ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation

Sen, George L., Boxer, Lisa D., Webster, Dan E., Bussat, Rose T., Qu, Kun, Zarnegar, Brian J., Johnston, Danielle, Siprashvili, Zurab +1 more·2012·Developmental Cell

Cited by (247)

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  1. The GRHL3-regulated long non-coding RNA lnc-DC modulates keratinocytes differentiation by interacting with IGF2BP2 and up-regulating ZNF750
    Xueting Hu, Xiao-feng Wu, Lu-min Sui, Luoquan Ao, Chengxiu Pu, Mu Yuan, Wei Xing, Xiang Ming Xu · 2024 · Journal of Dermatological Science
  2. The rough fur (ruf) mutation in mice is an allele of myelin protein zero-like 3 (Mpzl3)
    Kenneth M. Palanza, Legairre A Radden, Mohammed A. Rabah, Tu V. Nguyen, Audra C. Kohm, Malcolm E. Connor, Morgan M. Ricci, Jachius J. Stewart, Sidney Eragene, Thomas R. King · 2017 · Cogent Biology
  3. Epigenetic remodeling of downstream enhancer regions is linked to selective expression of the IL1F10 gene in differentiated human keratinocytes
    Dominique Talabot‐Ayer, Alejandro Díaz-Barreiro, Ali Modarressi, Gaby Palmer · 2022 · Gene
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    Steven A. Hoang-Phou, Ana Sastre-Perona, Matteo Abbruzzese, Zhe Ying, Jasmin M. Siegle, Beatriz Aranda-Orgillés, Pedro P. Rocha, Iannis Aifantis, Jane A. Skok, Slobodan Beronja et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  5. Use of zebrafish to test candidate genes and mutations associated with structural birth defects, primarily in cleft lip and palate
    Tiffany Lynn Smith, Robert A. Cornell, Douglas W. Houston, Fang Hua Lin · 2014
  6. PRIMA-1MET/APR-246 Can Partially Rescue In Vitro Cell Adhesion of Patient-Derived Junctional Epidermolysis Bullosa Epidermal Cells
    Clément Berthy, Laurent Gagnoux-Palacios, Marine Madrange, Christine Bodemer, Nicolas Cagnard, Smail Hadj-Rabia, Isabelle Petit, Daniel Aberdam · 2023 · Journal of Investigative Dermatology
  7. Tenascin C as a novel zinc finger protein 750 target regulating the immunogenicity via DNA damage in lung squamous cell carcinoma
    Lu Xia, Hexin Lin, Huifen Cao, Jiabian Lian · 2024 · BMC Cancer
  8. Overexpression of ZNF468 promotes esophageal squamous cell carcinoma progression via the AKT/mTOR pathway
    Luxia Ye, Yixiao Pan, Jiaqian Bao, Yiqing Guo, Lingxiao Lu, Jingmin Zheng · 2024 · International Immunopharmacology
  9. Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation
    Shaelin Lamb, Zuri Omari, Lindsey Seldin · 2026 · Frontiers in Cell and Developmental Biology
  10. ZNF831 suppresses triple-negative breast cancer progression through NLRP3-associated pyroptotic signaling and M1-like macrophage phenotypic remodeling
    Qingqing Liu, Jun Fan, Wantao Peng, Shuangwu Deng, Yupei Tan, Fei Guo, 钟江雪, Shimeng Zhou, Wenbin Liu, Yan Xu · 2026 · Breast Cancer Research
  11. Transcription Factor Regulation of Epidermal Differentiation and Inflammation
    Uyanga Batzorig, Grace Zhang, George L. Sen · 2026 · Cells
  12. Zinc finger protein 750 is a novel regulator of osteoblast differentiation and bone homeostasis by transcriptionally deactivating SNAI1 signaling
    Xiaoli Shi, Xueli Jia, Wei Xin Liu, Liwen Shi, Zheng Yang, Jie Zhou, Xiaoxia Li, Baoli Wang · 2025 · Stem Cells Translational Medicine
  13. ZNF750 safeguards upper hair follicle homeostasis to prevent inflammatory skin disease
    Uyanga Batzorig, Grace Zhang, Chang Yang, Ye Liu, Celia Fernández-Méndez, Samiksha Mahapatra, Jae‐Joong Kim, Neha Quadir, George L. Sen · 2026 · Journal of Investigative Dermatology
