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Cited by 181

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Membrane-Localized Estrogen Receptor α Is Required for Normal Organ Development and Function

Open access
Pedram, Ali, Razandi, Mahnaz, Lewis, Michael, Hammes, Stephen, Levin, Ellis R.·2014·Developmental Cell
DOI 10.1016/j.devcel.2014.04.016
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Abstract

SUMMARY Steroid receptors are found in discrete cellular locations but it is unknown whether extra-nuclear pools are necessary for normal organ development. To assess this we developed a point-mutant estrogen receptor alpha (ERα) knock-in mouse (C451A) that precludes palmitoylation and membrane trafficking of the steroid receptor in all organs. Homozygous knock-in female mice (nuclear-only ERα, NOER mice) show loss of rapid signaling that occurs from membrane ERα in wild type mice. Multiple developmental abnormalities were found including infertility, relatively hypoplastic uteri, abnormal ovaries, stunted mammary gland ductal development, and abnormal pituitary hormone regulation in NOER mice. These abnormalities were rescued in heterozygous NOER mice that were comparable to wild type mice. Messenger RNAs implicated in organ development were often poorly stimulated by estrogen only in homozygous NOER mice. We conclude that many organs require membrane ERα and resulting signal transduction to collaborate with nuclear ERα for normal development and function.

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Metadata

Authors
Pedram, A., Razandi, M., Lewis, M., Hammes, S., & Levin, E. R.
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2014-05
Volume
29
Issue
4
Pages
482-490
ISSN
1534-5807 (ISSN-L)
DOI
10.1016/j.devcel.2014.04.016
OpenAlex
W2012555137
Cited by
181
References
4
FWCI
13.27
Type
journal article
Language
en
Open access
bronze

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