The transforming growth factor-β superfamily of receptors

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

Massagué, J., Blain, S. W., & Lo, R. S. (2000) · Cell · doi:10.1016/s0092-8674(00)00121-5 · Cited by 2,391

Mechanism of activation of the TGF-β receptor

Wrana, J. L., Attisano, L., Wieser, R., Ventura, F., & Massagué, J. (1994) · Nature · doi:10.1038/370341a0 · Cited by 2,340

Transcriptional control by the TGF‐β/Smad signaling system

Massagué, J., & Wotton, D. (2000) · The EMBO Journal · doi:10.1093/emboj/19.8.1745 · Cited by 1,990

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

Nakao, A., Afrakhte, M., Morn, A., Nakayama, T., Christian, J. L., Heuchel, R. L., Itoh, S., Kawabata, M., Heldin, N., Heldin, C., et al. (1997) · Nature · doi:10.1038/39369 · Cited by 1,796

SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7

Inman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J., & Hill, C. S. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.1.65 · Cited by 1,636

Regulation of myostatin activity and muscle growth

Lee, S.-J., & McPherron, A. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151270098 · Cited by 1,616

TGFβ signals through a heteromeric protein kinase receptor complex

Wrana, J. L., Attisano, L., Cárcamo, J. M., Zentella‐Dehesa, A., Doody, J. F., Laiho, M., Wang, X.-F., & Massagué, J. (1992) · Cell · doi:10.1016/0092-8674(92)90395-s · Cited by 1,528

Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

Arber, S., Barbayannis, F. A., Hanser, H., Schneider, C., Stanyon, C. A., Bernard, O., & Caroni, P. (1998) · Nature · doi:10.1038/31729 · Cited by 1,426

Active and Inactive Protein Kinases: Structural Basis for Regulation

Johnson, L. N., Noble, M. E. M., & Owen, D. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81092-2 · Cited by 1,396

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

Kavsak, P., Rasmussen, R. K., Causing, C. G., Bonni, S., Zhu, H., Thomsen, G. H., & Wrana, J. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00134-9 · Cited by 1,205

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

Guglielmo, G. M. D., Roy, C. L., Goodfellow, A. F., & Wrana, J. L. (2003) · Nature Cell Biology · doi:10.1038/ncb975 · Cited by 1,152

Balancing the activation state of the endothelium via two distinct TGF‐β type I receptors

Goumans, M., Valdimarsdóttir, G., Itoh, S., Rosendahl, A., Sideras, P., & ten Dijke, P. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1743 · Cited by 1,127

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism.

Bhowmick, N., Ghiassi, M., Bakin, A. V., Aakre, M., Lundquist, C., Engel, M., Arteaga, C., & Moses, H. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.1.27 · Cited by 1,087

Smad6 inhibits signalling by the TGF-β superfamily

Imamura, T., Takase, M., Nishihara, A., Oeda, E., Hanai, J., Kawabata, M., & Miyazono, K. (1997) · Nature · doi:10.1038/39355 · Cited by 1,023

Phosphatidylinositol 3-Kinase Function Is Required for Transforming Growth Factor β-mediated Epithelial to Mesenchymal Transition and Cell Migration

Bakin, A. V., Tomlinson, A. K., Bhowmick, N. A., Moses, H. L., & Arteaga, C. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005912200 · Cited by 1,008

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

Tsukazaki, T., Chiang, T., Davison, A. F., Attisano, L., & Wrana, J. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81701-8 · Cited by 981

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

Miettinen, P. J., Ebner, R., Lopez, A. R., & Derynck, R. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.6.2021 · Cited by 939

Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β

Abreu, J. G., Ketpura, N. I., Reversade, B., & Robertis, E. M. D. (2002) · Nature Cell Biology · doi:10.1038/ncb826 · Cited by 901

Betaglycan presents ligand to the TGFβ signaling receptor

López‐Casillas, F., Wrana, J. L., & Massagué, J. (1993) · Cell · doi:10.1016/0092-8674(93)90368-z · Cited by 892

