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A Change in Nuclear Pore Complex Composition Regulates Cell Differentiation
Open accessAbstract
SUMMARY Nuclear pore complexes (NPCs) are built from ~30 different proteins called nucleoporins. Previous studies have shown that several Nups exhibit cell-type-specific expression and that mutations in NPC components result in tissue-specific diseases. Here we show that a specific change in NPC composition is required for both myogenic and neuronal differentiation. The transmembrane nucleoporin Nup210 is absent in proliferating myoblasts and embryonic stem (ES) cells but becomes expressed and incorporated into NPCs during cell differentiation. Preventing Nup210 production by RNAi blocks myogenesis and the differentiation of ES cells into neuroprogenitors. We found that the addition of Nup210 to NPCs does not affect nuclear transport but is required for the induction of genes that are essential for cell differentiation. Our results identify a single change in NPC composition as an essential step in cell differentiation and establish a role for Nup210 in gene expression regulation and cell fate determination.
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Metadata
- Authors
- D'Angelo, M. A., Gomez-Cavazos, J. S., Mei, A., Lackner, D. H., & Hetzer, M. W.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 22
- Issue
- 2
- Pages
- 446-458
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2038720616
- Cited by
- 241
- References
- 0
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- D'Angelo, M. A., Gomez-Cavazos, J. S., Mei, A., Lackner, D. H., & Hetzer, M. W. (2012). A Change in Nuclear Pore Complex Composition Regulates Cell Differentiation. Developmental Cell. https://doi.org/10.1016/j.devcel.2011.11.021
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
