ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation
Open accessAbstract
Disrupted epidermal differentiation characterizes numerous diseases that impact >25% of the population. In a search for dominant mediators of differentiation, we defined a requirement for ZNF750 in terminal epidermal differentiation. ZNF750 controlled genes mutated in numerous human skin diseases, including FLG, LOR, LCE3B, ALOXE3, and SPINK5. ZNF750 induced progenitor differentiation via an evolutionarily conserved C2H2 zinc finger motif. The epidermal master regulator, p63, bound the ZNF750 promoter and was necessary for its induction. ZNF750 restored differentiation to p63-deficient tissue, suggesting that it acts downstream of p63. A search for functionally important ZNF750 targets via analysis of ZNF750-regulated genes identified KLF4, a transcription factor that activates late epidermal differentiation. ZNF750 binds to KLF4 at multiple sites flanking the transcriptional start site and controls its expression. ZNF750 thus directly links a tissue-specifying factor, p63, to an effector of terminal differentiation, KLF4, and represents a potential future target for disorders of this process.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
KLF4 induces epidermal differentiation genes.
“We chose three Module 2 regulators: 1) KLF4, which induces epidermal differentiation genes, 2) ZNF750, a factor engaged in positive and negative gene regulation in epidermal differentiation, and 3) CEBPA, which has known role in murine epidermis (Lopez et al., 2009; Sen et al., 2012).”
From Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks (2019) · cites this paper as Sen et al., 2012
ZNF750 is engaged in positive and negative gene regulation in epidermal differentiation.
“We chose three Module 2 regulators: 1) KLF4, which induces epidermal differentiation genes, 2) ZNF750, a factor engaged in positive and negative gene regulation in epidermal differentiation, and 3) CEBPA, which has known role in murine epidermis (Lopez et al., 2009; Sen et al., 2012).”
From Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks (2019) · cites this paper as Sen et al., 2012
CEBPA has a known role in murine epidermis.
“We chose three Module 2 regulators: 1) KLF4, which induces epidermal differentiation genes, 2) ZNF750, a factor engaged in positive and negative gene regulation in epidermal differentiation, and 3) CEBPA, which has known role in murine epidermis (Lopez et al., 2009; Sen et al., 2012).”
From Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks (2019) · cites this paper as Sen et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nestle, F. O., Kaplan, D. H., & Barker, J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804595 · Cited by 2,788 · see citing works
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
Yang, A., Schweitzer, R., Sun, D., Kaghad, M., Walker, N., Bronson, R. T., Tabin, C. J., Sharpe, A. H., Caput, D., Crum, C. P., et al. (1999) · Nature · doi:10.1038/19539 · Cited by 2,224 · see citing works
p63 is a p53 homologue required for limb and epidermal morphogenesis
Mills, A. A., Zheng, B., Wang, X., Vogel, H. S., Roop, D. R., & Bradley, A. (1999) · Nature · doi:10.1038/19531 · Cited by 1,974 · see citing works
Incidence Estimate of Nonmelanoma Skin Cancer in the United States, 2006
Rogers, H. W., Weinstock, M. A., Harris, A. R., Hinckley, M. R., Feldman, S. R., Fleischer, A. B., & Coldiron, B. M. (2010) · Archives of Dermatology · doi:10.1001/archdermatol.2010.19 · Cited by 1,186 · see citing works
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
Smith, F. J. D., Irvine, A. D., Terron-Kwiatkowski, A., Sandilands, A., Campbell, L., Zhao, Y., Liao, H., Evans, A. T., Goudie, D. R., Lewis‐Jones, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1743 · Cited by 1,026 · see citing works
p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia
Senoo, M., Pinto, F., Crum, C. P., & McKeon, F. (2007) · Cell · doi:10.1016/j.cell.2007.02.045 · Cited by 881 · cited 2× · see citing works
“p63 acts in the latter setting to sustain stem cell function,(Senoo et al., 2007) to maintain stratified epithelial tissue fate by preventing reversion to simple epithelium as well as, paradoxically, to enable terminal differentiation (Truong and Khavari, 2007; Truong et al.”
