The Autophagy Lysosomal Pathway and Neurodegeneration

Autophagy in the Pathogenesis of Disease

Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894 · see citing works

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996 · cited 1× · see citing works

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882 · see citing works

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500 · see citing works

TFEB Links Autophagy to Lysosomal Biogenesis

Settembre, C., Di Malta, C., Polito, V. A., Arencibia, M. G., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Medina, D., Colella, P., et al. (2011) · Science · doi:10.1126/science.1204592 · Cited by 3,365 · see citing works

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347 · see citing works

Autophagy in immunity and inflammation

Levine, B., Mizushima, N., & Virgin, H. W. (2011) · Nature · doi:10.1038/nature09782 · Cited by 3,289 · see citing works

Mechanisms of mitophagy

Youle, R. J., & Narendra, D. P. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3028 · Cited by 3,273 · see citing works

Functions of Lysosomes

de Duve, C., & Wattiaux, R. (1966) · Annual Review of Physiology · doi:10.1146/annurev.ph.28.030166.002251 · Cited by 3,033 · cited 1× · see citing works

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835 · see citing works

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Lazarou, M., Sliter, D. A., Kane, L. A., Sarraf, S. A., Wang, C., Burman, J. L., Sideris, D. P., Fogel, A. I., & Youle, R. J. (2015) · Nature · doi:10.1038/nature14893 · Cited by 2,774 · see citing works

Autophagy in Health and Disease: A Double-Edged Sword

Shintani, T., & Klionsky, D. J. (2004) · Science · doi:10.1126/science.1099993 · Cited by 2,531 · see citing works

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y., Ueno, I., Sakamoto, A., Tong, K. I., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2021 · Cited by 2,422 · see citing works

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347 · see citing works

Impairment of starvation-induced and constitutive autophagy in <i>Atg7</i> -deficient mice

Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412022 · Cited by 2,331 · see citing works

In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,323 · see citing works

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311 · see citing works

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

Komatsu, M., Waguri, S., Koike, M., Sou, Y.-S., Ueno, T., Hara, T., Mizushima, N., Iwata, J.-I., Ezaki, J., Murata, S., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.035 · Cited by 2,124 · see citing works

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116 · see citing works

Autophagy and Aging

Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works

Decreased Clearance of CNS β-Amyloid in Alzheimer’s Disease

Mawuenyega, K. G., Sigurdson, W., Ovod, V., Munsell, L., Kasten, T., Morris, J. C., Yarasheski, K. E., & Bateman, R. J. (2010) · Science · doi:10.1126/science.1197623 · Cited by 2,078 · see citing works

The role of autophagy in neurodegenerative disease

Nixon, R. A. (2013) · Nature Medicine · doi:10.1038/nm.3232 · Cited by 2,059 · see citing works

Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy

Cuervo, A. M., Stefanis, L., Fredenburg, R., Lansbury, P. T., & Sulzer, D. (2004) · Science · doi:10.1126/science.1101738 · Cited by 2,024 · cited 1× · see citing works

Autophagy: from phenomenology to molecular understanding in less than a decade

Klionsky, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2245 · Cited by 1,938 · see citing works

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

Axe, E. L., Walker, S. A., Manifava, M., Chandra, P., Roderick, H. L., Habermann, A., Griffiths, G., & Ktistakis, N. T. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200803137 · Cited by 1,885 · see citing works

Role of autophagy in cancer

Mathew, R., Karantza-Wadsworth, V., & White, E. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2254 · Cited by 1,798 · see citing works

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

Settembre, C., Fraldi, A., Medina, D. L., & Ballabio, A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3565 · Cited by 1,689 · see citing works

Termination of autophagy and reformation of lysosomes regulated by mTOR

Yu, L., McPhee, C. K., Zheng, L., Mardones, G. A., Rong, Y., Peng, J., Mi, N., Zhao, Y., Liu, Z., Wan, F., et al. (2010) · Nature · doi:10.1038/nature09076 · Cited by 1,544 · see citing works

Pancreatic cancers require autophagy for tumor growth

Yang, S., Wang, X., Contino, G., Liesa, M., Sahin, E., Ying, H., Bause, A., Li, Y., Stommel, J. M., Dell'Antonio, G., et al. (2011) · Genes &amp; Development · doi:10.1101/gad.2016111 · Cited by 1,498 · see citing works

Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

Alers, S., Löffler, A. S., Wesselborg, S., & Stork, B. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06159-11 · Cited by 1,483 · see citing works

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

Webb, J. L., Ravikumar, B., Atkins, J., Skepper, J. N., & Rubinsztein, D. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300227200 · Cited by 1,429 · see citing works

DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis

Crighton, D., Wilkinson, S., O'Prey, J., Syed, N., Smith, P., Harrison, P. R., Gasco, M., Garrone, O., Crook, T., & Ryan, K. M. (2006) · Cell · doi:10.1016/j.cell.2006.05.034 · Cited by 1,380 · see citing works

Autophagy-deficient mice develop multiple liver tumors

Takamura, A., Komatsu, M., Hara, T., Sakamoto, A., Kishi, C., Waguri, S., Eishi, Y., Hino, O., Tanaka, K., & Mizushima, N. (2011) · Genes &amp; Development · doi:10.1101/gad.2016211 · Cited by 1,342 · cited 2× · see citing works

The role for autophagy in cancer

White, E. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73941 · Cited by 1,332 · see citing works

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

Guo, J. Y., Chen, H.-Y., Mathew, R., Fan, J., Strohecker, A. M., Karsli-Uzunbas, G., Kamphorst, J. J., Chen, G., Lemons, J. M. S., Karantza, V., et al. (2011) · Genes &amp; Development · doi:10.1101/gad.2016311 · Cited by 1,323 · see citing works

Phosphorylation of the Autophagy Receptor Optineurin Restricts <i>Salmonella</i> Growth

Wild, P., Farhan, H., McEwan, D. G., Wagner, S., Rogov, V. V., Brady, N. R., Richter, B., Korac, J., Waidmann, O., Choudhary, C., et al. (2011) · Science · doi:10.1126/science.1205405 · Cited by 1,298 · see citing works

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in <i>C. elegans</i>

Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270 · see citing works

A Unified Nomenclature for Yeast Autophagy-Related Genes

Klionsky, D. J., Cregg, J. M., Dunn, W. A., Emr, S. D., Sakai, Y., Sandoval, I. V., Sibirny, A. А., Subramani, S. E., Thumm, M., Marten Veenhuis, A., et al. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00296-x · Cited by 1,267 · see citing works

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS.

Pandey, U. B., Nie, Z., Batlevi, Y., McCray, B. A., Ritson, G. P., Nedelsky, N. B., Schwartz, S. L., DiProspero, N. A., Knight, M. A., Schuldiner, O., et al. (2007) · Nature · doi:10.1038/nature05853 · Cited by 1,234 · see citing works

A Role for Ubiquitin in Selective Autophagy

Kirkin, V., McEwan, D. G., Novak, I., & Đikić, I. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.026 · Cited by 1,227 · see citing works

Atg8, a Ubiquitin-like Protein Required for Autophagosome Formation, Mediates Membrane Tethering and Hemifusion

Nakatogawa, H., Ichimura, Y., & Ohsumi, Y. (2007) · Cell · doi:10.1016/j.cell.2007.05.021 · Cited by 1,215 · see citing works

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

Ramirez, A., Heimbach, A., Gründemann, J., Stiller, B., Hampshire, D., Cid, L. P., Goebel, I., Mubaidin, A. F., Wriekat, A.-L., Roeper, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1884 · Cited by 1,208 · see citing works

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

Oka, T., Hikoso, S., Yamaguchi, O., Taneike, M., Takeda, T., Tamai, T., Oyabu, J., Murakawa, T., Nakayama, H., Nishida, K., et al. (2012) · Nature · doi:10.1038/nature10992 · Cited by 1,201 · see citing works

Autophagy in malignant transformation and cancer progression

Galluzzi, L., Pietrocola, F., Bravo‐San Pedro, J. M., Amaravadi, R. K., Baehrecke, E. H., Cecconi, F., Codogno, P., Debnath, J., Gewirtz, D. A., Karantza, V., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201490784 · Cited by 1,182 · see citing works

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

Tang, G., Gudsnuk, K., Kuo, S.-H., Cotrina, M. L., Rosoklija, G., Sosunov, A., Sonders, M. S., Kanter, E., Castagna, C., Yamamoto, A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.040 · Cited by 1,146 · see citing works

Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and α-Synuclein

Sarkar, S., Davies, J. E., Huang, Z., Tunnacliffe, A., & Rubinsztein, D. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609532200 · Cited by 1,142 · see citing works

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

He, C., Bassik, M. C., Moresi, V., Sun, K., Wei, Y., Zou, Z., An, Z., Loh, J., Fisher, J., Sun, Q., et al. (2012) · Nature · doi:10.1038/nature10758 · Cited by 1,136 · see citing works

