The establishment of spemann's organizer and patterning of the vertebrate embryo

Wnt signaling and cancer

Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183 · see citing works

A molecular mechanism for the effect of lithium on development.

Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,305 · see citing works

MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,017 · see citing works

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824 · see citing works

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

Zimmerman, L. B., Jesús-Escobar, J. M. D., & Harland, R. M. (1996) · Cell · doi:10.1016/s0092-8674(00)80133-6 · Cited by 1,639 · see citing works

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C. (1998) · Nature · doi:10.1038/34848 · Cited by 1,608 · see citing works

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

Smith, W. C., & Harland, R. M. (1992) · Cell · doi:10.1016/0092-8674(92)90316-5 · Cited by 1,184 · see citing works

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

Piccolo, S., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Cell · doi:10.1016/s0092-8674(00)80132-4 · Cited by 1,127 · see citing works

Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes

Sasai, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90068-x · Cited by 1,122 · see citing works

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

Zeng, L., Fagotto, F., Zhang, T., Hsu, W., Vasicek, T. J., Perry, W. L., Lee, J. J., Tilghman, S. M., Gumbiner, B. M., & Costantini, F. D. (1997) · Cell · doi:10.1016/s0092-8674(00)80324-4 · Cited by 907 · see citing works

Requirement for Wnt3 in vertebrate axis formation

Liu, P., Wakamiya, M., Shea, M. J., Albrecht, U., Behringer, R. R., & Bradley, A. (1999) · Nature Genetics · doi:10.1038/11932 · Cited by 900 · see citing works

FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER

Harland, R., & Gerhart, J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.611 · Cited by 839 · see citing works

The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

Piccolo, S., Agius, E., Leyns, L., Bhattacharyya, S., Grunz, H., Bouwmeester, T., & Robertis, E. M. D. (1999) · Nature · doi:10.1038/17820 · Cited by 832 · see citing works

A common plan for dorsoventral patterning in Bilateria

De Robertis, E. M., & Sasai, Y. (1996) · Nature · doi:10.1038/380037a0 · Cited by 780 · see citing works

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

Conlon, F. L., Lyons, K. M., Takaesu, N. T., Barth, K. S., Kispert, A., Herrmann, B. G., & Robertson, E. J. (1994) · Development · doi:10.1242/dev.120.7.1919 · Cited by 772 · see citing works

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Nature · doi:10.1038/382595a0 · Cited by 759 · see citing works

Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer

Leyns, L., Bouwmeester, T., Kim, S., Piccolo, S., & Robertis, E. M. D. (1997) · Cell · doi:10.1016/s0092-8674(00)81921-2 · Cited by 736 · see citing works

Zebrafish organizer development and germ-layer formation require nodal-related signals

Feldman, B., Gates, M. A., Egan, E. S., Dougan, S. T., Rennebeck, G., Sirotkin, H. I., Schier, A. F., & Talbot, W. S. (1998) · Nature · doi:10.1038/26013 · Cited by 666 · see citing works

Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice

Huelsken, J., Vogel, R., Brinkmann, V., Erdmann, B., Birchmeier, C., & Birchmeier, W. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.3.567 · Cited by 660 · see citing works

Overexpression of cadherins and underexpression of ?-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

Heasman, J. (1994) · Cell · doi:10.1016/0092-8674(94)90069-8 · Cited by 643 · see citing works

Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation

Zhou, X., Sasaki, H., Lowe, L. A., Hogan, B. L. M., & Kuehn, M. R. (1993) · Nature · doi:10.1038/361543a0 · Cited by 615 · see citing works

Developmental Biology

Barresi, M. J. F., & Gilbert, S. F. (2023) · Oxford University Press eBooks · doi:10.1093/hesc/9780197574591.001.0001 · Cited by 600 · see citing works

The organizer factors Chordin and Noggin are required for mouse forebrain development

Bachiller, D., Klingensmith, J., Kemp, C. R., Belo, J. A., Anderson, R. M., May, S. R., McMahon, J. A., McMahon, A. P., Harland, R. M., Rossant, J., et al. (2000) · Nature · doi:10.1038/35001072 · Cited by 524 · see citing works

βCatenin Signaling Activity Dissected in the Early Xenopus Embryo: A Novel Antisense Approach

Heasman, J., Kofron, M. J., & Wylie, C. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9720 · Cited by 523 · see citing works

The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning

Kishimoto, Y., Lee, K., Zon, L. I., Hammerschmidt, M., & Schulte‐Merker, S. (1997) · Development · doi:10.1242/dev.124.22.4457 · Cited by 520 · see citing works

Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8

Wang, S., Krinks, M., Lin, K., Luyten, F. P., & Moos, M. (1997) · Cell · doi:10.1016/s0092-8674(00)81922-4 · Cited by 518 · see citing works

Nodal signalling in vertebrate development

Schier, A. F., & Shen, M. M. (2000) · Nature · doi:10.1038/35000126 · Cited by 515 · see citing works

β-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos

Schneider, S., Steinbeißer, H., Warga, R. M., & Hausen, P. (1996) · Mechanisms of Development · doi:10.1016/0925-4773(96)00546-1 · Cited by 515 · see citing works

The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos

Kao, K. R., & Elinson, R. P. (1988) · Developmental Biology · doi:10.1016/0012-1606(88)90189-3 · Cited by 513 · see citing works

Smads and early developmental signaling by the TGFβ superfamilyPreprint

Whitman, M. (1998) · Genes & Development · doi:10.1101/gad.12.16.2445 · Cited by 477 · see citing works

The Role of Maternal VegT in Establishing the Primary Germ Layers in Xenopus Embryos

Zhang, J., Houston, D. W., King, M. L., Payne, C., Wylie, C. C., & Heasman, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81592-5 · Cited by 470 · see citing works

Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer

Nishita, M., Hashimoto, M. K., Ogata, S., Laurent, M. N., Ueno, N., Shibuyà, H., & Cho, K. W. Y. (2000) · Nature · doi:10.1038/35001602 · Cited by 466 · see citing works

Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo

Iemura, S.-I., Yamamoto, T. S., Takagi, C., Uchiyama, H., Natsume, T., Shimasaki, S., Sugino, H., & Ueno, N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9337 · Cited by 450 · see citing works

Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-β and Wnt pathways

Labbé, É., Letamendı́a, A., & Attisano, L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.150152697 · Cited by 446 · see citing works

