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Cited by 576Autophagy in Disease and TherapyUbiquitin and proteasome pathwaysCalcium signaling and nucleotide metabolism

Cleaning house: selective autophagy of organelles

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Anding, Allyson L., Baehrecke, Eric H.·2017·Developmental Cell
DOI 10.1016/j.devcel.2017.02.016PMC PMC5395098
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Abstract

The selective clearance of organelles by autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. Removal of damaged organelles clears the cell of potentially toxic byproducts and enables reuse of organelle components for bioenergetics. Thus, defects in organelle clearance may be detrimental to the health of the cells, contributing to cancer, neurodegeneration, and inflammatory diseases. Organelle-specific autophagy can clear mitochondria, peroxisomes, lysosomes, ER, chloroplasts, and the nucleus. Here, we review our understanding of the mechanisms that regulate the clearance of organelles by autophagy and highlight gaps in our knowledge of these processes.

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  • The lysosome has numerous complex roles including cellular signaling, signal integration, trafficking cargo, and functional interaction with other organelles.

    “It is a center for cellular signaling and signal integration, has responsibilities in trafficking cargo, and functionally interacts with other organelles.1,9”

    From The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases (2025) · cites this paper as [9]

    The Introduction and Regulation of Autophagy sections describe cargo delivery to autophagosomes and their fusion with lysosomes for degradation, supporting the lysosome’s interaction with other cellular structures in cargo processing. The copy does not describe the lysosome as a center for cellular signaling or signal integration. Page numbers were not available in the indexed passages. (LLM, conf=0.83)

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  1. Aits S Jäättelä M 2013 Lysosomal cell death at a glance J Cell Sci 126 1905 1912 23720375
  2. Akinduro O Sully K Patel A Robinson DJ Chikh A McPhail G Braun KM Philpott MP Harwood CA Byrne C 2016 Constitutive Autophagy and Nucleophagy during Epidermal Differentiation J Invest Dermatol 136 1460 1470 27021405
  3. Anding AL Baehrecke EH 2015 Autophagy in Cell Life and Cell Death Curr Top Dev Biol 114 67 91 26431564
  4. Axe EL Walker SA Manifava M Chandra P Roderick HL Habermann A Griffiths G Ktistakis NT 2008 Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum J Cell Biol 182 685 701 18725538 PMC2518708
  5. Bellot G Garcia-Medina R Gounon P Chiche J Roux D Pouysségur J Mazure NM 2009 Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains Mol Cell Biol 29 2570 2581 19273585 PMC2682037
  6. Bernales S McDonald KL Walter P 2006 Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response PLoS Biol 4 e423 17132049 PMC1661684
  7. Deosaran E Larsen KB Hua R Sargent G Wang Y Kim S Lamark T Jauregui M Law K Lippincott-Schwartz J 2013 NBR1 acts as an autophagy receptor for peroxisomes J Cell Sci 126 939 952 23239026
  8. Diao J Liu R Rong Y Zhao M Zhang J Lai Y Zhou Q Wilz LM Li J Vivona S 2015 ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes Nature 520 563 566 25686604 PMC4442024
  9. Efe JA Botelho RJ Emr SD 2007 Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate Mol Biol Cell 18 4232 4244 17699591 PMC2043547
  10. Farré JC Burkenroad A Burnett SF Subramani S 2013 Phosphorylation of mitophagy and pexophagy receptors coordinates their interaction with Atg8 and Atg11 EMBO Rep 14 441 449 23559066 PMC3642380
  11. Farré JC Krick R Subramani S Thumm M 2009 Turnover of organelles by autophagy in yeast Curr Opin Cell Biol 21 522 530 19515549 PMC2725217
  12. Frank M Duvezin-Caubet S Koob S Occhipinti A Jagasia R Petcherski A Ruonala MO Priault M Salin B Reichert AS 2012 Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner Biochim Biophys Acta 1823 2297 2310 22917578
  13. Ge L Melville D Zhang M Schekman R 2013 The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis Elife 2 e00947 23930225 PMC3736544
  14. Green DR Kroemer G 2004 The pathophysiology of mitochondrial cell death Science 305 626 629 15286356
  15. Hachez C Veljanovski V Reinhardt H Guillaumot D Vanhee C Chaumont F Batoko H 2014 The Arabidopsis abiotic stress-induced TSPO-related protein reduces cellsurface expression of the aquaporin PIP2;7 through protein-protein interactions and autophagic degradation Plant Cell 26 4974 4990 25538184 PMC4311218
  16. Hailey DW Rambold AS Satpute-Krishnan P Mitra K Sougrat R Kim PK Lippincott-Schwartz J 2010 Mitochondria supply membranes for autophagosome biogenesis during starvation Cell 141 656 667 20478256 PMC3059894
  17. Hamasaki M Furuta N Matsuda A Nezu A Yamamoto A Fujita N Oomori H Noda T Haraguchi T Hiraoka Y 2013 Autophagosomes form at ER-mitochondria contact sites Nature 495 389 393 23455425
  18. Hanna RA Quinsay MN Orogo AM Giang K Rikka S Gustafsson ÅB 2012 Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy J Biol Chem 287 19094 19104 22505714 PMC3365942
  19. Hayashi-Nishino M Fujita N Noda T Yamaguchi A Yoshimori T Yamamoto A 2009 A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation Nat Cell Biol 11 1433 1437 19898463
  20. Honig A Avin-Wittenberg T Ufaz S Galili G 2012 A new type of compartment, defined by plant-specific Atg8-interacting proteins, is induced upon exposure of Arabidopsis plants to carbon starvation Plant Cell 24 288 303 22253227 PMC3289568
  21. Hung YH Chen LMW Yang JY Yang WY 2013 Spatiotemporally controlled induction of autophagy-mediated lysosome turnover Nat Commun 4 2111 23817530
  22. Ichimura Y Kominami E Tanaka K Komatsu M 2008 Selective turnover of p62/A170/SQSTM1 by autophagy Autophagy 4 1063 1066 18776737
  23. Ishida H Yoshimoto K Izumi M Reisen D Yano Y Makino A Ohsumi Y Hanson MR Mae T 2008 Mobilization of rubisco and stroma-localized fluorescent proteins of chloroplasts to the vacuole by an ATG gene-dependent autophagic process Plant Physiol 148 142 155 18614709 PMC2528122
  24. Itakura E Kishi C Inoue K Mizushima N 2008 Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG Mol Biol Cell 19 5360 5372 18843052 PMC2592660
  25. Itakura E Kishi-Itakura C Mizushima N 2012 The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes Cell 151 1256 1269 23217709
  26. Kageyama Y Hoshijima M Seo K Bedja D Sysa-Shah P Andrabi SA Chen W Höke A Dawson VL Dawson TM 2014 Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain Embo J 33 2798 2813 25349190 PMC4282557
  27. Kamada Y Funakoshi T Shintani T Nagano K Ohsumi M Ohsumi Y 2000 Tormediated induction of autophagy via an Apg1 protein kinase complex J Cell Biol 150 1507 1513 10995454 PMC2150712
  28. Kanki T Wang K Cao Y Baba M Klionsky DJ 2009 Atg32 is a mitochondrial protein that confers selectivity during mitophagy Dev Cell 17 98 109 19619495 PMC2746076
  29. Katarzyna ZR Suresh S 2016 Autophagic degradation of peroxisomes in mammals Biochem Soc Trans 44 431 440 27068951 PMC4958620
  30. Kim PK Hailey DW Mullen RT Lippincott-Schwartz J 2008 Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes Proc Natl Acad Sci USa 105 20567 20574 19074260 PMC2602605
