Cited by 76Dementia and Cognitive Impairment ResearchPsychosomatic Disorders and Their TreatmentsEmbodied and Extended Cognition

A predictive coding framework of allostatic–interoceptive overload in frontotemporal dementia

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Migeot, Joaquin A., Duran-Aniotz, Claudia A., Signorelli, Camilo M., Piguet, Olivier, Ibáñez, Agustín·2022·Trends in Neurosciences

Abstract

Recent allostatic-interoceptive explanations using predictive coding models propose that efficient regulation of the body's internal milieu is necessary to correctly anticipate environmental needs. We review this framework applied to understanding behavioral variant frontotemporal dementia (bvFTD) considering both allostatic overload and interoceptive deficits. First, we show how this framework could explain divergent deficits in bvFTD (cognitive impairments, behavioral maladjustment, brain atrophy, fronto-insular-temporal network atypicality, aberrant interoceptive electrophysiological activity, and autonomic disbalance). We develop a set of theory-driven predictions based on levels of allostatic interoception associated with bvFTD phenomenology and related physiopathological mechanisms. This approach may help further understand the disparate behavioral and physiopathological dysregulations of bvFTD, suggesting targeted interventions and strengthening clinical models of neurological and psychiatric disorders.

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Crossref · 10.1016/j.tins.2022.08.005

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  • Adverse conditions such as pollution, heatwaves, or social isolation contribute to maladaptive epigenetic changes, increased allostatic load, cognitive decline, and diminished resilience.

    “Conversely, adverse conditions such as pollution, heatwaves or social isolation contribute to maladaptive epigenetic changes, increased allostatic load, cognitive decline and diminished resilience21,22,63–67.”

    From Resilience and brain health in global populations (2025) · cites this paper as [67]

    In “Measurements of allostasis” (page unavailable), the paper says cumulative chronic stress and life events can produce allostatic overload through repeated environmental demands. That supports the allostatic-load component, but the paper does not establish that pollution, heatwaves, or social isolation cause the claimed epigenetic changes, cognitive decline, and diminished resilience. (LLM, conf=0.82)

    Experimental — accuracy not yet measured
  • Allostasis is linked to interoception, the brain's ability to sense and regulate internal bodily states.

    “Allostasis33 is linked to interoception, which is the brain’s ability to sense and regulate internal bodily states63–67.”

    From Resilience and brain health in global populations (2025) · cites this paper as [67]

    Experimental — accuracy not yet measured
  • Allostatic interoception is the brain's ability to anticipate and regulate bodily responses to environmental demands, involving neural, neuroendocrine, and immune mechanisms that enable adaptation.

    “Allostatic interoception (Fig. 2a) is the brain’s ability to anticipate and regulate bodily responses to environmental demands and involves neural, neuroendocrine and immune mechanisms that enable adaptation63–68.”

    From Resilience and brain health in global populations (2025) · cites this paper as [67]

  • Both atrophy and functional connectivity alterations observed in people with bvFTD substantially overlap with the AIN.

    “Moreover, both atrophy and functional connectivity alterations observed in people with bvFTD14,17,24 substantially overlap with the AIN.3”
  • Behavioural-variant frontotemporal dementia (bvFTD) provides an opportunity to investigate the PAIO-INT framework via a lesion model approach.

    “Behavioural-variant frontotemporal dementia (bvFTD) provides an opportunity to investigate the PAIO-INT framework via a lesion model approach.11,14,16”

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Authors
Migeot, J. A., Duran-Aniotz, C. A., Signorelli, C. M., Piguet, O., & Ibáñez, A.
Affiliations
  • Adolfo Ibáñez University (CL)
  • Inserm (FR)
  • The University of Sydney (AU)
  • Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
Corresponding author
Ibáñez, Agustín
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2022-11
Volume
45
Issue
11
Pages
838-853
ISSN
0166-2236 (ISSN-L)
OpenAlex
W4294142652
Cited by
76
References
138
Citations by year
2026: 11 · 2025: 24 · 2024: 18 · 2023: 20 · 2022: 3
FWCI
2.80
Type
journal article
Language
en
Open access
Locations
  • Trends in Neurosciences (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • ORBi (University of Liège) (submittedVersion, other-oa)
Funders
  • Alzheimer's Association (20-725707, SG-20- 725707, ACT210096, AARG-591107, SG-20-, UK-20-639295, 2018-AARG-591107, R01 AG057234)
  • Universidad de Santiago de Chile
  • Global Brain Health Institute (20-639295, 1210176, ALZ UK-20-639295)
  • Fonds De La Recherche Scientifique - FNRS
  • Consejo Nacional de Investigaciones Científicas y Técnicas (ANID/FONDAP/15150012, 2017-1820, 15150012, PICT 2017-, 1210176, 1210195)
  • Universidad del Valle (CI 5316)
  • Agencia Nacional de Investigación y Desarrollo (ACT210096, 15150012, FONCYT-PICT 2017-1820, ID20I10152, ANID/FONDAP/15150012, 1210195, 1210622, 1210176)
  • National Institutes of Health (UK-20-639295, 15150012)
  • Medical Research Council
  • National Health and Medical Research Council (2008020)
  • National Institute on Aging (R01AG057234)
  • Fondo para la Investigación Científica y Tecnológica (2017–1820, PICT-2017, 15150012, 1210195, 1210176)
  • Fondo de Fomento al Desarrollo Científico y Tecnológico (15150012, ANID/FONDAP/15150012, CW2680521, ID20I10152)
  • Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias (15150012, /FONDAP/15150012, 2017-1820, ANID/FONDAP/15150012)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Embodied and Extended Cognition
Keywords
behavioral variant frontotemporal dementia, predictive coding, allostatic overload, interoception, interoceptive deficits, autonomic dysfunction, brain atrophy
MeSH terms
Atrophy, Humans, Magnetic Resonance Imaging, Frontotemporal Dementia, Cognitive Dysfunction, Interoception

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