The DOI matches its Crossref record; 91 of the 92 references it cites were found in a registry or an index.
Long-lived effects of administering β-glucans: Indications for trained immunity in fish
Open accessAbstract
Over the past decades, it has become evident that immune-modulation of fish with β-glucans, using injection, dietary or even immersion routes of administration, has stimulating but presumed short-lived effects on both intestinal and systemic immunity and can increase protection against a subsequent pathogenic challenge. Although the exact effects can be variable depending on, among others, fish species and administration route, the immune-stimulating effects of β-glucans on the immune system of fish appear to be universal. This review provides a condensed update of the most recent literature describing the effects of β-glucans on the teleost fish immune system. We shortly discuss possible mechanisms influencing immune-stimulation by β-glucans, including microbial composition of the gut, receptor recognition and downstream signalling. Of interest, in mammalian monocytes, β-glucans are potent inducers of trained immunity. First, we screened the literature for indications of this phenomenon in fish. Criteria that we applied include indications for at least one out of three features considered characteristic of trained immunity; (i) providing protection against a secondary infection in a T- and B-lymphocyte independent manner, (ii) conferring increased resistance upon re-infection and, (iii) relying on key roles for innate immune cell types such as natural killer cells and macrophages. We conclude that several indications exist that support the notion that the innate immune system of teleost fish can be trained. Second, we screened the literature for indications of long-lived effects on innate immunity of fish after administering β-glucans, a criterion which could help to identify key roles for macrophages on resistance to infection. We discuss whether β-glucans, as well-known immune-stimulants, are able to train the immune system of fish and argue in favour of further studies designed to specifically investigate this phenomenon in fish.
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“Beta glucan is also a well-documented immune stimulant in fish (reviewed in [15])”
From Trained Immunity Provides Long-Term Protection against Bacterial Infections in Channel Catfish (2022) · cites this paper as [15]
Citations
Cites
Pathogen Recognition and Innate Immunity
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mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Cheng, S.-C., Quintin, J., Cramer, R. A., Shepardson, K. M., Saeed, S., Kumar, V., Giamarellos-Bourboulis, E. J., Martens, J. H. A., Rao, N. A., Aghajanirefah, A., et al. (2014) · Science · doi:10.1126/science.1250684 · Cited by 2,224
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Trained Immunity: A Memory for Innate Host Defense
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“437 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT 16 Effects induced by vaccination with BCG (Kleinnijenhuis et al., 2014; 438 Kleinnijenhuis et al., 2012), prepared from attenuated live Mycobacterium 439 bovis, support the proposed benchmarks of trained immunity that it can 440 elicit…”
BackgroundQuintin, J., Saeed, S., Martens, J. H. A., Giamarellos-Bourboulis, E. J., Ifrim, D. C., Logie, C., Jacobs, L., Jansen, T., Kullberg, B.-J., Wijmenga, C., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.06.006 · Cited by 1,289
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In Vitro Experimental Model of Trained Innate Immunity in Human Primary Monocytes
Bekkering, S., Blok, B. A., Joosten, L. A. B., Riksen, N. P., van Crevel, R., & Netea, M. G. (2016) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00349-16 · Cited by 364
Epigenetics and Trained Immunity
van der Heijden, C. D. C. C., Noz, M. P., Joosten, L. A. B., Netea, M. G., Riksen, N. P., & Keating, S. T. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7310 · Cited by 295
Exploring fish microbial communities to mitigate emerging diseases in aquaculture
de Bruijn, I., Liu, Y., Wiegertjes, G. F., & Raaijmakers, J. M. (2017) · FEMS Microbiology Ecology · doi:10.1093/femsec/fix161 · Cited by 279
Self-citationFeed, Microbiota, and Gut Immunity: Using the Zebrafish Model to Understand Fish Health
Nadal, A. L., Ikeda‐Ohtsubo, W., Sipkema, D., Peggs, D., McGurk, C., Forlenza, M., Wiegertjes, G. F., & Brugman, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00114 · Cited by 265
Self-citationAdvances in Aquaculture Vaccines Against Fish Pathogens: Global Status and Current Trends
Dadar, M., Dhama, K., Vakharia, V. N., Hoseinifar, S. H., Karthik, K., Tiwari, R., Khandia, R., Munjal, A. K., Salgado-Miranda, C., & Joshi, S. K. (2016) · Reviews in Fisheries Science & Aquaculture · doi:10.1080/23308249.2016.1261277 · Cited by 246
Metadata
- Authors
- Petit, J., & Wiegertjes, G. F.
- Affiliations
- Wageningen University & Research (NL)
- Corresponding author
- Wiegertjes, Geert F.
- Venue
- Developmental & Comparative Immunology
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 64
- Pages
- 93-102
- ISSN
- 0145-305X (ISSN-L)
- OpenAlex
- W2288992930
- Cited by
- 196
- References
- 92
- Citations by year
- 2026: 18 · 2025: 15 · 2024: 28 · 2023: 17 · 2022: 22 · 2021: 27 · 2020: 24 · 2019: 12 · 2018: 18 · 2017: 11 · 2016: 4
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Developmental & Comparative Immunology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Funders
- Netherlands Organisation for Scientific Research
- São Paulo Research Foundation, Brazil
- NWO-FAPESP Programme (729.004.002)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- β-glucan, trained immunity, teleosts, innate immunity, macrophages, natural killer cells, immunomodulation, gut microbiota, receptor recognition, fish farming
- MeSH terms
- Animals, Fishes, Immune System, Immunization, Immunologic Memory, Intestines, Killer Cells, Natural, Macrophages, Mammals, Signal Transduction, Immunity, Mucosal, beta-Glucans, Receptors, Pattern Recognition, Microbiota
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