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

Amaravadi, R. K., Yu, D., Lum, J. J., Bui, T., Christophorou, M. A., Evan, G. I., Thomas‐Tikhonenko, A., & Thompson, C. B. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28833 · Cited by 1,136 · see citing works

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

Senft, D., & Ronai, Z. A. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.01.002 · Cited by 1,121 · see citing works

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

Boland, B., Kumar, A., Lee, S., Platt, F. M., Wegiel, J., Yu, W. H., & Nixon, R. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0800-08.2008 · Cited by 1,119 · see citing works

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

Ravikumar, B. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.9.1107 · Cited by 1,099 · see citing works

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

Fujita, N., Itoh, T., Omori, H., Fukuda, M., Noda, T., & Yoshimori, T. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1257 · Cited by 1,083 · see citing works

Control of Macroautophagy by Calcium, Calmodulin-Dependent Kinase Kinase-β, and Bcl-2

Høyer-Hansen, M., Bastholm, L., Szyniarowski, P., Campanella, M., Szabadkai, G., Farkas, T., Bianchi, K., Fehrenbacher, N., Elling, F., Rizzuto, R., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.12.009 · Cited by 1,072 · see citing works

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

Anglade, P., Vyas, S., Javoy-Agid, F., Herrero, M. T., Michel, P. P., Marquez, J., Prigent, A., Ruberg, M., Hirsch, É. C., & Agid, Y. (1997) · PubMed · Cited by 1,045 · see citing works

Lysosomal Physiology

Xu, H., & Ren, D. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071649 · Cited by 1,028 · see citing works

Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response

Bernales, S., McDonald, K. L., & Walter, P. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040423 · Cited by 1,009 · see citing works

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

Ilieva, H., Polymenidou, M., & Cleveland, D. W. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200908164 · Cited by 1,008 · see citing works

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

Kang, C., Xu, Q., Martin, T. D., Li, M. Z., Demaria, M., Aron, L., Lu, T., Yankner, B. A., Campisi, J., & Elledge, S. J. (2015) · Science · doi:10.1126/science.aaa5612 · Cited by 982 · see citing works

The molecular machinery of autophagy: unanswered questions

Klionsky, D. J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01620 · Cited by 935 · see citing works

Role for Rab7 in maturation of late autophagic vacuoles

Jäger, S., Bucci, C., Tanida, I., Ueno, T., Kominami, E., Säftig, P., & Eskelinen, E. (2004) · Journal of Cell Science · doi:10.1242/jcs.01370 · Cited by 907 · see citing works

Microautophagy of Cytosolic Proteins by Late Endosomes

Sahu, R., Kaushik, S., Clement, C. C., Cannizzo, E. S., Scharf, B., Follenzi, A., Potolicchio, I., Nieves, E., Cuervo, A. M., & Santambrogio, L. (2011) · Developmental Cell · doi:10.1016/j.devcel.2010.12.003 · Cited by 902 · see citing works

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

Rouschop, K. M. A., van den Beucken, T., Dubois, L., Niessen, H., Bussink, J., Savelkouls, K., Keulers, T., Mujcic, H., Landuyt, W., Voncken, J. W., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40027 · Cited by 829 · see citing works

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

Winslow, A. R., Chen, C.-W., Corrochano, S., Acevedo-Arozena, A., Gordon, D. E., Peden, A. A., Lichtenberg, M., Menzies, F. M., Ravikumar, B., Imarisio, S., et al. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201003122 · Cited by 825 · see citing works

Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

Skibinski, G., Parkinson, N. J., Brown, J. M., Chakrabarti, L., Lloyd, S. L., Hummerich, H., Nielsen, J. E., Hodges, J. R., Spillantini, M. G., Thusgaard, T., et al. (2005) · Nature Genetics · doi:10.1038/ng1609 · Cited by 822 · see citing works

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

Williams, A., Sarkar, S., Cuddon, P., Ttofi, E. K., Saiki, S., Siddiqi, F. H., Jahreiss, L., Fleming, A., Pask, D., Goldsmith, P., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.79 · Cited by 800 · see citing works

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

Inoki, K., Kim, J., & Guan, K. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134537 · Cited by 800 · see citing works

Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

Perera, R. M., Stoykova, S., Nicolay, B. N., Ross, K. N., Fitamant, J., Boukhali, M., Lengrand, J., Deshpande, V., Selig, M. K., Ferrone, C. R., et al. (2015) · Nature · doi:10.1038/nature14587 · Cited by 799 · see citing works

Autophagy and aging: The importance of maintaining "clean" cells

Cuervo, A. M., Bergamini, E., Brunk, U. T., Dröge, W., Ffrench, M., & Terman, A. (2005) · Autophagy · doi:10.4161/auto.1.3.2017 · Cited by 792 · see citing works

HLA class I supertypes: a revised and updated classification

Sidney, J., Peters, B., Frahm, N., Brander, C., & Sette, A. (2008) · BMC Immunology · doi:10.1186/1471-2172-9-1 · Cited by 775 · see citing works

Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium

Høyer-Hansen, M. H., & Jäättelä, M. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402200 · Cited by 765 · see citing works

TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity

Decressac, M., Mattsson, B., Weikop, P., Lundblad, M., Jakobsson, J., & Björklund, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305623110 · Cited by 753 · see citing works

Autophagy, amyloidogenesis and Alzheimer disease

Nixon, R. A. (2007) · Journal of Cell Science · doi:10.1242/jcs.019265 · Cited by 749 · see citing works

Overexpression of Atg5 in mice activates autophagy and extends lifespan

Pyo, J.-O., Yoo, S.-M., Ahn, H.-H., Nah, J., Hong, S.-H., Kam, T.-I., Jung, S., & Jung, Y.-K. (2013) · Nature Communications · doi:10.1038/ncomms3300 · Cited by 721 · see citing works

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

Simonsen, A., Cumming, R. C., Brech, A., Isakson, P., Schubert, D. R., & Finley, K. D. (2008) · Autophagy · doi:10.4161/auto.5269 · Cited by 716 · see citing works

p53 status determines the role of autophagy in pancreatic tumour development

Rosenfeldt, M. T., O’Prey, J., Morton, J. P., Nixon, C., MacKay, G., Mrowinska, A., Au, A., Rai, T. S., Zheng, L., Ridgway, R., et al. (2013) · Nature · doi:10.1038/nature12865 · Cited by 713 · see citing works

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

Matsumoto, G., Wada, K., Okuno, M., Kurosawa, M., & Nukina, N. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.039 · Cited by 692 · see citing works

The Lysosome as a Regulatory Hub

Perera, R. M., & Zoncu, R. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125125 · Cited by 664 · see citing works

Dopamine-modified α-synuclein blocks chaperone-mediated autophagy

Martínez‐Vicente, M., Tallóczy, Z., Kaushik, S., Massey, A. C., Mazzulli, J. R., Mosharov, E. V., Hodara, R., Fredenburg, R. A., Wu, D.-C., Follenzi, A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32806 · Cited by 633 · see citing works

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

Wang, Y., Martinez-Vicente, M., Krüger, U., Kaushik, S., Wong, E., Mandelkow, E.-M., Cuervo, A. M., & Mandelkow, E. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp367 · Cited by 617 · see citing works

Activation of Chaperone-mediated Autophagy during Oxidative Stress

Kiffin, R., Christian, C., Knecht, E., & Cuervo, A. M. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-06-0477 · Cited by 611 · see citing works

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models

Sarkar, S., Perlstein, E. O., Imarisio, S., Pineau, S., Cordenier, A., Maglathlin, R. L., Webster, J. A., Lewis, T. A., O’Kane, C. J., Schreiber, S. L., et al. (2007) · Nature Chemical Biology · doi:10.1038/nchembio883 · Cited by 596 · see citing works

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases

Spencer, B., Potkar, R., Trejo, M., Rockenstein, E., Patrick, C., Gindi, R., Adame, A., Wyss-Coray, T., & Masliah, E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4390-09.2009 · Cited by 595 · see citing works

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

Guo, J. Y., Karsli-Uzunbas, G., Mathew, R., Aisner, S. C., Kamphorst, J. J., Strohecker, A. M., Chen, G., Price, S., Lu, W., Teng, X., et al. (2013) · Genes &amp; Development · doi:10.1101/gad.219642.113 · Cited by 589 · see citing works

The dynamic nature of autophagy in cancerPreprint

Kimmelman, A. C. (2011) · Genes & Development · doi:10.1101/gad.17558811 · Cited by 587 · see citing works

Cleaning house: selective autophagy of organelles

Anding, A. L., & Baehrecke, E. H. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.02.016 · Cited by 576 · see citing works

Autophagy is required for glucose homeostasis and lung tumor maintenance

Karsli-Uzunbas, G., Guo, J. Y., Price, S., Teng, X., Laddha, S. V., Khor, S., Kalaany, N. Y., Jacks, T., Chan, C. S., Rabinowitz, J. D., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0363 · Cited by 560 · see citing works

LC3, an Autophagosome Marker, Can be Incorporated into Protein Aggregates Independent of Autophagy: Caution in the Interpretation of LC3 Localization

