Cited by 147Tryptophan and brain disordersPsoriasis: Treatment and PathogenesisNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

IL-17A causes depression-like symptoms via NFκB and p38MAPK signaling pathways in mice: Implications for psoriasis associated depression

Nadeem, Ahmed, Ahmad, Sheikh F., Al-Harbi, Naif O., Fardan, Ali S., El-Sherbeeny, Ahmed M., Ibrahim, Khalid E., Attia, Sabry M.·2017·Cytokine

DOI 10.1016/j.cyto.2017.05.018

Open this paper in CoChat — free account

Abstract

Psoriasis has been shown to be associated with an increased prevalence of comorbid major depression. IL-17A plays an important role in both depression and psoriasis. IL-17A has been shown to be elevated in systemic circulation of psoriatic patients. IL-17A released from different immune cells during psoriasis may be responsible for the development of neuropsychiatric symptoms associated with depression. Therefore, this study explored the association of systemic IL-17A with depression. The present study utilized imiquimod model of psoriatic inflammation as well as IL-17A administration in mice to investigate the effect of IL-17A on depression-like behavior. Psoriatic inflammation led to enhanced IL-17A expression in peripheral immune cells of both innate and adaptive origin. This was associated with increased NFκB/p38MAPK signaling and inflammatory mediators in different brain regions, and depression-like symptoms (as reflected by sucrose preference and tail suspension tests). The role of IL-17A was further confirmed by administering it alone for ten days, followed by assessment of the same parameters. IL-17A administration produced effects similar to psoriasis-like inflammation on neurobehavior and NFκB/p38MAPK pathways. Moreover, both NFκB and p38MAPK inhibitors led to attenuation in IL-17A associated with depression-like behavior via reduction in inflammatory mediators, such as MCP-1, iNOS, IL-6, and CXCL-2. Furthermore, anti-IL17A antibody also led to a reduction in imiquimod-induced depression-like symptoms, as well as NFκB/p38MAPK signaling. The present study shows that IL-17A plays an important role in comorbid depression associated with psoriatic inflammation, where both NFκB and p38MAPK pathways play significant roles via upregulation of inflammatory mediators in the brain.

Integrity signals

Registry

Crossref · 10.1016/j.cyto.2017.05.018

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848
The tail suspension test: A new method for screening antidepressants in mice
Steru, L., Chermat, R., Thierry, B., & Simon, P. (1985) · Psychopharmacology · doi:10.1007/bf00428203 · Cited by 3,534
Psoriasis
Boehncke, W., & Schön, M. P. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61909-7 · Cited by 2,609
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759
Immunology of Psoriasis
Lowes, M. A., Suárez‐Fariñas, M., & Krueger, J. G. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120225 · Cited by 1,710
Structure and signalling in the IL-17 receptor family
Gaffen, S. L. (2009) · Nature reviews. Immunology · doi:10.1038/nri2586 · Cited by 1,475
Cytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365

