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Integration of Light- and Brassinosteroid-Signaling Pathways by a GATA Transcription Factor in Arabidopsis
Open accessAbstract
SUMMARY Light and brassinosteroid (BR) antagonistically regulate the developmental switch from etiolation in the dark to photomorphogenesis in the light in plants. Here we identify GATA2 as a key transcriptional regulator that mediates the crosstalk between BR- and light-signaling pathways. Overexpression of GATA2 causes constitutive photomorphogenesis in the dark, whereas suppression of GATA2 reduces photomorphogenesis caused by light, BR deficiency, or the constitutive photomorphogenesis mutant cop1. Genome profiling and chromatin immunoprecipitation experiments show that GATA2 directly regulates genes that respond to both light and BR. BR represses GATA2 transcription through the BR-activated transcription factor BZR1, whereas light causes accumulation of GATA2 protein and feedback inhibition of GATA2 transcription. Dark-induced proteasomal degradation of GATA2 is dependent on the COP1 E3 ubiquitin ligase, and COP1 can ubiquitinate GATA2 in vitro. This study illustrates a molecular framework for antagonistic regulation of gene expression and seedling photomorphogenesis by BR and light.
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Citations
Cited by
Brassinosteroid Signaling Network and Regulation of Photomorphogenesis
Wang, Z.-Y., Bai, M.-Y., Oh, E., & Zhu, J.-Y. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-102209-163450 · Cited by 490
Self-citationOsakabe, Y., Yamaguchi-Shinozaki, K., Shinozaki, K., & Tran, L.-S. P. (2013) · Journal of Experimental Botany · doi:10.1093/jxb/ers354 · Cited by 384
Zhu, J.-Y., Sae-Seaw, J., & Wang, Z.-Y. (2013) · Development · doi:10.1242/dev.060590 · Cited by 336
Self-citationTetrapyrrole Metabolism in Arabidopsis thaliana
Tanaka, R., Kobayashi, K., & Masuda, T. (2011) · The Arabidopsis Book · doi:10.1199/tab.0145 · Cited by 281
Trade-off between growth and immunity: role of brassinosteroids
Lozano-Durán, R., & Zipfel, C. (2015) · Trends in Plant Science · doi:10.1016/j.tplants.2014.09.003 · Cited by 262
Brassinosteroids regulate organ boundary formation in the shoot apical meristem of Arabidopsis
Gendron, J. M., Liu, J.-S., Fan, M., Bai, M.-Y., Wenkel, S., Springer, P. S., Barton, M. K., & Wang, Z.-Y. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210799110 · Cited by 205
Self-citation(2024) · doi:10.1007/s00344-024-11532-3 · Cited by 3
Metadata
- Authors
- Luo, X.-M., Lin, W.-H., Zhu, S., Zhu, J.-Y., Sun, Y., Fan, X.-Y., Cheng, M., Hao, Y., Oh, E., Tian, M., Liu, L., Zhang, M., Xie, Q., Chong, K., & Wang, Z.-Y.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 19
- Issue
- 6
- Pages
- 872-883
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2102129193
- Cited by
- 284
- References
- 0
- FWCI
- 15.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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