Kuma, A., Matsui, M., & Mizushima, N. (2007) · Autophagy · doi:10.4161/auto.4012 · Cited by 555 · cited 1× · see citing works

Huntingtin Expression Stimulates Endosomal–Lysosomal Activity, Endosome Tubulation, and Autophagy

Kegel, K. B., Kim, M., Sapp, E., McIntyre, C., Castaño, J. G., Aronin, N., & DiFiglia, M. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07268.2000 · Cited by 533 · see citing works

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

Hetz, C., Thielen, P., Matus, S., Nassif, M., Court, F., Kiffin, R., Martinez, G., Cuervo, A. M., Brown, R. H., & Glimcher, L. H. (2009) · Genes &amp; Development · doi:10.1101/gad.1830709 · Cited by 530 · see citing works

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

Ryan, B. J., Hoek, S., Fon, E. A., & Wade-Martins, R. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.02.003 · Cited by 524 · see citing works

Autophagy regulation by p53

Maiuri, M. C., Galluzzi, L., Morselli, E., Kepp, O., Malik, S. A., & Kroemer, G. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.001 · Cited by 498 · see citing works

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

Ju, J.-S., Fuentealba, R. A., Miller, S. E., Jackson, E., Piwnica-Worms, D., Baloh, R. H., & Weihl, C. C. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200908115 · Cited by 494 · see citing works

Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations

Yang, A., Rajeshkumar, N. V., Wang, X., Yabuuchi, S., Alexander, B. M., Chu, G. C., Von Hoff, D. D., Maitra, A., & Kimmelman, A. C. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0362 · Cited by 486 · see citing works

The Atg8 Conjugation System Is Indispensable for Proper Development of Autophagic Isolation Membranes in Mice

Sou, Y., Waguri, S., Iwata, J.-I., Ueno, T., Fujimura, T., Hara, T., Sawada, N., Yamada, A., Mizushima, N., Uchiyama, Y., et al. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-03-0309 · Cited by 475 · see citing works

The Roles of Therapy-Induced Autophagy and Necrosis in Cancer Treatment

Amaravadi, R. K., & Thompson, C. B. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1595 · Cited by 469 · see citing works

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

Lock, R., Roy, S., Kenific, C. M., Su, J. S., Salas, E., Ronen, S. M., & Debnath, J. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-06-0500 · Cited by 467 · see citing works

A dual role for autophagy in a murine model of lung cancer

Rao, S., Tortola, L., Perlot, T., Wirnsberger, G., Novatchkova, M., Nitsch, R., Sykacek, P., Frank, L., Schramek, D., Komnenovic, V., et al. (2014) · Nature Communications · doi:10.1038/ncomms4056 · Cited by 444 · see citing works

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

Tan, J. M. M., Wong, E. S. P., Kirkpatrick, D. S., Pletniková, O., Ko, H. S., Tay, S.-P., Ho, M. W. L., Troncoso, J. C., Gygi, S. P., Lee, M. K., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm320 · Cited by 444 · see citing works

Exosomes and Autophagy: Coordinated Mechanisms for the Maintenance of Cellular Fitness

Baixauli, F., López-Otı́n, C., & Mittelbrunn, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00403 · Cited by 443 · see citing works

PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

Tsunemi, T., Ashe, T. D., Morrison, B. E., Epilepsia, K. S., Au, J., Vázquez‐Roque, R. A., Lazarowski, E. R., Damian, V. A., Masliah, E., & Spada, A. R. L. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003799 · Cited by 440 · see citing works

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

Barmada, S. J., Serio, A., Arjun, A., Bilican, B., Daub, A., Ando, D. M., Tsvetkov, A., Pleiss, M., Li, X., Peisach, D., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1563 · Cited by 431 · see citing works

Maturation of autophagosomes and endosomes: A key role for Rab7

Hyttinen, J. M. T., Niittykoski, M., Salminen, A., & Kaarniranta, K. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.11.018 · Cited by 424 · see citing works

Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

Carnio, S., LoVerso, F., Baraibar, M. A., Longa, E., Khan, M. M., Maffei, M., Reischl, M., Canepari, M., Loefler, S., Kern, H., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.061 · Cited by 423 · see citing works

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death

Sellier, C., Campanari, M., Julie Corbier, C., Gaucherot, A., Kolb‐Cheynel, I., Oulad‐Abdelghani, M., Ruffenach, F., Page, A., Ciura, S., Kabashi, E., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201593350 · Cited by 414 · see citing works

Regulation of autophagy by the Rab GTPase network

Ao, X., Zou, L., & Wu, Y. (2014) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2013.187 · Cited by 411 · see citing works

The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation

Wong, Y. C., & Holzbaur, E. L. F. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1870-13.2014 · Cited by 395 · see citing works

Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells.

Kim, J. H., & Klionsky, D. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.303 · Cited by 387 · see citing works

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

Lucin, K. M., O’Brien, C. E., Bieri, G., Czirr, E., Mosher, K. I., Abbey, R. J., Mastroeni, D. F., Rogers, J., Spencer, B., Masliah, E., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.046 · Cited by 374 · see citing works

Autophagosome Biogenesis in Primary Neurons Follows an Ordered and Spatially Regulated Pathway

Maday, S., & Holzbaur, E. L. F. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.06.001 · Cited by 372 · see citing works

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

Lin, S.-Y., Li, T. Y., Liu, Q., Zhang, C., Li, X., Chen, Y., Zhang, S.-M., Lian, G., Liu, Q., Ruan, K., et al. (2012) · Science · doi:10.1126/science.1217032 · Cited by 365 · see citing works

Rapamycin treatment augments motor neuron degeneration in SOD1^G93Amouse model of amyotrophic lateral sclerosis

Zhang, X., Li, L., Chen, S., Yang, D., Wang, Y., Zhang, X., Wang, Z., & Le, W. (2011) · Autophagy · doi:10.4161/auto.7.4.14541 · Cited by 364 · see citing works

Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system

Lee, M. J., Lee, J. H., & Rubinsztein, D. C. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.03.001 · Cited by 364 · see citing works

Neurodegenerative lysosomal disorders: A continuum from development to late age

Nixon, R. A., Yang, D.-S., & Lee, J.-H. (2008) · Autophagy · doi:10.4161/auto.6259 · Cited by 362 · see citing works

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

Polito, V. A., Li, H., Martini‐Stoica, H., Wang, B., Li, Y., Xu, Y., Swartzlander, D. B., Palmieri, M., di Ronza, A., Lee, V. M. ‐., et al. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201303671 · Cited by 351 · see citing works

Autophagy in Huntington disease and huntingtin in autophagy

Martin, D. D. O., Ladha, S., Ehrnhoefer, D. E., & Hayden, M. R. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.09.003 · Cited by 344 · see citing works

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

Balgi, A. D., Fonseca, B. D., Donohue, E., Tsang, T. C. F., Lajoie, P., Proud, C. G., Nabi, I. R., & Roberge, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007124 · Cited by 344 · see citing works

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

Schaeffer, V., Lavenir, I., Ozcelik, S., Tolnay, M., Winkler, D. T., & Goedert, M. (2012) · Brain · doi:10.1093/brain/aws143 · Cited by 343 · see citing works

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

Castillo, K., Nassif, M., Valenzuela, V., Rojas, F., Matus, S., Mercado, G., Court, F. A., van Zundert, B., & Hetz, C. A. (2013) · Autophagy · doi:10.4161/auto.25188 · Cited by 338 · see citing works

PpAtg30 Tags Peroxisomes for Turnover by Selective Autophagy

Farré, J.-C., Manjithaya, R., Mathewson, R. D., & Subramani, S. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.12.011 · Cited by 331 · see citing works

Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

Lim, J., Lachenmayer, M. L., Wu, S., Liu, W., Kundu, M., Wang, R., Komatsu, M., Oh, Y. J., Zhao, Y., & Yue, Z. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004987 · Cited by 323 · see citing works

Proteome Half-Life Dynamics in Living Human Cells

Eden, E., Geva‐Zatorsky, N., Issaeva, I., Cohen, A., Dekel, E., Danon, T., Cohen, L., Mayo, A., & Alon, U. S. (2011) · Science · doi:10.1126/science.1199784 · Cited by 320 · see citing works

Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3)

Lemasters, J. J. (2014) · Redox Biology · doi:10.1016/j.redox.2014.06.004 · Cited by 318 · see citing works

Chaperone-mediated autophagy in aging and disease

Massey, A. C., Zhang, C., & Cuervo, A. M. (2006) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)73007-6 · Cited by 315 · see citing works

Autophagy in neurodegenerative disease: friend, foe or turncoat?

