Hypoxia requires Notch signaling to maintain the undifferentiated cell state

Notch Signaling: Cell Fate Control and Signal Integration in Development

Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909 · see citing works

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535 · see citing works

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · see citing works

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333 · see citing works

A conserved family of prolyl-4-hydroxylases that modify HIF

Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549 · see citing works

Mutations of the VHL tumour suppressor gene in renal carcinoma

Gnarra, J. R., Tory, K., Weng, Y., Schmidt, L., Wei, M. H., Li, H., Latif, F., Liu, S., Chen, F., Duh, F.-M., et al. (1994) · Nature Genetics · doi:10.1038/ng0594-85 · Cited by 1,730 · see citing works

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T.-Y., Huang, L. E., Pavletich, N., Chau, V., & Kaelin, W. G. (2000) · Nature Cell Biology · doi:10.1038/35017054 · Cited by 1,577 · see citing works

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J., & Whitelaw, M. L. (2002) · Science · doi:10.1126/science.1068592 · Cited by 1,558 · see citing works

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (2002) · Genes & Development · doi:10.1101/gad.991402 · Cited by 1,550 · cited 5× · see citing works

Signalling downstream of activated mammalian Notch

Jarriault, S., Brou, C., Logeat, F., Schroeter, E. H., Kopan, R., & Israël, A. (1995) · Nature · doi:10.1038/377355a0 · Cited by 1,390 · see citing works

Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.Preprint

Johe, K. K., Hazel, T. G., Müller, T. H., Dugich‐Djordjevic, M. M., & McKay, R. D. G. (1996) · Genes & Development · doi:10.1101/gad.10.24.3129 · Cited by 1,154 · see citing works

Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

Cockman, M. E., Masson, N., Mole, D. R., Jaakkola, P., Chang, G.-W., Clifford, S. C., Maher, E. R., Pugh, C. W., Ratcliffe, P. J., & Maxwell, P. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002740200 · Cited by 1,053 · see citing works

Notch Signaling: From the Outside In

Mumm, J. S., & Kopan, R. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9960 · Cited by 978 · see citing works

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

Semenza, G. L. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02090-1 · Cited by 930 · see citing works

Mechanism of regulation of the hypoxia‐inducible factor‐1α by the von Hippel‐Lindau tumor suppressor protein

Tanimoto, K., Makino, Y., Pereira, T., & Poellinger, L. (2000) · The EMBO Journal · doi:10.1093/emboj/19.16.4298 · Cited by 928 · see citing works

The role of Notch in tumorigenesis: oncogene or tumour suppressor?

Radtke, F., & Raj, K. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1186 · Cited by 785 · see citing works

Enhanced Proliferation, Survival, and Dopaminergic Differentiation of CNS Precursors in Lowered Oxygen

Studer, L., CSETE, M. E., Lee, S., Kabbani, N., Walikonis, J., Wold, B. J., & McKay, R. D. G. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07377.2000 · Cited by 709 · see citing works

Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

Varnum‐Finney, B., Xu, L., Brashem‐Stein, C., Nourigat, C., Flowers, D. A., Bakkour, S., Pear, W. S., & Bernstein, I. D. (2000) · Nature Medicine · doi:10.1038/81390 · Cited by 642 · see citing works

Mastermind Recruits CycC:CDK8 to Phosphorylate the Notch ICD and Coordinate Activation with Turnover

Fryer, C. J., White, B., & Jones, K. A. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.014 · Cited by 627 · see citing works

Conservation of the Notch signalling pathway in mammalian neurogenesis

de la Pompa, J. L., Wakeham, A. C., Correia, K. M., Samper, E., Brown, S., Aguilera, R. J., Nakano, T., Honjo, T., Mak, T. W., Rossant, J., et al. (1997) · Development · doi:10.1242/dev.124.6.1139 · Cited by 624 · see citing works

Jagged: A mammalian ligand that activates notch1

Lindsell, C. E., Shawber, C. J., Boulter, J., & Weinmaster, G. (1995) · Cell · doi:10.1016/0092-8674(95)90294-5 · Cited by 604 · see citing works