BackgroundKlf4 is a transcription factor required for establishing the barrier function of the skin
Segre, J. A., Bauer, C., & Fuchs, E. V. (1999) · Nature Genetics · doi:10.1038/11926 · Cited by 793 · see citing works
de Cid, R., Riveira‐Muñoz, E., Zeeuwen, P. L. J. M., Robarge, J., Liao, W. J., Dannhauser, E. N., Giardina, E., Stuart, P. E., Nair, R. P., Helms, C. A., et al. (2009) · Nature Genetics · doi:10.1038/ng.313 · Cited by 533 · see citing works
p63 regulates proliferation and differentiation of developmentally mature keratinocytesPreprint
Truong, A. B., Kretz, M., Ridky, T. W., Kimmel, R. A., & Khavari, P. A. (2006) · Genes & Development · doi:10.1101/gad.1463206 · Cited by 480 · see citing works
Self-citationDNMT1 maintains progenitor function in self-renewing somatic tissue
Sen, G. L., Reuter, J., Webster, D. E., Zhu, L., & Khavari, P. A. (2010) · Nature · doi:10.1038/nature08683 · Cited by 423 · see citing works
Self-citationPerp Is a p63-Regulated Gene Essential for Epithelial Integrity
Ihrie, R. A., Marques, M. R., Nguyen, B., Horner, J. S., Papazoglu, C., Bronson, R. T., Mills, A. A., & Attardi, L. D. (2005) · Cell · doi:10.1016/j.cell.2005.01.008 · Cited by 311 · see citing works
p63 induces key target genes required for epidermal morphogenesis
Koster, M. I., Dai, D., Marinari, B., Sano, Y., Costanzo, A., Karin, M., & Roop, D. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611376104 · Cited by 234 · see citing works
p63in Epithelial Survival, Germ Cell Surveillance, and Neoplasia
Crum, C. P., & McKeon, F. (2010) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102117 · Cited by 216 · see citing works
Kouwenhoven, E. N., van Heeringen, S. J., Tena, J. J., Oti, M., Dutilh, B. E., Alonso, M. E., de la Calle‐Mustienes, E., Smeenk, L., Rinne, T., Parsaulian, L., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001065 · Cited by 179 · see citing works
Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1
Magnúsdóttir, E., Kalachikov, S., Mizukoshi, K., Savitsky, D., Ishida-Yamamoto, A., Panteleyev, A. A., & Calame, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707323104 · Cited by 152 · cited 3× · see citing works
“Several transcription factors, including KLF4 (Patel et al., 2006; Segre et al., 1999), PRDM1/ Blimp1 (Magnúsdóttir et al., 2007), and OVOL1 (Teng et al., 2007) have been implicated in the induction of terminal differentiation; however, the mechanisms controlling their expression and how they are…”
Backgroundp63 in Skin Development and Ectodermal Dysplasias
Koster, M. I. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.119 · Cited by 100 · see citing works
Control of Keratinocyte Proliferation and Differentiation by p63
Truong, A. B., & Khavari, P. A. (2007) · Cell Cycle · doi:10.4161/cc.6.3.3753 · Cited by 95 · see citing works
Self-citationBirnbaum, R. Y., Zvulunov, A., Hallel-Halevy, D., Cagnano, E., Finer, G., Ofir, R., Geiger, D., Silberstein, E., Feferman, Y., & Birk, O. S. (2006) · Nature Genetics · doi:10.1038/ng1813 · Cited by 85 · see citing works
Patel, S., Xi, Z. F., Seo, E. Y., McGaughey, D. M., & Segre, J. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608658103 · Cited by 69 · see citing works
Teng, A., Nair, M., Wells, J., Segre, J. A., & Dai, X. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.08.012 · Cited by 64 · see citing works
A Promoter Sequence Variant of ZNF750 Is Linked with Familial Psoriasis
Yang, C., Hwu, W., Yang, L., Chung, W., Chien, Y., Hung, C.-F., Chen, H.-C., Tsai, P.-J., Fann, C. S. J., Liao, F., et al. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.1 · Cited by 44 · see citing works
A current and online genodermatosis database
Leech, S. N., & Moss, C. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.07834.x · Cited by 42 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Zinc-finger proteins in health and disease
Cassandri, M., Smirnov, A., Novelli, F., Pitolli, C., Agostini, M., Malewicz, M., Melino, G., & Raschellà, G. (2017) · Cell Death Discovery · doi:10.1038/cddiscovery.2017.71 · Cited by 844 · see citing works
