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Cited by 18Functional Brain Connectivity StudiesDementia and Cognitive Impairment ResearchTranscranial Magnetic Stimulation Studies

Altered functional connectivity strength in informant‐reported subjective cognitive decline: A resting‐state functional magnetic resonance imaging study

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Dong, Chao, Liu, Tao, Wen, Wei, Kochan, Nicole A., Jiang, Jiyang, Li, Qiongge, Liu, Hao, Niu, Haijun +4 more·2018·Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
DOI 10.1016/j.dadm.2018.08.011PMC PMC6222034
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Abstract

Introduction: Informant‐reported subjective cognitive decline (iSCD) has been associated with a higher risk of conversion to dementia, but the findings of whole brain functional connectivity strength (FCS) changes in iSCD are limited. Methods: The sample comprised 39 participants with iSCD and 39 age‐ and sex‐ matched healthy controls. The global absolute (aFCS) and relative functional connectivity strengths were estimated using weighted degree centrality and the z‐scores of the weighted degree centrality respectively. FreeSurfer was used for measuring cortical thickness. Results: The aFCS was lower in iSCD primarily in left medial superior frontal, left precuneus, left parietal, right cuneus, and bilateral calcarine; while relative functional connectivity strength was higher in posterior cingulate cortex/precuneus compared with healthy controls. No significant differences in cortical thickness were observed. Discussion: There are detectable changes of FCS in iSCD, with the precuneus possibly playing a compensatory role. FCS could therefore have a potential role to serve as one of the earliest neuroimaging markers of neurodegenerative disease.

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  • Subjects with subjective cognitive decline exhibit higher functional connectivity in the retrosplenial cortex and precuneus and lower functional connectivity in the frontal-parietal cortex and putative posterior memory system.

    “Subjects with SCD exhibited higher FC in the retrosplenial cortex and precuneus and lower FC in the frontal-parietal cortex and putative posterior memory system [115, 136, 137].”

    From Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease (2020) · cites this paper as [137]

    The Results (Group differences in aFCS and rFCS; page unavailable) report higher relative connectivity strength in the posterior cingulate cortex/precuneus and lower absolute connectivity strength in medial superior frontal and parietal regions among participants with informant-reported SCD. The paper does not report higher connectivity specifically in the retrosplenial cortex or identify the decreased regions as a 'putative posterior memory system'; the claim also omits the distinction between relative and absolute connectivity strength. (LLM, conf=0.87)

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Sorted by citations

Authors
Dong, C., Liu, T., Wen, W., Kochan, N. A., Jiang, J., Li, Q., Liu, H., Niu, H., Zhang, W., Wang, Y., Brodaty, H., & Sachdev, P. S.
Affiliations
  • Beihang University (CN)
  • UNSW Sydney (AU)
  • Capital Medical University (CN)
Corresponding author
Liu, Tao
ORCID
Venue
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Publisher
Wiley
Published
2018-01
Volume
10
Issue
1
Pages
688-697
ISSN
2352-8729 (ISSN-L)
DOI
10.1016/j.dadm.2018.08.011
PMC
PMC6222034
OpenAlex
W2893002536
Cited by
18
References
11
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 6 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 1
FWCI
1.19
Type
journal article
Language
en
Open access
Licence
Locations
  • Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (81871434)
  • National Health and Medical Research Council (350833)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords
subjective cognitive decline, resting-state functional connectivity, precuneus, posterior cingulate cortex, calcarine cortex, cortical thickness, dementia risk, neuroimaging biomarkers, neurodegeneration

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