LIN-12/Notch signaling: lessons from worms and fliesPreprint

Greenwald, I. (1998) · Genes & Development · doi:10.1101/gad.12.12.1751 · Cited by 541 · see citing works

Hypoxia-Inducible Factor 1α Is Essential for Cell Cycle Arrest during Hypoxia

Goda, N., Ryan, H. E., Khadivi, B., McNulty, W., Rickert, R. C., & Johnson, R. S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.359-369.2003 · Cited by 520 · see citing works

The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD

Kopan, R., Nye, J. S., & Weintraub, H. (1994) · Development · doi:10.1242/dev.120.9.2385 · Cited by 488 · see citing works

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

Kopan, R., Schroeter, E. H., Weintraub, H. M., & Nye, J. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1683 · Cited by 470 · see citing works

Inhibition of PPARγ2 Gene Expression by the HIF-1-Regulated Gene DEC1/Stra13

Yun, Z., Maecker, H. L., Johnson, R. S., & Giaccia, A. J. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00131-4 · Cited by 460 · see citing works

Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factorPreprint

Bruick, R. K. (2003) · Genes & Development · doi:10.1101/gad.1145503 · Cited by 435 · see citing works

The Notch Intracellular Domain Is Ubiquitinated and Negatively Regulated by the Mammalian Sel-10 Homolog

Öberg, C., Li, J., Pauley, A. M., Wolf, E., Gurney, M. E., & Lendahl, U. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103992200 · Cited by 412 · see citing works

Culture in Reduced Levels of Oxygen Promotes Clonogenic Sympathoadrenal Differentiation by Isolated Neural Crest Stem Cells

Morrison, S. J., CSETE, M. E., Groves, A. K., Melega, W. P., Wold, B. J., & Anderson, D. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07370.2000 · Cited by 403 · see citing works

Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype

Jögi, A., Øra, I., Nilsson, H., Lindeheim, Å., Makino, Y., Poellinger, L., Axelson, H., & Påhlman, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102660199 · Cited by 399 · see citing works

Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3

Blokzijl, A., Dahlqvist, C., Reissmann, E., Falk, A., Moliner, A., Lendahl, U., & Ibáñez, C. F. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200305112 · Cited by 396 · see citing works

Redox-Regulated Recruitment of the Transcriptional Coactivators CREB-Binding Protein and SRC-1 to Hypoxia-Inducible Factor 1α

Carrero, P., Okamoto, K., Coumailleau, P., O’Brien, S. L., Tanaka, H., & Poellinger, L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.402-415.2000 · Cited by 382 · see citing works

P19 embryonal carcinoma cells

McBurney, M. W. (1993) · The International Journal of Developmental Biology · doi:10.1387/ijdb.8507558 · Cited by 379 · see citing works

p300 Acts as a Transcriptional Coactivator for Mammalian Notch-1

Oswald, F., Täuber, B., Dobner, T., Bourteele, S., Kostezka, U., Adler, G., Liptay, S., & Schmid, R. M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.22.7761-7774.2001 · Cited by 318 · see citing works

N-CoR controls differentiation of neural stem cells into astrocytes

Hermanson, O., Jepsen, K., & Rosenfeld, M. G. (2002) · Nature · doi:10.1038/nature01156 · Cited by 308 · see citing works

An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells

Nye, J. S., Kopan, R., & Axel, R. (1994) · Development · doi:10.1242/dev.120.9.2421 · Cited by 297 · see citing works

Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts

Nofziger, D., Miyamoto, A., Lyons, K. M., & Weinmaster, G. (1999) · Development · doi:10.1242/dev.126.8.1689 · Cited by 294 · see citing works

Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives

Kato, H., Taniguchi, Y., Kurooka, H., Minoguchi, S., Sakai, T., Nomura-Okazaki, S., Tamura, K., & Honjo, T. (1997) · Development · doi:10.1242/dev.124.20.4133 · Cited by 285 · see citing works

Delta-induced Notch Signaling Mediated by RBP-J Inhibits MyoD Expression and Myogenesis