Show all 54 references

Sorted by citations

The Bidirectional Relationship of Depression and Inflammation: Double Trouble
Beurel, E., Toups, M., & Nemeroff, C. B. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.002 · Cited by 2,136
Th17 cells in depression
Beurel, E., & Lowell, J. A. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.08.001 · Cited by 187
IL-17A contributes to perioperative neurocognitive disorders through blood-brain barrier disruption in aged mice
Ni, P., Dong, H., Wang, Y., Zhou, Q., Xu, M., Qian, Y., & Sun, J. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1374-3 · Cited by 160
Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice
Kim, J., Suh, Y.-H., & Chang, K.-A. (2021) · Molecular Brain · doi:10.1186/s13041-020-00726-x · Cited by 116
Insights into hidradenitis suppurativa
van Straalen, K. R., Prens, E. P., & Gudjonsson, J. E. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.02.003 · Cited by 109
Th17 cells and inflammation in neurological disorders: Possible mechanisms of action
Shi, Y., Wei, B., Li, L., Wang, B., & Sun, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.932152 · Cited by 108
Roles of Infection in Psoriasis
Zhou, S., & Yao, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136955 · Cited by 95
Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease‐associated psychological morbidity
Bain, K. A., McDonald, E., Moffat, F., Tutino, M., Castelino, M., Barton, A. C., Cavanagh, J., Ijaz, U. Z., Siebert, S., McInnes, I. B., et al. (2019) · British Journal of Dermatology · doi:10.1111/bjd.18008 · Cited by 98
Dysregulation of the gut-brain-skin axis and key overlapping inflammatory and immune mechanisms of psoriasis and depression
Wang, X., Li, Y., Wu, L., Xiao, S., Ji, Y., Tan, Y., Jiang, C., & Zhang, G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111065 · Cited by 95
Nrf2 activator, sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signaling and rectification of oxidant-antioxidant imbalance in periphery and brain of BTBR T+tf/J mice
Nadeem, A., Ahmad, S. F., Al-Harbi, N. O., Attia, S. M., Bakheet, S. A., Ibrahim, K. E., Alqahtani, F., & Alqinyah, M. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.031 · Cited by 92
Self-citation
The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders
Dionysopoulou, S., Charmandari, E., Bargiota, Α., Vlahos, N., Mastorakos, G. P., & Valsamakis, G. (2021) · Nutrients · doi:10.3390/nu13020498 · Cited by 91
Environmental endocrine disruptor Bisphenol A induces metabolic derailment and obesity via upregulating IL-17A in adipocytes
Hong, X., Zhou, Y. M., Zhu, Z., Li, Y., Zuo, L., Zhang, Y., Hu, X., Zhu, F., Wang, Y., Fang, M., et al. (2023) · Environment International · doi:10.1016/j.envint.2023.107759 · Cited by 85
Review of microbiota gut brain axis and innate immunity in inflammatory and infective diseases
Yuan, C., He, Y., Xie, K., Feng, L., Gao, S., & Cai, L. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1282431 · Cited by 87
A systematic review on shared biological mechanisms of depression and anxiety in comorbidity with psoriasis, atopic dermatitis, and hidradenitis suppurativa
Fabrazzo, M., Cipolla, S., Signoriello, S., Camerlengo, A., Calabrese, G., Giordano, G. M., Argenziano, G., & Galderisi, S. (2021) · European Psychiatry · doi:10.1192/j.eurpsy.2021.2249 · Cited by 81
Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin
Corrigan, M., O’Rourke, A. M., Moran, B., Fletcher, J. M., & Harkin, A. (2023) · Neuronal Signaling · doi:10.1042/ns20220054 · Cited by 81
Long-term effectiveness and safety of secukinumab for treatment of refractory mucosal and articular Behçet's phenotype: a multicentre study
Fagni, F., Bettiol, A., Talarico, R., Lopalco, G., Silvestri, E., Urban, M. L., Russo, P., Scala, G. D., Emmi, G., & Prisco, D. (2020) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2020-217108 · Cited by 73
Advances in the study of IL-17 in neurological diseases and mental disorders
Lu, Y., Zhang, P., Xu, F., Zheng, Y., & Zhao, H. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1284304 · Cited by 71
Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety
Lee, B., Kwon, J.-T., Jeong, Y., Caris, H., Oh, D., Feng, M., Mejia, I. D., Zhang, X., Ishikawa, T., Watson, B. R., et al. (2025) · Cell · doi:10.1016/j.cell.2025.03.005 · Cited by 74
Assessing and Improving Psychological Well-Being in Psoriasis: Considerations for the Clinician