Synexpression groups in eukaryotes

Niehrs, C., & Pollet, N. (1999) · Nature · doi:10.1038/990025 · Cited by 440 · see citing works

Left–right asymmetric expression of the TGFβ-family member lefty in mouse embryos

Meno, C., Saijoh, Y., Fujii, H., Ikeda, M., Yokoyama, T., Yokoyama, M., Toyoda, Y., & Hamada, H. (1996) · Nature · doi:10.1038/381151a0 · Cited by 437 · see citing works

A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin

Holley, S. A., Jackson, P. D., Sasai, Y., Lu, B., Robertis, E. M. D., Hoffmann, F. M., & Ferguson, E. L. (1995) · Nature · doi:10.1038/376249a0 · Cited by 435 · see citing works

Endodermal Nodal-related signals and mesoderm induction in Xenopus

Agius, E., Oelgeschläger, M., Wessely, O., Kemp, C. R., & Robertis, E. M. D. (2000) · Development · doi:10.1242/dev.127.6.1173 · Cited by 420 · see citing works

Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation

Jones, C. M., Kuehn, M. R., Hogan, B. L. M., Smith, J. C., & Wright, C. V. E. (1995) · Development · doi:10.1242/dev.121.11.3651 · Cited by 419 · see citing works

Cleavage of Chordin by Xolloid Metalloprotease Suggests a Role for Proteolytic Processing in the Regulation of Spemann Organizer Activity

Piccolo, S., Agius, E., Lu, B., Goodman, S. A., Dale, L., & Robertis, E. M. D. (1997) · Cell · doi:10.1016/s0092-8674(00)80424-9 · Cited by 407 · see citing works

Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling Pathway

Larabell, C. A., Torres, M. A., Rowning, B. A., Yost, C., Miller, J. R., Wu, M., Kimelman, D., & Moon, R. T. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.5.1123 · Cited by 407 · see citing works

The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4

Fainsod, A., Deißler, K., Yelin, R., Marom, K., Epstein, M., Pillemer, G., Steinbeißer, H., & Blum, M. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00673-4 · Cited by 385 · see citing works

The zebrafish organizer requires chordino

Schulte-Merker, S., Lee, K. J., McMahon, A. P., & Hammerschmidt, M. (1997) · Nature · doi:10.1038/43092 · Cited by 380 · see citing works

Mouse Lefty2 and Zebrafish Antivin Are Feedback Inhibitors of Nodal Signaling during Vertebrate Gastrulation

Meno, C., Gritsman, K., Ohishi, S., Ohfuji, Y., Heckscher, E., Mochida, K., Shimono, A., Kondoh, H., Talbot, W. S., Robertson, E. J., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80331-7 · Cited by 374 · see citing works

Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus

Glinka, A., Wu, W., Onichtchouk, D., Blumenstock, C., & Niehrs, C. (1997) · Nature · doi:10.1038/39092 · Cited by 350 · see citing works

Production of a DPP Activity Gradient in the Early Drosophila Embryo through the Opposing Actions of the SOG and TLD Proteins

Marqués, G., Musacchio, M., Shimell, M., Wünnenberg-Stapleton, K., Cho, K. W. Y., & O’Connor, M. B. (1997) · Cell · doi:10.1016/s0092-8674(00)80425-0 · Cited by 349 · see citing works

Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos.Preprint

Hoppler, S., Brown, J. D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.21.2805 · Cited by 346 · see citing works

Wnt signaling in Xenopus embryos inhibits Bmp4 expression and activates neural developmentPreprint

Baker, J. C., Beddington, R. S. P., & Harland, R. M. (1999) · Genes & Development · doi:10.1101/gad.13.23.3149 · Cited by 337 · see citing works

Antivin, a novel and divergent member of the TGFβ superfamily, negatively regulates mesoderm induction

Thisse, C., & Thisse, B. (1999) · Development · doi:10.1242/dev.126.2.229 · Cited by 319 · see citing works

Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene.

Francois, V, Solloway, M., O'Neill, J. W., Emery, J., & Bier, E. (1994) · Genes & Development · doi:10.1101/gad.8.21.2602 · Cited by 308 · see citing works

The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling

Oelgeschläger, M., Larraı́n, J., Geissert, D., & Robertis, E. M. D. (2000) · Nature · doi:10.1038/35015500 · Cited by 279 · see citing works

Mammalian BMP-1/Tolloid-Related Metalloproteinases, Including Novel Family Member Mammalian Tolloid-Like 2, Have Differential Enzymatic Activities and Distributions of Expression Relevant to Patterning and Skeletogenesis

Scott, I. C., Blitz, I. L., Pappano, W. N., Imamura, Y., Clark, T. G., Steiglitz, B. M., Thomas‐Virnig, C. L., Maas, S. A., Takahara, K., Cho, K. W. Y., et al. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9383 · Cited by 278 · see citing works

Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motifPreprint

Germain, S., Howell, M. T., Esslemont, G., & Hill, C. S. (2000) · Genes & Development · doi:10.1101/gad.14.4.435 · Cited by 277 · see citing works

A Mouse Cerberus/Dan-Related Gene Family

Pearce, J., Penny, G. D., & Rossant, J. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9240 · Cited by 273 · see citing works

Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation

Schmid, B., Fürthauer, M., Connors, S. A., Trout, J., Thisse, B., Thisse, C., & Mullins, M. C. (2000) · Development · doi:10.1242/dev.127.5.957 · Cited by 272 · see citing works

Type IIA Procollagen Containing the Cysteine-rich Amino Propeptide Is Deposited in the Extracellular Matrix of Prechondrogenic Tissue and Binds to TGF-β1 and BMP-2

Zhu, Y., Oganesian, A., Keene, D. R., & Sandell, L. J. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.5.1069 · Cited by 271 · see citing works

The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controling dorsoventral patterning of Xenopus mesoderm

Onichtchouk, D., Gawantka, V., Dosch, R., Delius, H., Hirschfeld, K., Blumenstock, C., & Niehrs, C. (1996) · Development · doi:10.1242/dev.122.10.3045 · Cited by 270 · see citing works

Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFβ growth factors

Kofron, M. J., Demel, T., Xanthos, J., Lohr, J. L., Sun, B. I., Sive, H. L., Osada, S., Wright, C. V. E., Wylie, C., & Heasman, J. (1999) · Development · doi:10.1242/dev.126.24.5759 · Cited by 264 · see citing works