Genomic and molecular characterization of esophageal squamous cell carcinoma
Lin, D., Hao, J., Nagata, Y., Xu, L., Li, S., Meng, X., Sato, Y., Okuno, Y., Varela, A. M., Ding, L., et al. (2014) · Nature Genetics · doi:10.1038/ng.2935 · Cited by 622 · see citing works
Krüppel-like factor 4 (KLF4): What we currently know
Ghaleb, A. M., & Yang, V. W. (2017) · Gene · doi:10.1016/j.gene.2017.02.025 · Cited by 516 · see citing works
Li, B., Tsoi, L. C., Swindell, W. R., Gudjonsson, J. E., Tejasvi, T., Johnston, A. W. B., Ding, J., Stuart, P. E., Xing, X., Kochkodan, J. J., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.28 · Cited by 393 · see citing works
Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas
Campbell, J. D., Yau, C. S. F., Bowlby, R., Liu, Y., Brennan, K., Fan, H., Taylor, A. M., Wang, C., Walter, V., Akbani, R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.063 · Cited by 341 · see citing works
Zhang, L., Zhou, Y., Cheng, C., Cui, H., Cheng, L., Kong, P., Wang, J., Li, Y., Chen, W., Song, B., et al. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.02.017 · Cited by 331 · see citing works
Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population
Sawada, G., Niida, A., Uchi, R., Hirata, H., Shimamura, T., Suzuki, Y., Shiraishi, Y., Chiba, K., Imoto, S., Takahashi, Y., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.01.035 · Cited by 331 · see citing works
Rubin, A. J., Parker, K. R., Satpathy, A. T., Qi, Y., Wu, B., Ong, A. J., Mumbach, M. R., Ji, A. L., Kim, D. S., Cho, S. W., et al. (2019) · Cell · doi:10.1016/j.cell.2018.11.022 · Cited by 314 · see citing works
Self-citationRubin, A. J., Barajas, B. C., Furlan-Magaril, M., Lopez-Pajares, V., Mumbach, M. R., Howard, I., Kim, D. S., Boxer, L. D., Cairns, J., Spivakov, M., et al. (2017) · Nature Genetics · doi:10.1038/ng.3935 · Cited by 293 · see citing works
Self-citationCutaneous Squamous Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches
Fania, L., Didona, D., Pietro, F. R. D., Verkhovskaia, S., Morese, R., Paolino, G., Donati, M., Ricci, F., Coco, V., Ricci, F., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9020171 · Cited by 262 · see citing works
Lin, D., Wang, M., & Koeffler, H. P. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.06.066 · Cited by 249 · see citing works
A LncRNA-MAF:MAFB transcription factor network regulates epidermal differentiation
Lopez-Pajares, V., Qu, K., Zhang, J., Webster, D. E., Barajas, B. C., Siprashvili, Z., Zarnegar, B. J., Boxer, L. D., Rios, E. J., Tao, S., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.01.028 · Cited by 194 · see citing works
Self-citationMaster regulatory role of p63 in epidermal development and disease
Soares, E., & Zhou, H. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2701-z · Cited by 183 · see citing works
Seborrheic dermatitis—Looking beyond Malassezia
Wikramanayake, T. C., Borda, L. J., Miteva, M. I., & Paus, R. (2019) · Experimental Dermatology · doi:10.1111/exd.14006 · Cited by 164 · see citing works
Hayes, D. N., Waes, C. V., & Seiwert, T. Y. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.62.1086 · Cited by 150 · see citing works
Boxer, L. D., Barajas, B., Tao, S., Zhang, J., & Khavari, P. A. (2014) · Genes & Development · doi:10.1101/gad.246579.114 · Cited by 147 · see citing works
Self-citationXu, M., Horrell, J., Snitow, M. E., Cui, J., Gochnauer, H. R., Syrett, C. M., Kallish, S., Seykora, J. T., Liu, F., Gaillard, D., et al. (2017) · Nature Communications · doi:10.1038/ncomms15397 · Cited by 133 · see citing works
Li, Y., Moretto-Zita, M., Soncin, F., Wakeland, A. K., Wolfe, L., Leon-Garcia, S., Pandian, R., Pizzo, D. P., Cui, L., Nazor, K. L., et al. (2013) · Development · doi:10.1242/dev.092155 · Cited by 131 · see citing works
ACTL6a Enforces the Epidermal Progenitor State by Suppressing SWI/SNF-Dependent Induction of KLF4