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

Oh, S. P., Seki, T., Goss, K. A., Imamura, T., Yi, Y., Donahoe, P. K., Li, L., Miyazono, K., ten Dijke, P., Kim, S., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.6.2626 · Cited by 872

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

Ebisawa, T., Fukuchi, M., Murakami, G., Chiba, T., Tanaka, K., Imamura, T., & Miyazono, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100008200 · Cited by 845

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

Cheifetz, S., Bellón, T., Calés, C., Vera, S., Bernabéu, C., Massagué, J., & Letarte, M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41732-2 · Cited by 836

Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

Ulloa, L., Doody, J. F., & Massagué, J. (1999) · Nature · doi:10.1038/17826 · Cited by 812

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

Franzèn, P. (1993) · Cell · doi:10.1016/0092-8674(93)90489-d · Cited by 774

TGF‐β receptor‐activated p38 MAP kinase mediates Smad‐independent TGF‐β responses

Yu, L., DeRouen, M. C., & Zhang, Y. E. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf366 · Cited by 738

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

ten Dijke, P., Yamashita, H., Sampath, T. K., Reddi, A. H., Estevez, M., Riddle, D. L., Ichijo, H., Heldin, C., & Miyazono, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32506-1 · Cited by 730

Silencing of TGF-β signalling by the pseudoreceptor BAMBI

Onichtchouk, D., Chen, Y., Dosch, R., Gawantka, V., Delius, H., Massagué, J., & Niehrs, C. (1999) · Nature · doi:10.1038/46794 · Cited by 727

TGF‐β induces fibronectin synthesis through a c‐Jun N‐terminal kinase‐dependent, Smad4‐independent pathway

Hocevar, B. A., Brown, T. L., & Howe, P. H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1345 · Cited by 681

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system

López‐Casillas, F., Cheifetz, S., Doody, J. F., Andres, J., Lane, W. S., & Massagué, J. (1991) · Cell · doi:10.1016/0092-8674(91)90073-8 · Cited by 677

Caveolin-1 Regulates Transforming Growth Factor (TGF)-β/SMAD Signaling through an Interaction with the TGF-β Type I Receptor

Razani, B., Zhang, X. L., Bitzer, M., von Gersdorff, G., Böttinger, E. P., & Lisanti, M. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008340200 · Cited by 640

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

Attisano, L. (1993) · Cell · doi:10.1016/0092-8674(93)90488-c · Cited by 639

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis

Howe, J. R., Bair, J. L., Sayed, M. G., Anderson, M. E., Mitros, F. A., Petersen, G. M., Velculescu, V. E., Traverso, G., & Vogelstein, B. (2001) · Nature Genetics · doi:10.1038/88919 · Cited by 630

Extracellular Regulation of BMP Signaling in Vertebrates: A Cocktail of Modulators

Balemans, W., & Hul, W. V. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0779 · Cited by 616

Human Type II Receptor for Bone Morphogenic Proteins (BMPs): Extension of the Two-Kinase Receptor Model to the BMPs

Liu, F., Ventura, F., Doody, J. F., & Massagué, J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.7.3479 · Cited by 593

Betaglycan binds inhibin and can mediate functional antagonism of activin signalling

Lewis, K. A., Gray, P. C., Blount, A. L., MacConell, L., Wiater, E., Bilezikjian, L. M., & Vale, W. (2000) · Nature · doi:10.1038/35006129 · Cited by 585

Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis

Rebbapragada, A., Benchabane, H., Wrana, J. L., Celeste, A. J., & Attisano, L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7230-7242.2003 · Cited by 573

The Mode of Bone Morphogenetic Protein (BMP) Receptor Oligomerization Determines Different BMP-2 Signaling Pathways

Nohe, A., Haßel, S., Ehrlich, M., Neubauer, F. B., Sebald, W., Henis, Y. I., & Knaus, P. I. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m102750200 · Cited by 566

Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-β Superfamily

Pece-Barbara, N., Wrana, J. L., & Letarte, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.584 · Cited by 564

Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

ten Dijke, P., Yamashita, H., Ichijo, H., Franzèn, P., Laiho, M., Miyazono, K., & Heldin, C. (1994) · Science · doi:10.1126/science.8140412 · Cited by 551

Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

Rosenzweig, B., Imamura, T., Okadome, T., Cox, G. N., Yamashita, H., ten Dijke, P., Heldin, C., & Miyazono, K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7632 · Cited by 550

Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription

Engel, M. E., McDonnell, M. A., Law, B. K., & Moses, H. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37413 · Cited by 538

Structural basis of BMP signalling inhibition by the cystine knot protein Noggin

Groppe, J. C., Greenwald, J., Wiater, E., Rodríguez‐León, J., Economides, A. N., Kwiatkowski, W., Affolter, M., Vale, W., Belmonte, J. C. I., & Choe, S. (2002) · Nature · doi:10.1038/nature01245 · Cited by 534

Smads as transcriptional co-modulators

Attisano, L., & Wrana, J. L. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00081-2 · Cited by 530

Role of Transforming Growth Factor-beta Signaling in Cancer

de Caestecker, M. P. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.17.1388 · Cited by 521

Latent transforming growth factor-β: Structural features and mechanisms of activation

Munger, J. S., Harpel, J. G., Gleizes, P., Mazzieri, R., Nunes, I., & Rifkin, D. B. (1997) · Kidney International · doi:10.1038/ki.1997.188 · Cited by 513

Divergence and convergence of TGF‐β/BMP signaling

Miyazono, K., Kusanagi, K., & Inoue, H. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1080 · Cited by 503

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.

Yamashita, H., ten Dijke, P., Huylebroeck, D., Sampath, T. K., Andries, M., Smith, J. C., Heldin, C., & Miyazono, K. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.1.217 · Cited by 496

Connective Tissue Growth Factor: What's in a Name?

Moussad, E. E.-D. A., & Brigstock, D. R. (2000) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2000.3059 · Cited by 479

Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2

Macías‐Silva, M., Hoodless, P. A., Tang, S. J., Buchwald, M., & Wrana, J. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.25628 · Cited by 476

A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA.

Bitzer, M., von Gersdorff, G., Liang, D., Dominguez-Rosales, A., Beg, A. A., Rojkind, M., & Böttinger, E. P. (2000) · PubMed Central · Cited by 453

Crystal Structure of the Cytoplasmic Domain of the Type I TGF β Receptor in Complex with FKBP12

Huse, M., Chen, Y., Massagué, J., & Kuriyan, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80555-3 · Cited by 446

Involvement of the p38 Mitogen-activated Protein Kinase Pathway in Transforming Growth Factor-β-induced Gene Expression

Hanafusa, H., Ninomiya‐Tsuji, J., Masuyama, N., Nishita, M., Fujisawa, J., Shibuyà, H., Matsumoto, K., & Nishida, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.38.27161 · Cited by 441

Crystal Structure of Transforming Growth Factor-β2: an Unusual Fold for the Superfamily

Daopin, S., Piez, K. A., Ogawa, Y., & Davies, D. R. (1992) · Science · doi:10.1126/science.1631557 · Cited by 440

A mechanism of suppression of TGF–β/SMAD signaling by NF-κB/RelAPreprint

Bitzer, M., von Gersdorff, G., Liang, D., Dominguez-Rosales, A., Beg, A. A., Rojkind, M., & Böttinger, E. P. (2000) · Genes & Development · doi:10.1101/gad.14.2.187 · Cited by 422

Transforming Growth Factor-β–induced Mobilization of Actin Cytoskeleton Requires Signaling by Small GTPases Cdc42 and RhoA

Edlund, S., Landström, M., Heldin, C., & Aspenström, P. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-08-0398 · Cited by 418

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1–TAK1 in the BMP signaling pathway

Yamaguchi, K., Nagai, S., Ninomiya‐Tsuji, J., Nishita, M., Tamai, K., Irie, K., Ueno, N., Nishida, E., Shibuya, H., & Matsumoto, K. (1999) · The EMBO Journal · doi:10.1093/emboj/18.1.179 · Cited by 395