Endogenous patterns of TGFβ superfamily signaling during early Xenopus development

Faure, S., Lee, M. A., Keller, T. L., ten Dijke, P., & Whitman, M. (2000) · Development · doi:10.1242/dev.127.13.2917 · Cited by 257 · see citing works

Establishment of the Dorsal–Ventral Axis inXenopus Embryos Coincides with the Dorsal Enrichment of Dishevelled That Is Dependent on Cortical Rotation

Miller, J. R., Rowning, B. A., Larabell, C. A., Yang-Snyder, J., Bates, R. L., & Moon, R. T. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.2.427 · Cited by 254 · see citing works

BMP-binding modules in chordin: a model for signalling regulation in the extracellular space

Larraı́n, J., Bachiller, D., Lu, B., Agius, E., Piccolo, S., & Robertis, E. M. D. (2000) · Development · doi:10.1242/dev.127.4.821 · Cited by 251 · see citing works

A homeobox-containing marker of posterior neural differentiation shows the importance of predetermination in neural induction

Sharpe, C. R., Fritz, A., Robertis, E. M. D., & Gurdon, J. B. (1987) · Cell · doi:10.1016/0092-8674(87)90333-3 · Cited by 250 · see citing works

The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its Receptor

Holley, S. A., Neul, J. L., Attisano, L., Wrana, J. L., Sasai, Y., O’Connor, M. B., Robertis, E. M. D., & Ferguson, E. L. (1996) · Cell · doi:10.1016/s0092-8674(00)80134-8 · Cited by 239 · see citing works

The heritage of experimental embryology: Hans Spemann and the organizer

Slack, J. (1988) · Choice Reviews Online · doi:10.5860/choice.26-0295 · Cited by 233 · see citing works

Patterning the Xenopus blastula

Heasman, J. (1997) · Development · doi:10.1242/dev.124.21.4179 · Cited by 232 · see citing works

Localized enhancement and repression of the activity of the TGF-P family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo

Ferguson, E. L., & Anderson, K. V. (1992) · Development · doi:10.1242/dev.114.3.583 · Cited by 228 · see citing works

Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse.Preprint

Watabe, T., Kim, S., Candia, A. F., Rothbächer, U., Hashimoto, C., Inoue, K., & Cho, K. W. (1995) · Genes & Development · doi:10.1101/gad.9.24.3038 · Cited by 224 · see citing works

The Xenopus homeobox gene Twin mediates Wnt induction of Goosecoid in establishment of Spemann’s organizer

Laurent, M. N., Blitz, I. L., Hashimoto, C., Rothbächer, U., & Cho, K. W. Y. (1997) · Development · doi:10.1242/dev.124.23.4905 · Cited by 219 · see citing works

Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor.Preprint

Hammerschmidt, M., Serbedzija, G. N., & McMahon, A. P. (1996) · Genes & Development · doi:10.1101/gad.10.19.2452 · Cited by 217 · see citing works

Mixer , a Homeobox Gene Required for Endoderm Development

Henry, G. L., & Melton, D. A. (1998) · Science · doi:10.1126/science.281.5373.91 · Cited by 204 · see citing works

The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo

Hild, M., Dick, A., Rauch, G.-J., Meier, A., Bouwmeester, T., Haffter, P., & Hammerschmidt, M. (1999) · Development · doi:10.1242/dev.126.10.2149 · Cited by 197 · see citing works

Maternal β-catenin establishes a ‘dorsal signal’ in early Xenopus embryos

Wylie, C. C., Kofron, M. J., Payne, C., Anderson, R., Hosobuchi, M., Joseph, E. M., & Heasman, J. (1996) · Development · doi:10.1242/dev.122.10.2987 · Cited by 195 · see citing works

TGF-β signals and a prepattern in Xenopus laevis endodermal development

Henry, G. L., Brivanlou, I. H., Kessler, D. S., Hemmati‐Brivanlou, A., & Melton, D. A. (1996) · Development · doi:10.1242/dev.122.3.1007 · Cited by 193 · see citing works

Dynamic microtubules and specification of the zebrafish embryonic axis

Jesuthasan, S. J., & Strähle, U. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00025-x · Cited by 185 · see citing works

Local inhibition and long-range enhancement of Dpp signal transduction by Sog

Ashe, H. L., & Levine, M. (1999) · Nature · doi:10.1038/18892 · Cited by 183 · see citing works

Xnr4:AXenopusNodal-Related Gene Expressed in the Spemann Organizer

Joseph, E. M., & Melton, D. A. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8510 · Cited by 164 · see citing works

Direct neural induction and selective inhibition of mesoderm and epidermis inducers by Xnr3

Ezal, C., Marion, C. D., Steele, K. A., George, S. E., & Smith, W. C. (1997) · Development · doi:10.1242/dev.124.2.483 · Cited by 161 · see citing works

Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila

Conley, C. A., Silburn, R., Singer, M. A., Ralston, A., Rohwer-Nutter, D., Olson, D. J., Gelbart, W. M., & Blair, S. S. (2000) · Development · doi:10.1242/dev.127.18.3947 · Cited by 160 · see citing works

Sizzled: a secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos

Salic, A. N., Kroll, K. L., Esvans, L. M., & Kirschner, M. W. (1997) · Development · doi:10.1242/dev.124.23.4739 · Cited by 159 · see citing works

Microtubule-mediated transport of organelles and localization of β-catenin to the future dorsal side of Xenopus eggs

Rowning, B. A., Wells, J. N., Wu, M., Gerhart, J. C., Moon, R. T., & Larabell, C. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1224 · Cited by 157 · see citing works

Siamois is required for formation of Spemann’s organizer

Kessler, D. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13017 · Cited by 141 · see citing works

Dorsal midline fate in Drosophila embryos requires twisted gastrulation, a gene encoding a secreted protein related to human connective tissue growth factor.Preprint

Mason, E. D., Konrad, K. D., Webb, C. D., & Marsh, J. (1994) · Genes & Development · doi:10.1101/gad.8.13.1489 · Cited by 135 · see citing works

Activation ofSiamoisby theWntPathway

Brannon, M. K., & Kimelman, D. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0306 · Cited by 134 · see citing works

Determinants of Spatial Organization

(1979) · Elsevier eBooks · doi:10.1016/b978-0-12-612983-0.x5001-9 · Cited by 132 · see citing works

The lefty-related factor Xatv acts as a feedback inhibitor of Nodal signaling in mesoderm induction and L-R axis development in Xenopus