Nixon, R. A. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.003 · Cited by 315 · see citing works

Short-term fasting induces profound neuronal autophagy

Alirezaei, M., Kemball, C. C., Flynn, C. T., Wood, M. R., Whitton, J. L., & Kiosses, W. B. (2010) · Autophagy · doi:10.4161/auto.6.6.12376 · Cited by 312 · see citing works

Potential function for the Huntingtin protein as a scaffold for selective autophagy

Ochaba, J., Lukacsovich, T., Csikos, G., Zheng, S., Margulis, J., Salazar, L., Mao, K., Lau, A. L., Yeung, S. Y., Humbert, S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1420103111 · Cited by 308 · see citing works

Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of α-Synuclein and LRRK2 in the Brain

Friedman, L. G., Lachenmayer, M. L., Wang, J., He, L., Poulose, S. M., Komatsu, M., Holstein, G. R., & Yue, Z. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5809-11.2012 · Cited by 303 · see citing works

ATG12–ATG3 interacts with Alix to promote basal autophagic flux and late endosome function

Murrow, L. M., Malhotra, R., & Debnath, J. (2015) · Nature Cell Biology · doi:10.1038/ncb3112 · Cited by 301 · see citing works

A Population of Rat Liver Lysosomes Responsible for the Selective Uptake and Degradation of Cytosolic Proteins

Cuervo, A. M., Dice, J. F., & Knecht, E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5606 · Cited by 299 · see citing works

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

Rodríguez-Navarro, J. A., Rodríguez, L., Casarejos, M. J., Solano, R. M., Gómez, A., Perucho, J., Cuervo, A. M., García de Yébenes, J., & Mena, M. A. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.05.014 · Cited by 298 · see citing works

Autophagic degradation of tau in primary neurons and its enhancement by trehalose

Krüger, U., Wang, Y., Kumar, S., & Mandelkow, E.-M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.11.009 · Cited by 297 · see citing works

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

Congdon, E. E., Wu, J. W., Myeku, N., Figueroa, Y. H., Herman, M., Marinec, P. S., Gestwicki, J. E., Dickey, C. A., Yu, W. H., & Duff, K. E. (2012) · Autophagy · doi:10.4161/auto.19048 · Cited by 297 · see citing works

The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway

Sullivan, P. M., Zhou, X., Robins, A. M., Paushter, D. H., Kim, D., Smolka, M. B., & Hu, F. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0324-5 · Cited by 295 · see citing works

A comprehensive glossary of autophagy-related molecules and processes (2ndedition)

Klionsky, D. J., Baehrecke, E. H., Brumell, J. H., Chu, C. T., Codogno, P., Cuervo, A. M., Debnath, J., Deretic, V. P., Elazar, Z., Eskelinen, E., et al. (2011) · Autophagy · doi:10.4161/auto.7.11.17661 · Cited by 293 · see citing works

Iron Accumulation in Deep Cortical Layers Accounts for MRI Signal Abnormalities in ALS: Correlating 7 Tesla MRI and Pathology

Kwan, J. Y., Jeong, S. Y., van Gelderen, P., Deng, H., Quezado, M., Danielian, L. E., Butman, J. A., Chen, L., Bayat, E., Russell, J. W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035241 · Cited by 281 · see citing works

Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress

Dagda, R., Zhu, J.-H., Kulich, S., & Chu, C. T. (2008) · Autophagy · doi:10.4161/auto.6458 · Cited by 280 · see citing works

Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein

Bauer, P. O., Goswami, A., Wong, H. K., Okuno, M., Kurosawa, M., Yamada, M., Miyazaki, H., Matsumoto, G., Kino, Y., Nagai, Y., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1608 · Cited by 280 · see citing works

Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain

Keller, J. N., Dimayuga, E. R., Chen, Q., Thorpe, J. A., Gee, J. R., & Ding, Q. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.05.003 · Cited by 271 · see citing works

Golgi-resident Small GTPase Rab33B Interacts with Atg16L and Modulates Autophagosome Formation

Itoh, T., Fujita, N., Kanno, E., Yamamoto, A., Yoshimori, T., & Fukuda, M. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1231 · Cited by 271 · see citing works

The regulation of autophagy by calcium signals: Do we have a consensus?

Bootman, M. D., Chehab, T., Bultynck, G., Parys, J. B., & Rietdorf, K. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.08.005 · Cited by 271 · see citing works

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model

Tsvetkov, A. S., Miller, J., Arrasate, M., Wong, J. S., Pleiss, M. A., & Finkbeiner, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004498107 · Cited by 266 · see citing works

Emerging Role for Autophagy in the Removal of Aggresomes in Schwann Cells

Fortun, J., Dunn, W. A., Joy, S., Li, J., & Notterpek, L. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-33-10672.2003 · Cited by 261 · see citing works

The autophagic paradox in cancer therapy

Wu, W., Coffelt, S., Chi, H.-C., Wang, X., Lee, C. W., Chan, F., Yu, J., & Sung, J. J. (2012) · Oncogene · doi:10.1038/onc.2011.295 · Cited by 260 · see citing works

A dual role for Ca2+ in autophagy regulation

Decuypere, J.-P., Bultynck, G., & Parys, J. B. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.04.001 · Cited by 257 · see citing works

Autophagy promotes synapse development in <i>Drosophila</i>

Shen, W., & Ganetzky, B. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200907109 · Cited by 252 · see citing works

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation

Jinn, S., Drolet, R. E., Cramer, P. E., Wong, H. K., Toolan, D. M., Gretzula, C. A., Voleti, B., Vassileva, G., Disa, J., Tadin‐Strapps, M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616332114 · Cited by 245 · see citing works

Autophagy in neurons: a review.

Larsen, K. E., & Sulzer, D. L. (2002) · PubMed · doi:10.14670/hh-17.897 · Cited by 242 · see citing works

Snapin-Regulated Late Endosomal Transport Is Critical for Efficient Autophagy-Lysosomal Function in Neurons

Cai, Q., Lü, L., Tian, J.-H., Zhu, Y.-B., Qiao, H., & Sheng, Z. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.022 · Cited by 241 · see citing works

A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy

Yang, M., Liang, C., Swaminathan, K., Herrlinger, S., Lai, F., Shiekhattar, R., & Chen, J.-F. (2016) · Science Advances · doi:10.1126/sciadv.1601167 · Cited by 238 · see citing works

A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions

Lipinski, M. M., Hoffman, G., Ng, A., Zhou, W., Py, B. F., Hsu, E., Liu, X., Eisenberg, J. M., Liu, J. S., Blenis, J., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.05.005 · Cited by 223 · see citing works

Degradation of Amyotrophic Lateral Sclerosis-linked Mutant Cu,Zn-Superoxide Dismutase Proteins by Macroautophagy and the Proteasome

Kabuta, T., Suzuki, Y., & Wada, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603337200 · Cited by 217 · see citing works

Regulation of TDP-43 aggregation by phosphorylation andp62/SQSTM1: Regulation of TDP-43 aggregation by phosphorylation and p62

Brady, O. A., Meng, P., Zheng, Y., Mao, Y., & Hu, F. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07098.x · Cited by 215 · see citing works

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

Poehler, A.-M., Xiang, W., Spitzer, P., May, V. E. L., Meixner, H., Rockenstein, E. M., Chutna, O., Outeiro, T. F., Winkler, J., Masliah, E., et al. (2014) · Autophagy · doi:10.4161/auto.36436 · Cited by 210 · see citing works

Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

Petersén, Å. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.12.1243 · Cited by 210 · see citing works

Meta-analysis of brain iron levels of Parkinson’s disease patients determined by postmortem and MRI measurements

Wang, J., Zhuang, Q.-Q., Zhu, L.-B., Zhu, H., Li, T., Li, R., Chen, S., Huang, C.-P., Zhang, X., & Zhu, J. (2016) · Scientific Reports · doi:10.1038/srep36669 · Cited by 209 · see citing works

Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system

Wang, X., Fan, H., Ying, Z., Li, B., Wang, H., & Wang, G. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2009.11.055 · Cited by 207 · see citing works

Mitochondria in Neurodegeneration

Lezi, E., & Swerdlow, R. H. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_12 · Cited by 204 · see citing works

Autophagy and Its Normal and Pathogenic States in the Brain

Yamamoto, A., & Yue, Z. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014149 · Cited by 204 · see citing works

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2

Ferguson, C. J., Lenk, G. M., & Meisler, M. H. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp460 · Cited by 202 · see citing works

The GTPase Rab26 links synaptic vesicles to the autophagy pathway

Binotti, B., Pavlos, N. J., Riedel, D., Wenzel, D., Vorbrüggen, G., Schalk, A. M., Kühnel, K., Boyken, J., Erck, C., Martens, H., et al. (2015) · eLife · doi:10.7554/elife.05597 · Cited by 193 · see citing works

Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth

Lévy, J., Cacheux, W., Bara, M. A., L’Hermitte, A., Lepage, P., Fraudeau, M., Trentesaux, C., Lemarchand, J., Durand, A., Crain‐Denoyelle, A., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3206 · Cited by 190 · see citing works

Association Between Autophagy and Neurodegenerative Diseases

Fujikake, N., Shin, M., & Shimizu, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00255 · Cited by 190 · see citing works

Distinct roles for motor neuron autophagy early and late in the SOD1 ^G93A mouse model of ALS

Rudnick, N. D., Griffey, C. J., Guarnieri, P., Gerbino, V., Wang, X., Piersaint, J. A., Tapia, J. C., Rich, M. M., & Maniatis, T. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704294114 · Cited by 189 · see citing works

Activity-dependent exocytosis of lysosomes regulates the structural plasticity of dendritic spines

Padamsey, Z., McGuinness, L., Bardo, S. J., Reinhart, M., Tong, R., Hedegaard, A., Hart, M. L., & Emptage, N. J. (2017) · Neuron · doi:10.1016/j.neuron.2016.11.013 · Cited by 186 · see citing works

Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice

Zheng, S., Clabough, E. B. D., Sarkar, S., Futter, M., Rubinsztein, D. C., & Zeitlin, S. O. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000838 · Cited by 184 · see citing works

Neuronal macroautophagy: from development to degeneration.