Blackstone, B., Patel, R., & Bewley, A. (2022) · Psoriasis Targets and Therapy · doi:10.2147/ptt.s328447 · Cited by 69
Distinct characteristics of hippocampal pathogenic th17 cells in a mouse model of depression
Beurel, E., Lowell, J. A., & Jope, R. S. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.04.012 · Cited by 65
Increased oxidative stress in the cerebellum and peripheral immune cells leads to exaggerated autism-like repetitive behavior due to deficiency of antioxidant response in BTBR T + tf/J mice
Nadeem, A., Ahmad, S. F., Al-Harbi, N. O., Attia, S. M., Alshammari, M. A., Alzahrani, K. S., & Bakheet, S. A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.09.012 · Cited by 65
Self-citation
The Risk of Systemic Diseases in Those with Psoriasis and Psoriatic Arthritis: From Mechanisms to Clinic
Woo, Y. R., Park, C. J., Kang, H., & Kim, J. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197041 · Cited by 64
Targeting the Adaptive Immune System in Depression: Focus on T Helper 17 Cells
Beurel, E., Medina-Rodriguez, E. M., & Jope, R. S. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000256 · Cited by 60
The role of Th17 cells in the pathophysiology of pregnancy and perinatal mood and anxiety disorders
Osborne, L. M., Brar, A., & Klein, S. L. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.11.015 · Cited by 62
Oxidative and inflammatory mediators are upregulated in neutrophils of autistic children: Role of IL-17A receptor signaling
Nadeem, A., Ahmad, S. F., Attia, S. M., AL-Ayadhi, L. Y., Bakheet, S. A., & Al-Harbi, N. O. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.12.002 · Cited by 63
Long‐term safety profile of ixekizumab in patients with moderate‐to‐severe plaque psoriasis: an integrated analysis from 11 clinical trials
Langley, R. G. B., Kimball, A. B., Nak, H., Xu, W., Pangallo, B. A., Osuntokun, O. O., Agada, N. O., & Reich, K. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15242 · Cited by 61
UV irradiation to mouse skin decreases hippocampal neurogenesis and synaptic protein expression via HPA axis activation
Han, M., Ban, J.-J., Bae, J.-S., Shin, C.-Y., Lee, D. H., & Chung, J. H. (2017) · Scientific Reports · doi:10.1038/s41598-017-15773-z · Cited by 54
Depression and Obesity in Patients With Psoriasis and Psoriatic Arthritis: Is IL-17-Mediated Immune Dysregulation the Connecting Link?
Zafiriou, E., Daponte, A., Siokas, V., Tsigalou, C., Dardiotis, E., & Bogdanos, D. P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.699848 · Cited by 77
Immunotherapy for depression: Recent insights and future targets
Bai, Y., Cai, Y., Chang, D., Li, D., Huo, X., & Zhu, T. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108624 · Cited by 56
The Prevalent Comorbidome at the Onset of Psoriasis Diagnosis
Buja, A., Miatton, A., Cozzolino, C., Brazzale, A. R., Bue, R. L., Mercuri, S. R., Proft, F. N., Kridin, K., Cohen, A. D., & Damiani, G. B. (2023) · Dermatology and Therapy · doi:10.1007/s13555-023-00986-0 · Cited by 50
Dysregulated enzymatic antioxidant network in peripheral neutrophils and monocytes in children with autism
Nadeem, A., Ahmad, S. F., Attia, S. M., AL-Ayadhi, L. Y., Al-Harbi, N. O., & Bakheet, S. A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.08.020 · Cited by 50
Self-citation
Mechanisms and Therapeutic Targets of Depression After Intracerebral Hemorrhage
Wu, Y., Wang, L., Hu, K., Yu, C., Zhu, Y., Zhang, S., & Shao, A. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00682 · Cited by 49
Psoriasis and suicidality: A review of the literature
Liang, S. E., Cohen, J. M., & Ho, R. S. (2018) · Dermatologic Therapy · doi:10.1111/dth.12771 · Cited by 49
Repeated social defeat stress induces neutrophil mobilization in mice: maintenance after cessation of stress and strain‐dependent difference in response
Ishikawa, Y., Kitaoka, S., Kawano, Y., Ishii, S., Suzuki, T., Wakahashi, K., KATO, T., Katayama, Y., & Furuyashiki, T. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15203 · Cited by 50
Circulating T helper 17 and IFN-γ positive Th17 cells in Major Depressive Disorder
Ghosh, R., Kumar, P. K., Mitra, P., Purohit, P., Nebhinani, N., & Sharma, P. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112811 · Cited by 47
The Cytokine IL-17A as a Marker of Treatment Resistance in Major Depressive Disorder?
Nothdurfter, C., Milenkovic, V. M., Sarubin, N., Hilbert, S., Manook, A., Weigl, J., Almeqbaali, K., Wetzel, C. H., Rupprecht, R., & Baghai, T. C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14636 · Cited by 38
