Hidradenitis suppurativa
Abstract
Hidradenitis suppurativa (HS) is a chronic, inflammatory, scarring condition involving the intertriginous skin of the axillary, inguinal, inframammary, genital, and perineal areas of the body. It is also referred to as acne inversa and Verneuil disease. Follicular occlusion is the primary event in HS. It is now accepted that the first pathogenetic change is in the pilosebaceous follicular ducts, like acne, and so there has been a move to rename this disorder acne inversa. Despite the legitimate argument that hidradenitis suppurativa is a misnomer, the term has become generally accepted.
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Comorbidity with Crohn's disease and other Th17-induced autoinflammatory diseases, bacterial colonization, and response to anti-TNFα factors strongly suggest immune system involvement in hidradenitis suppurativa.
“Comorbidity with Crohn’s disease and other autoinflammatory Th17-induced diseases [238], subsequent bacterial colonization of the lesions [245, 246] and the response of HS patients to anti-TNFα factors strongly suggest involvement of the immune system.”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [238]
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Steroidogenesis in the skin: Implications for local immune functions
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works
- Authors
- Danby, F. W., & Margesson, L. J.
- Affiliations
- Dartmouth College (US)
- Corresponding author
- Danby, F. William
- ORCID
- Danby, F. William
- Venue
- Dermatologic Clinics
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 28
- Issue
- 4
- Pages
- 779-793
- ISSN
- 0733-8635 (ISSN-L)
- OpenAlex
- W4254397001
- Cited by
- 85
- References
- 92
- Citations by year
- 2025: 2 · 2024: 8 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 8 · 2018: 8 · 2017: 6 · 2016: 11 · 2015: 5 · 2014: 5 · 2013: 2 · 2012: 9
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dermatologic Clinics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Hidradenitis Suppurativa and Treatments
- Health Sciences › Medicine › Epidemiology › Autoimmune and Inflammatory Disorders
- Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
- Keywords
- hidradenitis suppurativa, Verneuil disease, follicular occlusion, pilosebaceous follicle, intertriginous skin, chronic inflammatory skin disease, pathogenesis
- MeSH terms
- Androgen Antagonists, Anti-Inflammatory Agents, Anti-Bacterial Agents, Chronic Disease, Diagnosis, Differential, Diet Therapy, Female, Humans, Immunosuppressive Agents, Quality of Life, Retinoids, Surgical Procedures, Operative, Prevalence, Hidradenitis Suppurativa, Therapies, Investigational
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