The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
MAP Kinase Cascades Regulate the Cold Response by Modulating ICE1 Protein Stability
Open accessAbstract
SUMMARY Mitogen-activated protein kinase cascades are important signaling modules that convert environmental stimuli into cellular responses. We show that MPK3, MPK4, and MPK6 are rapidly activated after cold treatment. The mpk3 and mpk6 mutants display increased expression of CBF genes and enhanced freezing tolerance, whereas constitutive activation of the MKK4/5-MPK3/6 cascade in plants causes reduced expression of CBF genes and hypersensitivity to freezing, suggesting that the MKK4/5-MPK3/6 cascade negatively regulates the cold response. MPK3 and MPK6 can phosphorylate ICE1, a bHLH transcription factor that regulates the expression of CBF genes, and the phosphorylation promotes the degradation of ICE1. Interestingly, the MEKK1-MKK2-MPK4 pathway constitutively suppresses MPK3 and MPK6 activities, and has a positive role in the cold response. Furthermore, the MAPKKK YDA, and two calcium/calmodulin-regulated receptor-like kinases, CRLK1 and CRLK2, negatively modulate the cold-activation of MPK3/6. Our results uncover important roles of MAPK cascades in the regulation of plant cold response.
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Chen, X., Ding, Y., Yang, Y., Song, C., Wang, B., Yang, S., Guo, Y., & Gong, Z. (2021) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13061 · Cited by 608
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Ding, Y., & Yang, S. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.03.010 · Cited by 396
Rapid and Dynamic Alternative Splicing Impacts the Arabidopsis Cold Response Transcriptome
Calixto, C. P. G., Guo, W., James, A. B., Tzioutziou, N. A., Entizne, J. C., Panter, P. E., Knight, H., Nimmo, H. G., Zhang, R., & Brown, J. W. S. (2018) · The Plant Cell · doi:10.1105/tpc.18.00177 · Cited by 298
Wen, J., Jiang, F., Weng, Y., Sun, M., Shi, X., Zhou, Y., Yu, L., & Wu, Z. (2019) · BMC Plant Biology · doi:10.1186/s12870-019-2008-3 · Cited by 185
Metadata
- Authors
- Zhao, C., Wang, P., Si, T., Hsu, C.-C., Wang, L., Zayed, O., Yu, Z., Zhu, Y., Dong, J., Tao, W. A., & Zhu, J.-K.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 43
- Issue
- 5
- Pages
- 618-629.e5
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2765553891
- Cited by
- 498
- References
- 4
- FWCI
- 32.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhao, C., Wang, P., Si, T., Hsu, C.-C., Wang, L., Zayed, O., Yu, Z., Zhu, Y., Dong, J., Tao, W. A., & Zhu, J.-K. (2017). MAP Kinase Cascades Regulate the Cold Response by Modulating ICE1 Protein Stability. Developmental Cell. https://doi.org/10.1016/j.devcel.2017.09.024
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