The Mind Body Connection in Dermatologic Conditions: A Literature Review
Mar, K., & Rivers, J. K. (2023) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/12034754231204295 · Cited by 54
Formononetin improves cardiac function and depressive behaviours in myocardial infarction with depression by targeting GSK-3β to regulate macrophage/microglial polarization
Yang, Y., Huang, T., Zhang, H., Li, X., Shi, S., Tian, X., Huang, Z., Zhang, R., Liu, Z., & Cheng, Y. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154602 · Cited by 46
Modulation of neuroimmune cytokine networks by antidepressants: implications in mood regulation
Nava, R. G., Adri, A. S., Filgueiras, I. S., Nóbile, A. L., Barcelos, P. M., Corrêa, Y. L. G., de Oliveira, S. F., Cabral‐Miranda, G., Dias, H. D., Schimke, L. F., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03532-y · Cited by 53
Exploration of the mechanism by which icariin modulates hippocampal neurogenesis in a rat model of depression
Yan, C., Wu, L., Zeng, N.-X., Li, H., Wang, H., Liu, K., Gong, X., & Luo, W.-L. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.320993 · Cited by 44
Molecular pathways underlying lung-brain axis signaling in asthma: Relevance for psychopathology and neuroinflammation
Dill‐McFarland, K. A., Altman, M. C., Esnault, S. J., Jarjour, N. N., Busse, W. W., & Rosenkranz, M. A. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.07.025 · Cited by 44
Major depression accompanied with inflammation and multiple cytokines alterations: Evidences from clinical patients to macaca fascicularis and LPS-induced depressive mice model
He, Y., Li, W., Wang, Y., Tian, Y., Chen, X., Wu, Z., Lan, T., Li, Y., Bai, M., Liu, J., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.131 · Cited by 46
The Role of Inflammation in the Pathophysiology of Depression and Suicidal Behavior
Serafini, G., Costanza, A., Aguglia, A., Amerio, A., Trabucco, A., Escelsior, A., Sher, L., & Amore, M. (2022) · Medical Clinics of North America · doi:10.1016/j.mcna.2022.09.001 · Cited by 48
Th17 Cells in Depression: Are They Crucial for the Antidepressant Effect of Ketamine?
Cui, M., Dai, W., Kong, J., & HongZhi, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.649144 · Cited by 38
Hidradenitis Suppurativa Burdens on Mental Health: A Literature Review of Associated Psychiatric Disorders and Their Pathogenesis
Caccavale, S., Tancredi, V., Boccellino, M. P., Babino, G., Fulgione, E., & Argenziano, G. (2023) · Life · doi:10.3390/life13010189 · Cited by 39
Chronic stress predisposes to the aggravation of inflammation in autoimmune diseases with focus on rheumatoid arthritis and psoriasis
Chaudhary, R., Prasad, A., Agarwal, V., Rehman, M., Kumar, A., Kaushik, A. S., Srivastava, S., Srivastava, S., & Mishra, V. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111046 · Cited by 40
Th17 Cells, Glucocorticoid Resistance, and Depression
Khantakova, J. N., Mutovina, A., Ayriyants, K. A., & Bondar, N. P. (2023) · Cells · doi:10.3390/cells12232749 · Cited by 36
New Frontiers in Psoriatic Disease Research, Part II: Comorbidities and Targeted Therapies
Yan, D., Blauvelt, A., Dey, A. K., Golpanian, R. S., Hwang, S. T., Mehta, N. N., Myers, B. A., Shi, Z., Yosipovitch, G., Bell, S. J., et al. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.02.743 · Cited by 35
T helper cells in depression: central role of Th17 cells
Ghosh, R., Mitra, P., Kumar, P. V. S. N. K., Goyal, T., & Sharma, P. (2021) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2021.1965535 · Cited by 37
Proinflammatory cytokines and neuropeptides in psoriasis, depression, and anxiety
Keenan, E. L., & Granstein, R. D. (2025) · Acta Physiologica · doi:10.1111/apha.70019 · Cited by 39
Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights
Kulkarni, N. P., Vaidya, B., Narula, A. S., & Sharma, S. S. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210608165509 · Cited by 31
IL-17A-induced neutrophilic airway inflammation is mediated by oxidant-antioxidant imbalance and inflammatory cytokines in mice
Nadeem, A., Al-Harbi, N. O., Alfardan, A. S., Ahmad, S. F., Alasmari, A. F., & Al‐Harbi, M. M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.123 · Cited by 31
Self-citation
Effects of cytokines on nuclear factor-kappa B, cell viability, and synaptic connectivity in a human neuronal cell line
Matelski, L., Morgan, R. K., Grodzki, A. C., de Water, J. V., & Lein, P. J. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0647-2 · Cited by 31
