The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration
Open accessAbstract
Collective cell migration is a mode of movement crucial for morphogenesis and cancer metastasis. However, little is known about how migratory cells coordinate collectively. Here we show that mutual cell-cell attraction (named here coattraction) is required to maintain cohesive clusters of migrating mesenchymal cells. Coattraction can counterbalance the natural tendency of cells to disperse via mechanisms such as contact inhibition and epithelial-to-mesenchymal transition. Neural crest cells are coattracted via the complement fragment C3a and its receptor C3aR, revealing an unexpected role of complement proteins in early vertebrate development. Loss of coattraction disrupts collective and coordinated movements of these cells. We propose that coattraction and contact inhibition act in concert to allow cell collectives to self-organize and respond efficiently to external signals, such as chemoattractants and repellents.
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Cites
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Complement: a key system for immune surveillance and homeostasis
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654 · cited 1×
“C3 is cleaved to produce C3a, a small anaphylatoxin peptide with known chemotactic properties in the immune system (Ricklin et al., 2010), and thus, a good candidate to be the chemoattractant required for coattraction.”
BackgroundSelf-citationThe small GTP-binding protein rac regulates growth factor-induced membrane ruffling
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Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
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Cited by
Complement component C3 – The “Swiss Army Knife” of innate immunity and host defense
Ricklin, D., Reis, E. S., Mastellos, D. C., Gros, P., & Lambris, J. D. (2016) · Immunological Reviews · doi:10.1111/imr.12500 · Cited by 484
Self-citationComplement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration
Haynes, T., Luz-Madrigal, A., Reis, E. S., Echeverri Ruiz, N. P., Grajales-Esquivel, E., Tzekou, A., Tsonis, P. A., Lambris, J. D., & Del Rio-Tsonis, K. (2013) · Nature Communications · doi:10.1038/ncomms3312 · Cited by 87
Self-citationComplement deficiency promotes cutaneous wound healing in mice
Rafail, S., Kourtzelis, I., Foukas, P. G., Markiewski, M. M., DeAngelis, R. A., Guariento, M., Ricklin, D., Grice, E. A., & Lambris, J. D. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402354 · Cited by 72
“Inhibition of C3aR was performed as previously described (18).”
MethodSelf-citation
Metadata
- Authors
- Carmona-Fontaine, C., Theveneau, E., Tzekou, A., Tada, M., Woods, M., Page, K. M., Parsons, M., Lambris, J. D., & Mayor, R.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 21
- Issue
- 6
- Pages
- 1026-1037
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2022777558
- Cited by
- 317
- References
- 41
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Carmona-Fontaine, C., Theveneau, E., Tzekou, A., Tada, M., Woods, M., Page, K. M., Parsons, M., Lambris, J. D., & Mayor, R. (2011). Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration. Developmental Cell. https://doi.org/10.1016/j.devcel.2011.10.012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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