The Immunophilin FKBP12 Functions as a Common Inhibitor of the TGFβ Family Type I Receptors

Wang, T., Li, B.-Y., Danielson, P. D., Shah, P. C., Rockwell, S., Lechleider, R. J., Martin, J. M., Manganaro, T. F., & Donahoe, P. K. (1996) · Cell · doi:10.1016/s0092-8674(00)80116-6 · Cited by 388

The TGFβ Receptor Activation Process

Huse, M., Muir, T. W., Xu, L., Chen, Y., Kuriyan, J., & Massagué, J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00332-x · Cited by 381

Nodal Signals to Smads through Cripto-Dependent and Cripto-Independent Mechanisms

Yeo, C., & Whitman, M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00249-0 · Cited by 376

Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily.

Sampath, T. K., Coughlin, J. E., Whetstone, R., Banach, D. L., Corbett, C., Ridge, R. J., Özkaynak, E., Oppermann, H., & Rueger, D. C. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38285-7 · Cited by 373

Characterization and Cloning of a Receptor for BMP-2 and BMP-4 from NIH 3T3 Cells

Koenig, B. B., Cook, J. S., Wolsing, D. H., Ting, J., Tiesman, J. P., Correa, P. E., Olson, C. A., Pecquet, A. L., Ventura, F., Grant, R. A., et al. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5961 · Cited by 366

Cross‐talk between ERK MAP kinase and Smad‐signaling pathways enhances TGF‐β dependent responses in human mesangial cells

Hayashida, T., deCaestecker, M. P., & Schnaper, H. W. (2003) · The FASEB Journal · doi:10.1096/fj.03-0037fje · Cited by 362

Consequences of knocking out BMP signaling in the mouse

Zhao, G.-Q. (2002) · genesis · doi:10.1002/gene.10167 · Cited by 361

Determinants of specificity in TGF-β signal transductionPreprint

Chen, Y., Hata, A., Lo, R. S., Wotton, D., Shi, Y., Pavletich, N. P., & Massagué, J. (1998) · Genes & Development · doi:10.1101/gad.12.14.2144 · Cited by 361

Crystal structure of human bone morphogenetic protein-2 at 2.7 Å resolution 1 1Edited by R. Huber

Scheufler, C., Sebald, W., & Hülsmeyer, M. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.2590 · Cited by 356

Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-β and bone morphogenetic protein

Lee, K., Hong, S.-H., & Bae, S. (2002) · Oncogene · doi:10.1038/sj.onc.1205937 · Cited by 353

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

ten Dijke, P., Ichijo, H., Franzèn, P., Schulz, P. J., Saras, J., Toyoshima, H., Heldin, C., & Miyazono, K. (1993) · PubMed · Cited by 351

TGF-β-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

Perlman, R., Schiemann, W. P., Brooks, M. W., Lodish, H. F., & Weinberg, R. A. (2001) · Nature Cell Biology · doi:10.1038/35087019 · Cited by 349

Heterodimeric Bone Morphogenetic Proteins Show Enhanced ActivityIn VitroandIn Vivo

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Identification of Type I and Type II Serine/Threonine Kinase Receptors for Growth/Differentiation Factor-5

Nishitoh, H., Ichijo, H., Kimura, M., Matsumoto, T., Makishima, F., Yamaguchi, A., Yamashita, H., ENOMOTO, S., & Miyazono, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.35.21345 · Cited by 329

Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.

Yamashita, H., ten Dijke, P., Franzèn, P., Miyazono, K., & Heldin, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32142-7 · Cited by 326

Molecular Basis of Bone Morphogenetic Protein-15 Signaling in Granulosa Cells

Moore, R. K., Otsuka, F., & Shimasaki, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207362200 · Cited by 326

Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1

Foletta, V. C., Lim, M. A., Soosairajah, J., Kelly, A. P., Stanley, E. G., Shannon, M., He, W., Das, S., Massagué, J., & Bernard, O. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212060 · Cited by 325

Crystal structure of the BMP-2–BRIA ectodomain complex

Kirsch, T., Sebald, W., & Dreyer, M. (2000) · Nature Structural Biology · doi:10.1038/75903 · Cited by 320

GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines.