Decryption of Active Constituents and Action Mechanism of the Traditional Uighur Prescription (BXXTR) Alleviating IMQ-Induced Psoriasis-Like Skin Inflammation in BALB/c Mice
Pang, X., Zhang, K., Huang, J. M., Wang, H., Gao, L., Wang, T., Sun, Y., Chen, L., & Wang, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071822 · Cited by 30
Protease activated receptor-2 mediated upregulation of IL-17 receptor signaling on airway epithelial cells is responsible for neutrophilic infiltration during acute exposure of house dust mite allergens in mice
Nadeem, A., Al-Harbi, N. O., Ahmad, S. F., Ibrahim, K. E., Alotaibi, M. R., Siddiqui, N. M., AlSharari, S. D., Attia, S. M., & Al-Harbi, M. M. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.03.001 · Cited by 29
Self-citation
The histamine H3R and dopamine D2R/D3R antagonist ST-713 ameliorates autism-like behavioral features in BTBR T+tf/J mice by multiple actions
Venkatachalam, K., Eissa, N., Awad, M. A., Jayaprakash, P., Zhong, S., Stölting, F., Stark, H., & Sadek, B. S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111517 · Cited by 30
Angelica Yinzi alleviates 1-chloro-2,4-dinitrobenzene-induced atopic dermatitis by inhibiting activation of NLRP3 inflammasome and down-regulating the MAPKs/NF-kB signaling pathway
Liu, W., Song, W., Luo, Y., Dan, H., Li, L., Zhang, Z., Zhou, D., & You, P. (2022) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2022.07.003 · Cited by 25
Acetyl-11-keto-β-boswellic acid improves clinical symptoms through modulation of Nrf2 and NF-κB pathways in SJL/J mouse model of experimental autoimmune encephalomyelitis
Nadeem, A., Ahmad, S. F., Al-Harbi, N. O., Sarawi, W. S., Attia, S. M., Alanazi, W. A., Ibrahim, K. E., Alsanea, S., Alqarni, S. A., Alfardan, A. S., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108703 · Cited by 26
Self-citation
Investigating the correlation between mucus cytokine levels, inflammatory cell counts, and baseline quality‐of‐life measures in chronic rhinosinusitis
Chowdhury, N. I., Chandra, R. K., Li, P., Ely, K., & Turner, J. H. (2019) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22287 · Cited by 24
Graves’ disease as a driver of depression: a mechanistic insight
Song, Y., Wang, X., Ma, W., Yang, Y., Yan, S., Sun, J., Zhu, X., & Tang, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1162445 · Cited by 26
Alleviation of cisplatin-induced neuropathic pain, neuronal apoptosis, and systemic inflammation in mice by rapamycin
Alotaibi, M. R., Alaqil, F. A., Alqahtani, F., Alanazi, M., Nadeem, A., Ahmad, S. F., Lapresa, R., Alharbi, M., Alshammari, A., Alotaibi, M., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.891593 · Cited by 23
Self-citation
Association of Psoriasis With Anxiety and Depression: A Case–Control Study in Chinese Patients
Jing, D., Xiao, H., Shen, M., Chen, X., Han, X., Kuang, Y., Zhu, W., & Xiao, Y. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.771645 · Cited by 20
Th17-cells in depression: Implication in multiple sclerosis
Melnikov, M., & Lopatina, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1010304 · Cited by 20
Optimization of psoriasis mouse models
Karamani, C., Antoniadou, I. T., Dimou, A., Andreou, E., Kostakis, G. E., Sideri, A., Vitsos, A., Gkavanozi, A., Sfiniadakis, I., Skaltsa, H. D., et al. (2021) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2021.107054 · Cited by 19
Psychological burden of psoriatic patients in a German university hospital dermatology department
Sondermann, W., Fiege, O., Körber, A., & Scherbaum, N. (2020) · The Journal of Dermatology · doi:10.1111/1346-8138.15721 · Cited by 19
Inhibition of ITK Signaling Causes Amelioration in Sepsis-Associated Neuroinflammation and Depression-like State in Mice
Algahtani, M., Alshehri, S., Alqarni, S. S., Ahmad, S. F., Al-Harbi, N. O., Alqarni, S. A., Alfardan, A. S., Ibrahim, K. E., Attia, S. M., & Nadeem, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098101 · Cited by 19
Self-citation
Effects of Lycium barbarum polysaccharide on cytokines in adolescents with subthreshold depression: a randomized controlled study
Li, X., Liu, T., Mo, X., Wang, R., Kong, X., Shao, R., McIntyre, R. S., So, K., & Lin, K. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.389360 · Cited by 18
An update on the impact of depression on the treatment of psoriasis
Bell, K. A., Balogh, E. A., & Feldman, S. R. (2020) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2020.1849141 · Cited by 18
Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6J mice by inactivating STAT3 and NF-κB
Meng, X., Zheng, S., Yin, Z., Wang, X., Yang, D., Zou, T., Li, H., Chen, Y., Liao, C., Xie, Z., et al. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250018 · Cited by 17
Inhibition of basal cell carcinoma cells by cold atmospheric plasma‑activated solution and differential gene expression analysis
Yang, X., Yang, C., Wang, L., Cao, Z., Wang, Y., Cheng, C., Zhao, G., & Zhao, Y. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5009 · Cited by 17
Role of Inflammation and Cytokine Dysregulation in Depression in Patients with Inflammatory Skin Conditions
Katamanin, O. M., Tan, I. J., Barry, J., & Jafferany, M. (2024) · American Journal of Clinical Dermatology · doi:10.1007/s40257-024-00905-9 · Cited by 16
Programming of Vascular Dysfunction by Maternal Stress: Immune System Implications
Costa, T. J. D., de Oliveira, J. C., Giachini, F. R. C., Lima, V. V., Tostes, R. C., & Bomfim, G. F. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.787617 · Cited by 16
Childhood trauma: a risk for major depression in patients with psoriasis
Erfanian, M. (2018) · Psychiatry and Clinical Psychopharmacology · doi:10.1080/24750573.2018.1452521 · Cited by 15
The effect of human umbilical cord mesenchymal stem cell-derived exosomes on diabetic retinal neurodegeneration in a rat model
Fu, Y., Xie, T., Zhang, Y., & Gu, Z.-H. (2022) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2022.102181 · Cited by 14
Immunomodulation with IL-17 and TNF-α in spondyloarthritis: focus on the eye and the central nervous system
Koy, E. H. S., Labauge, P. M., Baillet, A. C., Prati, C., Marotte, H., & Pers, Y. (2021) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x211025894 · Cited by 15
Brain inflammaging in the pathogenesis of late-life depression
Ishizuka, T., Nagata, W., Nakagawa, K., & Takahashi, S. (2024) · Human Cell · doi:10.1007/s13577-024-01132-4 · Cited by 13
Psychosocial burden and body mass index are associated with dermatology-related quality of life in psoriasis patients
Sondermann, W., Schreiber, A., Körber, A., Fiege, O., Scherbaum, N., Benson, S., & Schedlowski, M. (2020) · European Journal of Dermatology · doi:10.1684/ejd.2020.3755 · Cited by 13
Mood Symptoms and Chronic Fatigue Syndrome Due to Relapsing-Remitting Multiple Sclerosis Are Associated with Immune Activation and Aberrations in the Erythron
Almulla, A., Jaleel, A. K. A., Algon, A. A. A., Tunvirachaisakul, C., Hassoun, H., Al-hakeim, H., & Maes, M. (2022) · medRxiv · doi:10.3390/brainsci13071073 · Cited by 10
Serum cytokines associated with behavior: A cross-sectional study in 5-year-old children
Barbosa, S., Khalfallah, O., Forhan, A., Galéra, C., Heude, B., Glaichenhaus, N., & Davidovic, L. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.01.005 · Cited by 15
Psychosocial stress affects the change of mental distress under dermatological treatment—A prospective cohort study in patients with psoriasis
Wintermann, G., Bierling, A. L., Peters, E. M. J., Abraham, S., Beissert, S., & Weidner, K. (2023) · Stress and Health · doi:10.1002/smi.3263 · Cited by 15
Interleukin-17A and Chronic Stress in Pregnant Women at 24–28 Weeks Gestation
Moore, T. A., Case, A. J., Mathews, T. L., Epstein, C. M., Kaiser, K. L., & Zimmerman, M. C. (2018) · Nursing Research · doi:10.1097/nnr.0000000000000334 · Cited by 12
The complex relationship between gut microbiota dysregulation and mood disorders: A narrative review
Minuti, A., Brufani, F., Menculini, G., Moretti, P., & Tortorella, A. A. V. (2022) · Current Research in Neurobiology · doi:10.1016/j.crneur.2022.100044 · Cited by 13
Comparative Analysis of HPA-Axis Dysregulation and Dynamic Molecular Mechanisms in Acute Versus Chronic Social Defeat Stress
Yang, J., Jia, Y., Guo, T., Zhang, S., Huang, J., Lu, H., Li, L., Xu, J., Liu, G., & Xiao, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136063 · Cited by 11
CCR6–CCL20-Mediated Immunologic Pathways in Inflammatory Bowel Disease
Ranasinghe, R., & Eri, R. D. (2018) · Gastrointestinal Disorders · doi:10.3390/gidisord1010003 · Cited by 11
Downregulated NPAS4 in multiple brain regions is associated with major depressive disorder
Selçuk, B., Aksu, T., Dereli, O., & Adebalı, O. (2023) · Scientific Reports · doi:10.1038/s41598-023-48646-9 · Cited by 11
Metabolic Associated Fatty Liver Disease as a Risk Factor for the Development of Central Nervous System Disorders
