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Cited by 250

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Maternal Control of Vertebrate Development before the Midblastula Transition

Open access
Dosch, Roland, Wagner, Daniel S, Mintzer, Keith A, Runke, Greg, Wiemelt, Anthony P, Mullins, Mary C·2004·Developmental Cell

Abstract

Maternal factors control development prior to the activation of the embryonic genome. In vertebrates, little is known about the molecular mechanisms by which maternal factors regulate embryonic development. To understand the processes controlled by maternal factors and identify key genes involved, we embarked on a maternal-effect mutant screen in the zebrafish. We identified 68 maternal-effect mutants. Here we describe 15 mutations in genes controlling processes prior to the midblastula transition, including egg development, blastodisc formation, embryonic polarity, initiation of cell cleavage, and cell division. These mutants exhibit phenotypes not previously observed in zygotic mutant screens. This collection of maternal-effect mutants provides the basis for a molecular genetic analysis of the maternal control of embryogenesis in vertebrates.

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Crossref · 10.1016/j.devcel.2004.05.002

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Metadata

Authors
Dosch, R., Wagner, D. S., Mintzer, K. A., Runke, G., Wiemelt, A. P., & Mullins, M. C.
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2004-06
Volume
6
Issue
6
Pages
771-780
ISSN
1534-5807 (ISSN-L)
OpenAlex
W1980124652
Cited by
250
References
1
FWCI
2.84
Type
journal article
Language
en
Open access
bronze

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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