Bao, X., Tang, J., Lopez-Pajares, V., Tao, S., Qu, K., Crabtree, G. R., & Khavari, P. A. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.12.014 · Cited by 118 · see citing works
Self-citationMechanisms by which HPV Induces a Replication Competent Environment in Differentiating Keratinocytes
Moody, C. A. (2017) · Viruses · doi:10.3390/v9090261 · Cited by 114 · see citing works
Genetic pathways in disorders of epidermal differentiation
Lopez-Pajares, V., Yan, K., Zarnegar, B. J., Jameson, K. L., & Khavari, P. A. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.10.005 · Cited by 113 · see citing works
Self-citationp53/p63/p73 in the Epidermis in Health and DiseasePreprint
Botchkarev, V. A., & Flores, E. R. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015248 · Cited by 111 · see citing works
GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells
Gao, X., Bali, A. S., Randell, S. H., & Hogan, B. L. M. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201506014 · Cited by 110 · see citing works
ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma
Hazawa, M., Lin, D.-C., Handral, H. K., Xu, L., Chen, Y., Yy, J., Mayakonda, A., Ding, L.-W., Meng, X., Sharma, A., et al. (2016) · Oncogene · doi:10.1038/onc.2016.377 · Cited by 106 · see citing works
m6A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression
Zhang, P., He, Q., Lei, Y., Li, Y., Wen, X., Hong, M., Zhang, J., Ren, X., Wang, Y., Yang, X., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1224-3 · Cited by 103 · see citing works
Wang, Y., Arribas-Layton, M., Chen, Y., Lykke‐Andersen, J., & Sen, G. L. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.08.014 · Cited by 99 · see citing works
Self-citationMolecular Biology of Atopic Dermatitis
Mu, Z., Zhao, Y. P., Liu, X., Chang, C. C.-C., & Zhang, J. (2014) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-014-8415-1 · Cited by 95 · see citing works
Human Papillomaviruses Modulate MicroRNA 145 Expression To Directly Control Genome Amplification
Gunasekharan, V., & Laimins, L. A. (2013) · Journal of Virology · doi:10.1128/jvi.00153-13 · Cited by 94 · see citing works
Monteleon, C. L., Agnihotri, T., Dahal, A., Liu, M., Rebecca, V. W., Beatty, G. L., Amaravadi, R. K., & Ridky, T. W. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.02.035 · Cited by 91 · see citing works
Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma
North, J. P., Golovato, J., Vaske, C. J., Sanborn, Z., Nguyen, A., Wu, W., Goode, B., Stevers, M., McMullen, K., White, B. E. P., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04008-y · Cited by 90 · see citing works
Xu, Q., Γεωργίου, Γ., Frölich, S., van der Sande, M., Veenstra, G. J. C., Zhou, H., & van Heeringen, S. J. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab598 · Cited by 88 · see citing works
FOXM1 regulates proliferation, senescence and oxidative stress in keratinocytes and cancer cells
Smirnov, A., Panatta, E., Lena, A. M., Castiglia, D., Daniele, N. D., Melino, G., & Candi, E. (2016) · Aging · doi:10.18632/aging.100988 · Cited by 86 · see citing works
Hazawa, M., Lin, D., Kobayashi, A., Jiang, Y., Xu, L., Dewi, F. R. P., Mohamed, M. S., Hartono, H., Nakada, M., Meguro‐Horike, M., et al. (2017) · EMBO Reports · doi:10.15252/embr.201744523 · Cited by 85 · see citing works
Gatti, V., Fierro, C., Annicchiarico‐Petruzzelli, M., Melino, G., & Peschiaroli, A. (2019) · Molecular Oncology · doi:10.1002/1878-0261.12473 · Cited by 83 · see citing works
Mahapatra, K. D., Pasquali, L., Søndergaard, J. N., Lapins, J., Németh, I. B., Baltás, E., Kemény, L. V., Homey, B., Moldovan, L.-I., Kjems, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-59660-6 · Cited by 80 · see citing works
Riz, I., Hawley, T. S., & Hawley, R. G. (2015) · Oncotarget · doi:10.18632/oncotarget.4530 · Cited by 80 · see citing works
SNAI2 Controls the Undifferentiated State of Human Epidermal Progenitor Cells
Mistry, D. S., Chen, Y., Wang, Y., Zhang, K., & Sen, G. L. (2014) · Stem Cells · doi:10.1002/stem.1809 · Cited by 79 · see citing works
Self-citationDesmosomes as Signaling Hubs in the Regulation of Cell Behavior
