The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Cell-Type-Specific Profiling of Gene Expression and Chromatin Binding without Cell Isolation: Assaying RNA Pol II Occupancy in Neural Stem Cells
Open accessAbstract
Cell-type-specific transcriptional profiling often requires the isolation of specific cell types from complex tissues. We have developed "TaDa," a technique that enables cell-specific profiling without cell isolation. TaDa permits genome-wide profiling of DNA- or chromatin-binding proteins without cell sorting, fixation, or affinity purification. The method is simple, sensitive, highly reproducible, and transferable to any model system. We show that TaDa can be used to identify transcribed genes in a cell-type-specific manner with considerable temporal precision, enabling the identification of differential gene expression between neuroblasts and the neuroepithelial cells from which they derive. We profile the genome-wide binding of RNA polymerase II in these adjacent, clonally related stem cells within intact Drosophila brains. Our data reveal expression of specific metabolic genes in neuroepithelial cells, but not in neuroblasts, and highlight gene regulatory networks that may pattern neural stem cell fates.
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Cites
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
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Decoding gene regulation in the fly brain
Janssens, J., Aibar, S., Taskiran, I. I., Ismail, J. N., Spanier, K. I., Bravo González-Blas, C., Quan, X. J., Papasokrati, D., Hulselmans, G., Makhzami, S., et al. (2021) · doi:10.1101/2021.08.11.454937 · Cited by 170
Decoding gene regulation in the fly brain
Janssens, J., Aibar, S., Taskiran, I. I., Ismail, J. N., Gomez, A. E., Aughey, G., Spanier, K. I., De Rop, F. V., González-Blas, C. B., Dionne, M., et al. (2022) · Nature · doi:10.1038/s41586-021-04262-z · Cited by 170
Self-citationEarly stem cell aging in the mature brain
Ibrayeva, A., Bay, M., Pu, E., Jörg, D. J., Peng, L., Jun, H., Zhang, N., Aaron, D., Lin, C., Resler, G., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.03.018 · Cited by 137
Aughey, G. N., Estacio Gomez, A., Thomson, J., Yin, H., & Southall, T. D. (2018) · eLife · doi:10.7554/elife.32341 · Cited by 89
Self-citationSOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling
Sun, D., Llora Batlle, O., van den Ameele, J., Thomas, J. C., He, P., Lim, K., Tang, W., Xu, C., Meyer, K. B., Teichmann, S. A., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2022111338 · Cited by 38
Self-citationSukumar, S. K., Antonydhason, V., Molander, L., Sandakly, J., Umapathy, G., Mendoza-Garcia, P., Masudi, T., Schlossser, A., Nässel, D. R., Wegener, C., et al. (2023) · doi:10.7554/elife.88985.1 · Cited by 1
Metadata
- Authors
- Southall, T. D., Gold, K. S., Egger, B., Davidson, C. M., Caygill, E. E., Marshall, O. J., & Brand, A. H.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 26
- Issue
- 1
- Pages
- 101-112
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2114709909
- Cited by
- 256
- References
- 77
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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