Kuroda, K., Tani, S., Tamura, K., Minoguchi, S., Kurooka, H., & Honjo, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.7238 · Cited by 273 · see citing works

Notch signaling in development and disease

Hansson, E. M., Lendahl, U., & Chapman, G. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2004.04.011 · Cited by 257 · see citing works

Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation

Dahlqvist, C., Blokzijl, A., Chapman, G., Falk, A., Dannaeus, K., Ibáñez, C. F., & Lendahl, U. (2003) · Development · doi:10.1242/dev.00834 · Cited by 251 · see citing works

The von Hippel–Lindau Tumor Suppressor Gene

Kondo, K., & Kaelin, W. G. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5139 · Cited by 215 · see citing works

Multiple niches for Notch in cancer: context is everything

Weng, A. P., & Aster, J. C. (2003) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2003.11.004 · Cited by 210 · see citing works

The von Hippel-Lindau Tumor Suppressor Gene

Elias, R. M., Zhang, Q. H., & Brugarolas, J. (2020) · The Cancer Journal · doi:10.1097/ppo.0000000000000480 · Cited by 209 · see citing works

BMPs signal alternately through a SMAD or FRAP–STAT pathway to regulate fate choice in CNS stem cells

Rajan, P., Panchision, D. M., Newell, L. F., & McKay, R. D. G. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211021 · Cited by 207 · see citing works

Delta/Notch signaling promotes formation of zebrafish neural crest by repressing Neurogenin 1 function

Cornell, R. A., & Eisen, J. S. (2002) · Development · doi:10.1242/dev.129.11.2639 · Cited by 185 · see citing works

Turning it up a Notch: cross-talk between TGFβ and Notch signaling: What the papers say

Klüppel, M., & Wrana, J. L. (2005) · BioEssays · doi:10.1002/bies.20187 · Cited by 121 · see citing works

Functional Analysis of Hypoxia-inducible Factor-1α-mediated Transactivation

Ruas, J. L., Poellinger, L., & Pereira, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205051200 · Cited by 112 · see citing works

The antimycotic ciclopirox olamine induces HIF‐1α stability, VEGF expression, and angiogenesis

Linden, T., Katschinski, D. M., Eckhardt, K., Scheid, A., Pagel, H., & Wenger, R. H. (2003) · The FASEB Journal · doi:10.1096/fj.02-0586fje · Cited by 102 · see citing works

The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity

Beatus, P., Lundkvist, J., Öberg, C., Pedersen, K., & Lendahl, U. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00373-2 · Cited by 92 · see citing works

Epolones induce erythropoietin expression via hypoxia-inducible factor-1α activation

Wanner, R. M., Spielmann, P., Stroka, D., Camenisch, G., Camenisch, I., Scheid, A., Houck, D. R., Bauer, C., Gassmann, M., & Wenger, R. H. (2000) · Blood · doi:10.1182/blood.v96.4.1558.h8001558_1558_1565 · Cited by 88 · see citing works

Expression of myosin heavy chain isoforms and myogenesis of intrafusal fibres in rat muscle spindles

Soukup, T., Domellöf, F. P., & Thornell, L. (1995) · Microscopy Research and Technique · doi:10.1002/jemt.1070300506 · Cited by 39 · see citing works

Expression of Rat Thyrotropin-Releasing Hormone (TRH) Gene in TRH-Producing Tissues of Transgenic Mice Requires Sequences Located in Exon 1

Balkan, W., Tavianini, M. A., Gkonos, P. J., & Roos, B. A. (1998) · Endocrinology · doi:10.1210/endo.139.1.5684 · Cited by 29 · see citing works

Hypoxia-inducible factors in physiology and medicine

Semenza, G. L. (2012) · Cell · doi:10.1016/j.cell.2012.01.021 · Cited by 3,645 · see citing works

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251 · see citing works

Signaling mechanisms of the epithelial-mesenchymal transition

Gonzalez, D. M., & Medici, D. (2014) · Science Signaling · doi:10.1126/scisignal.2005189 · Cited by 1,721 · see citing works