Müller, L., Hatzfeld, M., & Keil, R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.745670 · Cited by 78 · see citing works
Progenitor Function in Self-Renewing Human Epidermis is Maintained by the Exosome
Mistry, D. S., Chen, Y., & Sen, G. L. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.04.022 · Cited by 77 · see citing works
Self-citationSun, B. K., Boxer, L. D., Ransohoff, J. D., Siprashvili, Z., Qu, K., Lopez-Pajares, V., Hollmig, S. T., & Khavari, P. A. (2015) · Genes & Development · doi:10.1101/gad.267708.115 · Cited by 76 · see citing works
Self-citationEph receptor and ephrin function in breast, gut, and skin epithelia
White, B. E. P., & Getsios, S. (2014) · Cell Adhesion & Migration · doi:10.4161/19336918.2014.970012 · Cited by 75 · see citing works
The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation
Kim, D. S., Risca, V. I., Reynolds, D. L., Chappell, J., Rubin, A. J., Jung, N., Donohue, L. K. H., Lopez-Pajares, V., Kathiria, A. S., Shi, M., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00947-3 · Cited by 74 · see citing works
Self-citationSingle Cell and Open Chromatin Analysis Reveals Molecular Origin of Epidermal Cells of the Skin
Fan, X., Wang, D., Burgmaier, J. E., Teng, Y., Romano, R., Sinha, S., & Yi, R. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.08.010 · Cited by 68 · see citing works
Hypoxia-Inducible Factors Regulate Filaggrin Expression and Epidermal Barrier Function
Wong, W. J., Richardson, T., Seykora, J. T., Cotsarelis, G., & Simon, M. C. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.283 · Cited by 67 · see citing works
Egolf, S., Aubert, Y., Doepner, M., Anderson, A., López, A. M. M., Pacella, G., Lee, J., Ko, E. K., Zou, J., Lan, Y., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.058 · Cited by 65 · see citing works
Swindell, W. R., Johnston, A. W. B., Xing, X., Voorhees, J. J., Elder, J. T., & Gudjonsson, J. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079253 · Cited by 63 · see citing works
ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes
Cassandri, M., Butera, A., Amelio, I., Lena, A. M., Montanaro, M., Mauriello, A., Anemona, L., Candi, E., Knight, R. A., Agostini, M., et al. (2020) · Oncogene · doi:10.1038/s41388-020-1277-5 · Cited by 62 · see citing works
IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes
Satoh, T. K., Mellett, M., Meier-Schiesser, B., Fenini, G., Otsuka, A., Beer, H., Rordorf, T., Maul, J., Hafner, J., Navarini, A. A., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128678 · Cited by 61 · see citing works
Network Analysis Identifies Mitochondrial Regulation of Epidermal Differentiation by MPZL3 and FDXR
Bhaduri, A., Ungewickell, A., Boxer, L. D., Lopez-Pajares, V., Zarnegar, B. J., & Khavari, P. A. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.10.023 · Cited by 60 · see citing works
Self-citationChakravarthi, V. P., Ratri, A., Masumi, S., Borosha, S., Ghosh, S., Christenson, L. K., Roby, K. F., Wolfe, M. W., & Rumi, M. A. K. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111212 · Cited by 60 · see citing works
Liu, H., Leslie, E. J., Carlson, J. C., Beaty, T. H., Marazita, M. L., Lidral, A. C., & Cornell, R. A. (2017) · Nature Communications · doi:10.1038/ncomms14759 · Cited by 60 · see citing works
Dai, W., Ko, J. M. Y., Choi, S. S. A., Yu, Z., Ning, L., Zheng, H., Gopalan, V., Chan, K. T., Lee, N. P. Y., Chan, K. W., et al. (2017) · The Journal of Pathology · doi:10.1002/path.4925 · Cited by 60 · see citing works
Cohen, I., Birnbaum, R. Y., Liani-Leibson, K., Taube, R., Sivan, S., & Birk, O. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042628 · Cited by 59 · see citing works
Duperret, E. K., Dahal, A., & Ridky, T. W. (2015) · Journal of Cell Science · doi:10.1242/jcs.175539 · Cited by 58 · see citing works
Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibitionPreprint
Webster, D. E., Barajas, B. C., Bussat, R. T., Yan, K., Neela, P. H., Flockhart, R. J., Kovalski, J. R., Zehnder, A. M., & Khavari, P. A. (2014) · Genome Research · doi:10.1101/gr.166231.113 · Cited by 58 · see citing works