Boland, B., & Nixon, R. (2006) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2006.08.009 · Cited by 181 · see citing works

OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation

Itoh, T., Kanno, E., Uemura, T., Waguri, S., & Fukuda, M. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201008107 · Cited by 174 · see citing works

Integration of autophagy, proteasomal degradation, unfolded protein response and apoptosis.

Benbrook, D. M., & Long, A. (2012) · PubMed · Cited by 173 · see citing works

Cortical iron reflects severity of Alzheimer's disease

van Duijn, S., Bulk, M., van Duinen, S. G., Nabuurs, R. J. A., van Buchem, M. A., van der Weerd, L., & Natté, R. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161143 · Cited by 172 · see citing works

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

Inoue, K., Rispoli, J., Kaphzan, H., Klann, E., Chen, E. I., Kim, J., Komatsu, M., & Abeliovich, A. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-48 · Cited by 168 · see citing works

Degradation of tau protein by autophagy and proteasomal pathways

Wang, Y., & Mandelkow, E. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120071 · Cited by 166 · see citing works

Regulation of Autophagy by Neuropathological Protein TDP-43

Bose, J. K., Huang, C.-C., & Shen, C.-K. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.237115 · Cited by 165 · see citing works

ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages

Biswas, D., Qureshi, O. S., Lee, W.-Y. J., Croudace, J. E., Mura, M., & Lammas, D. A. (2008) · BMC Immunology · doi:10.1186/1471-2172-9-35 · Cited by 156 · see citing works

A Caspase Cleaved Form of Tau Is Preferentially Degraded through the Autophagy Pathway

Dolan, P. J., & Johnson, G. V. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.110940 · Cited by 147 · see citing works

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy

Montie, H. L., Cho, M. S., Holder, L., Liu, Y., Tsvetkov, A. S., Finkbeiner, S. M., & Merry, D. E. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp115 · Cited by 147 · see citing works

Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy

Ahmed, I., Liang, Y., Schools, S., Dawson, V. L., Dawson, T. M., & Savitt, J. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0209-12.2012 · Cited by 144 · see citing works

Autophagy Genes Protect Against Disease Caused by Polyglutamine Expansion Proteins inCaenorhabditis elegans

Jia, K., Hart, A. C., & Levine, B. (2007) · Autophagy · doi:10.4161/auto.3528 · Cited by 142 · see citing works

The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases

Bergamini, E., Cavallini, G., Donati, A., & Gori, Z. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.05.007 · Cited by 142 · see citing works

The Role of Autophagy in Aging

Bergamini, E., Cavallini, G., Donati, A., & Gori, Z. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1396.020 · Cited by 136 · see citing works

The PI3K, Metabolic, and Autophagy Networks: Interactive Partners in Cellular Health and Disease

Shanware, N. P., Bray, K., & Abraham, R. T. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134717 · Cited by 130 · see citing works

Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

Suh, D. H., Kim, M., Kim, H. S., Chung, H. H., & Song, Y. S. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06739.x · Cited by 129 · see citing works

The Stress Rheostat: An Interplay Between the Unfolded Protein Response (UPR) and Autophagy in Neurodegeneration

Matus, S., Lisbona, F., Torres, M., Leon, C., Thielen, P., & Hetz, C. A. (2008) · Current Molecular Medicine · doi:10.2174/156652408784221324 · Cited by 128 · see citing works

Autophagy in Neurite Injury and Neurodegeneration: In Vitro and In Vivo Models

Chu, C., Plowey, E., Dagda, R., Hickey, R., Cherra, S. J., & Clark, R. (2009) · Methods in Enzymology · doi:10.1016/s0076-6879(08)04011-1 · Cited by 120 · see citing works

Rapamycin Inhibits Polyglutamine Aggregation Independently of Autophagy by Reducing Protein Synthesis

King, M. A., Hands, S., Hafiz, F., Mizushima, N., Tolkovsky, A. M., & Wyttenbach, A. (2008) · Molecular Pharmacology · doi:10.1124/mol.107.043398 · Cited by 120 · see citing works

MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age

Ferree, A. W., Trudeau, K. M., Zik, E., Benador, I. Y., Twig, G., Gottlieb, R. A., & Shirihai, O. S. (2013) · Autophagy · doi:10.4161/auto.26503 · Cited by 119 · see citing works

Autophagy is a part of ultrastructural synaptic pathology in Creutzfeldt–Jakob disease: a brain biopsy study

Sikorska, B., Liberski, P. P., Giraud, P., Kopp, N., & Brown, P. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.04.014 · Cited by 117 · see citing works

The puzzling origin of the autophagosomal membrane

Mari, M. C., Tooze, S. A., & Reggiori, F. (2011) · F1000 Biology Reports · doi:10.3410/b3-25 · Cited by 117 · see citing works

Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy

Marrone, L., Poser, I., Casci, I., Japtok, J., Reinhardt, P., Janosch, A., Andree, C., Lee, H. O., Moebius, C., Koerner, E., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.12.018 · Cited by 104 · see citing works

Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors

Lopez, G., Torres, K. E., Liu, J.-H., Hernandez, B., Young, E. D., Belushov, R., Bolshakov, S. V., Lazar, A., Slopis, J., McCutcheon, I., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2799 · Cited by 94 · see citing works

Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model

Roscic, A., Baldo, B., Crochemore, C., Marcellin, D., & Paganetti, P. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07435.x · Cited by 92 · see citing works

Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation

Wang, Y., Martinez-Vicente, M., Krüger, U., Kaushik, S., Wong, E., Mandelkow, E.-M., Cuervo, A. M., & Mandelkow, E. (2010) · Autophagy · doi:10.4161/auto.6.1.10815 · Cited by 90 · see citing works

Inhibition of autophagy with 3-methyladenine results in impaired turnover of lysosomes and accumulation of lipofuscin-like material

Stroikin, Y., Dalen, H., Lööf, S., & Terman, A. (2004) · European Journal of Cell Biology · doi:10.1078/0171-9335-00433 · Cited by 88 · see citing works

Lysosomal dysfunction in Parkinson disease

Dehay, B., Martínez‐Vicente, M., Ramı́rez, A., Perier, C., Klein, C., Vila, M., & Bézard, E. (2012) · Autophagy · doi:10.4161/auto.21011 · Cited by 88 · see citing works

The emerging role of autophagy in Parkinson's disease

Cheung, Z. H., & Ip, N. Y. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-29 · Cited by 88 · see citing works

Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs

Szalai, P., Hagen, L. K., Sætre, F., Luhr, M., Sponheim, M., Øverbye, A., Mills, I. G., Seglen, P. O., & Engedal, N. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.02.003 · Cited by 82 · see citing works

Syntaxin 13, a Genetic Modifier of Mutant CHMP2B in Frontotemporal Dementia, Is Required for Autophagosome Maturation

Lu, Y., Zhang, Z., Sun, D., Sweeney, S. T., & Gao, F. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.041 · Cited by 79 · see citing works

Autophagy Captures the Nobel Prize

Tooze, S. A., & Đikić, I. (2016) · Cell · doi:10.1016/j.cell.2016.11.023 · Cited by 77 · see citing works

Autophagy and disease: unanswered questions

Yang, Y., & Klionsky, D. J. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-019-0480-9 · Cited by 369 · see citing works

Redox regulation: mechanisms, biology and therapeutic targets in diseases

Li, B., Ming, H., Qin, S., Nice, E. C., Dong, J., Du, Z., & Huang, C. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02095-6 · Cited by 364 · see citing works

Lysosomal dysfunction in neurodegeneration: emerging concepts and methods

Udayar, V., Chen, Y., Sidransky, E., & Jagasia, R. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2021.12.004 · Cited by 238 · see citing works

The lysosome as an imperative regulator of autophagy and cell death

Mahapatra, K. K., Mishra, S. R., Behera, B. P., Patil, S., Gewirtz, D. A., & Bhutia, S. K. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03988-3 · Cited by 231 · see citing works