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693 · see citing works

Hypoxia signalling in cancer and approaches to enforce tumour regression

Pouysségur, J., Dayan, F., & Mazure, N. M. (2006) · Nature · doi:10.1038/nature04871 · Cited by 1,676 · see citing works

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

Mohyeldin, A., Garzón-Muvdi, T., & Quiñones‐Hinojosa, A. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.07.007 · Cited by 1,536 · see citing works

Angiogenic signaling pathways and anti-angiogenic therapy for cancer

Liu, Z., Chen, H., Zheng, L., Sun, L., & Shi, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01460-1 · Cited by 1,387 · see citing works

Hypoxia-Induced Angiogenesis: Good and Evil

Krock, B. L., Skuli, N., & Simon, M. C. (2011) · Genes & Cancer · doi:10.1177/1947601911423654 · Cited by 1,179 · see citing works

Hypoxia-Inducible Factors, Stem Cells, and Cancer

Keith, B., & Simon, M. C. (2007) · Cell · doi:10.1016/j.cell.2007.04.019 · Cited by 1,179 · see citing works

Notch Signaling in Development, Tissue Homeostasis, and Disease

Siebel, C., & Lendahl, U. (2017) · Physiological Reviews · doi:10.1152/physrev.00005.2017 · Cited by 968 · see citing works

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

Higgins, D. F., Kimura, K., Bernhardt, W. M., Shrimanker, N., Akai, Y., Hohenstein, B., Saito, Y., Johnson, R. S., Kretzler, M., Cohen, C. D., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30487 · Cited by 976 · see citing works

The role of oxygen availability in embryonic development and stem cell function

Simon, M. C., & Keith, B. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2354 · Cited by 966 · see citing works

Notch signalling regulates stem cell numbers in vitro and in vivo

Androutsellis‐Theotokis, A., Leker, R. R., Soldner, F., Hoeppner, D. J., Ravin, R., Poser, S., Rueger, M. A., Bae, S., Kittappa, R., & McKay, R. D. G. (2006) · Nature · doi:10.1038/nature04940 · Cited by 952 · see citing works

Notch signaling: simplicity in design, versatility in function

Andersson, E. R., Sandberg, R., & Lendahl, U. (2011) · Development · doi:10.1242/dev.063610 · Cited by 950 · see citing works

Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

Parmar, K., Mauch, P., Vergilio, J.-A., Sackstein, R., & Down, J. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701152104 · Cited by 867 · see citing works

Signaling pathways and targeted therapy for myocardial infarction

Zhang, Q., Wang, L., Wang, S., Cheng, H., Xu, L., Pei, G., Wang, Y., Fu, C., Jiang, Y., He, C., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00925-z · Cited by 855 · see citing works

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

Sahlgren, C., Gustafsson, M. V., Jin, S., Poellinger, L., & Lendahl, U. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802047105 · Cited by 823 · see citing works

Exploring the role of cancer stem cells in radioresistance

Baumann, M. A., Krause, M., & Hill, R. P. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2419 · Cited by 817 · see citing works

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

Heddleston, J. M., Li, Z., McLendon, R. E., Hjelmeland, A. B., & Rich, J. N. (2009) · Cell Cycle · doi:10.4161/cc.8.20.9701 · Cited by 813 · see citing works

Mechanisms of disease: pulmonary arterial hypertension

SCHERMULY, R. T., Ghofrani, H. A., Wilkins, M. R., & Grimminger, F. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2011.87 · Cited by 798 · see citing works

The role of hypoxia-inducible factors in tumorigenesis

Rankin, E. B., & Giaccia, A. J. (2008) · Cell Death & Differentiation · doi:10.1038/cdd.2008.21 · Cited by 806 · see citing works

Regulation of erythropoiesis by hypoxia-inducible factors

Haase, V. H. (2013) · Blood Reviews · doi:10.1016/j.blre.2012.12.003 · Cited by 787 · see citing works

Transcriptional regulation by hypoxia inducible factors

Dengler, V. L., Galbraith, M. D., & Espinosa, J. M. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.838205 · Cited by 774 · see citing works

