Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase
Open accessAbstract
MAP kinases phosphorylate specific groups of substrate proteins.Here we show that the amino acid sequence FXFP is an evolutionarily conserved docking site that mediates ERK MAP kinase binding to substrates in multiple protein families.FXFP and the D box, a different docking site, form a modular recognition system, as they can function independently or in combination.FXFP is specific for ERK, whereas the D box mediates binding to ERK and JNK MAP kinase, suggesting that the partially overlapping substrate specificities of ERK and JNK result from recognition of shared and unique docking sites.These findings enabled us to predict new ERK substrates and design peptide inhibitors of ERK that functioned in vitro and in vivo.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
FxFP motifs in certain MAPK substrates and a separate docking groove for such motifs on ERK suggest that two docking grooves on ERK may operate in combination; Elk1 contains both an FxFP and a D-motif.
“Moreover, the existence of FxFP (Phe-any amino acid-Phe-Pro) motifs in certain MAPK (especially ERK) substrates and a separate docking groove for such motifs on ERK suggest that in some cases two docking grooves on ERK may operate in combination: Elk1 for example contains both an FxFP and a D-motif (35-37).”
From Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove (2012) · cites this paper as [37]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684 · see citing works
Oncogenes and signal transduction
Cantley, L. C., Auger, K. R., Carpenter, C. F., Duckworth, B. C., Graziani, A., Kapeller, R., & Soltoff, S. P. (1991) · Cell · doi:10.1016/0092-8674(91)90639-g · Cited by 2,697 · see citing works
The mitogen-activated protein kinase signal transduction pathway
Davis, R. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82362-6 · Cited by 2,112 · see citing works
Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886 · see citing works
Whitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543 · see citing works
Regulation of transcription by MAP kinase cascades
Treisman, R. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80067-6 · Cited by 1,296 · see citing works
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
Marais, R., Wynne, J., & Treisman, R. (1993) · Cell · doi:10.1016/0092-8674(93)90237-k · Cited by 1,275 · see citing works
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
Marshall, C. J. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90095-7 · Cited by 1,005 · see citing works
Activation mechanism of the MAP kinase ERK2 by dual phosphorylation
Canagarajah, B. J., Khokhlatchev, A., Cobb, M. H., & Goldsmith, E. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80351-7 · Cited by 729 · see citing works
Ternary complex factors: growth factor regulated transcriptional activators
Treisman, R. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90097-3 · Cited by 676 · see citing works
Kallunki, T., Su, B., Tsigelny, I., Sluss, H. K., Dérijard, B., Moore, G., Davis, R., & Karin, M. (1994) · Genes & Development · doi:10.1101/gad.8.24.2996 · Cited by 642 · see citing works
Songyang, Z., Lu, K. P., Kwon, Y. T., Tsai, L., Filhol, O., Cochet, C., Brickey, D. A., Soderling, T. R., Bartleson, C., Graves, D. J., et al. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6486 · Cited by 550 · see citing works
c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions
Kallunki, T., Deng, T., Hibi, M., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81999-6 · Cited by 492 · see citing works
Regulation and function of the JNK subgroup of MAP kinases
Minden, A., & Karin, M. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(97)00018-8 · Cited by 486 · see citing works
Sturgill, T. W., & Wu, J. (1991) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(97)90012-4 · Cited by 430 · see citing works
GATA transcription factors: key regulators of hematopoiesis.
Weiss, M. J., & Orkin, S. H. (1995) · PubMed · Cited by 415 · see citing works
Adams, P. D., Sellers, W. R., Sharma, S. K., Wu, A. D., Nalin, C. M., & Kaelin, W. G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.6623 · Cited by 373 · see citing works
KSR, a novel protein kinase required for RAS signal transduction
Therrien, M., Chang, H. C., Solomon, N. M., Karim, F. D., Wassarman, D. A., & Rubin, G. M. (1995) · Cell · doi:10.1016/0092-8674(95)90204-x · Cited by 340 · see citing works
The regulation of AP-1 activity by mitogen-activated protein kinases
Karin, M., & Marshall, C. J. (1996) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1996.0008 · Cited by 332 · see citing works
Sundaram, M. V., & Han, M. (1995) · Cell · doi:10.1016/0092-8674(95)90205-8 · Cited by 308 · see citing works
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
Kornfeld, K., Hom, D. B., & Horvitz, H. R. (1995) · Cell · doi:10.1016/0092-8674(95)90206-6 · Cited by 299 · see citing works
Self-citationDifferential targeting of MAP kinases to the ETS‐domain transcription factor Elk‐1
Yang, S., Whitmarsh, A. J., Davis, R. J., & Sharrocks, A. D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1740 · Cited by 299 · see citing works
The riddle of MAP kinase signaling specificity
Madhani, H. D., & Fink, G. R. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(98)01425-5 · Cited by 293 · see citing works
Comparative analysis of the ternary complex factors Elk‐1, SAP‐1a and SAP‐2 (ERP/NET).
