A very light lunch: Interoceptive deficits and food aversion at onset in a case of behavioral variant frontotemporal dementia
Open accessAbstract
Introduction: Patients affected by the behavioral variant frontotemporal dementia (bvFTD) frequently experience, at a delayed onset, abnormal eating behavior involving increased food intake. Although delusional food‐related symptoms have attracted much attention, the behavioral and neural features of food aversion manifestations in bvFTD remain poorly documented. Methods: We describe the rare case of a patient with bvFTD presenting with lack of interoception for swallowing and digestion, coupled with a dramatic food aversion at onset. We also compared his MRI scan to 84 healthy individuals using a voxel‐based morphometry approach. Results: We found gray matter density reductions involving the postcentral gyrus bilaterally, insulae, and right medial orbitofrontal cortex. Discussion: Our results shed new light on the behavioral and neuroanatomical features of food aversion and interoception deficits in bvFTD, suggesting that besides orbitofrontal cortex, also a distributed system associated with interoception might play a role in such behavioral manifestation.
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Atypical interoception and high alexithymia have been observed in neurological conditions such as Frontotemporal dementia, Alzheimer's Disease, Parkinson's Disease, and Multiple Sclerosis.
“Atypical interoception and high alexithymia have also been observed in neurological conditions with similar symptom profiles, such as Frontotemporal dementia (behavioural variant; García-Cordero et al., 2016; Salvato et al., 2018; semantic variant; Sturm and Levenson, 2011), Alzheimer’s Disease (García-Cordero et al., 2016), Parkinson’s Disease (Assogna et al., 2012; Ricciardi et al., 2016), and”
From Atypical interoception as a common risk factor for psychopathology: A review (2021) · cites this paper as Salvato et al., 2018
The Methods (Case report) and Discussion (page numbers unavailable) describe interoceptive deficits in a patient with behavioral-variant frontotemporal dementia. The paper also describes emotional dysfunction, but it does not report high alexithymia in that patient; its explicit discussion of alexithymia concerns other pathological populations. This citation supports the frontotemporal-dementia portion of the sentence, not the other named conditions. (LLM, conf=0.86)
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Sorted by citations
Atypical interoception as a common risk factor for psychopathology: A review
Brewer, R., Murphy, J., & Bird, G. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.036 · Cited by 180 · see citing works
Interoception primes emotional processing: multimodal evidence from neurodegeneration
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A predictive coding framework of allostatic–interoceptive overload in frontotemporal dementia
Migeot, J. A., Duran-Aniotz, C. A., Signorelli, C. M., Piguet, O., & Ibáñez, A. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.08.005 · Cited by 76 · see citing works
- Authors
- Salvato, G., Mercurio, M., Sberna, M., Paulesu, E., & Bottini, G.
- Affiliations
- University of Pavia (IT)
- University of Milan (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- IRCCS Ospedale Galeazzi - Sant'Ambrogio (IT)
- Corresponding author
- Salvato, Gerardo
- Venue
- Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
- Publisher
- Wiley
- Published
- 2018-01
- Volume
- 10
- Issue
- 1
- Pages
- 750-754
- ISSN
- 2352-8729 (ISSN-L)
- PMC
- PMC6240841
- OpenAlex
- W2898852846
- Cited by
- 11
- References
- 4
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2019: 3
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- behavioral variant frontotemporal dementia, food aversion, interoception, interoceptive deficits, dietary habits, swallowing, digestion, postcentral gyrus, insula, medial orbitofrontal cortex, gray matter density, voxel-based morphometry
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