The porcine innate immune system: an update
Open accessAbstract
Over the last few years, we have seen an increasing interest and demand for pigs in biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans in terms of their anatomy, genetics, and physiology, and often are the model of choice for the assessment of novel vaccines and therapeutics in a preclinical stage. However, the pig as a model has much more to offer, and can serve as a model for many biomedical applications including aging research, medical imaging, and pharmaceutical studies to name a few. In this review, we will provide an overview of the innate immune system in pigs, describe its anatomical and physiological key features, and discuss the key players involved. In particular, we compare the porcine innate immune system to that of humans, and emphasize on the importance of the pig as model for human disease.
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The domestic pig is a large animal model that exhibits relevant physiological and anatomical similarities to humans.
“We next analyzed immunogenicity in domestic pigs, a large animal model that exhibits relevant physiological and anatomical similarities to humans [44,45].”
Humans and pigs share similarities with regards to their immune systems, which is an advantage for studying diseases with a strong immune component like AMD.
“Moreover, an advantage of porcine eyes is that humans and pigs share similarities with regards to their immune systems, which is an advantage for studying diseases with a strong immune component like age-related macular degeneration (AMD) (Mair et al., 2014).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Mair et al., 2014
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References 332 · Cited by 264
Research works printed but not linked: 1
- Summerfield A. McCullough K.C. The porcine dendritic cell family Dev. Comp. Immunol. 33 2009 299 309 18582937 PMC7103208
- Authors
- Mair, K. H., Sedlak, C., Käser, T., Pasternak, A., Levast, B., Gerner, W., Saalmüller, A., Summerfield, A., Gerdts, V., Wilson, H. L., & Meurens, F.
- Affiliations
- University of Veterinary Medicine Vienna (AT)
- University of Saskatchewan (CA)
- Institut für Virologie und Immunologie (CH)
- Corresponding author
- Meurens, F.
- ORCID
- Venue
- Developmental & Comparative Immunology
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 45
- Issue
- 2
- Pages
- 321-343
- ISSN
- 0145-305X (ISSN-L)
- PMC
- PMC7103209
- OpenAlex
- W2042962853
- Cited by
- 264
- References
- 332
- Citations by year
- 2026: 12 · 2025: 21 · 2024: 30 · 2023: 19 · 2022: 29 · 2021: 26 · 2020: 39 · 2019: 24 · 2018: 16 · 2017: 9 · 2016: 15 · 2015: 14 · 2014: 10
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Developmental & Comparative Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Veterinary › Small Animals › Animal health and immunology
- Health Sciences › Medicine › Surgery › Xenotransplantation and immune response
- Keywords
- pigs, biomedical research models
- MeSH terms
- Animals, Immunity, Innate, Inflammation, Swine, Swine Diseases, Receptors, Cytoplasmic and Nuclear, Sus scrofa, Receptors, Pattern Recognition
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