Cited by 294Chemokine receptors and signalingAdipokines, Inflammation, and Metabolic DiseasesInflammation biomarkers and pathways

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Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism

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Bondue, Benjamin, Wittamer, Valérie, Parmentier, Marc·2011·Cytokine & Growth Factor Reviews

DOI 10.1016/j.cytogfr.2011.11.004

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Abstract

Chemerin was isolated as the natural ligand of the G protein-coupled receptor ChemR23. Chemerin acts as a chemotactic factor for leukocyte populations expressing ChemR23, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Chemerin is expressed by epithelial and non-epithelial cells as an inactive precursor, present at nanomolar concentrations in plasma. Processing of the precursor C-terminus is required for generating bioactive forms of chemerin. Various proteases mediate this processing, including neutrophil serine proteases and proteases from coagulation and fibrinolytic cascades. ChemR23-expressing cells are recruited in human inflammatory diseases, such as psoriasis and lupus. In animal models, both pro-inflammatory and anti-inflammatory roles of chemerin have been reported. Recently, two other receptors for chemerin were described, GPR1 and CCRL2, but their functional relevance is largely unknown. Both chemerin and ChemR23 are also expressed by adipocytes, and the emerging role of chemerin as an adipokine regulating lipid and carbohydrate metabolism is an area of intense research.

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Authors: Bondue, B., Wittamer, V., & Parmentier, M.
Affiliations: Université Libre de Bruxelles (BE)
Corresponding author: Parmentier, Marc
ORCID: Bondue, Benjamin
Wittamer, Valérie
Parmentier, Marc
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 2011-10
Volume: 22
Issue: 5-6
Pages: 331-338
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/j.cytogfr.2011.11.004
OpenAlex: W2015466197
Cited by: 294
References: 61
Citations by year: 2026: 14 · 2025: 9 · 2024: 24 · 2023: 19 · 2022: 27 · 2021: 23 · 2020: 23 · 2019: 25 · 2018: 26 · 2017: 21 · 2016: 24 · 2015: 7 · 2014: 20 · 2013: 23 · 2012: 9
FWCI: 1.53
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cytokine & Growth Factor Reviews (publishedVersion)
PubMed (publishedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: chemerin, ChemR23, GPR1, CCRL2, leukocyte migration, inflammation, chemotaxis, plasmacytoid dendritic cells, macrophages, natural killer cells, precursor processing, serine protease, psoriasis, lupus, adipokines, adipocytes, lipid metabolism, carbohydrate metabolism
MeSH terms: Amino Acid Sequence, Animals, Chemotaxis, Leukocyte, Inflammation, Oligopeptides, Chemokines, Receptors, Chemokine, Intercellular Signaling Peptides and Proteins

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Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism

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