Yoshikawa, S., Taniguchi, K., Sawamura, H., Ikeda, Y., Asai, T. T., Tsuji, A., & Matsuda, S. (2023) · Livers · doi:10.3390/livers3010002 · Cited by 9
Resting‐state f MRI reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis‐like skin lesions
Chen, T., Zhu, S., Xu, S., Wang, Y., Aji, A., Zhang, C., Wang, H., Li, F., & Chu, Y. (2023) · Experimental Dermatology · doi:10.1111/exd.14914 · Cited by 10
Differentially Expressed Cell Cycle Genes and STAT1/3-Driven Multiple Cancer Entanglement in Psoriasis, Coupled with Other Comorbidities
Dorai, S., & Anand, D. A. (2022) · Cells · doi:10.3390/cells11233867 · Cited by 10
IL‐17A is involved in the hyperplasia of blood vessels in local lesions of psoriasis by inhibiting autophagy
Wang, J., Zhou, L., Hou, H., Li, J., Zhao, X., Li, J., Li, J., Niu, X., Hou, R., & Zhang, K. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15975 · Cited by 9
Behavioral and Cognitive Consequences of Obesity in Parents and Offspring in Female and Male Rats: Implications of Neuroinflammation and Neuromodulation
Demir, E. A., Duran, G. G., Küçük, M. U., Doğan, H. D., Tutuk, O., Açıkgül, F. Ç., Bayırlı, M., Tümer, C., & Duran, N. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02831-5 · Cited by 8
Loureirin C and Xanthoceraside Attenuate Depression-Like Behaviors and Expression of Interleukin-17 in the Prefrontal Cortex Induced by Chronic Unpredictable Mild Stress in Mice
Kunisawa, K., Shan, J., Lu, Q., Yang, Y., Kosuge, A., Kurahashi, H., Saito, K., Zou, L., Nabeshima, T., & Mouri, A. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03692-z · Cited by 9
The role of interleukin-17 in neurological disorders
Park, S. E., Ferreira, A. F. F., Kwon, H., Yu, J., Diniz, L., Ulrich, H., Britto, L. R. G., & Kim, E. (2025) · Animal Cells and Systems · doi:10.1080/19768354.2025.2510994 · Cited by 8
The complex interplay between psoriasis and depression: from molecular mechanisms to holistic treatment approaches
Wang, Y., Xing, J., Liang, Y., Liang, H., Niu, X., Li, J., & Zhang, K. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1659346 · Cited by 8
Imipramine Administration in Brucella abortus 2308-Infected Mice Restores Hippocampal Serotonin Levels, Muscle Strength, and Mood, and Decreases Spleen CFU Count
Maldonado-García, J. L., Pérez‐Sánchez, G., Becerril‐Villanueva, E., Álvarez-Herrera, S., Pavón, L., Sánchez‐Torres, L. E., Gutiérrez‐Ospina, G., Girón‐Pérez, M. I., Damián-Morales, G., Maldonado-Tapia, J. O., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16111525 · Cited by 8
Elevated risk for psychiatric outcomes in pediatric patients with Multisystem Inflammatory Syndrome (MIS-C): A review of neuroinflammatory and psychosocial stressors
Pan, T., Gallo, M. E., Donald, K. A., Webb, K., & Bath, K. G. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100760 · Cited by 9
Neuroserpin, IL-33 and IL-17A as potential markers of mild symptoms of depressive syndrome in Toxoplasma gondii-infected pregnant women
Silva, Z. M., de Toledo, D. N. M., Pio, S., Machado, B. A. A., dos Santos, P. V., Hó, F. G., Medina, Y. N., Cordeiro, P. H. D. M., Perucci, L. O., Pinto, K. M. D. C., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1394456 · Cited by 8
Circulating T‐cell subsets discrepancy between bipolar disorder and major depressive disorder during mood episodes: A naturalistic, retrospective study of 1015 cases
Li, S., Lv, D., Qian, C., Jiang, J., Zhang, P., Xi, C., Wu, L., Gao, X., Fu, Y., Zhang, D., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14361 · Cited by 10
Increased Interleukin-17-Producing γδT Cells in the Brain Exacerbate the Pathogenesis of Sepsis-Associated Encephalopathy and Sepsis-Induced Anxiety in Mice
Moriyama, N., Saito, M., Ono, Y., Yamashita, K., Aoi, T., & Kotani, J. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12134309 · Cited by 7
Stress-induced VIPergic activation mediates microbiota/Th17cell-dependent depressive-like behaviors
Medina-Rodriguez, E. M., Han, D., Zeltzer, S. E., Moraskie, M., O’Connor, G., Daunert, S., & Beurel, E. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.016 · Cited by 7
Unbalanced CD4+IL-10+ and more activated and exhausted CD8+ lymphocytes characterized patients with a major depressive episode
Tifner, V., Daray, F. M., López-Carvajal, J. E., Arena, Á. R., Grendas, L. N., Casiani, R. I. Á., Olaviaga, A., Chiapella, L. C., Penna, M. B., Hunter, F., et al. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103563 · Cited by 7