  31. Kitada T Asakawa S Hattori N Matsumine H Yamamura Y Minoshima S Yokochi M Mizuno Y Shimizu N 1998 Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism Nature 392 605 608 9560156
  32. Kondo-Okamoto N Noda NN Suzuki SW Nakatogawa H Takahashi I Matsunami M Hashimoto A Inagaki F Ohsumi Y Okamoto K 2012 Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy J Biol Chem 287 10631 10638 22308029 PMC3323008
  33. Kovács AL Réz G Pálfia Z Kovács J 2000 Autophagy in the epithelial cells of murine seminal vesicle in vitro. Formation of large sheets of nascent isolation membranes, sequestration of the nucleus and inhibition by wortmannin and 3-ethyladenine Cell Tissue Res 302 253 261 11131136
  34. Kovács AL Pálfia Z Réz G Vellai T Kovács J 2007 Sequestration revisited: integrating traditional electron microscopy, de novo assembly and new results Autophagy 3 655 662 17603297
  35. Koyano F Okatsu K Kosako H Tamura Y Go E Kimura M Kimura Y Tsuchiya H Yoshihara H Hirokawa T 2014 Ubiquitin is phosphorylated by PINK1 to activate parkin Nature 510 162 166 24784582
  36. Kraft C Reggiori F Peter M 2009 Selective types of autophagy in yeast Biochim Biophys Acta 1793 1404 1412 19264099
  37. Krick R Muehe Y Prick T Bremer S Schlotterhose P Eskelinen EL Millen J Goldfarb DS Thumm M 2008 Piecemeal microautophagy of the nucleus requires the core macroautophagy genes Mol Biol Cell 19 4492 4505 18701704 PMC2555948
  38. Kvam E Goldfarb DS 2007 Nucleus-vacuole junctions and piecemeal microautophagy of the nucleus in S. cerevisiae Autophagy 3 85 92 17204844
  39. Lazarou M Sliter DA Kane LA Sarraf SA Wang C Burman JL Sideris DP Fogel AI Youle RJ 2015 The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy Nature 524 309 314 26266977 PMC5018156
  40. Lemasters JJ 2005 Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging Rejuvenation Res 8 3 5 15798367
  41. Lin W Wittenbach VA 1981 Subcellular localization of proteases in wheat and corn mesophyll protoplasts Plant Physiol 67 969 972 16661803 PMC425811
  42. Liu L Feng D Chen G Chen M Zheng Q Song P Ma Q Zhu C Wang R Qi W 2012a Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells Nat Cell Biol 14 177 185 22267086
  43. Liu XH Gao HM Xu F Lu JP Devenish RJ Lin FC 2012b Autophagy vitalizes the pathogenicity of pathogenic fungi Autophagy 8 1415 1425 22935638
  44. Manjithaya R Nazarko TY Farré JC Subramani S 2010 Molecular mechanism and physiological role of pexophagy FEBS Lett 584 1367 1373 20083110 PMC2843806
  45. Matsuura A Tsukada M Wada Y Ohsumi Y 1997 Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae Gene 192 245 250 9224897
  46. McLelland GL Lee SA McBride HM Fon EA 2016 Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system J Cell Biol 114 jcb.201603105 PMC4970327 27458136
  47. McLelland GL Soubannier V Chen CX McBride HM Fon EA 2014 Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control Embo J 33 282 295 24446486 PMC3989637
  48. Mijaljica D Prescott M Devenish RJ 2012 A late form of nucleophagy in Saccharomyces cerevisiae PLoS ONE 7 e40013 22768199 PMC3386919
  49. Millen JI Krick R Prick T Thumm M Goldfarb DS 2009 Measuring piecemeal microautophagy of the nucleus in Saccharomyces cerevisiae Autophagy 5 75 81 18989095
  50. Minamikawa T Toyooka K Okamoto T Hara-Nishimura I Nishimura M 2001 Degradation of ribulose-bisphosphate carboxylase by vacuolar enzymes of senescing French bean leaves: immunocytochemical and ultrastructural observations Protoplasma 218 144 153 11770431
  51. Mizushima N Noda T Yoshimori T Tanaka Y Ishii T George MD Klionsky DJ Ohsumi M Ohsumi Y 1998 A protein conjugation system essential for autophagy Nature 395 395 398 9759731
  52. Mizushima N Levine B Cuervo AM Klionsky DJ 2008 Autophagy fights disease through cellular self-digestion Nature 451 1069 1075 18305538 PMC2670399
  53. Mochida K Oikawa Y Kimura Y Kirisako H Hirano H Ohsumi Y Nakatogawa H 2015 Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus Nature 522 359 362 26040717
  54. Motley AM Nuttall JM Hettema EH 2012 Pex3-anchored Atg36 tags peroxisomes for degradation in Saccharomyces cerevisiae Embo J 31 2852 2868 22643220 PMC3395097
  55. Narendra D Kane LA Hauser DN Fearnley IM Youle RJ 2010b p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both Autophagy 6 1090 1106 20890124 PMC3359490
  56. Niwa Y Kato T Tabata S Seki M Kobayashi M Shinozaki K Moriyasu Y 2004 Disposal of chloroplasts with abnormal function into the vacuole in Arabidopsis thaliana cotyledon cells Protoplasma 223 229 232 15221529
  57. Nixon RA 2013 The role of autophagy in neurodegenerative disease Nat Med 19 983 997 23921753
  58. Noda NN Kumeta H Nakatogawa H Satoo K Adachi W Ishii J Fujioka Y Ohsumi Y Inagaki F 2008 Structural basis of target recognition by Atg8/LC3 during selective autophagy Genes Cells 13 1211 1218 19021777
  59. Nordgren M Francisco T Lismont C Hennebel L Brees C Wang B Van Veldhoven PP Azevedo JE Fransen M 2015 Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts Autophagy 11 1326 1340 26086376 PMC4590649
  60. Nordgren M Wang B Apanasets O Fransen M 2013 Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives Frontiers in Physiology 4 PMC3682127 23785334
  61. Obara K Sekito T Niimi K Ohsumi Y 2008 The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function J Biol Chem 283 23972 23980 18586673 PMC3259791
  62. Ohashi Y Munro S 2010 Membrane delivery to the yeast autophagosome from the Golgi-endosomal system Mol Biol Cell 21 3998 4008 20861302 PMC2982105
  63. Okamoto K Kondo-Okamoto N Ohsumi Y 2009 Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy Dev Cell 17 87 97 19619494
  64. Oku M Sakai Y 2016 Pexophagy in yeasts Biochim Biophys Acta 1863 992 998 26409485
  65. Park YE Hayashi YK Bonne G Arimura T Noguchi S Nonaka I Nishino I 2009 Autophagic degradation of nuclear components in mammalian cells Autophagy 5 795 804 19550147
  66. Poole AC Thomas RE Andrews LA McBride HM Whitworth AJ Pallanck LJ 2008 The PINK1/Parkin pathway regulates mitochondrial morphology Proc Natl Acad Sci USa 105 1638 1643 18230723 PMC2234197
  67. Prinz WA 2014 Bridging the gap: membrane contact sites in signaling, metabolism, and organelle dynamics J Cell Biol 205 759 769 24958771 PMC4068136
  68. Pryde KR Smith HL Chau KY Schapira AHV 2016 PINK1 disables the antifission machinery to segregate damaged mitochondria for mitophagy J Cell Biol 213 163 171 27091447 PMC5084273
  69. Ravikumar B Sarkar S Davies JE Futter M Garcia-Arencibia M Green-Thompson ZW Jimenez-Sanchez M Korolchuk VI Lichtenberg M Luo S 2010b Regulation of mammalian autophagy in physiology and pathophysiology Physiol Rev 90 1383 1435 20959619
  70. Rawi Al S Louvet-Vallée S Djeddi A Sachse M Culetto E Hajjar C Boyd L Legouis R Galy V 2011 Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission Science 334 1144 1147 22033522
  71. Roberts P Moshitch-Moshkovitz S Kvam E O’Toole E Winey M Goldfarb DS 2003 Piecemeal microautophagy of nucleus in Saccharomyces cerevisiae Mol Biol Cell 14 129 141 12529432 PMC140233
  72. Rogov V Dötsch V Johansen T Kirkin V 2014 Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy Mol Cell 53 167 178 24462201
  73. Ruggiano A Foresti O Carvalho P 2014 Quality control: ER-associated degradation: protein quality control and beyond J Cell Biol 204 869 879 24637321 PMC3998802
  74. Sargent G van Zutphen T Shatseva T Zhang L Di Giovanni V Bandsma R Kim PK 2016 PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation J Cell Biol 214 677 690 27597759 PMC5021090
