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Semaphorin-PlexinD1 Signaling Limits Angiogenic Potential via the VEGF Decoy Receptor sFlt1
Open accessAbstract
Summary Sprouting angiogenesis expands the embryonic vasculature enabling survival and homeostasis. Yet how the angiogenic capacity to form sprouts is allocated among endothelial cells (ECs) to guarantee the reproducible anatomy of stereotypical vascular beds remains unclear. Here we show that Sema-PlxnD1 signaling, previously implicated in sprout guidance, represses angiogenic potential to ensure the proper abundance and stereotypical distribution of the trunk’s Segmental Arteries (SeAs). We find that Sema-PlxnD1 signaling exerts this effect by antagonizing the pro-angiogenic activity of Vascular Endothelial Growth Factor (VEGF). Specifically, Sema-PlxnD1 signaling ensures the proper endothelial abundance of soluble flt1 (sflt1), an alternatively spliced form of the VEGF receptor Flt1 encoding a potent secreted decoy. Hence Sema-PlxnD1 signaling regulates distinct but related aspects of angiogenesis: the spatial allocation of angiogenic capacity within a primary vessel and sprout guidance.
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Identification and functional analysis of endothelial tip cell–enriched genes
del Toro, R., Prahst, C., Mathivet, T., Siegfried, G., Kaminker, J. S., Larrivee, B., Breant, C., Duarte, A., Takakura, N., Fukamizu, A., et al. (2010) · Blood · doi:10.1182/blood-2010-02-270819 · Cited by 474
Raab, S., & Plate, K. H. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0228-3 · Cited by 120
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Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304
Tumor angiogenesis: molecular pathways and therapeutic targets
Weis, S. M., & Cheresh, D. A. (2011) · Nature Medicine · doi:10.1038/nm.2537 · Cited by 1,736
New genetic loci link adipose and insulin biology to body fat distribution
The ADIPOGen Consortium, Shungin, D., The CARDIOGRAMplusC4D Consortium, The CKDGen Consortium, The GEFOS Consortium, The GENIE Consortium, The, G. L. G. C., The, I. C. B. P., The International Endogene Consortium, Study, T. L. C., et al. (2015) · Nature · doi:10.1038/nature14132 · Cited by 1,580
Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence
Espín-Palazón, R., Stachura, D. L., Campbell, C. A., García-Moreno, D., Del Cid, N., Kim, A. D., Candel, S., Meseguer, J., Mulero, V., & Traver, D. (2014) · Cell · doi:10.1016/j.cell.2014.10.031 · Cited by 333
Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance
Nakajima, H., Yamamoto, K., Agarwala, S., Terai, K., Fukui, H., Fukuhara, S., Ando, K., Miyazaki, T., Yokota, Y., Schmelzer, E., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.02.019 · Cited by 305
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Metadata
- Authors
- Zygmunt, T., Gay, C. M., Blondelle, J., Singh, M. K., Flaherty, K. M., Means, P. C., Herwig, L., Krudewig, A., Belting, H.-G., Affolter, M., Epstein, J. A., & Torres-Vázquez, J.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 21
- Issue
- 2
- Pages
- 301-314
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2120335426
- Cited by
- 168
- References
- 2
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zygmunt, T., Gay, C. M., Blondelle, J., Singh, M. K., Flaherty, K. M., Means, P. C., Herwig, L., Krudewig, A., Belting, H.-G., Affolter, M., Epstein, J. A., & Torres-Vázquez, J. (2011). Semaphorin-PlexinD1 Signaling Limits Angiogenic Potential via the VEGF Decoy Receptor sFlt1. Developmental Cell. https://doi.org/10.1016/j.devcel.2011.06.033
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