Self-citationZinc and its binding proteins: essential roles and therapeutic potential
Kiouri, D. P., Chasapis, C. T., Mavromoustakos, T., Spiliopoulou, C., & Stefanidou, M. E. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03891-3 · Cited by 56 · see citing works
RAC1 activation drives pathologic interactions between the epidermis and immune cells
Winge, M. C. G., Ohyama, B., Dey, C. N., Boxer, L. D., Li, W., Ehsani‐Chimeh, N., Truong, A. K., Wu, D. S., Armstrong, A. W., Makino, T., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85738 · Cited by 56 · see citing works
Self-citationTranscription Factor MafB Coordinates Epidermal Keratinocyte Differentiation
Miyai, M., Hamada, M., Moriguchi, T., Hiruma, J., Kamitani, A., Watanabe, H., Hara‐Chikuma, M., Takahashi, K., Takahashi, S., & Kataoka, K. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.05.088 · Cited by 55 · see citing works
Li, J., Chen, Y., Xu, X., Jones, J., Tiwari, M., Ling, J., Wang, Y., Harismendy, O., & Sen, G. L. (2019) · Nature Communications · doi:10.1038/s41467-019-12238-x · Cited by 55 · see citing works
Self-citationKlein, R. H., Lin, Z., Hopkin, A. S., Gordon, W., Tsoi, L. C., Liang, Y., Gudjonsson, J. E., & D, B. A. M. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006745 · Cited by 54 · see citing works
Zarnegar, B. J., Webster, D. E., Lopez-Pajares, V., Hunt, B. V. S., Qu, K., Yan, K., Berk, D. R., Sen, G. L., & Khavari, P. A. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.07.007 · Cited by 52 · see citing works
Self-citationHarbison, R. A., Kubik, M. W., Konnick, E. Q., Zhang, Q. H., Lee, S., Park, H., Zhang, J., Carlson, C. S., Chen, C., Schwartz, S. M., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.99327 · Cited by 52 · see citing works
Murai, K., Dentro, S. C., Ong, S. H., Sood, R. K., Fernández‐Antorán, D., Herms, A., Kostiou, V., Abnizova, I., Hall, B. A., Gerstung, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33945-y · Cited by 51 · see citing works
Guo, T. W., Gaykalova, D. A., Considine, M., Wheelan, S. J., Pallavajjala, A., Bishop, J. A., Westra, W. H., Ideker, T. E., Koch, W. M., Khan, Z. H., et al. (2016) · International Journal of Cancer · doi:10.1002/ijc.30081 · Cited by 51 · see citing works
Swindell, W. R., Sarkar, M. K., Liang, Y., Xing, X., Baliwag, J., Elder, J. T., Johnston, A., Ward, N. L., & Gudjonsson, J. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-18404-9 · Cited by 49 · see citing works
Cheng, L.-C., Tu, K. C., Seidel, C. W., Robb, S. M. C., Guo, F., & Alvarado, A. S. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.08.030 · Cited by 48 · see citing works
p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate
Richardson, R., Mitchell, K., Hammond, N. L., Mollo, M. R., Kouwenhoven, E. N., Wyatt, N., Donaldson, I. J., Zeef, L. A. H., Burgis, T., Blance, R., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006828 · Cited by 47 · see citing works
Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression
Bailey, P. J., Ridgway, R. A., Cammareri, P., Treanor-Taylor, M., Bailey, U., Schoenherr, C., Bone, M., Schreyer, D., Purdie, K. J., Thomson, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40822-9 · Cited by 46 · see citing works
Dissecting the DNA binding landscape and gene regulatory network of p63 and p53
Riege, K., Kretzmer, H., Sahm, A., McDade, S. S., Hoffmann, S., & Fischer, M. (2020) · eLife · doi:10.7554/elife.63266 · Cited by 46 · see citing works
Highly Rapid and Efficient Conversion of Human Fibroblasts to Keratinocyte-Like Cells
Chen, Y., Mistry, D. S., & Sen, G. L. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.327 · Cited by 45 · see citing works
Self-citationBi, Y., Guo, S., Xu, X., Kong, P., Cui, H., Yan, T., Ma, Y., Cheng, Y., Chen, Y., Liu, X., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2492-2 · Cited by 44 · see citing works
