Hypoxia requires Notch signaling to maintain the undifferentiated cell state

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Items 101–200 of 1,000

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2. Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia
   Bell, Eric L., Klimova, Tatyana A., Eisenbart, James, Schumacker, Paul T., Chandel, Navdeep S. · 2007 · Molecular and Cellular Biology
3. Siah2-Dependent Concerted Activity of HIF and FoxA2 Regulates Formation of Neuroendocrine Phenotype and Neuroendocrine Prostate Tumors
   Jianfei Qi, Koh Nakayama, Robert D. Cardiff, Alexander D. Borowsky, Karen Lynn Kaul, Roy M. Williams, Stan Krajewski, Dan Mercola, Philip M. Carpenter, David D.L. Bowtell et al. · 2010 · Cancer Cell
4. Turn me on: regulating HIF transcriptional activity
   Karolina Lisy, Daniel J. Peet · 2008 · Cell Death and Differentiation
5. Deadly crosstalk: Notch signaling at the intersection of EMT and cancer stem cells
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6. EMT and Oxidative Stress: A Bidirectional Interplay Affecting Tumor Malignancy
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7. Hypoxic Culture Conditions as a Solution for Mesenchymal Stem Cell Based Regenerative Therapy
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8. Drug Resistance in Non-Small Cell Lung Cancer: A Potential for NOTCH Targeting?
   Venus Sosa Iglesias, Lorena Giuranno, Ludwig Jerome Dubois, Jan Theys, Marc Vooijs · 2018 · Frontiers in Oncology
9. Hypoxia Triggers Meiotic Fate Acquisition in Maize
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10. Enhanced Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells in Low Oxygen Environment Micropellet Cultures
    Brandon D. Markway, Guak‐Kim Tan, Gary P. Brooke, James E. Hudson, Justin John Cooper-White, Michael Robert Doran · 2010 · Cell Transplantation
11. Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate
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12. Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor
    Coleman, Mathew L., McDonough, Michael A., Hewitson, Kirsty S., Coles, Charlotte, Mecinovicí, Jasmin, Edelmann, Mariola, Cook, Kristina M., Cockman, Matthew E., Lancaster, David E., Kessler, Benedikt M. et al. · 2007 · Journal of Biological Chemistry
13. Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer
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14. Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies
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15. Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells
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16. Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin
    Daniel Delgado‐Bellido, Santiago Serrano, Mónica Fernández‐Cortés, Francisco Javier Oliver · 2017 · Molecular Cancer
17. Relevance of Oxygen Concentration in Stem Cell Culture for Regenerative Medicine
    Cristina Mas‐Bargues, Jorge Sanz‐Ros, Aurora Román-Domínguez, Marta Inglés, Lucía Gimeno-Mallench, Marya El Alami, José Viña‐Almunia, Juan Gambini, José Viña, Consuelo Borrás · 2019 · International Journal of Molecular Sciences
18. Research Resource: Transcriptional Profiling Reveals Different Pseudohypoxic Signatures in SDHB and VHL-Related Pheochromocytomas
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19. Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma
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20. Notch1 is an effector of Akt and hypoxia in melanoma development
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21. Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer
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22. Hes1: a key role in stemness, metastasis and multidrug resistance
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23. Neurogenesis Continues in the Third Trimester of Pregnancy and Is Suppressed by Premature Birth
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24. Lying low but ready for action: the quiescent muscle satellite cell
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25. Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes
    Nicolas Skuli, Amar J. Majmundar, Bryan L. Krock, Rickson C. Mesquita, Lijoy K. Mathew, Zachary L. Quinn, Anja Runge, Liping Liu, Meeri N. Kim, Jiaming Liang et al. · 2012 · Journal of Clinical Investigation
26. The hypoxic microenvironment: A determinant of cancer stem cell evolution
    Amancio Carnero, Matilde Esther LLeonart · 2016 · BioEssays
27. Interaction Between Notch and Hif-α in Development and Survival of Drosophila Blood Cells
    Tina Mukherjee, William Sang Kim, Lolitika Mandal, Utpal K. Banerjee · 2011 · Science
28. Receptor Channel TRPC6 Is a Key Mediator of Notch-Driven Glioblastoma Growth and Invasiveness
    Srinivasulu Chigurupati, Rajarajeswari Venkataraman, Daniel Barrera, Anusha Naganathan, Meenu Madan, Leena Paul, Jogi V. Pattisapu, George A. Kyriazis, Kimio Sugaya, Sergey Bushnev et al. · 2009 · Cancer Research
29. Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation
    Weiyi Liu, Yefei Wen, Pengpeng Bi, Xinsheng Lai, Xiaoqi Liu, Xiaoqi Liu, Shihuan Kuang · 2012 · Development
30. Notch Signaling Regulates Platelet-Derived Growth Factor Receptor-β Expression in Vascular Smooth Muscle Cells
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31. A Role for Partial Endothelial–Mesenchymal Transitions in Angiogenesis?