Autophagy and ALS: mechanistic insights and therapeutic implications

Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189 · see citing works

Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment

Esmaeili, Y., Yarjanli, Z., Paknia, F., Bidram, E., Łoś, M., Eshraghi, M., Klionsky, D. J., Ghavami, S., & Zarrabi, A. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.001 · Cited by 180 · see citing works

Axonal transport defects and neurodegeneration: Molecular mechanisms and therapeutic implications

Guo, W., Dittlau, K. S., & Bosch, L. V. D. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.07.010 · Cited by 172 · see citing works

Cell-Nonautonomous Regulation of Proteostasis in Aging and DiseasePreprint

Morimoto, R. I. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a034074 · Cited by 97 · see citing works

Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation

Li, C., Wang, X., Li, X., Qiu, K., Jiao, F., Liu, Y., Kong, Q., Liu, Y., & Wu, Y. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00170 · Cited by 90 · see citing works

Modulation of Amyloid States by Molecular ChaperonesPreprint

Wentink, A. S., Nussbaum-Krammer, C. I., & Bukau, B. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a033969 · Cited by 91 · see citing works

CGAS is a micronucleophagy receptor for the clearance of micronuclei

Zhao, M., Wang, F., Wu, J., Cheng, Y., Cao, Y., Wu, X., Ma, M., Tang, F., Liu, Z., Liu, H., et al. (2021) · Autophagy · doi:10.1080/15548627.2021.1899440 · Cited by 89 · see citing works

Lysosomal quality control: molecular mechanisms and therapeutic implications

Yang, H., & Tan, J. X. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.01.001 · Cited by 84 · see citing works

TDP-43 pathology: From noxious assembly to therapeutic removal

Keating, S. S., Gil, R. S., Swanson, M. E. V., Scotter, E. L., & Walker, A. K. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102229 · Cited by 74 · see citing works

Adiponectin alleviated Alzheimer‐like pathologies via autophagy‐lysosomal activation

He, K., Nie, L., Ali, T., Wang, S., Chen, X., Liu, Z., Li, W., Zhang, K., Xu, J., Liu, J., et al. (2021) · Aging Cell · doi:10.1111/acel.13514 · Cited by 65 · see citing works

Acid Sphingomyelinase, a Lysosomal and Secretory Phospholipase C, Is Key for Cellular Phospholipid Catabolism

Breiden, B., & Sandhoff, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169001 · Cited by 62 · see citing works

Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases

Chu, S., Xie, X., Payan, C., & Stochaj, U. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00639-y · Cited by 58 · see citing works

Transcription factor EB: an emerging drug target for neurodegenerative disorders

Song, J., Liu, J., Jiang, Y., Wang, Z., & Li, M. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.10.013 · Cited by 59 · see citing works

Dexmedetomidine Mitigated NLRP3-Mediated Neuroinflammation via the Ubiquitin-Autophagy Pathway to Improve Perioperative Neurocognitive Disorder in Mice

Zhang, L., Xiao, F., Zhang, J., Wang, X., Ying, J., Wei, G., Chen, S., Huang, X., Yu, W., Liu, X., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.646265 · Cited by 57 · see citing works

Peroxisomal Dysfunction in Neurological Diseases and Brain Aging

Uzor, N.-E., McCullough, L. D., & Tsvetkov, A. S. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00044 · Cited by 56 · see citing works

Effect of Fluoride on Cytotoxicity Involved in Mitochondrial Dysfunction: A Review of Mechanism

Wei, M., Ye, Y., Ali, M. M., Chamba, Y., Tang, J., & Shang, P. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.850771 · Cited by 56 · see citing works

Regulation of autophagy by inhibitory CSPG interactions with receptor PTPσ and its impact on plasticity and regeneration after spinal cord injury

Tran, A. P., Warren, P. M., & Silver, J. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113276 · Cited by 53 · see citing works

Lipophagy: a new player in CNS disorders

Haidar, M., Loix, M., Bogie, J. F. J., & Hendriks, J. J. A. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.08.010 · Cited by 51 · see citing works

The phytochemical and pharmacological profile of taraxasterol

Jiao, F., Tan, Z., Yu, Z., Zhou, B., Meng, L., & Shi, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.927365 · Cited by 50 · see citing works

β-Synuclein: An Enigmatic Protein with Diverse Functionality

Hayashi, J., & Carver, J. (2022) · Biomolecules · doi:10.3390/biom12010142 · Cited by 39 · see citing works

Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice

Ritzel, R. M., Li, Y., Lei, Z., Carter, J., He, J., Choi, H., Khan, N., Li, H., Allen, S., Lipinski, M. M., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00562-y · Cited by 46 · see citing works

A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases

Fernandes, T., Domingues, M. R., Moreira, P. I., & Pereira, C. (2023) · Biology · doi:10.3390/biology12030414 · Cited by 44 · see citing works

Different Roles of Apoptosis and Autophagy in the Development of Human Colorectal Cancer

Orlandi, G., Roncucci, L., Carnevale, G., & Sena, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210201 · Cited by 43 · see citing works

Elevated Glucosylsphingosine in Gaucher Disease induced Pluripotent Stem Cell Neurons Deregulates Lysosomal Compartment through Mammalian Target of Rapamycin Complex 1

Srikanth, M. P., Jones, J. W., Kane, M. A., Awad, O., Park, T. S., Zambidis, E. T., & Feldman, R. A. (2021) · Stem Cells Translational Medicine · doi:10.1002/sctm.20-0386 · Cited by 42 · see citing works

Protecting the future: balancing proteostasis for reproduction

Sala, A. J., & Morimoto, R. I. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.09.009 · Cited by 41 · see citing works

Cargo and cell‐specific differences in extracellular vesicle populations identified by multiplexed immunofluorescent analysis

Burbidge, K. J., Zwikelmaier, V., Cook, B., Long, M. M., Balva, B., Lonigro, M., Ispas, G., Rademacher, D. J., & Campbell, E. M. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1789326 · Cited by 40 · see citing works

HSPA8 Activates Wnt/β‐Catenin Signaling to Facilitate BRAF V600E Colorectal Cancer Progression by CMA‐Mediated CAV1 Degradation

Li, B., Ming, H., Qin, S., Zhou, L., Huang, Z., Jin, P., Peng, L., Luo, M., Zhang, T., Wang, K., et al. (2023) · Advanced Science · doi:10.1002/advs.202306535 · Cited by 38 · see citing works

Pharmacological targets at the lysosomal autophagy–NLRP3 inflammasome crossroads

Bonam, S. R., Mastrippolito, D., Georgel, P., & Muller, S. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.11.005 · Cited by 37 · see citing works

Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease

Ramírez-Jarquín, U. N., Sharma, M., Zhou, W., Shahani, N., & Subramaniam, S. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2107187119 · Cited by 36 · see citing works

Accumulation of F-actin drives brain aging and limits healthspan in Drosophila

Schmid, E. T., Schinaman, J. M., Liu-Abramowicz, N., Williams, K. S., & Walker, D. W. (2024) · Nature Communications · doi:10.1038/s41467-024-53389-w · Cited by 34 · see citing works

Cyclotriphosphazene-Based “Butterfly” Fluorescence Probe for Lysosome Targeting

Liu, P., Wang, L., Chen, L., Su, X., & Shi, X. (2021) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.1c00160 · Cited by 31 · see citing works

Research Progress on Neuroprotective Effects of Isoquinoline Alkaloids

Li, J., Wu, Y., Dong, S., Ye, Y., Wu, Y., Xiang, B., & Qin, L. (2023) · Molecules · doi:10.3390/molecules28124797 · Cited by 31 · see citing works

Inhibitors of Immune Checkpoints: Small Molecule- and Peptide-Based Approaches

Fuchs, N. S., Zhang, L., Calvo‐Barreiro, L., Kuncewicz, K., & Gabr, M. T. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14010068 · Cited by 29 · see citing works

Torin 1 alleviates impairment of TFEB-mediated lysosomal biogenesis and autophagy in TGFBI (p.G623_H626del)-linked Thiel-Behnke corneal dystrophy

Wang, L., Zhao, C., Zheng, T., Zhang, Y., Liu, H., Wang, X., Tang, X., Zhao, B., & Liu, P. (2021) · Autophagy · doi:10.1080/15548627.2021.1955469 · Cited by 28 · see citing works

Current Evidence for a Bidirectional Loop Between the Lysosome and Alpha-Synuclein Proteoforms

Wildburger, N. C., Hartke, A.-S., Schidlitzki, A., & Richter, F. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.598446 · Cited by 26 · see citing works

NDRG1 overcomes resistance to immunotherapy of pancreatic ductal adenocarcinoma through inhibiting ATG9A-dependent degradation of MHC-1

Zhang, Z., Song, B., Wei, H., Liu, Y., Zhang, W., Yang, Y., & Sun, B. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2023.101040 · Cited by 26 · see citing works

Tau accumulation in degradative organelles is associated to lysosomal stress

Piovesana, E., Magrin, C., Ciccaldo, M., Sola, M., Bellotto, M., Molinari, M., Papin, S., & Paganetti, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-44979-7 · Cited by 26 · see citing works