Cheng, A. M. S., Thisse, B., Thisse, C., & Wright, C. V. E. (2000) · Development · doi:10.1242/dev.127.5.1049 · Cited by 129 · see citing works

A two-step model for the fate determination of presumptive endodermal blastomeres in Xenopus embryos

Yasuo, H., & Lemaire, P. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80391-1 · Cited by 126 · see citing works

The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo

Connors, S. A., Trout, J., Ekker, M., & Mullins, M. C. (1999) · Development · doi:10.1242/dev.126.14.3119 · Cited by 125 · see citing works

Interpretation of a BMP Activity Gradient in Drosophila Embryos Depends on Synergistic Signaling by Two Type I Receptors, SAX and TKV

Nguyen, M. Q., Park, S., Marqués, G., & Arora, K. (1998) · Cell · doi:10.1016/s0092-8674(00)81617-7 · Cited by 121 · see citing works

A direct screen for secreted proteins in Xenopus embryos identifies distinct activities for the Wnt antagonists Crescent and Frzb-1

Pera, E. M., & Robertis, E. M. D. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00394-4 · Cited by 117 · see citing works

Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish

Shimizu, T., Yamanaka, Y., Ryu, S.-L., Hashimoto, H., Yabe, T., Hirata, T., Bae, Y., Hibi, M., & Hirano, T. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00319-6 · Cited by 116 · see citing works

Signals from the Yolk Cell Induce Mesoderm, Neuroectoderm, the Trunk Organizer, and the Notochord in Zebrafish

Ober, E. A., & Schulte‐Merker, S. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9455 · Cited by 115 · see citing works

The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways

Fekany-Lee, K., González, E. M., Miller-Bertoglio, V. E., & Solnica‐Krezel, L. (2000) · Development · doi:10.1242/dev.127.11.2333 · Cited by 106 · see citing works

The putative Wnt receptor Xenopus frizzled-7 functions upstream of β-catenin in vertebrate dorsoventral mesoderm patterning

Sumanas, S., Strege, P. R., Heasman, J., & Ekker, S. C. (2000) · Development · doi:10.1242/dev.127.9.1981 · Cited by 105 · see citing works

Patterning the Early Zebrafish by the Opposing Actions of bozozok and vox/vent

Melby, A. E., Beach, C., Mullins, M. C., & Kimelman, D. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9780 · Cited by 104 · see citing works

Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity

Yu, K., Srinivasan, S., Shimmi, O., Biehs, B., Rashka, K. E., Kimelman, D., O’Connor, M. B., & Bier, E. (2000) · Development · doi:10.1242/dev.127.10.2143 · Cited by 103 · see citing works

Patterning the zebrafish axial skeleton requires early chordin function

Fisher, S., & Halpern, M. E. (1999) · Nature Genetics · doi:10.1038/70557 · Cited by 102 · see citing works

Removal of vegetal yolk causes dorsal deficencies and impairs dorsal-inducing ability of the yolk cell in zebrafish

Mizuno, T., Yamaha, E., Kuroiwa, A., & Takeda, H. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00202-0 · Cited by 102 · see citing works

Spatially Restricted Activation of the SAX Receptor by SCW Modulates DPP/TKV Signaling in Drosophila Dorsal–Ventral Patterning

Neul, J. L., & Ferguson, E. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81616-5 · Cited by 98 · see citing works

CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis

Kolle, G., Georgas, K. M., Holmes, G., Little, M. H., & Yamada, T. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00248-8 · Cited by 97 · see citing works

Gastrulation : movements, patterns, and molecules

Keller, R. E., Clark, W. H., & Griffin, F. J. (1991) · Plenum Press eBooks · Cited by 96 · see citing works

New gene, nel, encoding a Mr 93 K protein with EGF‐like repeats is strongly expressed in neural tissues of early stage chick embryos

Matshuhashi, S., Noji, S., Koyama, E., Myokai, F., Ohuchi, H., Taniguchi, S., & Hori, K. (1995) · Developmental Dynamics · doi:10.1002/aja.1002030209 · Cited by 86 · see citing works

bozozok and squint act in parallel to specify dorsal mesoderm and anterior neuroectoderm in zebrafish

Sirotkin, H. I., Dougan, S. T., Schier, A. F., & Talbot, W. S. (2000) · Development · doi:10.1242/dev.127.12.2583 · Cited by 85 · see citing works

The nieuwkoid/dharma Homeobox Gene Is Essential for bmp2b Repression in the Zebrafish Pregastrula

Koos, D. S., & Ho, R. K. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9479 · Cited by 82 · see citing works

Animal and vegetal pole cells of early Xenopus embryos respond differently to maternal dorsal determinants: implications for the patterning of the organiser

Darras, S., Marikawa, Y., Elinson, R. P., & Lemaire, P. (1997) · Development · doi:10.1242/dev.124.21.4275 · Cited by 79 · see citing works

Organizing the Xenopus Organizer

Gerhart, J. C., Doniach, T., & Stewart, R. (1991) · Springer eBooks · doi:10.1007/978-1-4684-6027-8_4 · Cited by 75 · see citing works

High-frequency twinning of Xenopus laevis embryos from eggs centrifuged before first cleavage

Black, S. D., & Gerhart, J. C. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90059-x · Cited by 73 · see citing works

Xenopus Kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline

Matsui, M., Mizuseki, K., Nakatani, J., Nakanishi, S., & Sasai, Y. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090020497 · Cited by 61 · see citing works

Chapter 5 An Old Enigma: the Gray Crescent of Amphibian Eggs

Bracket, J. (1977) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)60745-0 · Cited by 59 · see citing works

Regulation of Dorsal Gene Expression in Xenopus by the Ventralizing Homeodomain Gene Vox

Melby, A. E., Clements, W. K., & Kimelman, D. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9296 · Cited by 49 · see citing works

Vererbung und Entwicklungsmechanik

Spemann, H. (1924) · Die Naturwissenschaften · doi:10.1007/bf01506346 · Cited by 33 · see citing works

Combinatorial signaling by Twisted Gastrulation and Decapentaplegic

Mason, E. D., Williams, S. J., Grotendorst, G. R., & Marsh, J. L. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00049-x · Cited by 32 · see citing works

The Ultrastructure and Role of the Polar Lobe in Development of Molluscs

Dohmen, M., & Verdonk, N. H. (1979) · Elsevier eBooks · doi:10.1016/b978-0-12-612983-0.50008-0 · Cited by 27 · see citing works