The Varied Roles of Notch in Cancer

Aster, J. C., Pear, W. S., & Blacklow, S. C. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100127 · Cited by 707 · see citing works

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

Wigerup, C., Påhlman, S., & Bexell, D. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.009 · Cited by 687 · see citing works

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

Soeda, A., Park, M., Lee, D., Mintz, A., Androutsellis-Theotokis, A., McKay, R. D., Engh, J., Iwama, T., Kunisada, T., Kassam, A. B., et al. (2009) · Oncogene · doi:10.1038/onc.2009.252 · Cited by 656 · see citing works

The Role of Hypoxia in Development of the Mammalian Embryo

Dunwoodie, S. L. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.11.008 · Cited by 651 · see citing works

Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2

Prabhakar, N. R., & Semenza, G. L. (2012) · Physiological Reviews · doi:10.1152/physrev.00030.2011 · Cited by 641 · see citing works

Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

Yang, M., Hsu, D. S., Wang, H., Wang, H.-J., Lan, H., Yang, W., Huang, C.-H., Kao, S., Tzeng, C., Tai, S., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2099 · Cited by 631 · see citing works

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

Mole, D. R., Blancher, C., Copley, R. R., Pollard, P. J., Gleadle, J. M., Ragoussis, J., & Ratcliffe, P. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901790200 · Cited by 552 · see citing works

The updated biology of hypoxia-inducible factor

Greer, S. N., Metcalf, J. L., Wang, Y., & Ohh, M. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.125 · Cited by 545 · see citing works

Invasive growth: a MET-driven genetic programme for cancer and stem cells

Boccaccio, C., & Comoglio, P. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1912 · Cited by 541 · see citing works

Muscle stem cells in development, regeneration, and diseasePreprint

Shi, X., & Garry, D. J. (2006) · Genes & Development · doi:10.1101/gad.1419406 · Cited by 502 · see citing works

Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning

Semenza, G. L. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.08.006 · Cited by 484 · see citing works

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia

Benita, Y., Kikuchi, H., Smith, A. D., Zhang, M. Q., Chung, D. C., & Xavier, R. J. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp425 · Cited by 469 · see citing works

The hematopoietic stem cell niche: Low in oxygen but a nice place to be

Eliasson, P., & Jönsson, J. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21908 · Cited by 473 · see citing works

Hypoxic gene expression and metastasis

Le, Q., Denko, N. C., & Giaccia, A. J. (2004) · Cancer and Metastasis Reviews · doi:10.1023/b:canc.0000031768.89246.d7 · Cited by 466 · see citing works

Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments

Wei, X., Chen, Y., Jiang, X., Miao, P., Liu, Y., Mo, Y., Ren, D., Hua, Y., Yu, B., Zhou, Y., et al. (2021) · Molecular Cancer · doi:10.1186/s12943-020-01288-1 · Cited by 465 · see citing works

Not(ch) just development: Notch signalling in the adult brain

Ables, J. L., Breunig, J. J., Eisch, A. J., & RAKIC, P. T. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3024 · Cited by 460 · see citing works

Therapeutic modulation of Notch signalling — are we there yet?

Andersson, E. R., & Lendahl, U. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4252 · Cited by 452 · see citing works

O2 regulates stem cells through Wnt/β-catenin signalling

Mazumdar, J., O'Brien, W. T., Johnson, R. S., LaManna, J. C., Chavez, J. C., Klein, P. S., & Simon, M. C. (2010) · Nature Cell Biology · doi:10.1038/ncb2102 · Cited by 456 · see citing works

Hypoxia-inducible factors: central regulators of the tumor phenotype

Gordan, J. D., & Simon, M. C. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.12.006 · Cited by 450 · see citing works

Hypoxia inducible factors in cancer stem cells

Heddleston, J. M., Li, Z., Lathia, J. D., Bao, S., Hjelmeland, A. B., & Rich, J. N. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605551 · Cited by 453 · see citing works