Harnessing BDNF Signaling to Promote Resilience in Aging

Faraji, J., & Metz, G. A. S. (2024) · Aging and Disease · doi:10.14336/ad.2024.0961 · Cited by 28 · see citing works

Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity

Riera-Tur, I., Schäfer, T., Hornburg, D., Mishra, A., Padilha, M. D. S., Fernández-Mosquera, L., Feigenbutz, D., Auer, P., Mann, M., Baumeister, W. P., et al. (2021) · Life Science Alliance · doi:10.26508/lsa.202101185 · Cited by 29 · see citing works

Synuclein Proteins in MPTP-Induced Death of Substantia Nigra Pars Compacta Dopaminergic Neurons

Goloborshcheva, V., Kucheryanu, V. G., Voronina, N. A., Teterina, E. V., Ustyugov, A. A., & Morozov, S. (2022) · Biomedicines · doi:10.3390/biomedicines10092278 · Cited by 24 · see citing works

Mitochondrial and autophagy-lysosomal pathway polygenic risk scores predict Parkinson's disease

Dehestani, M., Liu, H., Sreelatha, A. A. K., Schulte, C., Bansal, V., & Gasser, T. (2022) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2022.103751 · Cited by 24 · see citing works

The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology

Obergasteiger, J., Castonguay, A.-M., Pizzi, S., Magnabosco, S., Frapporti, G., Lobbestael, E., Baekelandt, V., Hicks, A. A., Pramstaller, P. P., Gravel, C., et al. (2023) · npj Parkinson s Disease · doi:10.1038/s41531-023-00484-2 · Cited by 24 · see citing works

A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome PathwayPreprint

coordination, O., Elsasser, S., Elia, L. P., Morimoto, R. I., Powers, E. T., Elsasser, S., Finley, D. J., Costa, B., Budron, M., Tokuno, Z., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.22.533675 · Cited by 24 · see citing works

The regulatory mechanism and therapeutic potential of transcription factor EB in neurodegenerative diseases

Jiao, F., Zhou, B., & Meng, L. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13985 · Cited by 21 · see citing works

TFEB agonist clomiphene citrate activates the autophagy-lysosomal pathway and ameliorates Alzheimer's disease symptoms in mice

Lin, J. E., Yuan, Y., Huang, C., Zi, J., Li, L., Liu, J., Wu, X., Li, W., Zhao, Q. H., Li, Y., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107929 · Cited by 22 · see citing works

LRRK2 and Proteostasis in Parkinson’s Disease

Pérez‐Carrión, M. D., Posadas, I., Solera, J., & Ceña, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126808 · Cited by 22 · see citing works

Redox Imbalance in Neurological Disorders in Adults and Children

Rey, F., Berardo, C., Maghraby, E., Mauri, A., Messa, L., Esposito, L., Casili, G., Ottolenghi, S., Bonaventura, E., Cuzzocrea, S., et al. (2023) · Antioxidants · doi:10.3390/antiox12040965 · Cited by 23 · see citing works

Mystery of methamphetamine-induced autophagosome accumulation in hippocampal neurons: loss of syntaxin 17 in defects of dynein–dynactin driving and autophagosome–late endosome/lysosome fusion

Xu, H., Zhu, Y., Chen, X., Yang, T., Wang, X., Xu, S., Xie, X., Hu, M., Jiang, L., Cheng, J., et al. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03131-y · Cited by 20 · see citing works

The Potential Roles of Extracellular Vesicles as Biomarkers for Parkinson’s Disease: A Systematic Review

Valencia, J., Ferreira, M. S., Merino-Torres, J. F., Marcilla, A., & Soriano, J. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911508 · Cited by 20 · see citing works

Enhanced autophagic clearance of amyloid-β via histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer’s disease in vitro and in vivo

Long, Z., Ge, C., Zhao, Y., Liu, Y., Zeng, Q., Tang, Q., Dong, Z., & He, G. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01633 · Cited by 19 · see citing works

Dog Aging: A Comprehensive Review of Molecular, Cellular, and Physiological Processes

Guelfi, G., Capaccia, C., Tedeschi, M., Bufalari, A., Leonardi, L., Cenci-Goga, B. T., & Maranesi, M. (2024) · Cells · doi:10.3390/cells13242101 · Cited by 18 · see citing works

Cell Non-autonomous Proteostasis Regulation in Aging and Disease

Ferreira, J. V., Soares, A. D. R., & Pereira, P. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.878296 · Cited by 19 · see citing works

From Molecular Therapies to Lysosomal Transplantation and Targeted Drug Strategies: Present Applications, Limitations, and Future Prospects of Lysosomal Medications

Alhowyan, A., & Harisa, G. I. (2025) · Biomolecules · doi:10.3390/biom15030327 · Cited by 19 · see citing works

Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease

Hernandez, S. J., Fote, G. M., Reyes-Ortiz, A., Steffan, J. S., & Thompson, L. (2021) · Matrix Biology Plus · doi:10.1016/j.mbplus.2021.100089 · Cited by 17 · see citing works

A series of meso amide BODIPY based lysosome-targeting fluorescent probe with high photostability and sensitivity

Ruan, L., Bai, J., Ji, X., Zhao, W., & Dong, X. (2022) · Analytica Chimica Acta · doi:10.1016/j.aca.2022.339771 · Cited by 18 · see citing works

Extracellular Vesicles as Tools for Crossing the Blood–Brain Barrier to Treat Lysosomal Storage Diseases

Lerussi, G., Villagrasa-Araya, V., Moltó‐Abad, M., del Toro, M., Pintos‐Morell, G., Seras‐Franzoso, J., & Abasolo, I. (2025) · Life · doi:10.3390/life15010070 · Cited by 19 · see citing works

Proteasomal inhibition preferentially stimulates lysosome activity relative to autophagic flux in primary astrocytes

Yuan, R., Hahn, Y., Stempel, M. H., Sidibe, D. K., Laxton, O., Chen, J., Kulkarni, A., & Maday, S. (2022) · Autophagy · doi:10.1080/15548627.2022.2084884 · Cited by 18 · see citing works

Vitamin B6, B12 and folate modulate deregulated pathways and protein aggregation in yeast model of Huntington disease

Pradhan, S. S., Rao, K. R., Manjunath, M., Saiswaroop, R., Patnana, D. P., Kanikaram, S. P., Choudhary, B., & Sivaramakrishnan, V. (2023) · 3 Biotech · doi:10.1007/s13205-023-03525-y · Cited by 16 · see citing works

Non-enzymatic posttranslational protein modifications in protein aggregation and neurodegenerative diseases

Baldensperger, T., Preissler, M., & Becker, C. F. W. (2024) · RSC Chemical Biology · doi:10.1039/d4cb00221k · Cited by 16 · see citing works

Non-canonical autophagy in aging and age-related diseases

Kumar, A. V., & Mills, J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1137870 · Cited by 14 · see citing works

Redox modulatory role of DJ-1 in Parkinson’s disease

Alshammari, Q. A. (2025) · Biogerontology · doi:10.1007/s10522-025-10227-w · Cited by 14 · see citing works

Vesicular dysfunction and pathways to neurodegeneration

Lewis, P. A. (2021) · Essays in Biochemistry · doi:10.1042/ebc20210034 · Cited by 13 · see citing works

An altered extracellular matrix–integrin interface contributes to Huntington’s disease-associated CNS dysfunction in glial and vascular cells

Hernandez, S. J., Lim, R. G., Onur, T. S., Dane, M. A., Smith, R. L., Wang, K. Q., Jean, G. E., Reyes-Ortiz, A. M., Devlin, K. L., Miramontes, R., et al. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac303 · Cited by 13 · see citing works

Dementia with Lewy Bodies: Genomics, Transcriptomics, and Its Future with Data Science

Goddard, T. R., Brookes, K. J., Sharma, R., Moemeni, A., & Rajkumar, A. P. (2024) · Cells · doi:10.3390/cells13030223 · Cited by 13 · see citing works

PTPRS is a novel marker for early Tau pathology and synaptic integrity in Alzheimer’s disease

Poirier, A., Picard, C., Labonté, A., Aubry, I., Auld, D. S., Zetterberg, H., Blennow, K., Poirier, J., Breitner, J. C. S., Poirier, A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-65104-2 · Cited by 13 · see citing works

Interaction among inflammasome, autophagy and non-coding RNAs: new horizons for drug

Pu, Q., Lin, P., Wang, Z., Gao, P., Qin, S., Cui, L., & Wu, M. (2019) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbz019 · Cited by 13 · see citing works

Parkinson’s disease physiopathology—beyond the α-synuclein aggregation: a narrative review

Macêdo, V. F. B., Macedo, V. K. B., Coelho, J. A. P. D. M., & Barboza, A. M. D. M. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1664269 · Cited by 12 · see citing works

Proteostasis, disease and the ageing neuron: Compartmental complexity in non-renewing cells