Regulation of early expression of Dlx3, a Xenopus anti-neural factor, by β-catenin signaling

Beanan, M. J., Feledy, J. A., & Sargent, T. D. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00303-2 · Cited by 25 · see citing works

Erratum

(1996) · Developmental Dynamics · doi:10.1002/1097-0177(199610)207:2 · Cited by 21 · see citing works

Hemochromatosis: a genetic defect in iron metabolism

Jazwinska, E. C. (1998) · BioEssays · doi:10.1002/(sici)1521-1878(199807)20:7 · Cited by 15 · see citing works

Wnt signal transduction pathways

Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528 · see citing works

MicroRNA control of signal transduction

Inui, M., Martello, G., & Piccolo, S. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2868 · Cited by 1,262 · see citing works

Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors

Maretto, S., Cordenonsi, M., Dupont, S., Braghetta, P., Broccoli, V., Hassan, A. B., Volpin, D., Bressan, G. M., & Piccolo, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0434590100 · Cited by 759 · see citing works

Morphogen gradient interpretation

Gurdon, J. B., & Bourillot, P.-Y. (2001) · Nature · doi:10.1038/35101500 · Cited by 746 · see citing works

DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN <i>XENOPUS</i> EMBRYOS

De Robertis, E. M., & Kuroda, H. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.011403.154124 · Cited by 671 · see citing works

Balancing cell adhesion and Wnt signaling, the key role of β-catenin

Brembeck, F. H., Rosário, M., & Birchmeier, W. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.12.007 · Cited by 668 · see citing works

A Maternal-Zygotic Effect Gene, Zfp57, Maintains Both Maternal and Paternal Imprints

Li, X., Ito, M., Zhou, F., Youngson, N. A., Zuo, X., Leder, P., & Ferguson‐Smith, A. C. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.08.014 · Cited by 647 · see citing works

Extracellular Regulation of BMP Signaling in Vertebrates: A Cocktail of Modulators

Balemans, W., & Hul, W. V. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0779 · Cited by 616 · see citing works

A morphogen gradient of Wnt/β-catenin signalling regulates anteroposterior neural patterning inXenopus

Kiecker, C. M., & Niehrs, C. (2001) · Development · doi:10.1242/dev.128.21.4189 · Cited by 515 · see citing works

The evolution of signalling pathways in animal development

Pires-daSilva, A., & Sommer, R. J. (2003) · Nature Reviews Genetics · doi:10.1038/nrg977 · Cited by 466 · see citing works

Reprogramming metastatic tumour cells with embryonic microenvironments

Hendrix, M. J. C., Seftor, E. A., Seftor, R. E. B., Kasemeier‐Kulesa, J. C., Kulesa, P. M., & Postovit, L.-M. M. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2108 · Cited by 470 · see citing works

Early Steps in the Development of the Forebrain

Wilson, S. W., & Houart, C. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00027-9 · Cited by 460 · see citing works

The Zebrafish Glypican Knypek Controls Cell Polarity during Gastrulation Movements of Convergent Extension

Topczewski, J., Sepich, D. S., Myers, D. C., Walker, C., Amores, A., Lele, Z., Hammerschmidt, M., Postlethwait, J. H., & Solnica‐Krezel, L. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00005-3 · Cited by 454 · see citing works

Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness

Topczewska, J. M., Postovit, L.-M. M., Margaryan, N. V., Sam, A., Hess, A. R., Wheaton, W. W., Nickoloff, B. J., Topczewski, J., & Hendrix, M. J. C. (2006) · Nature Medicine · doi:10.1038/nm1448 · Cited by 438 · see citing works

Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural inductionPreprint

Pera, E. M., Ikeda, A., Eivers, E., & Robertis, E. M. D. (2003) · Genes & Development · doi:10.1101/gad.1153603 · Cited by 421 · see citing works

Conserved Patterns of Cell Movements during Vertebrate Gastrulation

Solnica-Krezel, L. (2005) · Current Biology · doi:10.1016/j.cub.2005.03.016 · Cited by 391 · see citing works

Intracellular BMP Signaling Regulation in Vertebrates: Pathway or Network?

von Bubnoff, A., & Cho, K. W. Y. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0388 · Cited by 393 · see citing works

Structural Biology and Evolution of the TGF-β FamilyPreprint

Hinck, A. P., Mueller, T. D., & Springer, T. A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022103 · Cited by 364 · see citing works

Gastrulation: Making and Shaping Germ Layers

Solnica‐Krezel, L., & Sepich, D. S. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154043 · Cited by 366 · see citing works

<i>Smed-</i> β <i>catenin-1</i> Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration

Petersen, C. P., & Reddien, P. W. (2008) · Science · doi:10.1126/science.1149943 · Cited by 364 · see citing works

Germ-Layer Specification and Control of Cell Growth by Ectodermin, a Smad4 Ubiquitin Ligase

Dupont, S., Zacchigna, L., Cordenonsi, M., Soligo, S., Adorno, M., Rugge, M., & Piccolo, S. (2005) · Cell · doi:10.1016/j.cell.2005.01.033 · Cited by 357 · see citing works

Nodal and BMP2/4 Signaling Organizes the Oral-Aboral Axis of the Sea Urchin Embryo

Duboc, V., Röttinger, É., Besnardeau, L., & Lepage, T. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00056-5 · Cited by 353 · see citing works

Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity

Gray, R. S., Roszko, I., & Solnica‐Krezel, L. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.06.011 · Cited by 314 · see citing works

Essential role of BCL9-2 in the switch between β-catenin's adhesive and transcriptional functionsPreprint

Brembeck, F. H., Schwarz, T., Bakkers, J., Wilhelm, S., Hammerschmidt, M., & Birchmeier, W. (2004) · Genes & Development · doi:10.1101/gad.317604 · Cited by 318 · see citing works

Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

Yamamoto, M., Saijoh, Y., Perea-Gómez, A., Shawlot, W., Behringer, R. R., Ang, S., Hamada, H., & Meno, C. (2004) · Nature Cell Biology · doi:10.1038/nature02418 · Cited by 307 · see citing works

T‐box genes in early embryogenesis

Showell, C., Binder, O., & Conlon, F. L. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10480 · Cited by 297 · see citing works

Regionally specific induction by the Spemann–Mangold organizer

Niehrs, C. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1347 · Cited by 294 · see citing works

Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition

Delaune, E. A., Lemaire, P., & Kodjabachian, L. (2004) · Development · doi:10.1242/dev.01582 · Cited by 290 · see citing works

Spemann's organizer and self-regulation in amphibian embryos

De Robertis, E. M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1855 · Cited by 267 · see citing works

Wnt and TGF-β Expression in the Sponge Amphimedon queenslandica and the Origin of Metazoan Embryonic Patterning

Adamska, M., Degnan, S. M., Green, K. M., Adamski, M., Craigie, A., Larroux, C., & Degnan, B. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001031 · Cited by 257 · see citing works

Axial patterning in cephalochordates and the evolution of the organizer

Yu, J., Satou, Y., Holland, N. D., Shin‐I, T., Kohara, Y., Satoh, N., Bronner-Fraser, M. E., & Holland, L. Z. (2007) · Nature · doi:10.1038/nature05472 · Cited by 256 · see citing works

Maternal Control of Vertebrate Development before the Midblastula Transition

Dosch, R., Wagner, D. S., Mintzer, K. A., Runke, G., Wiemelt, A. P., & Mullins, M. C. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.05.002 · Cited by 251 · see citing works

The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm

Kinder, S. J., Tsang, T. E., Wakamiya, M., Sasaki, H., Behringer, R. R., Nagy, A., & Tam, P. (2001) · Development · doi:10.1242/dev.128.18.3623 · Cited by 247 · see citing works

Nodal Signaling in Early Vertebrate Embryos

Whitman, M. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00076-4 · Cited by 242 · see citing works

Depletion of Three BMP Antagonists from Spemann's Organizer Leads to a Catastrophic Loss of Dorsal Structures

Khokha, M. K., Yeh, J., Grammer, T. C., & Harland, R. M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.01.013 · Cited by 230 · see citing works

Neural and Head Induction by Insulin-like Growth Factor Signals

Pera, E. M., Wessely, O., Li, S.-Y., & Robertis, E. M. D. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00069-7 · Cited by 229 · see citing works

Integration of Smad and MAPK pathways: a link and a linker revisitedPreprint

Massagué, J. (2003) · Genes & Development · doi:10.1101/gad.1167003 · Cited by 229 · see citing works

Blastomeres arising from the first cleavage division have distinguishable fates in normal mouse development

Piotrowska, K., Wianny, F., Pedersen, R. A., & Zernicka‐Goetz, M. (2001) · Development · doi:10.1242/dev.128.19.3739 · Cited by 225 · see citing works

Constructing the hindbrain: Insights from the zebrafish

Moens, C. B., & Prince, V. (2002) · Developmental Dynamics · doi:10.1002/dvdy.10086 · Cited by 225 · see citing works

Models of Biological Pattern Formation: From Elementary Steps to the Organization of Embryonic Axes

Meinhardt, H. (2007) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(07)81001-5 · Cited by 214 · see citing works

Mesoderm induction: from caps to chips

Kimelman, D. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1837 · Cited by 210 · see citing works

Neurodevelopmental effects of insulin-like growth factor signaling

OʼKusky, J. R., & Ye, P. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.06.002 · Cited by 210 · see citing works

The role of the zebrafishnodal-related genessquintandcyclopsin patterning of mesendoderm

Dougan, S. T., Warga, R. M., Kane, D. A., Schier, A. F., & Talbot, W. S. (2003) · Development · doi:10.1242/dev.00400 · Cited by 200 · see citing works

Neural Induction in Xenopus: Requirement for Ectodermal and Endomesodermal Signals via Chordin, Noggin, β-Catenin, and Cerberus

Kuroda, H., Wessely, O., & Robertis, E. M. D. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020092 · Cited by 195 · see citing works

USP15 is a deubiquitylating enzyme for receptor-activated SMADs

Inui, M., Manfrin, A., Mamidi, A., Martello, G., Morsut, L., Soligo, S., Enzo, E., Moro, S., Polo, S., Dupont, S., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2346 · Cited by 193 · see citing works

The ankyrin repeat protein Diversin recruits Casein kinase Iε to the β-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signalingPreprint

Schwarz-Romond, T., Asbrand, C., Bakkers, J., Kühl, M., Schaeffer, H.-J., Huelsken, J., Behrens, J., Hammerschmidt, M., & Birchmeier, W. (2002) · Genes & Development · doi:10.1101/gad.230402 · Cited by 189 · see citing works

MicroRNA control of Nodal signalling

Martello, G., Zacchigna, L., Inui, M., Montagner, M., Adorno, M., Mamidi, A., Morsut, L., Soligo, S., Tran, U., Dupont, S., et al. (2007) · Nature · doi:10.1038/nature06100 · Cited by 186 · see citing works

A WNT of things to come: Evolution of Wnt signaling and polarity in cnidarians

LEE, P., PANG, K., Matus, D. Q., & Martindale, M. Q. (2006) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2006.05.002 · Cited by 185 · see citing works

β-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation

Morkel, M., Huelsken, J., Wakamiya, M., Ding, J., van de Wetering, M., Clevers, H. C., Taketo, M. M., Behringer, R. R., Shen, M. M., & Birchmeier, W. (2003) · Development · doi:10.1242/dev.00859 · Cited by 184 · see citing works

Shisa Promotes Head Formation through the Inhibition of Receptor Protein Maturation for the Caudalizing Factors, Wnt and FGF

Yamamoto, A., Nagano, T., Takehara, S., Hibi, M., & Aizawa, S. (2005) · Cell · doi:10.1016/j.cell.2004.11.051 · Cited by 183 · see citing works

Stat3 Controls Cell Movements during Zebrafish Gastrulation

Yamashita, S., Miyagi, C., Carmany-Rampey, A., Shimizu, T., Fujii, R., Schier, A. F., & Hirano, T. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00126-0 · Cited by 178 · see citing works

Convergence and extension in vertebrate gastrulae: cell movements according to or in search of identity?

