The DOI matches its Crossref record; 204 of the 204 references it cites were found in a registry or an index.
Molecular mechanism of estrogen–estrogen receptor signaling
Open accessAbstract
17β‐Estradiol (E2), as the main circulating estrogen hormone, regulates many tissue and organ functions in physiology. The effects of E2 on cells are mediated by the transcription factors and estrogen receptor (ER)α and ER β that are encoded by distinct genes. Localized at the peri‐membrane, mitochondria, and the nucleus of cells that are dependent on estrogen target tissues, the ER s share similar, as well as distinct, regulatory potentials. Different intracellular localizations of the ER s result in dynamically integrated and finely tuned E2 signaling cascades that orchestrate cellular growth, differentiation, and death. The deregulation of E2–ER signaling plays a critical role in the initiation and progression of target tissue malignancies. A better understanding of the complex regulatory mechanisms that underlie ER actions in response to E2 therefore holds a critical trajectory for the development of novel prognostic and therapeutic approaches with substantial impacts on the systemic management of target tissue diseases.
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Cites
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Estrogens in adipose tissue physiology and obesity-related dysfunction
Kuryłowicz, A. (2023) · Biomedicines · doi:10.3390/biomedicines11030690 · Cited by 178
Oosthuyse, T., Strauss, J. A., & Hackney, A. C. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-05090-3 · Cited by 70
Our evolving understanding of how 27-hydroxycholesterol influences cancer
Ma, L., Cho, W., & Nelson, E. R. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114621 · Cited by 53
Kisspeptin-neuron control of LH pulsatility and ovulation
Stevenson, H., Bartram, S., Charalambides, M. M., Murthy, S., Petitt, T., Pradeep, A., Vineall, O., Abaraonye, I., Lancaster, A., Koysombat, K., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.951938 · Cited by 48
Metadata
- Authors
- Yaşar, P., Ayaz, G., User, S. D., Güpür, G., & Muyan, M.
- Venue
- Reproductive Medicine and Biology
- Publisher
- Wiley
- Published
- 2016-12-05
- Volume
- 16
- Issue
- 1
- Pages
- 4-20
- ISSN
- 1445-5781 (ISSN-L)
- 1447-0578
- OpenAlex
- W2575891648
- Cited by
- 482
- References
- 204
- FWCI
- 16.63
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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