  14. Enhanced Expression of Kallikrein-related Peptidase 7 in Lichen Planus, Lichen Sclerosis, Porokeratosis and Psoriasis Vulgaris
    Zhongyin He, Xinhua Zhan, Qinian Zheng, Leqing Zhu, Xiao Wang, Liehua Deng, Lianghua Bin · 2017 · Journal of Dermatological Research
  15. Fanning the Flames: IRAK2 Signaling in Differentiated Epithelium Potentiates Skin Inflammation
    Rochelle Castillo, Ipsita Subudhi, Shruti Naik · 2021 · Journal of Investigative Dermatology
  16. Zfp750 prevents oral adhesions and promotes temporary epithelial fusions
    Sunil Kumar Singh, Emily Adelizzi, Caleb S. Heffner, Sarah W. Curtis, Kaylia Mekelda Duncan, Waheed A. Awotoye, Joy Olotu, Tamara D. Busch, Wasiu Adeyemo, Lord Jephthah Joojo Gowans et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  17. Overview of Transcription Factors in Esophagus Cancer
    Pallaval Veera Bramhachari, A. M. V. N. Prathyusha, Dachuru Rama Sekhara Reddy · 2017 · Springer eBooks
  18. Unravelling gene regulation in the epidermis during differentiation
    Anisa Banu Abdul Rahim · 2018
  19. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration
    Vladimir A. Botchkarev, Andrey A. Sharov, Michael Y. Fessing · 2018 · Stem cell biology and regenerative medicine
  20. brt index: an integration of biological relevance and p -value for -omics data along with demonstration in microarray data using a developed R package
    Le Zheng, Jin Li, Peng Yu · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  21. Function and Regulation of the α6 Integrins in Mammary Epithelial Biology and Breast Cancer: A Dissertation
    Cheng Chang · 2015 · eScholarship@UMassChan
  22. Oral Cancer
    Srinivas Vinod Saladi, Leif William Ellisen · 2015 · Springer eBooks
  23. Faculty Opinions recommendation of Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks.
    Kevin Yuk-Lap Yip · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  24. WITHDRAWN: NMR structure verifies the eponymous zinc finger domain of transcription factor ZNF750
    Antonio J. Rua, Richard D. Whitehead, Andrei T. Alexandrescu · 2023 · Journal of Structural Biology · Retracted
  25. A comprehensive analysis of mRNA expression profiles of Esophageal Squamous Cell Carcinoma reveals downregulation of Desmoglein 1 and crucial genomic targets
    Amal Alotaibi, Veerendra P. Gadekar, Pranav Swaroop Gundla, Sumana Mandarthi, Subramanyeshwari Ravi, Dhyeya Mallya, Asna Tungekar, B Lavanya, Ashok Kumar Bhagavath, Mary Anne W. Cordero et al. · 2023 · Cancer Biomarkers
  26. Superficial ice and deep blaze: A defense strategy of the skin
    Zhuoqiong Qiu, Wei Li · 2024 · Immunity
  27. Elucidating the transcriptional regulation underlying neural induction
    Sarah E. Hirsch · 2017
  28. Additional file 1 of Tenascin C as a novel zinc finger protein 750 target regulating the immunogenicity via DNA damage in lung squamous cell carcinoma
    Lu Xia, Hexin Lin, Huifen Cao, Lian, Jiabian · 2024 · Figshare
  29. Additional file 2 of Tenascin C as a novel zinc finger protein 750 target regulating the immunogenicity via DNA damage in lung squamous cell carcinoma
    Lu Xia, Lin, Hexin, Huifen Cao, Lian, Jiabian · 2024 · Figshare
  30. Additional file 4 of Tenascin C as a novel zinc finger protein 750 target regulating the immunogenicity via DNA damage in lung squamous cell carcinoma
    Lu Xia, Hexin Lin, Huifen Cao, Lian, Jiabian · 2024 · Figshare
  31. Additional file 3 of Tenascin C as a novel zinc finger protein 750 target regulating the immunogenicity via DNA damage in lung squamous cell carcinoma
    Lu Xia, Hexin Lin, Huifen Cao, Lian, Jiabian · 2024 · Figshare