Targeting Notch to Target Cancer Stem Cells

Pannuti, A., Foreman, K. E., Rizzo, P., Osipo, C., Golde, T. E., Osborne, B. A., & Miele, L. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2823 · Cited by 452 · see citing works

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

Fearon, U., Canavan, M., Biniecka, M., & Veale, D. J. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.69 · Cited by 445 · see citing works

Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

Bouras, T., Pal, B., Vaillant, F., Harburg, G. C., Asselin-Labat, M.-L., Oakes, S. R., Lindeman, G. J., & Visvader, J. E. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.08.001 · Cited by 443 · see citing works

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

Seidel, S., Garvalov, B. K., Wirta, V., von Stechow, L., Schänzer, A., Meletis, K., Wolter, M., Sommerlad, D., Henze, A., Nistér, M., et al. (2010) · Brain · doi:10.1093/brain/awq042 · Cited by 438 · see citing works

Regulation of Angiogenesis by Oxygen and Metabolism

Fraisl, P., Mazzone, M., Schmidt, T., & Carmeliet, P. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.003 · Cited by 409 · see citing works

Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies

Wang, Y., Liu, Y., Malek, S. N., Zheng, P., & Liu, Y. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.02.006 · Cited by 410 · see citing works

Delta Notch and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors

Fischer, A., & Gessler, M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm477 · Cited by 400 · see citing works

Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST

Tsai, C., Chen, Y.-J., Yew, T., Chen, L., Wang, J., Chiu, C., & Hung, S. (2010) · Blood · doi:10.1182/blood-2010-05-287508 · Cited by 376 · see citing works

Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer

Bae, T., Hallis, S. P., & Kwak, M. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01180-8 · Cited by 387 · see citing works

Notch3 signaling promotes the development of pulmonary arterial hypertension

Li, X., Zhang, X., Leathers, R. N., Makino, A., Huang, C., Parsa, P., Macías, J., Yuan, J. X. ‐., Jamieson, S. W., & Thistlethwaite, P. A. (2009) · Nature Medicine · doi:10.1038/nm.2021 · Cited by 358 · see citing works

Hypoxic regulation of erythropoiesis and iron metabolism

Haase, V. H. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00174.2010 · Cited by 347 · see citing works

Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion

Chen, J., Imanaka, N., Chen, J., & Griffin, J. D. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605486 · Cited by 346 · see citing works

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

Bielesz, B. O., Sirin, Y., Si, H., Niranjan, T., Gruenwald, A., Ahn, S.-H., Kato, H., Pullman, J. M., Gessler, M., Haase, V. H., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43025 · Cited by 345 · see citing works

Notch and cancer: a double-edged sword

Koch, U., & Radtke, F. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7164-1 · Cited by 335 · see citing works

Hypoxia-inducible factors in the kidney

Haase, V. H. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00071.2006 · Cited by 329 · see citing works

Generating specificity and diversity in the transcriptional response to hypoxia

Lendahl, U., Lee, K. L., Yang, H. H., & Poellinger, L. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2665 · Cited by 330 · see citing works

Biology of hypoxia-inducible factor-2α in development and disease

Patel, S. A., & Simon, M. C. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.17 · Cited by 325 · see citing works

Intratumoral Hypoxic Gradient Drives Stem Cells Distribution and MGMT Expression in Glioblastoma

Pistollato, F., Abbadi, S., Rampazzo, E., Persano, L., Puppa, A. D., Frasson, C., Sarto, E., Scienza, R., D’Avella, D., & Basso, G. (2010) · Stem Cells · doi:10.1002/stem.415 · Cited by 321 · see citing works

HIF1α regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis

Amarilio, R., Viukov, S. V., Sharir, A., Eshkar-Oren, I., Johnson, R. S., & Zelzer, E. (2007) · Development · doi:10.1242/dev.008441 · Cited by 317 · see citing works

Notch signaling.

