Cited by 1,217Plant Molecular Biology ResearchPlant-Microbe Interactions and ImmunityPlant biochemistry and biosynthesis

BRI1/BAK1, a Receptor Kinase Pair Mediating Brassinosteroid Signaling

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Nam, Kyoung Hee, Li, Jianming·2002·Cell

Abstract

The Arabidopsis BAK1 (BRI1 Associated receptor Kinase 1) was identified by a yeast two-hybrid screen as a specific interactor for BRI1, a critical component of a membrane brassinosteroid (BR) receptor. In yeast, BAK1/BRI1 interaction activates their kinase activities through transphosphorylation. BAK1 and BRI1 share similar gene expression and subcellular localization patterns and physically associate with each other in plants. Overexpression of the BAK1 gene leads to a phenotype reminiscent of BRI1-overexpression transgenic plants and rescues a weak bri1 mutant. In contrast, a bak1 knockout mutation gives rise to a weak bri1-like phenotype and enhances a weak bri1 mutation. We propose that BAK1 and BRI1 function together to mediate plant steroid signaling.

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Crossref · 10.1016/s0092-8674(02)00814-0

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  • Animal steroid hormones act through the nuclear receptor family of transcription factors, while plant brassinosteroids signal through a cell surface receptor kinase-mediated signal transduction pathway.

    “While animal steroid hormones act through nuclear receptor family of transcription factors, plant brassinosteroids signal through a cell surface receptor kinase-mediated signal transduction pathway (8, 9).”

    From Anabolic effect of plant brassinosteroid (2011) · cites this paper as [9]

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Authors
Nam, K. H., & Li, J.
Affiliations
University of Michigan (US)
Corresponding author
Li, Jianming
Venue
Cell
Publisher
Elsevier BV
Published
2002-07
Volume
110
Issue
2
Pages
203-212
ISSN
0092-8674 (ISSN-L)
OpenAlex
W1978179863
Cited by
1,217
References
40
Citations by year
2026: 48 · 2025: 61 · 2024: 56 · 2023: 55 · 2022: 71 · 2021: 70 · 2020: 66 · 2019: 59 · 2018: 58 · 2017: 62 · 2016: 52 · 2015: 50 · 2014: 55 · 2013: 57 · 2012: 33
FWCI
43.07
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of General Medical Sciences (GM60519, R01GM060519)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Keywords
BRI1, BAK1, brassinosteroid signaling, transphosphorylation, kinase activation, Arabidopsis thaliana, gene overexpression, steroid hormone signaling
MeSH terms
Amino Acid Sequence, DNA, Bacterial, Enzyme Activation, Hydroxysteroids, Membrane Proteins, Molecular Sequence Data, Phenotype, Protein Kinases, Saccharomyces cerevisiae, Signal Transduction, Gene Expression, Mutagenesis, Insertional, Genes, Plant, Protein Serine-Threonine Kinases, Arabidopsis, Two-Hybrid System Techniques, Arabidopsis Proteins

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