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IL-17A causes depression-like symptoms via NFκB and p38MAPK signaling pathways in mice: Implications for psoriasis associated depression
Abstract
Psoriasis has been shown to be associated with an increased prevalence of comorbid major depression. IL-17A plays an important role in both depression and psoriasis. IL-17A has been shown to be elevated in systemic circulation of psoriatic patients. IL-17A released from different immune cells during psoriasis may be responsible for the development of neuropsychiatric symptoms associated with depression. Therefore, this study explored the association of systemic IL-17A with depression. The present study utilized imiquimod model of psoriatic inflammation as well as IL-17A administration in mice to investigate the effect of IL-17A on depression-like behavior. Psoriatic inflammation led to enhanced IL-17A expression in peripheral immune cells of both innate and adaptive origin. This was associated with increased NFκB/p38MAPK signaling and inflammatory mediators in different brain regions, and depression-like symptoms (as reflected by sucrose preference and tail suspension tests). The role of IL-17A was further confirmed by administering it alone for ten days, followed by assessment of the same parameters. IL-17A administration produced effects similar to psoriasis-like inflammation on neurobehavior and NFκB/p38MAPK pathways. Moreover, both NFκB and p38MAPK inhibitors led to attenuation in IL-17A associated with depression-like behavior via reduction in inflammatory mediators, such as MCP-1, iNOS, IL-6, and CXCL-2. Furthermore, anti-IL17A antibody also led to a reduction in imiquimod-induced depression-like symptoms, as well as NFκB/p38MAPK signaling. The present study shows that IL-17A plays an important role in comorbid depression associated with psoriatic inflammation, where both NFκB and p38MAPK pathways play significant roles via upregulation of inflammatory mediators in the brain.
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“The sustained activation of the IL-17 pathway in chronic social defeat stress conditions suggests a maladaptive neuroimmune response, which may underlie the persistent behavioral changes observed”
From Comparative Analysis of HPA-Axis Dysregulation and Dynamic Molecular Mechanisms in Acute Versus Chronic Social Defeat Stress (2025) · cites this paper as [48]
In the citing paper
“Preclinical studies in rodents corroborate these findings, showing that IL-17A administration induces depressive-like behaviors [48] and stress exposure elevates IL-17A levels [66,67,68,69].”
From Comparative Analysis of HPA-Axis Dysregulation and Dynamic Molecular Mechanisms in Acute Versus Chronic Social Defeat Stress (2025) · cites this paper as [48]
In the citing paper
“administration of IL-17A in rodents promotes depressive-like behaviors (Nadeem et al., 2017)”
From Distinct characteristics of hippocampal pathogenic th17 cells in a mouse model of depression (2018) · cites this paper as Nadeem et al., 2017
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848
The tail suspension test: A new method for screening antidepressants in mice
Steru, L., Chermat, R., Thierry, B., & Simon, P. (1985) · Psychopharmacology · doi:10.1007/bf00428203 · Cited by 3,534
Boehncke, W., & Schön, M. P. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61909-7 · Cited by 2,609
Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759
Lowes, M. A., Suárez‐Fariñas, M., & Krueger, J. G. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120225 · Cited by 1,710
Structure and signalling in the IL-17 receptor family
Gaffen, S. L. (2009) · Nature reviews. Immunology · doi:10.1038/nri2586 · Cited by 1,475
Cytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365
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Items 101–147 of 147