Myers, D. C., Sepich, D. S., & Solnica‐Krezel, L. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02725-7 · Cited by 169 · see citing works

Wnt/β-catenin and FGF signalling direct the specification and maintenance of a neuromesodermal axial progenitor in ensembles of mouse embryonic stem cells

Turner, D. A., Hayward, P. C., Baillie‐Johnson, P., Rué, P., Broome, R., Faunes, F., & Arias, A. M. (2014) · Development · doi:10.1242/dev.112979 · Cited by 158 · see citing works

The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome

Bachiller, D., Klingensmith, J., Shneyder, N., Tran, U., Anderson, R. M., Rossant, J., & Robertis, E. M. D. (2003) · Development · doi:10.1242/dev.00581 · Cited by 167 · see citing works

Proteolytic cleavage of Chordin as a switch for the dual activities of Twisted gastrulation in BMP signaling

Larraı́n, J., Oelgeschläger, M., Ketpura, N. I., Reversade, B., Zakin, L., & Robertis, E. M. D. (2001) · Development · doi:10.1242/dev.128.22.4439 · Cited by 156 · see citing works

RTK and TGF-β signaling pathways genes in the sea urchin genome

Lapraz, F., Röttinger, É., Duboc, V., Range, R., Duloquin, L., Walton, K. D., Wu, S.-Y., Bradham, C. A., Loza‐Coll, M., Hibino, T., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.048 · Cited by 153 · see citing works

Chordin Is Required for the Spemann Organizer Transplantation Phenomenon in Xenopus Embryos

Oelgeschläger, M., Kuroda, H., Reversade, B., & Robertis, E. M. D. (2003) · Developmental Cell · doi:10.1016/s1534-5807(02)00404-5 · Cited by 145 · see citing works

Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos

Reversade, B., Kuroda, H., Lee, H. X., Mays, A. N., & Robertis, E. M. D. (2005) · Development · doi:10.1242/dev.01901 · Cited by 147 · see citing works

Evolutionary crossroads in developmental biology: amphioxus

Bertrand, S., & Escrivá, H. (2011) · Development · doi:10.1242/dev.066720 · Cited by 144 · see citing works

Axis formation and patterning in zebrafish

Schier, A. F. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00209-4 · Cited by 141 · see citing works

Recent Development of Wnt Signaling Pathway Inhibitors for Cancer Therapeutics

Harb, J., Lin, P., & Hao, J.-J. (2019) · Current Oncology Reports · doi:10.1007/s11912-019-0763-9 · Cited by 116 · see citing works

The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm–specific protein with an extracellular cysteine-rich domain

Kalantry, S., Manning, S., Haub, O., Tomihara-Newberger, C., Lee, H.-G., Fangman, J., Distèche, C. M., Manova, K., & Lacy, E. (2001) · Nature Genetics · doi:10.1038/86912 · Cited by 138 · see citing works

Axis specification in the spider embryo:dppis required for radial-to-axial symmetry transformation andsogfor ventral patterning

Akiyama‐Oda, Y., & Oda, H. (2006) · Development · doi:10.1242/dev.02400 · Cited by 139 · see citing works

BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo

Graham, S. J. L., Wicher, K. B., Jędrusik, A., Guo, G., Herath, W. B., Robson, P., & Zernicka‐Goetz, M. (2014) · Nature Communications · doi:10.1038/ncomms6667 · Cited by 126 · see citing works

Ethanol exposure affects gene expression in the embryonic organizer and reduces retinoic acid levels

Yelin, R., Schyr, R. B., Kot-Leibovich, H., Rousso, S. Z., Frumkin, A., Pillemer, G., & Fainsod, A. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2004.12.014 · Cited by 125 · see citing works

Neural Induction in the Absence of Mesoderm: β-Catenin-Dependent Expression of Secreted BMP Antagonists at the Blastula Stage in Xenopus

Wessely, O., Agius, E., Oelgeschläger, M., Pera, E. M., & Robertis, E. M. D. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0258 · Cited by 124 · see citing works

Two FGFRL-Wnt circuits organize the planarian anteroposterior axis

Scimone, M. L., Cote, L. E., Rogers, T., & Reddien, P. W. (2016) · eLife · doi:10.7554/elife.12845 · Cited by 123 · see citing works

Ciliation and gene expression distinguish between node and posterior notochord in the mammalian embryo

Blum, M., Andre, P., Feistel, K., Schweickert, A., Fischer, A., Bitzer, E., Bogusch, S., Beyer, T., van Straaten, H. W. M., & Viebahn, C. (2006) · Differentiation · doi:10.1111/j.1432-0436.2006.00124.x · Cited by 123 · see citing works

On the evolution of bilaterality

Genikhovich, G., & Technau, U. (2017) · Development · doi:10.1242/dev.141507 · Cited by 121 · see citing works

Nodal signaling and the evolution of deuterostome gastrulation

Chea, H. K., Wright, C. V. E., & Swalla, B. J. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20549 · Cited by 119 · see citing works

High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures

Minn, K. T., Fu, Y. C., He, S., Dietmann, S., George, S. C., Anastasio, M. A., Morris, S. A., & Solnica‐Krezel, L. (2020) · eLife · doi:10.7554/elife.59445 · Cited by 110 · see citing works

MultiTag: Multiple Error-Tolerant Sequence Tag Search for the Sequence-Similarity Identification of Proteins by Mass Spectrometry

Sunyaev, S. R., Liska, A. J., Golod, A., Shevchenko, A., & Shevchenko, A. (2003) · Analytical Chemistry · doi:10.1021/ac026199a · Cited by 116 · see citing works

Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox

Ramel, M., & Lekven, A. C. (2004) · Development · doi:10.1242/dev.01277 · Cited by 116 · see citing works

On the nature and function of organizers

Arias, A. M., & Steventon, B. (2018) · Development · doi:10.1242/dev.159525 · Cited by 115 · see citing works

Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/β-catenin-dependent cell fate decisions during vertebrate development

Hayes, M. N., Naito, M., Daulat, A. M., Angers, S., & Ciruna, B. G. (2013) · Development · doi:10.1242/dev.090183 · Cited by 113 · see citing works

Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling

Yabe, T., Shimizu, T., Muraoka, O., Bae, Y., Hirata, T., Nojima, H., Kawakami, A., Hirano, T., & Hibi, M. (2003) · Development · doi:10.1242/dev.00506 · Cited by 110 · see citing works

Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation

Rentzsch, F., Zhang, J., Kramer, C., Sebald, W., & Hammerschmidt, M. (2006) · Development · doi:10.1242/dev.02250 · Cited by 107 · see citing works

β-Catenin specifies the endomesoderm and defines the posterior organizer of the hemichordate Saccoglossus kowalevskii

Darras, S., Gerhart, J. C., Terasaki, M., Kirschner, M. W., & Lowe, C. J. (2011) · Development · doi:10.1242/dev.059493 · Cited by 106 · see citing works

