Dopamine release in the nucleus accumbens core signals perceived saliency

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Kutlu, Munir Gunes, Zachry, Jennifer E., Melugin, Patrick R., Cajigas, Stephanie A., Chevee, Maxime F., Kelly, Shannon J., Kutlu, Banu, Tian, Lin, Siciliano, Cody A., Calipari, Erin S.·2021·Current Biology

DOI 10.1016/j.cub.2021.08.052PMC PMC9084920

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Abstract

A large body of work has aimed to define the precise information encoded by dopaminergic projections innervating the nucleus accumbens (NAc). Prevailing models are based on reward prediction error (RPE) theory, in which dopamine updates associations between rewards and predictive cues by encoding perceived errors between predictions and outcomes. However, RPE cannot describe multiple phenomena to which dopamine is inextricably linked, such as behavior driven by aversive and neutral stimuli. We combined a series of behavioral tasks with direct, subsecond dopamine monitoring in the NAc of mice, machine learning, computational modeling, and optogenetic manipulations to describe behavior and related dopamine release patterns across multiple contingencies reinforced by differentially valenced outcomes. We show that dopamine release only conforms to RPE predictions in a subset of learning scenarios but fits valence-independent perceived saliency encoding across conditions. Here, we provide an extended, comprehensive framework for accumbal dopamine release in behavioral control.

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Authors: Kutlu, M. G., Zachry, J. E., Melugin, P. R., Cajigas, S. A., Chevee, M. F., Kelly, S. J., Kutlu, B., Tian, L., Siciliano, C. A., & Calipari, E. S.
Affiliations: Vanderbilt University (US)
Pennsylvania State University (US)
University of California, Davis (US)
Corresponding author: Calipari, Erin S.
ORCID: Kutlu, Munir Gunes
Zachry, Jennifer E.
Melugin, Patrick R.
Cajigas, Stephanie A.
Chevee, Maxime F.
Tian, Lin
Siciliano, Cody A.
Calipari, Erin S.
Venue: Current Biology
Publisher: Elsevier BV
Published: 2021-11
Volume: 31
Issue: 21
Pages: 4748-4761.e8
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2021.08.052
PMC: PMC9084920
OpenAlex: W3199237971
Cited by: 238
References: 84
Citations by year: 2026: 33 · 2025: 64 · 2024: 64 · 2023: 47 · 2022: 25 · 2021: 4
FWCI: 16.11
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 372 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (5dp1da048931-05, KL2TR002245)
National Institute on Drug Abuse (K99DA045103, F31DA031533, K99DA042111, DP1-DA048931, R00DA042111, R00DA045103, R01DA052317)
National Institute of General Medical Sciences (T32GM007628, T32GM007347, T32GM152284)
National Center for Advancing Translational Sciences
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD103537)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: dopamine release, nucleus accumbens core, reward prediction error, valence, aversive stimuli, neutral stimuli, dopaminergic pathways, reinforcement learning, behavioral control
MeSH terms: Animals, Cues, Dopamine, Nucleus Accumbens, Reward, Mice, Optogenetics

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Dopamine release in the nucleus accumbens core signals perceived saliency

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