    Katrina M. Welch, Nan Wu, Christopher C.W. Hughes · 2014 · Arteriosclerosis Thrombosis and Vascular Biology
32. Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin
    Smythies, James A, Sun, Min, Masson, Norma, Salama, Rafik, Simpson, Peter D, Murray, Elizabeth, Neumann, Viviana, Cockman, Matthew E, Choudhry, Hani, Ratcliffe, Peter J et al. · 2019 · The EMBO Reports
33. Hypoxia-inducible factor signaling in the development of tissue fibrosis
    Debra F. Higgins, Kuniko Kimura, Masayuki Iwano, Volker H. Haase · 2008 · Cell Cycle
34. The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways
    Tilman Borggrefe, Matthias Lauth, An Zwijsen, Danny Huylebroeck, Franz Oswald, Benedetto Daniele Giaimo · 2015 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
35. Precision medicine for human cancers with Notch signaling dysregulation (Review)
    Masuko Katoh, Masaru Katoh · 2019 · International Journal of Molecular Medicine
36. Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway
    Kung-Chun Chiu, David, Pui-Wah Tse, Aki, Law, Cheuk-Ting, Ming-Jing Xu, Iris, Lee, Derek, Chen, Mengnuo, Kit-Ho Lai, Robin, Wai-Hin Yuen, Vincent, Wing-Sum Cheu, Jacinth, Wai-Hung Ho, Daniel et al. · 2019 · Cell Death & Disease
37. GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α
    Daniela Flügel, Agnes Görlach, Thomas Kietzmann · 2011 · Blood
38. Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy
    Asha Borah, Sreejith Raveendran, Ankit Rochani, Toru Maekawa, D. Sakthi Kumar · 2015 · Oncogenesis
39. p66Shc/Notch-3 Interplay Controls Self-Renewal and Hypoxia Survival in Human Stem/Progenitor Cells of the Mammary Gland Expanded In Vitro as Mammospheres
    Pasquale Sansone, Gianluca Storci, Catia Giovannini, Silvia Pandolfi, Simona Pianetti, Mario Taffurelli, Donatella Santini, Claudio Ceccarelli, Pasquale Chieco, Massimiliano Bonafè · 2006 · Stem Cells
40. Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients
    Annika Fendler, Daniel E. Bauer, Jonas Felix Busch, Klaus Jung, Annika Wulf-Goldenberg, Séverine Kunz, Kun Song, Adam Myszczyszyn, Sefer Elezkurtaj, Bettina Erguen et al. · 2020 · Nature Communications
41. Targeted genes and interacting proteins of hypoxia inducible factor-1.
    Wei Liu, Shao Ming Shen, Xu Zhao, Guo Qiang Chen · 2012 · Europe PMC (PubMed Central)
42. TNFalpha up‐regulates SLUG via the NF‐kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell‐like phenotype
    Gianluca Storci, Pasquale Sansone, Sara Mari, Gabriele D’Uva, Simona Tavolari, Tiziana Guarnieri, Mario Taffurelli, Claudio Ceccarelli, Donatella Santini, Pasquale Chieco et al. · 2010 · Journal of Cellular Physiology
43. The molecular programme of tumour reversion: the steps beyond malignant transformation
    Adam Telerman, Robert B. Amson · 2009 · Nature reviews. Cancer
44. Notch3 Is Critical for Proper Angiogenesis and Mural Cell Investment
    Hua Liu, Wenbo Zhang, Simone Kennard, Ruth B. Caldwell, Brenda Lilly · 2010 · Circulation Research
45. Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2
    Siddhesh Aras, Oleg Pak, Natascha Sommer, Russell L. Finley, Maik Hüttemann, Norbert Weißmann, Lawrence I. Grossman · 2013 · Nucleic Acids Research
46. Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells
    Jianghong Man, Xingjiang Yu, Haidong Huang, Wenchao Zhou, Chaomei Xiang, Haohao Huang, Lucio Miele, Zheng-gang Liu, Gürkan Bebek, Shideng Bao et al. · 2017 · Cell stem cell
47. Mitochondrial Metabolism Modulates Differentiation and Teratoma Formation Capacity in Mouse Embryonic Stem Cells
    Stefan M. Schieke, Mingchao Ma, Liu Cao, John Philip McCoy, Chengyu Liu, Nancy F. Hensel, A. John Barrett, Manfred Boehm, Toren Finkel · 2008 · Journal of Biological Chemistry
48. Hypoxic Tumor Microenvironment and Cancer Cell Differentiation
    Yuri Kim, Qun Lin, Peter M. Glazer, Zhong Yun · 2009 · Current Molecular Medicine
49. Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo
    Jonas Sjölund, Martin Johansson, Sugata Manna, Carl Norin, Alexander Pietras, Siv Beckman, Elise Nilsson, Börje Ljungberg, Håkan Axelson · 2008 · Journal of Clinical Investigation
50. The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness
    Bin Bao, Asfar Sohail Azmi, Shadan S. Ali, Aamir Ahmad, Yiwei Li, Sanjeev Banerjee, Dejuan Kong, Fazlul H. Sarkar · 2012 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
51. Hypoxia-Induced Aggressiveness of Pancreatic Cancer Cells Is Due to Increased Expression of VEGF, IL-6 and miR-21, Which Can Be Attenuated by CDF Treatment
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52. The VHL tumor suppressor: master regulator of HIF
    Haase, Volker · 2009 · Current Pharmaceutical Design
53. The role of hypoxia in inflammatory disease (Review)
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54. HIF in Kidney Disease and Development
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55. Hypoxia-Induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells
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56. The cancer stem cell niche(s): The crosstalk between glioma stem cells and their microenvironment
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57. Zebrafish as an Animal Model for Drug Discovery in Parkinson’s Disease and Other Movement Disorders: A Systematic Review
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58. Radioresistance in Glioblastoma and the Development of Radiosensitizers
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59. The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease
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60. Modulation of neuronal stem cell differentiation by hypoxia and reactive oxygen species