  75. Sarraf SA Raman M Guarani-Pereira V Sowa ME Huttlin EL Gygi SP Harper JW 2013 Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization Nature 496 372 376 23503661 PMC3641819
  76. Sato M Sato K 2011 Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans embryos Science 334 1141 1144 21998252
  77. Schuck S Gallagher CM Walter P 2014 ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery J Cell Sci 127 4078 4088 25052096 PMC4163648
  78. Schweers RL Zhang J Randall MS Loyd MR Li W Dorsey FC Kundu M Opferman JT Cleveland JL Miller JL 2007 NIX is required for programmed mitochondrial clearance during reticulocyte maturation Proc Natl Acad Sci USa 104 19500 19505 18048346 PMC2148318
  79. Seibenhener ML Babu JR Geetha T Wong HC Krishna NR Wooten MW 2004 Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation Mol Cell Biol 24 8055 8068 15340068 PMC515032
  80. Shintani T Mizushima N Ogawa Y Matsuura A Noda T Ohsumi Y 1999 Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast Embo J 18 5234 5241 10508157 PMC1171594
  81. Shoji JY Kikuma T Arioka M Kitamoto K 2010 Macroautophagy-mediated degradation of whole nuclei in the filamentous fungus Aspergillus oryzae PLoS ONE 5 e15650 21187926 PMC3004950
  82. Strappazzon F Nazio F Corrado M Cianfanelli V Romagnoli A Fimia GM Campello S Nardacci R Piacentini M Campanella M 2015 AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1 Cell Death Differ 22 419 432 25215947 PMC4326570
  83. Subramani S 2015 A mammalian pexophagy target Nat Cell Biol 17 1371 1373 26458245 PMC4957398
  84. Sugiura A McLelland GL Fon EA McBride HM 2014 A new pathway for mitochondrial quality control: mitochondrial-derived vesicles Embo J 33 2142 2156 25107473 PMC4282503
  85. Suzuki K Kirisako T Kamada Y Mizushima N Noda T Ohsumi Y 2001 The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation Embo J 20 5971 5981 11689437 PMC125692
  86. Svenning S Lamark T Krause K Johansen T 2011 Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1 Autophagy 7 993 1010 21606687 PMC3210314
  87. Takáts S Nagy P Varga Á Pircs K Kárpáti M Varga K Kovács AL Hegedűs K Juhász G 2013 Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila J Cell Biol 201 531 539 23671310 PMC3653357
  88. Tanaka C Tan LJ Mochida K Kirisako H Koizumi M Asai E Sakoh-Nakatogawa M Ohsumi Y Nakatogawa H 2014 Hrr25 triggers selective autophagy-related pathways by phosphorylating receptor proteins J Cell Biol 207 91 105 25287303 PMC4195827
  89. Tanida I Mizushima N Kiyooka M Ohsumi M Ueno T Ohsumi Y Kominami E 1999 Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy Mol Biol Cell 10 1367 1379 10233150 PMC25280
  90. Till A Lakhani R Burnett SF Subramani S 2012 Pexophagy: the selective degradation of peroxisomes Int J Cell Biol 2012 512721 18 22536249 PMC3320016
  91. Toyama EQ Herzig S Courchet J Lewis TL Losón OC Hellberg K Young NP Chen H Polleux F Chan DC 2016 Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress Science 351 275 281 26816379 PMC4852862
  92. Tripathi DN Walker CL 2016 The peroxisome as a cell signaling organelle Curr Opin Cell Biol 39 109 112 26967755 PMC5657427
  93. Tumbarello DA Manna PT Allen M Bycroft M Arden SD Kendrick-Jones J Buss F 2015 The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy PLoS Pathog 11 e1005174 26451915 PMC4599966
  94. Vanhee C Zapotoczny G Masquelier D Ghislain M Batoko H 2011 The Arabidopsis multistress regulator TSPO is a heme binding membrane protein and a potential scavenger of porphyrins via an autophagy-dependent degradation mechanism Plant Cell 23 785 805 21317376 PMC3077796