Authors: Nadeem, A., Ahmad, S. F., Al-Harbi, N. O., Fardan, A. S., El-Sherbeeny, A. M., Ibrahim, K. E., & Attia, S. M.
Affiliations: King Saud University (SA)
Corresponding author: Nadeem, Ahmed
ORCID: Nadeem, Ahmed
Ahmad, Sheikh F.
Ibrahim, Khalid E.
Attia, Sabry M.
Venue: Cytokine
Publisher: Elsevier BV
Published: 2017-09
Volume: 97
Pages: 14-24
ISSN: 1043-4666 (ISSN-L)
DOI: 10.1016/j.cyto.2017.05.018
OpenAlex: W2617690685
Cited by: 147
References: 54
Citations by year: 2026: 10 · 2025: 18 · 2024: 10 · 2023: 31 · 2022: 24 · 2021: 18 · 2020: 14 · 2019: 6 · 2018: 14 · 2017: 2
FWCI: 3.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cytokine (publishedVersion)
PubMed (publishedVersion)
Funders: Deanship of Scientific Research at King Saud University (RG-1438-019)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: IL-17A, depression-like behavior, psoriasis, NF-κB signaling, p38 MAPK signaling, neuroinflammation, anti-IL-17A antibody, comorbid depression
MeSH terms: Imiquimod, Aminoquinolines, Animals, Brain, Depression, Major Depressive Disorder, Depressive Disorder, Major, Disease Models, Animal, Humans, Inflammation, Psoriasis, NF-kappa B, Interleukin-17, MAP Kinase Signaling System, p38 Mitogen-Activated Protein Kinases, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

IL-17A causes depression-like symptoms via NFκB and p38MAPK signaling pathways in mice: Implications for psoriasis associated depression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks