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Highly Coordinated Proteome Dynamics during Reprogramming of Somatic Cells to Pluripotency

Hansson, Jenny, Rafiee, Mahmoud Reza, Reiland, Sonja, Polo, Jose M., Gehring, Julian, Okawa, Satoshi, Huber, Wolfgang, Hochedlinger, Konrad, Krijgsveld, Jeroen·2012·Cell Reports
DOI 10.1016/j.celrep.2012.10.014PMC PMC4438680
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Crossref · 10.1016/j.celrep.2012.10.014

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  • Cellular reprogramming to pluripotency by forced expression of the Yamanaka factors occurs through global remodeling of epigenetic marks.

    “Cellular reprogramming to pluripotency by forced expression of the Yamanaka factors (Oct4, Sox2, Klf4, and c-Myc [OSKM]) occurs through the global remodeling of epigenetic marks”

    From In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. (2016) · cites this paper as Hansson et al., 2012

    The Introduction (page unavailable) states that forced expression of Oct4, Klf4, Sox2 and c-Myc reprograms somatic cells and that reprogramming is accompanied by remodeling of chromatin programs. The Results (page unavailable) also describe DNA methyltransferases involved in altering the epigenetic landscape. These passages support epigenetic remodeling during reprogramming, but do not establish that global remodeling of epigenetic marks is the mechanism through which it occurs. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Electron transport chain proteins are downregulated in the first 3 days of reprogramming before a gradual metabolic switch to glycolysis, a characteristic typically seen in rapidly proliferating cells.

    “Similar to gene expression changes, clustering analysis of proteins with temporal expression dynamics similar to gene expression changes reveals that electron transport chain proteins are downregulated in the first 3 days of reprogramming before a gradual metabolic switch to glycolysis, a characteristic that is typically seen in rapidly proliferating cells 84,97 .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [84]

    The Results section, “The metabolic switch to glycolysis is preceded by a stoichiometric change in the electron transport system,” supports an early decrease in some electron transport proteins followed by a gradual shift toward glycolysis, which it describes as characteristic of fast-proliferating cells. But it specifies that only complexes I and IV were downregulated by day 3; complexes II, III and V increased. The claim overgeneralizes the downregulation to electron transport chain proteins as a whole. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Such changes were highly correlated with altered cell division, DNA replication, chromatin modification and DNA damage response protein levels.

    “Such changes were highly correlated with altered cell division, DNA replication, chromatin modification and the DNA damage response protein levels 84 .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [84]

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Research works printed but not linked: 74

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Metadata

Authors
Hansson, J., Rafiee, M. R., Reiland, S., Polo, J. M., Gehring, J., Okawa, S., Huber, W., Hochedlinger, K., & Krijgsveld, J.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2012-12
Volume
2
Issue
6
Pages
1579-1592
ISSN
2211-1247
DOI
10.1016/j.celrep.2012.10.014
PMC
PMC4438680
Cited by
229
References
9
Language
en
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