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Spatial Regulation of Wingless Morphogen Distribution and Signaling by Dally-like Protein
Open accessAbstract
Wingless (Wg) is a morphogen required for the patterning of many Drosophila tissues. Several lines of evidence implicate heparan sulfate-modified proteoglycans (HSPGs) such as Dally-like protein (Dlp) in the control of Wg distribution and signaling. We show that dlp is required to limit Wg levels in the matrix, contrary to the expectation from overexpression studies. dlp mutants show ectopic activation of Wg signaling at the presumptive wing margin and a local increase in extracellular Wg levels. dlp somatic cell clones disrupt the gradient of extracellular Wg, producing ectopic activation of high threshold Wg targets but reducing the expression of lower threshold Wg targets where Wg is limiting. Notum encodes a secreted protein that also limits Wg distribution, and genetic interaction studies show that dlp and Notum cooperate to restrict Wg signaling. These findings suggest that modification of an HSPG by a secreted hydrolase can control morphogen levels in the matrix.
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Cites
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
Cited by
Sarrazin, S., Lamanna, W. C., & Esko, J. D. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004952 · Cited by 1,516
Functions of heparan sulfate proteoglycans in cell signaling during development
Lin, X. (2004) · Development · doi:10.1242/dev.01522 · Cited by 678
The Molecular Diversity of Glycosaminoglycans Shapes Animal Development
Bülow, H. E., & Hobert, O. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010605.093433 · Cited by 344
Heparan Sulfate in trans Potentiates VEGFR-Mediated Angiogenesis
Jakobsson, L., Kreuger, J., Holmborn, K., Lundin, L., Eriksson, I., Kjellén, L., & Claesson-Welsh, L. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.03.009 · Cited by 274
Metadata
- Authors
- Kirkpatrick, C. A., Dimitroff, B. D., Rawson, J. M., & Selleck, S. B.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 7
- Issue
- 4
- Pages
- 513-523
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2093957890
- Cited by
- 161
- References
- 1
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kirkpatrick, C. A., Dimitroff, B. D., Rawson, J. M., & Selleck, S. B. (2004). Spatial Regulation of Wingless Morphogen Distribution and Signaling by Dally-like Protein. Developmental Cell. https://doi.org/10.1016/j.devcel.2004.08.004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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