Coleman, R. A., Johnson, M. E., Konopka, A., & Chew, Y. L. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103073 · Cited by 12 · see citing works

Autophagy Markers Are Altered in Alzheimer’s Disease, Dementia with Lewy Bodies and Frontotemporal Dementia

Longobardi, A., Catania, M., Geviti, A., Salvi, E., Vecchi, E. R., Bellini, S., Saraceno, C., Nicsanu, R., Squitti, R., Binetti, G. G., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021125 · Cited by 12 · see citing works

Mechanisms and therapeutic strategies for NLRP3 degradation via post-translational modifications in ubiquitin-proteasome and autophagy lysosomal pathway

Su, K., Tang, M., Wu, J., Ye, N., Jiang, X., Zhao, M., Zhang, R., Cai, X., Zhang, X., Lin, L., et al. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117476 · Cited by 12 · see citing works

Neuroprotective Effects of a Novel Demeclocycline Derivative Lacking Antibiotic Activity: From a Hit to a Promising Lead Compound

Tomas‐Grau, R. H., González‐Lizárraga, F., Ploper, D., Ávila, C. L., Socías, S. B., Besnault, P., Tourville, A., Mella, R. M., Villacé, P., Salado, C., et al. (2022) · Cells · doi:10.3390/cells11172759 · Cited by 12 · see citing works

VEXAS: A review of current understandings and emerging treatment strategies

Holden, R., Jeelall, Y., McLean‐Tooke, A. P., Pathmanathan, K., & Nolan, D. A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1644404 · Cited by 11 · see citing works

Redox System Dysfunction as a Key Mechanism in Autism Spectrum Disorder Pathogenesis

de Oliveira, C. A., Iorio, E. L., & Espíndola, F. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26209850 · Cited by 12 · see citing works

Lead exposure induced lipid metabolism disorders by regulating the lipophagy process in microglia

Hu, M., Zhang, J., Wu, J., & Su, P. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-31086-3 · Cited by 11 · see citing works

Lysosomal Storage Disease

Rajkumar, V., & Dumpa, V. (2021) · StatPearls · Cited by 11 · see citing works

Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society

Dierssen, M., Hérault, Y., Helguera, P. R., de Lagrán, M. M., Vázquez, A. V., Christian, B. T., Carmona‐Iragui, M., Wiseman, F. K., Mobley, W. C., Fisher, E., et al. (2021) · Molecular Syndromology · doi:10.1159/000514437 · Cited by 11 · see citing works

Astrocytic proteostasis in the tale of aging and neurodegeneration

Cabral‐Miranda, F., Matias, I. C. P., & Gomes, F. C. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102580 · Cited by 10 · see citing works

Unveiling the mTOR pathway modulation by SGLT2 inhibitors: a novel approach to Alzheimer’s disease in type 2 diabetes

Ramakrishan, P., Rajangam, J., Mahinoor, S. S., Bisht, S., Mekala, S., Upadhyay, D. K., Solomon, V. R., Sabarees, G., & Pelluri, R. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01555-4 · Cited by 10 · see citing works

Urolithin A analog inhibits castration-resistant prostate cancer by targeting the androgen receptor and its variant, androgen receptor-variant 7

Chandrasekaran, B., Tyagi, A., Saran, U., Kolluru, V., Baby, B. V., Chirasani, V. R., Dokholyan, N. V., Lin, J.-M., Singh, A., Sharma, A. K., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1137783 · Cited by 10 · see citing works

Dysregulation of neuroproteasomes by ApoE isoforms drives endogenous Tau aggregationPreprint

Paradise, V., Sabu, M., Bafia, J., Sharif, N., Nguyen, C., Konrad-Vicario, K., Mukim, R. D., Wang, X., Corjuc, B., Fu, J. M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.29.518293 · Cited by 10 · see citing works

Therapeutic Potential of MCC950 in Restoring Autophagy and Cognitive Function in STZ-Induced Rat Model of Alzheimer's Disease

Naeem, A., Waseem, A., Khan, M. A., Robertson, A. A. B., & Raza, S. S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04662-y · Cited by 9 · see citing works

Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils

Sulatsky, M. I., Stepanenko, O. V., Stepanenko, O. V., & Sulatskaya, A. I. (2025) · Aggregate · doi:10.1002/agt2.70078 · Cited by 9 · see citing works

Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis

Jung, Y., Kim, W., Shin, N. K., Bae, Y. M., & Wie, J. (2023) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2023.27.4.311 · Cited by 9 · see citing works

A splicing variant of TFEB negatively regulates the TFEB-autophagy pathway

Park, J.-Y., Sohn, H., Koh, Y. H., & Jo, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-00613-y · Cited by 9 · see citing works

Acrylamide‐induced autophagy‐lysosomal pathway dysfunction contributing to neurotoxicity through targeting transcription factor EB

Yang, L., Li, D., Zhang, L., Li, D., Luo, Y., & Chen, F. (2023) · Food Frontiers · doi:10.1002/fft2.258 · Cited by 9 · see citing works

Molecular Visualization of Neuronal TDP43 Pathology In SituPreprint

Erwin, A. L., Fernandez, M. G., Chang, M. L., Attili, D., Bekier, M., Pinarbasi, E. S., Russ, J. E., Sutanto, R., Thomas, D., Shen, X., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.19.608477 · Cited by 9 · see citing works

TFEB-dependent autophagy-lysosomal pathway is required for NRF2-driven antioxidative action in obstructive sleep apnea-induced neuronal injury

Song, J., Wang, T., Hong, J., Wang, Y., & Feng, J. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111630 · Cited by 8 · see citing works

SOD1 is delivered to lysosomes via autophagy to maintain lysosomal function and integrity

Zheng, Y., Li, M., Chen, X., Zheng, Z., Chen, Z., Tian, R., & Zhao, Y. G. (2025) · The Journal of Cell Biology · doi:10.1083/jcb.202501007 · Cited by 8 · see citing works

Neurofilament accumulation disrupts autophagy in giant axonal neuropathy

Paumier, J., Zewe, J. P., Panja, C., Pergande, M. R., Venkatesan, M., Israeli, E., Prasad, S., Snider, N. T., Savas, J. N., & Opal, P. (2025) · JCI Insight · doi:10.1172/jci.insight.177999 · Cited by 7 · see citing works

Dual functionality of MDM2 in PROTACs expands the horizons of targeted protein degradation

Zhao, J., Chen, H., & Liang, C. (2025) · Biomarker Research · doi:10.1186/s40364-025-00826-7 · Cited by 7 · see citing works

Sex differences in response to obesity and caloric restriction on cognition and hippocampal measures of autophagic-lysosomal transcripts and signaling pathways

Baer, S. B., Dorn, A. D., & Osborne, D. M. (2024) · BMC Neuroscience · doi:10.1186/s12868-023-00840-1 · Cited by 7 · see citing works

Lysosomal Dysfunction and Autophagy Blockade Contribute to MDMA-Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells

Li, I., Shih, J., Yeh, T.-Y., Lin, H., Chen, M., & Huang, Y. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00437 · Cited by 7 · see citing works

Tubulin deacetylase NDST3 modulates lysosomal acidification: Implications in neurological diseases

Tang, Q., Li, X., & Wang, J. (2022) · BioEssays · doi:10.1002/bies.202200110 · Cited by 7 · see citing works

Secondary Mitochondrial Dysfunction in Gaucher Disease Type I, II and III—Review of the Experimental and Clinical Evidence

Dewsbury, M., Purcell, T. T., Hughes, D. A., Donald, A., Hargreaves, I. P., & Stępień, K. M. (2025) · Genes · doi:10.3390/genes16111269 · Cited by 6 · see citing works

Digital neuropathology of neurodegenerative disorders: Foundations, research advances, and future directions

Rosado, A. M., Vizcarra, J. C., Sharma, S. R. R., Keene, C. D., White, C. L., Kim, A., Forrest, S. L., Kovács, G. G., Chuah, C., Flanagan, M. E., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70775 · Cited by 7 · see citing works

The crucial role of VPS35 and SHH in Parkinson’s disease: Understanding the mechanisms behind the neurodegenerative disorder

Bhardwaj, K., Jha, A., Roy, A., & Kumar, H. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149204 · Cited by 6 · see citing works

Autophagy-lysosomal pathway in neurodegeneration

McDonough, S. R., Rao, A. K., McAleer, J. M., Babrowicz, B. M., & Sharma, M. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00041-0

Molecular mechanisms of autophagy-lysosomal pathway dysfunction in neurodegenerative diseases and therapeutic strategies for lysosomal repair: a review

Wang, W., & Meng, X. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1819002

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

Martini-Stoica, H., Xu, Y., Ballabio, A., & Zheng, H. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.02.002 · Cited by 436 · see citing works

The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy

John, J. S. (2007) · Frontiers in bioscience · doi:10.2741/2714 · Cited by 134 · see citing works

The role of autophagy in neurodegenerative disease

Nixon, R. A. (2013) · Nature Medicine · doi:10.1038/nm.3232 · Cited by 2,059 · see citing works