The long non-coding RNA NEAT1 is a ΔNp63 target gene modulating epidermal differentiation
Fierro, C., Gatti, V., Banca, V. L., Domenico, S. D., Scalera, S., Corleone, G., Fanciulli, M., Nicola, F. D., Mauriello, A., Montanaro, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39011-5 · Cited by 42 · see citing works
Control of p53-dependent transcription and enhancer activity by the p53 family member p63
Uzunbas, G. K., Ahmed, F., & Sammons, M. A. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.007965 · Cited by 41 · see citing works
Fortunel, N. O., Chadli, L., Coutier, J., Lemaı̂tre, G., Auvré, F., Domingues, S., Cadio, E., Vaigot, P., Cavallero, S., Deleuze, J., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0464-6 · Cited by 41 · see citing works
Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis
Ogawa, Y., Kinoshita, M., Shimada, S., & Kawamura, T. (2018) · Journal of Immunology Research · doi:10.1155/2018/5404093 · Cited by 40 · see citing works
Sethi, I., Sinha, S., & Buck, M. J. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-1042 · Cited by 40 · see citing works
Gunasekharan, V., Li, Y., Andrade, J., & Laimins, L. A. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005747 · Cited by 39 · see citing works
ZFP750 affects the cutaneous barrier through regulating lipid metabolism
Butera, A., Agostini, M., Cassandri, M., Nicola, F. D., Fanciulli, M., D’Ambrosio, L., Falasca, L., Nardacci, R., Wang, L., Piacentini, M., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg5423 · Cited by 38 · see citing works
Human endogenous retrovirus onco-exaptation counters cancer cell senescence through calbindin
Attig, J., Pape, J., Doglio, L. E., Kazachenka, A., Ottina, E., Young, G. R., Enfield, K. S. S., Aramburu, I. V., Ng, K. W., Faulkner, N., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci164397 · Cited by 38 · see citing works
Glucocorticoid receptor and Klf4 co-regulate anti-inflammatory genes in keratinocytes
Sevilla, L. M., Latorre, V., Carceller, E., Boix, J., Vodák, D., Mills, I. G., & Pérez, P. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.05.015 · Cited by 38 · see citing works
Kong, P., Xu, E., Bi, Y., Xu, X., Liu, X., Song, B., Zhang, L., Cheng, C., Yan, T., Qian, Y., et al. (2020) · Theranostics · doi:10.7150/thno.38210 · Cited by 37 · see citing works
Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma
Hoffmann, M. J., & Schulz, W. A. (2021) · Cancers · doi:10.3390/cancers13236040 · Cited by 37 · see citing works
Identification of ZNF395 as a novel modulator of adipogenesis
Hasegawa, R., Tomaru, Y., de Hoon, M., Suzuki, H., Hayashizaki, Y., & Shin, J. W. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.11.003 · Cited by 36 · see citing works
Pondeljak, N., Lugović‐Mihić, L., Tomić, L., Parać, E., Pedić, L., & Mosler, E. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010236 · Cited by 35 · see citing works
p63 Is a Promising Marker in the Diagnosis of Unusual Skin Cancer
Smirnov, A., Anemona, L., Novelli, F., Piro, M. C., Annicchiarico‐Petruzzelli, M., Melino, G., & Candi, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225781 · Cited by 35 · see citing works
Role of the reprogramming factor KLF4 in blood formation
Park, C. S., Shen, Y., Lewis, A. H., & Lacorazza, H. D. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.1ru1215-539r · Cited by 34 · see citing works
The role of barrier genes in epidermal malignancy
Darido, C., Georgy, S. R., & Jane, S. M. (2016) · Oncogene · doi:10.1038/onc.2016.84 · Cited by 33 · see citing works
The Retinoid-Related Orphan Receptor RORα Promotes Keratinocyte Differentiation via FOXN1
Dai, J., Brooks, Y., Lefort, K., Getsios, S., & Dotto, G. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070392 · Cited by 32 · see citing works
Gene regulatory mechanisms orchestrated by p63 in epithelial development and related disorders
Kouwenhoven, E. N., van Bokhoven, H., & Zhou, H. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.03.003 · Cited by 32 · see citing works
