Cited by 197Aquaculture disease management and microbiotaImmune responses and vaccinationsImmune Response and Inflammation

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Long-lived effects of administering β-glucans: Indications for trained immunity in fish

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Petit, Jules, Wiegertjes, Geert F.·2016·Developmental & Comparative Immunology

DOI 10.1016/j.dci.2016.03.003

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Abstract

Over the past decades, it has become evident that immune-modulation of fish with β-glucans, using injection, dietary or even immersion routes of administration, has stimulating but presumed short-lived effects on both intestinal and systemic immunity and can increase protection against a subsequent pathogenic challenge. Although the exact effects can be variable depending on, among others, fish species and administration route, the immune-stimulating effects of β-glucans on the immune system of fish appear to be universal. This review provides a condensed update of the most recent literature describing the effects of β-glucans on the teleost fish immune system. We shortly discuss possible mechanisms influencing immune-stimulation by β-glucans, including microbial composition of the gut, receptor recognition and downstream signalling. Of interest, in mammalian monocytes, β-glucans are potent inducers of trained immunity. First, we screened the literature for indications of this phenomenon in fish. Criteria that we applied include indications for at least one out of three features considered characteristic of trained immunity; (i) providing protection against a secondary infection in a T- and B-lymphocyte independent manner, (ii) conferring increased resistance upon re-infection and, (iii) relying on key roles for innate immune cell types such as natural killer cells and macrophages. We conclude that several indications exist that support the notion that the innate immune system of teleost fish can be trained. Second, we screened the literature for indications of long-lived effects on innate immunity of fish after administering β-glucans, a criterion which could help to identify key roles for macrophages on resistance to infection. We discuss whether β-glucans, as well-known immune-stimulants, are able to train the immune system of fish and argue in favour of further studies designed to specifically investigate this phenomenon in fish.

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Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 12,401
Innate immune recognition
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Cheng, S.-C., Quintin, J., Cramer, R. A., Shepardson, K. M., Saeed, S., Kumar, V., Giamarellos-Bourboulis, E. J., Martens, J. H. A., Rao, N. A., Aghajanirefah, A., et al. (2014) · Science · doi:10.1126/science.1250684 · Cited by 2,224
Innate immunity of fish (overview).
Magnadóttir, B. (2006) · Fish and Shellfish Immunology · doi:10.1016/j.fsi.2004.09.006 · Cited by 2,203
Systemic Acquired Resistance.
Ryals, J. A., Neuenschwander, U. H., Willits, M. G., Molina, A., Steiner, H., & Hunt, D. M. (1996) · The Plant Cell · doi:10.1105/tpc.8.10.1809 · Cited by 2,060
Trained Immunity: A Memory for Innate Host Defense
Netea, M. G., Quintin, J., & van der Meer, J. W. M. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.006 · Cited by 1,760
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Kleinnijenhuis, J., Quintin, J., Preijers, F., Joosten, L. A. B., Ifrim, D. C., Saeed, S., Jacobs, C., van Loenhout, J., de Jong, D., Stunnenberg, H. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202870109 · Cited by 1,728
Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes
Quintin, J., Saeed, S., Martens, J. H. A., Giamarellos-Bourboulis, E. J., Ifrim, D. C., Logie, C., Jacobs, L., Jansen, T., Kullberg, B.-J., Wijmenga, C., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.06.006 · Cited by 1,289
Systemic Acquired Resistance
Ryals, J. A., Neuenschwander, U. H., Willits, M. G., Molina, A., Steiner, H., & Hunt, M. D. (1996) · The Plant Cell · doi:10.2307/3870231 · Cited by 1,109
Dietary intake of immunostimulants by rainbow trout affects non-specific immunity and protection against furunculosis
Siwicki, A. K., Anderson, D. P., & Rumsey, G. L. (1994) · Veterinary Immunology and Immunopathology · doi:10.1016/0165-2427(94)90062-0 · Cited by 813

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Authors: Petit, J., & Wiegertjes, G. F.
Affiliations: Wageningen University & Research (NL)
Corresponding author: Wiegertjes, Geert F.
ORCID: Petit, Jules
Wiegertjes, Geert F.
Venue: Developmental & Comparative Immunology
Publisher: Elsevier BV
Published: 2016-11
Volume: 64
Pages: 93-102
ISSN: 0145-305X (ISSN-L)
DOI: 10.1016/j.dci.2016.03.003
OpenAlex: W2288992930
Cited by: 196
References: 92
Citations by year: 2026: 18 · 2025: 15 · 2024: 28 · 2023: 17 · 2022: 22 · 2021: 27 · 2020: 24 · 2019: 12 · 2018: 18 · 2017: 11 · 2016: 4
FWCI: 1.45
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Developmental & Comparative Immunology (publishedVersion, cc-by)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion, cc-by)
Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
Funders: Netherlands Organisation for Scientific Research
São Paulo Research Foundation, Brazil
NWO-FAPESP Programme (729.004.002)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: β-glucan, trained immunity, teleosts, innate immunity, macrophages, natural killer cells, immunomodulation, gut microbiota, receptor recognition, fish farming
MeSH terms: Animals, Fishes, Immune System, Immunization, Immunologic Memory, Intestines, Killer Cells, Natural, Macrophages, Mammals, Signal Transduction, Immunity, Mucosal, beta-Glucans, Receptors, Pattern Recognition, Microbiota

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Long-lived effects of administering β-glucans: Indications for trained immunity in fish

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