The route to spinal cord cell types: a tale of signals and switches

Gouti, M., Metzis, V., & Briscoe, J. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.03.001 · Cited by 103 · see citing works

Tsukushi Functions as an Organizer Inducer by Inhibition of BMP Activity in Cooperation with Chordin

Ohta, K., Lupo, G., Kuriyama, S., Keynes, R. J., Holt, C. E., Harris, W. A., Tanaka, H., & Ohnuma, S. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.08.014 · Cited by 102 · see citing works

Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse

Engert, S., Burtscher, I., Liao, W. P., Dulev, S., Schotta, G., & Lickert, H. (2013) · Development · doi:10.1242/dev.088765 · Cited by 101 · see citing works

Dynamics of Notch-Dependent Transcriptional Bursting in Its Native Context

Lee, C., Shin, H., & Kimble, J. E. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.07.001 · Cited by 93 · see citing works

Biglycan is a new extracellular component of the Chordin–BMP4 signaling pathway

Moreno, M., Muñoz, R., Aroca, F., Labarca, M., Brandan, E., & Larraı́n, J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600615 · Cited by 99 · see citing works

Lefty acts as an essential modulator of Nodal activity during sea urchin oral–aboral axis formation

Duboc, V., Lapraz, F., Besnardeau, L., & Lepage, T. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.04.012 · Cited by 96 · see citing works

Syntabulin, a motor protein linker, controls dorsal determination

Nojima, H., Rothhämel, S., Shimizu, T., Kim, C., Yonemura, S., Marlow, F. L., & Hibi, M. (2010) · Development · doi:10.1242/dev.046425 · Cited by 95 · see citing works

Dkk1 and noggin cooperate in mammalian head inductionPreprint

Barrantes, I. D. B., Davidson, G. R., Gröne, H., Westphal, H., & Niehrs, C. (2003) · Genes & Development · doi:10.1101/gad.269103 · Cited by 93 · see citing works

Organizer activity of the polar cells duringDrosophilaoogenesis

Grammont, M., & Irvine, K. D. (2002) · Development · doi:10.1242/dev.129.22.5131 · Cited by 92 · see citing works

RAPGEF5 Regulates Nuclear Translocation of β-Catenin

Griffin, J. N., Viso, F. D., Duncan, A. R., Robson, A., Hwang, W. Y., Kulkarni, S. S., Liu, K. J., & Khokha, M. K. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.12.001 · Cited by 91 · see citing works

PP2A:B56ϵ is required for Wnt/β-catenin signaling during embryonic development

Yang, J., Wu, J., Tan, C. L., & Klein, P. S. (2003) · Development · doi:10.1242/dev.00762 · Cited by 91 · see citing works

Symmetry breakage in the vertebrate embryo: When does it happen and how does it work?

Blum, M., Schweickert, A., Vick, P., Wright, C. V. E., & Danilchik, M. V. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.06.014 · Cited by 90 · see citing works

Essential roles of a zebrafishprdm1/blimp1homolog in embryo patterning and organogenesis

Wilm, T. P., & Solnica‐Krezel, L. (2004) · Development · doi:10.1242/dev.01572 · Cited by 90 · see citing works

Mechanical Forces Reshape Differentiation Cues That Guide Cardiomyogenesis

Happe, C. L., & Engler, A. J. (2016) · Circulation Research · doi:10.1161/circresaha.115.305139 · Cited by 90 · see citing works

The pivotal role of TGF-β/Smad pathway in fibrosis pathogenesis and treatment

Chen, F., Lyu, L., Xing, C., Chen, Y., Hu, S., Wang, M., & Ai, Z. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1649179 · Cited by 99 · see citing works

Xenopus: An Undervalued Model Organism to Study and Model Human Genetic Disease

Blum, M., & Ott, T. (2018) · Cells Tissues Organs · doi:10.1159/000490898 · Cited by 88 · see citing works

Noggin and Chordin Have Distinct Activities in Promoting Lineage Commitment of Mouse Embryonic Stem (ES) Cells

Gratsch, T. E., & O’Shea, K. S. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0629 · Cited by 85 · see citing works

Goosecoid promotes head organizer activity by direct repression of Xwnt8 in Spemann’s organizer

Yao, J., & Kessler, D. S. (2001) · Development · doi:10.1242/dev.128.15.2975 · Cited by 84 · see citing works

An amphioxusnodalgene (AmphiNodal ) with early symmetrical expression in the organizer and mesoderm and later asymmetrical expression associated with left–right axis formation

Yu, J., Holland, L. Z., & Holland, N. D. (2002) · Evolution & Development · doi:10.1046/j.1525-142x.2002.02030.x · Cited by 84 · see citing works

Nucleo-cytoplasmic Shuttling of Axin, a Negative Regulator of the Wnt-β-Catenin Pathway

Wiechens, N., Heinle, K., Englmeier, L., Schohl, A., & Fagotto, F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307253200 · Cited by 84 · see citing works

Single-cell internalization during zebrafish gastrulation

Carmany-Rampey, A., & Schier, A. F. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00353-0 · Cited by 80 · see citing works

The maternally expressed zebrafish T-box gene eomesodermin regulates organizer formation

Bruce, A. E. E., Howley, C., Zhou, Y., Vickers, S. L., Silver, L. M., King, M. L., & Ho, R. K. (2003) · Development · doi:10.1242/dev.00763 · Cited by 77 · see citing works

The Vertebrate Organizer

(2004) · Springer eBooks · doi:10.1007/978-3-662-10416-3 · Cited by 22 · see citing works

The Spemann-Mangold organizer: the control of fate specification and morphogenetic rearrangements during gastrulation in Xenopus

Bouwmeester, T. (2001) · The International Journal of Developmental Biology · doi:10.1387/ijdb.11291854 · Cited by 32 · see citing works

Cell signaling pathways controlling an axis organizing center in the zebrafish

Jones, W. D., & Mullins, M. C. (2022) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2022.03.005 · Cited by 22 · see citing works

Signaling Components in Dorsal-Ventral Patterning and the Organizer in Xenopus

Robertis, E. M. D., & Tejeda‐Muñoz, N. (2022) · CRC Press eBooks · doi:10.1201/9781003050230-5

Formation of the vertebrate embryo: Moving beyond the Spemann organizer

Thisse, B., & Thisse, C. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.05.007 · Cited by 39 · see citing works