McPherron, A. C., & Lee, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53714-5 · Cited by 319

Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium

Topper, J. N., Cai, J., Qiu, Y., Anderson, K. R., Xu, Y., Deeds, J. D., Feeley, R., Gimeno, C. J., Woolf, E. A., Tayber, O., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9314 · Cited by 319

Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation

Ebisawa, T., Tada, K., Kitajima, I., Tojo, K., Sampath, T. K., Kawabata, M., Miyazono, K., & Imamura, T. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.20.3519 · Cited by 318

Activation of Signalling by the Activin Receptor Complex

Attisano, L., Wrana, J. L., Montalvo, E., & Massagué, J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1066 · Cited by 316

Transforming Growth Factor β Activation of p44mapk in Proliferating Cultures of Epithelial Cells

Hartsough, M. T., & Mulder, K. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7117 · Cited by 310

Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)

Callahan, J. F., Burgess, J. L., Fornwald, J. A., Gaster, L. M., Harling, J. D., Harrington, F. P., Heer, J. P., Kwon, C., Lehr, R. V., Mathur, A., et al. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm010493y · Cited by 309

The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate developmentPreprint

Reissmann, E., Jörnvall, H., Blokzijl, A., Andersson, O., Chang, C., Minchiotti, G., Persico, M. G., Ibáñez, C. F., & Brivanlou, A. H. (2001) · Genes & Development · doi:10.1101/gad.201801 · Cited by 307

Regulation of Bone Morphogenetic Protein Activity by Pro Domains and Proprotein Convertases

Constam, D. B., & Robertson, E. J. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.1.139 · Cited by 300

Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily.

Griffith, D. L., Keck, P. C., Sampath, T. K., Rueger, D. C., & Carlson, W. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.878 · Cited by 299

Requirement of BMP-2-induced Phosphatidylinositol 3-Kinase and Akt Serine/Threonine Kinase in Osteoblast Differentiation and Smad-dependent BMP-2 Gene Transcription

Ghosh‐Choudhury, N., Abboud, S. L., Nishimura, R., Celeste, A. J., Mahimainathan, L., & Choudhury, G. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205053200 · Cited by 299

Structural Basis of Smad2 Recognition by the Smad Anchor for Receptor Activation

Wu, G., Chen, Y., Ozdamar, B., Gyuricza, C. A., Chong, P. A., Wrana, J. L., Massagué, J., & Shi, Y. (2000) · Science · doi:10.1126/science.287.5450.92 · Cited by 298

Evidence for a Role of Rho-like GTPases and Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) in Transforming Growth Factor β-mediated Signaling

Atfi, A., Djelloul, S., Chastre, E., Davis, R. J., & Gespach, C. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.3.1429 · Cited by 297

Regulation of signal transduction by endocytosis

Ceresa, B. P., & Schmid, S. L. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00077-0 · Cited by 297

Transcriptional Cross-talk between Smad, ERK1/2, and p38 Mitogen-activated Protein Kinase Pathways Regulates Transforming Growth Factor-β-induced Aggrecan Gene Expression in Chondrogenic ATDC5 Cells

Watanabe, H., de Caestecker, M. P., & Yamada, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005724200 · Cited by 275

Disruption of Transforming Growth Factor-β Signaling in ELF β-Spectrin-Deficient Mice

Tang, Y., Katuri, V., Dillner, A., Mishra, B., Deng, C., & Mishra, L. (2003) · Science · doi:10.1126/science.1075994 · Cited by 266

The BMP7/ActRII Extracellular Domain Complex Provides New Insights into the Cooperative Nature of Receptor Assembly

Greenwald, J., Groppe, J. C., Gray, P. C., Wiater, E., Kwiatkowski, W., Vale, W., & Choe, S. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00094-7 · Cited by 263

Determination of Type I Receptor Specificity by the Type II Receptors for TGF-β or Activin

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The EGF-CFC gene family in vertebrate development

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