The role of cytokines in the pathogenesis of rheumatoid arthritis – Practical and potential application of cytokines as biomarkers and targets of personalized therapy
Abstract
Rheumatoid arthritis (RA), as a common chronic disease leading to severe disability, requires early diagnosis and introduction of proper treatment. Deregulation in the cytokine network plays an undoubtedly crucial role in the pathogenesis of RA. The understanding of the role of cytokines in RA can be used for patients' benefit. Technological advances had already allowed introduction of the tailor-made cytokine-targeted therapies (so far anti-TNF, anti-IL-1 and anti-IL-6) into clinical practice. This type of treatment is currently developing very fast. Moreover, cytokines are considered to be potential powerful biomarkers of RA with roles predicted to grow in the future. Detailed understanding of the cytokine balance in RA may assist both the diagnostic process and therapy.
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Multiplex immunoassays permit more general profiling but suffer from cross-reactivity and matrix effects, whereas ELISAs offer sensitivity and specificity for particular cytokines.
“Multiplex immunoassays permit more general profiling but suffer from cross-reactivity and matrix effects, whereas ELISAs offer sensitivity and specificity for particular cytokines [52].”
From Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease (2025) · cites this paper as [52]
Cites
The Pathogenesis of Rheumatoid Arthritis
McInnes, I. B., & Schett, G. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1004965 · Cited by 5,514 · see citing works
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Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases
Leyva-López, N., Gutierrez-Grijalva, E., Ambriz-Perez, D., & Heredia, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060921 · Cited by 337 · see citing works
Bhattaram, P., & Chandrasekharan, U. (2017) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2016.05.009 · Cited by 136 · see citing works
Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease
Kumar, R., Sporn, K., Borole, A., Khanna, A., Gowda, C., Paladugu, P., Ngo, A., Jagadeesan, R., Zaman, N., & Tavakkoli, A. (2025) · Diagnostics · doi:10.3390/diagnostics15111418 · Cited by 10 · see citing works
“Multiplex immunoassays permit more general profiling but suffer from cross-reactivity and matrix effects, whereas ELISAs offer sensitivity and specificity for particular cytokines [52].”
- Authors
- Brzustewicz, E., & Bryl, E.
- Corresponding author
- Bryl, Ewa
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 76
- Issue
- 2
- Pages
- 527-536
- ISSN
- 1043-4666 (ISSN-L)
- OpenAlex
- W1209106218
- Cited by
- 196
- References
- 1
- Citations by year
- 2026: 8 · 2025: 20 · 2024: 15 · 2023: 11 · 2022: 15 · 2021: 19 · 2020: 24 · 2019: 16 · 2018: 20 · 2017: 25 · 2016: 21 · 2015: 1 · 2014: 1
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- The Polish National Science Centre (N N402 640440)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- rheumatoid arthritis, cytokines, cytokine biomarkers, personalized treatment, cytokine-targeted therapy, anti-TNF therapy, anti-IL-1 therapy, IL-6 inhibition, pathogenesis, early diagnosis
- MeSH terms
- Antibodies, Monoclonal, Arthritis, Rheumatoid, Humans, Biomarkers, Cytokines, Precision Medicine
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