Kim, K.-H., Shim, J. S., Kim, H.-J., & Son, E. D. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112337 · Cited by 31 · see citing works
Szigety, K. M., Liu, F., Yuan, C. Y., Moran, D., Horrell, J., Gochnauer, H. R., Cohen, R., Katz, J. P., Kaestner, K. H., Seykora, J. T., et al. (2020) · Genes & Development · doi:10.1101/gad.333674.119 · Cited by 31 · see citing works
Lambert, S., Swindell, W. R., Tsoi, L. C., Stoll, S. W., & Elder, J. T. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.12.032 · Cited by 30 · see citing works
Wikramanayake, T. C., Hirt, P. A., Almastadi, M., Mitchell, H., Tomic‐Canic, M., Romero, L., Garcia, D., & Štrbo, N. (2018) · Experimental Dermatology · doi:10.1111/exd.13798 · Cited by 29 · see citing works
Gatti, V., Fierro, C., Compagnone, M., Banca, V. L., Mauriello, A., Montanaro, M., Scalera, S., Nicola, F. D., Candi, E., Ricci, F., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2104718119 · Cited by 29 · see citing works
Unraveling cancer lineage drivers in squamous cell carcinomas
Guan, Y., Wang, G., Fails, D., Nagarajan, P., & Ge, Y. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107448 · Cited by 29 · see citing works
KLF5 governs sphingolipid metabolism and barrier function of the skinPreprint
Lyu, Y., Guan, Y., Deliu, L. P., Humphrey, E., Frontera, J. K., Yang, Y. J., Zamler, D. B., Kim, K. H., Mohanty, V., Jin, K., et al. (2022) · Genes & Development · doi:10.1101/gad.349662.122 · Cited by 29 · see citing works
Isoform-Specific Roles of Mutant p63 in Human Diseases
Osterburg, C., Osterburg, S., Zhou, H., Missero, C., & Dötsch, V. (2021) · Cancers · doi:10.3390/cancers13030536 · Cited by 28 · see citing works
Liu, Y., Chen, Y., Batzorig, U., Li, J., Fernández-Méndez, C., Mahapatra, S., Li, F., Sam, S., Dokoshi, T., Hong, S., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.09.002 · Cited by 27 · see citing works
Self-citationDissecting key contributions of TH2 and TH17 cytokines to atopic dermatitis pathophysiology
Meesters, L. D., Roubroeks, J. A. Y., Gerritsen, A., Velthuijs, N., Klijnhout, J. A., Laberthonnìère, C., van Vlijmen-Willems, I. M., Hübenthal, M., Rodijk‐Olthuis, D., Peters, R. H. W., et al. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.05.007 · Cited by 27 · see citing works
Regulatory network decoded from epigenomes of surface ectoderm-derived cell types
Lowdon, R. F., Zhang, B., Bilenky, M., Mauro, T., Li, D., Gascard, P. D., Sigaroudinia, M., Farnham, P., Bastian, B. C., Tlsty, T. D., et al. (2014) · Nature Communications · doi:10.1038/ncomms6442 · Cited by 27 · see citing works
- Authors
- Sen, G. L., Boxer, L. D., Webster, D. E., Bussat, R. T., Qu, K., Zarnegar, B. J., Johnston, D., Siprashvili, Z., & Khavari, P. A.
- Affiliations
- University of California San Diego (US)
- Stanford University (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Khavari, Paul A.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 22
- Issue
- 3
- Pages
- 669-677
- ISSN
- 1534-5807 (ISSN-L)
- PMC
- PMC3306457
- OpenAlex
- W2091776694
- Cited by
- 246
- References
- 22
- Citations by year
- 2026: 18 · 2025: 9 · 2024: 22 · 2023: 19 · 2022: 18 · 2021: 19 · 2020: 22 · 2019: 16 · 2018: 17 · 2017: 28 · 2016: 14 · 2015: 16 · 2014: 15 · 2013: 8 · 2012: 5
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 539 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AR49737, K01AR057828-04, R01 AR45192)
- U.S. Department of Veterans Affairs
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Keywords
- ZNF750, p63, KLF4, epidermal differentiation disorders, C2H2 zinc finger, transcriptional regulation, skin diseases, FLG, LOR, ALOXE3, SPINK5
- MeSH terms
- Epidermal Cells, Kruppel-Like Factor 4, Filaggrin Proteins, Amino Acid Sequence, Cell Differentiation, Cells, Cultured, Epidermis, Gene Expression Regulation, Humans, Male, Membrane Proteins, Molecular Sequence Data, Transcription Factors, Keratinocytes, Tumor Suppressor Proteins, Kruppel-Like Transcription Factors, Foreskin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