O’Regan, G., Plummer, Z., Christie, B. R., Shultz, S. R., & Allen, J. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03717-2 · Cited by 11
Yu, Y., Zhang, S., Li, Q., Li, W., Zhou, X., Xue, R., Liang, J., & Zhang, X. (2023) · International Journal of Dermatology and Venereology · doi:10.1097/jd9.0000000000000307 · Cited by 6
Tan, M., Luo, Y., Hu, J., Hu, K., Li, X., Yang, J., Chen, J., Zhu, W., & Kuang, Y. (2023) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s401934 · Cited by 6
Genome-wide analysis of emotional lability in adult attention deficit hyperactivity disorder (ADHD)
Gisbert, L., Vilar‐Ribó, L., Rovira, P., Sánchez‐Mora, C., Pagerols, M., Iris Garcia-martinez, A., Vanesa Richarte, B., Montse Corrales, F., Casas, M., Ramos‐Quiroga, J. A., et al. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.04.004 · Cited by 7
Esposito, M., Giunta, A., DUCA, E. D., Manfreda, V., Troisi, A., Bianchi, L., & Fargnoli, M. C. (2020) · Postgraduate Medicine · doi:10.1080/00325481.2020.1712153 · Cited by 6
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Lu, D., Chen, W., Sun, W., Wei, C., Xie, X., Li, N., Yan, H., Chen, Y., Wu, Y., Lei, Z., et al. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf019 · Cited by 5
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Wang, Y., Zhang, P., Lv, Y., Deng, Y. L., Yao, M., Wang, L., & Pan, G. (2023) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s439110 · Cited by 5
Lin, P.-Y., Jhuo, C., Lin, N.-H., Chen, W., & Tzen, J. T. C. (2022) · Compounds · doi:10.3390/compounds2040024 · Cited by 4
Nascimento, C. F., Nunes, P. V., Leite, R. E. P., Grinberg, L. T., Suemoto, C. K., & Lafer, B. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.03.001 · Cited by 4
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Li, F., Zhang, Y.-L., Chen, X., Zhang, J., Fu, L., Chai, B., & Chen, H. (2023) · International Journal of Dermatology and Venereology · doi:10.1097/jd9.0000000000000317 · Cited by 6
Li, Z., Qin, P., Sun, Z., Li, L., Liang, P., Zhao, Y., Ren, S., Wang, G., & Yang, J. (2026) · Communications Biology · doi:10.1038/s42003-026-09525-x · Cited by 5
Dose-Dependent Effect of a New Biotin Compound in Hippocampal Remyelination in Rats
Yuluğ, B., Kılıç, E., Oğuz, T., Orhan, C., Er, B., Tuzcu, M., Özercan, İ. H., Şahin, N., Canpolat, S., Komorowski, J. R., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04686-y · Cited by 3
Vijayakumar, S., Yesudhason, B. V., Anandharaj, J. L., Vedakumari, S. W., & Christyraj, J. R. S. S. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09693-1 · Cited by 4
Yahia, R., Masoud, M. A., Sheded, M. S., & Mansour, H. A. (2020) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22495 · Cited by 3
Congio, A. C., Rossaneis, A. C., Verri, W. A., Jr., Urbano, M. R., & Nunes, S. O. V. (2022) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2022.100357 · Cited by 5
Almulla, A. F., Jaleel, A.-K. K. A., Algon, A. A. A., Tunvirachaisakul, C., Hassoun, H. K., Al‐Hakeim, H. K., & Maes, M. H. J. (2023) · Research Square · doi:10.21203/rs.3.rs-2569742/v1 · Cited by 3
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Immune links in comorbid depression and psoriasis: A narrative mini-review and perspective
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He, S., Gu, C., Su, T., Zhou, C., Lhamo, T., Draga, D., Yin, L., & Qiu, Q. (2022) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207325666220407112018 · Cited by 2
Wang, W., Zhai, G., Xin, M., Li, J., Liao, J.-J., Liang, J., & Li, C. (2024) · Medicine · doi:10.1097/md.0000000000039309 · Cited by 3
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Ye, J., Yan, L., Tang, Z., Xu, J., Weng, J., Yuan, T., & Peng, D. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01549-3 · Cited by 1
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Zhang, Q., Luo, T., Yuan, D., Liu, J., Fu, Y., & Yuan, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-31439-5 · Cited by 1
RetractedZhang, K., Zeng, M., Lei, L., Fu, C., Huang, J., Zhou, S., Wen, Y., Huang, J., Chen, J., & Zeng, Q. (2024) · Postgraduate Medical Journal · doi:10.1093/postmj/qgae173 · Cited by 1
Inan, S., Wiah, S., Szmacinski, A., Dunn, S., Meissler, J. J., Koltsova, E. K., Grivennikov, S., & Rawls, S. M. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110571 · Cited by 1
Litchman, G. H., Thibodeaux, Q. G., Rivera‐Oyola, R., Koo, J. Y. M., Fried, R., Goldenberg, G., Han, G., Hsu, S., Kircik, L., Knuckles, M. L. F., et al. (2021) · SKIN The Journal of Cutaneous Medicine · doi:10.25251/skin.5.1.1 · Cited by 1
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Madeshiya, A. K., & Pillai, A. (2022) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2022.100055
Li, X., Liu, T., Mo, X., Wang, R., Kong, X., Shao, R., McIntyre, R. S., So, K., & Lin, K. (2022) · Research Square · doi:10.21203/rs.3.rs-2031269/v1
Liu, Z., Huang, H., Yu, Y., Jia, Y., Dang, X., Wang, Y., & Huang, L. F. (2022) · Natural Product Communications · doi:10.1177/1934578x221143637
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Sondermann, W., Elkhalii-Wilhelm, S., Krefting, F., & Hölsken, S. (2023) · Deutsche Dermatologie · doi:10.1007/s15011-023-5929-y
Virgolino, G. L., Rodrigues, B. V. L., Virgolino, A., Bezerra, V. M., Anijar, V. H., Rodrigues, K. A., Conceição, H. C. D. S., & Alves, G. R. M. (2023) · Revista Contemporânea · doi:10.56083/rcv3n12-117
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McConnell, I., Yosipovitch, G., & Mishra, S. K. (2025) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.04.019
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Müller-Ladner, U. (2025) · rheuma plus · doi:10.1007/s12688-025-00909-1
Wang, S., Zhao, Y. P., Pan, J., Zhang, D., Wang, A., & Ma, K. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06978-6
Kim, J., Suh, Y.-H., & Chang, K.-A. (2021) · Figshare · doi:10.6084/m9.figshare.13572106
Hinks, M., Maekawa, A. S., Corrigan, M. D., Hasan, S. M. N., Wan-Yan-Chan, D., Burry, T. N., Salia, S., Burke, F. F., Bambico, F. R., & Swift‐Gallant, A. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101248
Lu, Z., Yang, Q., Hu, S., Wu, H., Lu, L., Shao, Y., Ye, B., Li, L. L., Li, Z., Li, R., et al. (2026) · Cytokine · doi:10.1016/j.cyto.2026.157175
Han, D., & Beurel, E. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124672
Zhang, S., Zeng, Z.-L., Lin, X.-E., Ran, J., Wang, Q., Yang, J.-B., Wu, Y., & Lin, N.-X. (2026) · Current Medical Science · doi:10.1007/s11596-026-00226-4
Mazaheri, M., Radahmadi, M., Hosseini-Nasab, F., & Eskandari, N. (2026) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2026.10.009
Metadata
- Authors
- Nadeem, A., Ahmad, S. F., Al-Harbi, N. O., Fardan, A. S., El-Sherbeeny, A. M., Ibrahim, K. E., & Attia, S. M.
- Affiliations
- King Saud University (SA)
- Corresponding author
- Nadeem, Ahmed
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 97
- Pages
- 14-24
- ISSN
- 1043-4666 (ISSN-L)
- OpenAlex
- W2617690685
- Cited by
- 147
- References
- 54
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 10 · 2023: 31 · 2022: 24 · 2021: 18 · 2020: 14 · 2019: 6 · 2018: 14 · 2017: 2
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deanship of Scientific Research at King Saud University (RG-1438-019)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- IL-17A, depression-like behavior, psoriasis, NF-κB signaling, p38 MAPK signaling, neuroinflammation, anti-IL-17A antibody, comorbid depression
- MeSH terms
- Imiquimod, Aminoquinolines, Animals, Brain, Depression, Major Depressive Disorder, Depressive Disorder, Major, Disease Models, Animal, Humans, Inflammation, Psoriasis, NF-kappa B, Interleukin-17, MAP Kinase Signaling System, p38 Mitogen-Activated Protein Kinases, Mice
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