The DOI matches its Crossref record; 162 of the 162 references it cites were found in a registry or an index.
The transforming growth factor-β superfamily of receptors
Abstract
The transforming growth factor-beta (TGF-beta) superfamily of receptors comprises two groups of transmembrane serine-threonine kinase receptors, so called type I, and type II receptors, that are activated following engagement by members of the TGF-beta superfamily of ligands. These events specify diverse downstream responses that are differentially regulated by controlling access and activation of the ligands, their receptors and downstream substrates in different cell types. The purpose of this review is to describe the biochemical properties of these receptors, focusing specifically on the mechanisms regulating receptor/ligand interactions and activation in mammalian cells.
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“Once activated, it has high affinity to ACTRIIB Activins receptors (de Caestecker, 2004).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as de Caestecker, 2004
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1 retracted
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RetractedTGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
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Transcriptional control by the TGF‐β/Smad signaling system
Massagué, J., & Wotton, D. (2000) · The EMBO Journal · doi:10.1093/emboj/19.8.1745 · Cited by 1,990
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
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Regulation of myostatin activity and muscle growth
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TGFβ signals through a heteromeric protein kinase receptor complex
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Loeys, B., Chen, J., Neptune, E., Judge, D. P., Podowski, M., Holm, T. M., Meyers, J. L., Leitch, C. C., Katsanis, N., Sharifi, N., et al. (2005) · Nature Genetics · doi:10.1038/ng1511 · Cited by 1,786
The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis
Wojdasiewicz, P., Poniatowski, Ł. A., & Szukiewicz, D. (2014) · Mediators of Inflammation · doi:10.1155/2014/561459 · Cited by 1,608
Efficient differentiation of human embryonic stem cells to definitive endoderm
D'Amour, K. A., Agulnick, A. D., Eliazer, S., Kelly, O. G., Kroon, E., & Baetge, E. E. (2005) · Nature Biotechnology · doi:10.1038/nbt1163 · Cited by 1,730
Bone Morphogenetic Protein (BMP) signaling in development and human diseases
Wang, R. N., Green, J. J., Wang, Z., Deng, Y., Qiao, M., Peabody, M., Zhang, Q., Ye, J., Yan, Z., Denduluri, S. K., et al. (2014) · Genes & Diseases · doi:10.1016/j.gendis.2014.07.005 · Cited by 1,036
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
Tanno, T., Bhanu, N. V., Oneal, P. A., Goh, S.-H., Staker, P., Lee, Y. T., Moroney, J. W., Reed, C. H., Luban, N. L., Wang, R.-H., et al. (2007) · Nature Medicine · doi:10.1038/nm1629 · Cited by 854
Metadata
- Authors
- de Caestecker, M.
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 15
- Issue
- 1
- Pages
- 1-11
- ISSN
- 1359-6101 (ISSN-L)
- OpenAlex
- W2084954119
- Cited by
- 464
- References
- 161
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 11 · 2023: 13 · 2022: 14 · 2021: 16 · 2020: 19 · 2019: 20 · 2018: 23 · 2017: 17 · 2016: 14 · 2015: 11 · 2014: 21 · 2013: 23 · 2012: 25
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine & Growth Factor Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- TGF-beta superfamily, TGF-beta receptor, type I receptor, type II receptor, serine/threonine kinase receptors, receptor activation, ligand-receptor interactions, mammalian cells
- MeSH terms
- Animals, Gene Expression Regulation, Multigene Family, Humans, Ligands, Models, Biological, Protein Binding, Endosomes, Signal Transduction, Receptors, Transforming Growth Factor beta, Activins
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