  95. Vives-Bauza C Zhou C Huang Y Cui M de Vries RLA Kim J May J Tocilescu MA Liu W Ko HS 2010 PINK1-dependent recruitment of Parkin to mitochondria in mitophagy Proc Natl Acad Sci USa 107 378 383 19966284 PMC2806779
  96. Wada S Ishida H Izumi M Yoshimoto K Ohsumi Y Mae T Makino A 2009 Autophagy plays a role in chloroplast degradation during senescence in individually darkened leaves Plant Physiol 149 885 893 19074627 PMC2633819
  97. Wang S Kaufman RJ 2012 The impact of the unfolded protein response on human disease J Cell Biol 197 857 867 22733998 PMC3384412
  98. Wang Z Miao G Xue X Guo X Yuan C Wang Z Zhang G Chen Y Feng D Hu J 2016 The Vici Syndrome Protein EPG5 Is a Rab7 Effector that Determines the Fusion Specificity of Autophagosomes with Late Endosomes/Lysosomes Mol Cell 63 781 795 27588602
  99. Wild P Farhan H McEwan DG Wagner S Rogov VV Brady NR Richter B Korac J Waidmann O Choudhary C 2011 Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth Science 333 228 233 21617041 PMC3714538
  100. Wittenbach VA Lin W Hebert RR 1982 Vacuolar localization of proteases and degradation of chloroplasts in mesophyll protoplasts from senescing primary wheat leaves Plant Physiol 69 98 102 16662193 PMC426153
  101. Wong YC Holzbaur ELF 2014 Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation Proc Natl Acad Sci USa 111 E4439 E4448 25294927 PMC4210283
  102. Yamashita SI Abe K Tatemichi Y Fujiki Y 2014 The membrane peroxin PEX3 induces peroxisome-ubiquitination-linked pexophagy Autophagy 10 1549 1564 25007327 PMC4206534
  103. Yang H Ni HM Guo F Ding Y Shi YH Lahiri P Fröhlich LF Rülicke T Smole C Schmidt VC 2016 Sequestosome-1/p62 is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice J Biol Chem jbc.M116.739821 PMC5009243 27325701
  104. Yang Y Ouyang Y Yang L Beal MF McQuibban A Vogel H Lu B 2008 Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery Proc Natl Acad Sci USa 105 7070 7075 18443288 PMC2383971
  105. Zhang H Bosch-Marce M Shimoda LA Tan YS Baek JH Wesley JB Gonzalez FJ Semenza GL 2008 Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia J Biol Chem 283 10892 10903 18281291 PMC2447655
  106. Zhang J Ney PA 2009 Role of BNIP3 and NIX in cell death, autophagy, and mitophagy Cell Death Differ 16 939 946 19229244 PMC2768230
  107. Zhang J Ney PA 2008 NIX induces mitochondrial autophagy in reticulocytes Autophagy 4 354 356 18623629
  108. Zhang J Tripathi DN Jing J Alexander A Kim J Powell RT Dere R Tait-Mulder J Lee JH Paull TT 2015 ATM functions at the peroxisome to induce pexophagy in response to ROS Nat Cell Biol 17 1259 1269 26344566 PMC4589490

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Authors
Anding, A. L., & Baehrecke, E. H.
Affiliations
University of Massachusetts Chan Medical School (US)
Corresponding author
Baehrecke, Eric H.
ORCID
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2017-04
Volume
41
Issue
1
Pages
10-22
ISSN
1534-5807 (ISSN-L)
DOI
10.1016/j.devcel.2017.02.016
PMC
PMC5395098
OpenAlex
W2606699511
Cited by
576
References
18
Citations by year
2026: 25 · 2025: 43 · 2024: 51 · 2023: 55 · 2022: 69 · 2021: 96 · 2020: 78 · 2019: 73 · 2018: 65 · 2017: 21
FWCI
8.59
Type
journal article
Language
en
Open access
Licence
Locations
  • Developmental Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship@UMassChan (submittedVersion)
Funders
National Institute of General Medical Sciences (R01GM079431, R01GM111658)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords
selective autophagy, cellular homeostasis, mitochondrial clearance, lysosomal clearance, organelle biogenesis, neurodegeneration, cancer, inflammatory diseases
MeSH terms
Animals, Autophagy, Humans, Models, Biological, Organelles, Mitophagy

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