The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
An Essential Role for 14-3-3 Proteins in Brassinosteroid Signal Transduction in Arabidopsis
Open accessAbstract
Brassinosteroids (BRs) are essential hormones for plant growth and development. BRs regulate gene expression by inducing dephosphorylation of two key transcription factors, BZR1 and BZR2/BES1, through a signal transduction pathway that involves cell-surface receptors (BRI1 and BAK1) and a GSK3 kinase (BIN2). How BR-regulated phosphorylation controls the activities of BZR1/BZR2 is not fully understood. Here, we show that BIN2-catalyzed phosphorylation of BZR1/BZR2 not only inhibits DNA binding, but also promotes binding to the 14-3-3 proteins. Mutations of a BIN2-phosphorylation site in BZR1 abolish 14-3-3 binding and lead to increased nuclear localization of BZR1 protein and enhanced BR responses in transgenic plants. Further, BR deficiency increases cytoplasmic localization, and BR treatment induces rapid nuclear localization of BZR1/BZR2. Thus, 14-3-3 binding is required for efficient inhibition of phosphorylated BR transcription factors, largely through cytoplasmic retention. This study demonstrates that multiple mechanisms are required for BR regulation of gene expression and plant growth.
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Cites
BRASSINOSTEROIDS: Essential Regulators of Plant Growth and Development
Clouse, S. D., & Sasse, J. M. (1998) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.49.1.427 · Cited by 1,462
BRI1/BAK1, a Receptor Kinase Pair Mediating Brassinosteroid Signaling
Nam, K. H., & Li, J. (2002) · Cell · doi:10.1016/s0092-8674(02)00814-0 · Cited by 1,217
Cited by
Kim, T.-W., Guan, S., Sun, Y., Deng, Z., Tang, W., Shang, J.-X., Sun, Y., Burlingame, A. L., & Wang, Z.-Y. (2009) · Nature Cell Biology · doi:10.1038/ncb1970 · Cited by 693
Self-citationYu, X., Li, L., Zola, J., Aluru, M., Ye, H., Foudree, A., Guo, H., Anderson, S., Aluru, S., Liu, P., et al. (2011) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04449.x · Cited by 666
Brassinosteroids control meristem size by promoting cell cycle progression in Arabidopsis roots
González-García, M.-P., Vilarrasa-Blasi, J., Zhiponova, M., Divol, F., Mora-García, S., Russinova, E., & Caño-Delgado, A. I. (2011) · Development · doi:10.1242/dev.057331 · Cited by 522
Brassinosteroid Signaling Network and Regulation of Photomorphogenesis
Wang, Z.-Y., Bai, M.-Y., Oh, E., & Zhu, J.-Y. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-102209-163450 · Cited by 490
Self-citationGallego-Bartolomé, J., Minguet, E. G., Grau-Enguix, F., Abbas, M., Locascio, A., Thomas, S. G., Alabadí, D., & Blázquez, M. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119992109 · Cited by 371
Metadata
- Authors
- Gampala, S. S., Kim, T.-W., He, J.-X., Tang, W., Deng, Z., Bai, M.-Y., Guan, S., Lalonde, S., Sun, Y., Gendron, J. M., Chen, H., Shibagaki, N., Ferl, R. J., Ehrhardt, D., Chong, K., Burlingame, A. L., & Wang, Z.-Y.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 13
- Issue
- 2
- Pages
- 177-189
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2078895980
- Cited by
- 520
- References
- 2
- FWCI
- 30.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gampala, S. S., Kim, T.-W., He, J.-X., Tang, W., Deng, Z., Bai, M.-Y., Guan, S., Lalonde, S., Sun, Y., Gendron, J. M., Chen, H., Shibagaki, N., Ferl, R. J., Ehrhardt, D., Chong, K., Burlingame, A. L., & Wang, Z.-Y. (2007). An Essential Role for 14-3-3 Proteins in Brassinosteroid Signal Transduction in Arabidopsis. Developmental Cell. https://doi.org/10.1016/j.devcel.2007.06.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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