  32. Additional file 5 of Tenascin C as a novel zinc finger protein 750 target regulating the immunogenicity via DNA damage in lung squamous cell carcinoma
    Lu Xia, Lin, Hexin, Huifen Cao, Lian, Jiabian · 2024 · Figshare
  33. Additional file 6 of Tenascin C as a novel zinc finger protein 750 target regulating the immunogenicity via DNA damage in lung squamous cell carcinoma
    Lu Xia, Hexin Lin, Huifen Cao, Lian, Jiabian · 2024 · Figshare
  34. Additional file 1 of Long-term expansion of directly reprogrammed keratinocyte-like cells and in vitro reconstitution of human skin
    Zheng, Jie, Wonjin Yun, Park, Junghyun, Kang, Phil Jun, Gilju Lee, Song, Gwonhwa, Kim, In Yong, You, Seungkwon · 2020 · Figshare
  35. ZFP42 maintains stemness and rhythmic transcription in human epidermal stem and progenitor cells via CRY1
    Shuiying Gao, Hao Tan, Shuqia Xu, Zhaoyu Zhang, Yushuang Sun, Yaqiong Li, Dan Jian, Xiaowen Qi, Qing Tang, Run Chen et al. · 2026 · Communications Biology
  36. Expression dynamics and functional roles of KLF4 during embryonic hair follicle development in cashmere goats
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  37. A Novel Model System to Identify Cellular and Molecular Defects Underlying Rare Genetic Disorders
    Maddison N. Salois, Saiphone Webb, Isaiah A. Proctor, Peter J. Koch, Maranke I. Koster · 2026 · Experimental Dermatology
  38. ZNF750 deficiency induces lipid metabolic reprogramming and enhances ferroptosis sensitivity in esophageal squamous cell carcinoma
    Xin Yang, Huijuan Liu, Mengyuan Yang, Heng Xiao, Zhinan Zhou, Kai Yang, Yan Zhou, Yingying Zhang, Jing Ren, Meng Sun et al. · 2026 · Genes & Diseases
  39. SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation
    Yushuang Sun, Shuqia Xu, Dongyu Wang, Shuiying Gao, Xiaowen Qi, Miao Jiang, Dan Jian, Yaqiong Li, Zhaoyan Jiang, Miao Zhen et al. · 2026 · Cellular and Molecular Immunology
  40. Contrôle de l’expansion ex vivo de précurseurs kératinocytaires humains fonctionnels : implication des facteurs de transcription KLF4 et MAD4
    Julien Coutier · 2020 · theses.fr (ABES)
  41. Exosomes ou vecteurs de communication entre les fibroblastes et les kératinocytes : modélisation des échanges dans la peau saine et au cours du vieillissement
    Julie Rorteau · 2022 · theses.fr (ABES)
  42. Caractérisation du système de réparation des mésappariements de l'ADN ou « mismatch repair » dans les tumeurs sébacées et analyse de leur microenvironnement inflammatoire
    É. Frouin · 2023
  43. Species and strain diversity in Staphylococcus drive divergent host responses in human skin
    Ruoyu Yang, Morgan M. Severn, Elizabeth S. Aiken, Wei Zhou, Anita Yvonne Voigt, Gabrielle Walker, Aaron Y. Koh, Minghao Gong, Maheshwor Thapa, Shuzhao Li et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  44. Angiotensin II type 1 receptor blockade inhibits gastric cancer metastasis through tight junction restoration
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  45. Squamous-state excursions activate APOBEC3A in cancer
    Josefine Striepen, Alexandra Dananberg, Aušrinė Ruzgaitė, Alyssa Hurley, Eléonore Toufektchan, Ashley Nichols, Hannah Rosenberg, Cameron Cordero, Tony M. Mertz, R. M. Norman et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  46. ΔNP63 regulates epithelial stratification and differentiation in the murine ureter
    Fairouz Qasrawi, Florian Bergmann, Philipp Straube, Hauke Thiesler, Herbert Hildebrandt, Satrajit Sinha, Elsa Renee Flores, Mark‐Oliver Trowe, Carsten Rudat, Andreas Kispert · 2026 · American Journal of Physiology-Renal Physiology
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