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61. The effects of spheroid formation of adipose-derived stem cells in a microgravity bioreactor on stemness properties and therapeutic potential
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62. Glioblastoma cancer stem cells: Role of the microenvironment and therapeutic targeting
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63. HIF1α delays premature senescence through the activation of MIF
    Scott M. Welford, Barbara Bedogni, Katarina Gradin, Lorenz Poellinger, Marianne Broome Powell, Amato J. Giaccia · 2006 · Genes & Development
64. Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia
    Begoña Díaz, Angela Yuen, Shinji Iizuka, Shigeki Higashiyama, Sara A. Courtneidge · 2013 · The Journal of Cell Biology
65. Oxygen tension controls the expansion of human CNS precursors and the generation of astrocytes and oligodendrocytes
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66. Notch Inhibition as a Promising New Approach to Cancer Therapy
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67. Increased Proliferation and Analysis of Differential Gene Expression in Human Wharton's Jelly-derived Mesenchymal Stromal Cells under Hypoxia
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68. Redox Regulation in Cancer Stem Cells
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69. Notch and Vascular Smooth Muscle Cell Phenotype
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70. The VHL tumor suppressor and HIF: insights from genetic studies in mice
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71. Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis
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72. Oxygen Tension Regulates Survival and Fate of Mouse Central Nervous System Precursors at Multiple Levels
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73. Hypoxia, HIFs and bone development
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74. Interaction of Hypoxia-Inducible Factor-1α and Notch Signaling Regulates Medulloblastoma Precursor Proliferation and Fate
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75. A Combined Ex Vivo and In Vivo RNAi Screen for Notch Regulators in Drosophila Reveals an Extensive Notch Interaction Network
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76. Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway
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77. Endothelial‐to‐mesenchymal transition in cardiovascular diseases: Developmental signaling pathways gone awry
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78. Oxygen Concentration Determines the Biological Effects of NOTCH-1 Signaling in Adenocarcinoma of the Lung
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79. Impaired oligodendrocyte maturation in preterm infants: Potential therapeutic targets
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80. Medulloblastoma Stem Cells
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81. Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice
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82. INTRARENAL OXYGENATION IN CHRONIC RENAL FAILURE
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83. Crosstalk between Notch, HIF-1α and GPER in Breast Cancer EMT
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84. Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia
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85. Notch in the kidney: development and disease
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86. HIF-1, Metabolism, and Diabetes in the Embryonic and Adult Heart
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87. Mechanisms of neovascularization and resistance to anti-angiogenic therapies in glioblastoma multiforme
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88. Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ
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89. Notch1 controls development of the extravillous trophoblast lineage in the human placenta
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90. Hypoxia Inducible Factor Pathway Inhibitors as Anticancer Therapeutics
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91. Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer
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92. Mechanisms Underlying Hypoxia Tolerance in Drosophila melanogaster: hairy as a Metabolic Switch
    Dan Zhou, Jin Xue, James C. K. Lai, Nicholas J. Schork, Kevin P. White, Gabriel G. Haddad · 2008 · PLoS Genetics
93. HIF-2α maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells
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94. Hypoxia and Hypoxia Inducible Factors in Cancer Stem Cell Maintenance
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95. Syndecan-3 and Notch cooperate in regulating adult myogenesis
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96. The functional role of Notch signaling in human gliomas
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97. Hypoxia, melanocytes and melanoma – survival and tumor development in the permissive microenvironment of the skin
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98. Hypoxic Regulation of Nucleus Pulposus Cell Survival
    Makarand V. Risbud, Ernestina Schipani, Irving M. Shapiro · 2010 · American Journal Of Pathology
99. MiR‐21 regulates epithelial‐mesenchymal transition phenotype and hypoxia‐inducible factor‐1α expression in third‐sphere forming breast cancer stem cell‐like cells
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100. Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms
     Sebastian K.-J. Landor, Anders Peter Mutvei, Veronika Mamaeva, Shaobo Jin, Morten Busk, Ronald Borra, Tove J. Grönroos, Pauliina Kronqvist, Urban Lendahl, Cecilia Sahlgren · 2011 · Proceedings of the National Academy of Sciences