Miele, L. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2570 · Cited by 317 · see citing works

γ-Secretase in Alzheimer’s disease

Hur, J. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00754-8 · Cited by 325 · see citing works

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development

Hamanaka, R. B., Glasauer, A., Hoover, P., Yang, S., Blatt, H., Mullen, A. R., Getsios, S., Gottardi, C. J., DeBerardinis, R. J., Lavker, R. M., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2003638 · Cited by 315 · see citing works

HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway

Qiang, L., Wu, T., Zhang, H.-W., Lu, N., Hu, R., Wang, Y.-J., Zhao, L., Chen, F.-H., Wang, X.-T., You, Q.-D., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.95 · Cited by 313 · see citing works

Oxygen homeostasis

Semenza, G. L. (2009) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.69 · Cited by 311 · see citing works

Regulation of cell proliferation by hypoxia-inducible factors

Hubbi, M. E., & Semenza, G. L. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00279.2015 · Cited by 298 · see citing works

Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond

Tam, S. Y., Wu, V., & Law, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00486 · Cited by 304 · see citing works

Oxygen sensing and hypoxia signalling pathways in animals: The implications of physiology for cancer

Ratcliffe, P. J. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.251470 · Cited by 294 · see citing works

The multifaceted role of Notch in cancer

Roy, M., Pear, W. S., & Aster, J. C. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.12.001 · Cited by 292 · see citing works

Molecular Pathways: Vasculogenic Mimicry in Tumor Cells: Diagnostic and Therapeutic Implications

Kirschmann, D. A., Seftor, E. A., Hardy, K. M., Seftor, R. E. B., & Hendrix, M. J. C. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-3237 · Cited by 291 · see citing works

Regulation of reactive oxygen species in stem cells and cancer stem cells

Kobayashi, C. I., & Suda, T. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22764 · Cited by 290 · see citing works

Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells

Colwell, N. A., Larion, M., Giles, A. J., Seldomridge, A. N., Sizdahkhani, S., Gilbert, M. R., & Park, D. M. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now258 · Cited by 287 · see citing works

Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

Cockman, M. E., Lancaster, D. E., Stolze, I. P., Hewitson, K. S., McDonough, M. A., Coleman, M. L., Coles, C. H., Yu, X., Hay, R. T., Ley, S. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606877103 · Cited by 285 · see citing works

Up-down regulation of HIF-1α in cancer progression

Rashid, M., Zadeh, L. R., Baradaran, B., Molavi, O., Ghesmati, Z., Sabzichi, M., & Ramezani, F. (2021) · Gene · doi:10.1016/j.gene.2021.145796 · Cited by 291 · see citing works

Stem cells living with a Notch

Koch, U., Lehal, R., & Radtke, F. (2013) · Development · doi:10.1242/dev.080614 · Cited by 283 · see citing works

Energy Metabolism in Mesenchymal Stem Cells During Osteogenic Differentiation

Shum, L. C., White, N., Mills, B. N., Bentley, K. L. D. M., & Eliseev, R. A. (2015) · Stem Cells and Development · doi:10.1089/scd.2015.0193 · Cited by 283 · see citing works

Changes in primary lymphoid organs with aging

Chinn, I. K., Blackburn, C. C., Manley, N. R., & Sempowski, G. D. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.005 · Cited by 282 · see citing works

Energy metabolism in adult neural stem cell fate

Rafalski, V. A., & Brunet, A. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.10.007 · Cited by 280 · see citing works

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

Zheng, X., Linke, S., Dias, J. M., Zheng, X., Gradin, K., Wallis, T. P., Hamilton, B. R., Gustafsson, M. V., Ruas, J. L., Wilkins, S. E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711591105 · Cited by 271 · see citing works

Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells

Wen, Y., Bi, P., Liu, W., Asakura, A., Keller, C., & Kuang, S. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06753-11 · Cited by 271 · see citing works

Notch inhibitors for cancer treatment

Espinoza, I. C., & Miele, L. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.02.003 · Cited by 272 · see citing works

Regulation of Angiogenesis by Hypoxia and Hypoxia‐Inducible Factors

Hickey, M. M., & Simon, M. C. (2006) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(06)76007-0 · Cited by 268 · see citing works

Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity

Maekawa, Y., Minato, Y., Ishifune, C., Kurihara, T., Kitamura, A., Kojima, H., Yagita∥, H., Sakata‐Yanagimoto, M., Saito, T., Taniuchi, I., et al. (2008) · Nature Immunology · doi:10.1038/ni.1649 · Cited by 269 · see citing works

Emerging role of Notch in stem cells and cancer

Wang, Z. P., Li, Y., Banerjee, S., & Sarkar, F. H. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.09.030 · Cited by 269 · see citing works

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

Xi, Y., Kim, T., Brumwell, A. N., Driver, I. H., Wei, Y., Tan, V. M., Jackson, J., Xu, J., Lee, D.-K., Gotts, J. E., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3580 · Cited by 268 · see citing works

Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆

Pathania, D., Millard, M., & Neamati, N. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.05.010 · Cited by 265 · see citing works

Role of Notch and its oncogenic signaling crosstalk in breast cancer

Guo, S., Liu, M., & Gonzalez-Perez, R. R. (2010) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2010.12.002 · Cited by 260 · see citing works

Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133− cells, and the CD133+ sector is enlarged by hypoxia

Blazek, E. R., Foutch, J. L., & Maki, G. (2006) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2006.09.037 · Cited by 259 · see citing works

Revisiting the HIF switch in the tumor and its immune microenvironment.

Cowman, S. J., & Koh, M. Y. (2022) · Trends in Cancer · doi:10.1016/j.trecan.2021.10.004 · Cited by 256 · see citing works

Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: Potential role of hypoxia

Marie-Egyptienne, D. T., Lohse, I., & Hill, R. P. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.11.019 · Cited by 256 · see citing works

The role of oxygen in regulating neural stem cells in development and disease

Panchision, D. M. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21812 · Cited by 252 · see citing works

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

Strowitzki, M. J., Cummins, E. P., & Taylor, C. T. (2019) · Cells · doi:10.3390/cells8050384 · Cited by 248 · see citing works

Metabolic Alterations in Highly Tumorigenic Glioblastoma Cells

Zhou, Y., Zhou, Y., Shingu, T., Feng, L., Chen, Z., Ogasawara, M. A., Keating, M. J., Kondo, S., & Huang, P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.260935 · Cited by 250 · see citing works

GSEA-InContext: identifying novel and common patterns in expression experiments

Powers, R. K., Goodspeed, A., Pielke-Lombardo, H., Tan, A. C., & Costello, J. C. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty271 · Cited by 240 · see citing works

Cancer Stem Cells, Hypoxia and Metastasis

Hill, R. P., Marie-Egyptienne, D. T., & Hedley, D. W. (2009) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2008.12.002 · Cited by 240 · see citing works

Epithelial-to-mesenchymal transition: What is the impact on breast cancer stem cells and drug resistance

Mallini, P., Lennard, T. W. J., Kirby, J. A., & Meeson, A. P. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.09.008 · Cited by 240 · see citing works

NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation

Xu, J., Chi, F., Guo, T., Punj, V., Lee, W. N. P., French, S. W., & Tsukamoto, H. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76468 · Cited by 241 · see citing works

A systematic review of p53 regulation of oxidative stress in skeletal muscle

Beyfuss, K. A., & Hood, D. A. (2018) · Redox Report · doi:10.1080/13510002.2017.1416773 · Cited by 239 · see citing works

Signal integration between notch and hypoxia : insights into development and disease

Gustafsson, M. V. (2007) · Figshare

Notch as Link from Hypoxia to Differentiation

(2005) · Science s STKE · doi:10.1126/stke.3092005tw390

Linking Oxygen to Differentiation

Chin, G. (2005) · Science · doi:10.1126/science.310.5751.1093b

A New Notch in the HIF Belt: How Hypoxia Impacts Differentiation

Cejudo–Martín, P., & Johnson, R. S. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.10.001 · Cited by 41 · see citing works

The interplay between the cellular hypoxic response and Notch signaling

Landor, S. K.-J., & Lendahl, U. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.04.030 · Cited by 31 · see citing works