Price, M. A., Rogers, A. F., & Treisman, R. (1995) · EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07257.x · Cited by 274 · see citing works
Yang, S., Yates, P. R., Whitmarsh, A. J., Davis, R. J., & Sharrocks, A. D. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.710 · Cited by 255 · see citing works
Cook, J. G., Bardwell, L., Kron, S. J., & Thorner, J. W. (1996) · Genes & Development · doi:10.1101/gad.10.22.2831 · Cited by 221 · see citing works
Tan, P. B. O., Lackner, M. R., & Kim, S. K. (1998) · Cell · doi:10.1016/s0092-8674(00)81186-1 · Cited by 202 · see citing works
Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK
Yu, W., Fantl, W. J., Harrowe, G., & Williams, L. T. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70020-x · Cited by 197 · see citing works
Deshpande, A. K., & Kung, H. F. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.3.1285 · Cited by 181 · see citing works
The protein kinase KSR interacts with 14-3-3 protein and Raf
Xing, H., Kornfeld, K., & Muslin, A. J. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00152-7 · Cited by 173 · see citing works
Self-citationBeitel, G. J., Tuck, S., Greenwald, I., & Horvitz, H. R. (1995) · Genes & Development · doi:10.1101/gad.9.24.3149 · Cited by 161 · see citing works
Bardwell, L., Cook, J. G., Chang, E. C., Cairns, B. R., & Thorner, J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3637 · Cited by 161 · see citing works
[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf
Alessi, D. R., Cohen, P., Ashworth, A., Cowley, S. A., Leevers, S. J., & Marshall, C. J. (1995) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(95)55031-3 · Cited by 158 · see citing works
Adler, V., Franklin, C. C., & Kraft, A. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5341 · Cited by 140 · see citing works
Matsuda, S., Gotoh, Y., & Nishida, E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53690-5 · Cited by 126 · see citing works
Lopez, M., Oettgen, P., Akbarali, Y., Dendorfer, U., & Libermann, T. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.5.3292 · Cited by 118 · see citing works
Muslin, A. J., MacNicol, A. M., & Williams, L. T. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.4197 · Cited by 116 · see citing works
Self-citationJacobs, D., Beitel, G. J., Clark, S. G., Horvitz, H. R., & Kornfeld, K. (1998) · Genetics · doi:10.1093/genetics/149.4.1809 · Cited by 109 · see citing works
Self-citation1 MAP Kinases in Mitogenesis and Development
Ferrell, J. E. (1996) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)60336-1 · Cited by 104 · see citing works
Regulation of GATA-2 Phosphorylation by Mitogen-activated Protein Kinase and Interleukin-3
Towatari, M., May, G. E., Marais, R., Perkins, G. R., Marshall, C. J., Cowley, S. A., & Enver, T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.8.4101 · Cited by 101 · see citing works
Bardwell, L. (1996) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(96)30032-7 · Cited by 95 · see citing works
Regulation of Cardiac Gene Expression by GATA-4/5/6
Evans, T. (1997) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(97)00010-8 · Cited by 74 · see citing works
Cuozzo, J. W., Tao, K. X., Cygler, M., Mort, J. S., & Sahagian, G. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.21067 · Cited by 62 · see citing works
Regulation of Growth Factor-Induced Signaling by Protein-Tyrosine-Phosphatases
Byon, J. C. H., Kenner, K. A., Kusari, A. B., & Kusari, J. (1997) · Experimental Biology and Medicine · doi:10.3181/00379727-216-44153 · Cited by 47 · see citing works
Nebreda, Á. R., Porrás, A., & Santos, E. (1993) · PubMed · Cited by 46 · see citing works
raf oncogenes in carcinogenesis.
Storm, S. M., Brennscheidt, U., Sithanandam, G., & Rapp, U. R. (1990) · PubMed · Cited by 28 · see citing works
(1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90051-5 · Cited by 12 · see citing works
Flagged first, then by citations
2 of the 49 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
Pearson, G. W., Robinson, F. L., Gibson, T. B., Xu, B.-E., Karandikar, M. S., Berman, K. S., & Cobb, M. H. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0428 · Cited by 4,037 · see citing works
Hunter, T. (2000) · Cell · doi:10.1016/s0092-8674(00)81688-8 · Cited by 2,586 · see citing works
Roux, P. P., & Blenis, J. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.2.320-344.2004 · Cited by 2,494 · see citing works
ERK1/2 MAP kinases: Structure, function, and regulation
Roskoski, R. J. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.04.005 · Cited by 1,642 · see citing works
Mechanisms of specificity in protein phosphorylation
Ubersax, J. A., & Ferrell Jr, J. E. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2203 · Cited by 1,451 · see citing works
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
Kölch, W. (2000) · Biochemical Journal · doi:10.1042/bj3510289 · Cited by 1,443 · see citing works
Differential regulation and properties of MAPKs
Raman, M., Chen, W., & Cobb, M. H. (2007) · Oncogene · doi:10.1038/sj.onc.1210392 · Cited by 1,430 · see citing works
The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions
Yoon, S., & Seger, R. (2006) · Growth Factors · doi:10.1080/02699050500284218 · Cited by 1,278 · see citing works
ERK signalling: A master regulator of cell behaviour, life and fate
Lavoie, H., Gagnon, J., & Therrien, M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0255-7 · Cited by 1,185 · see citing works
The ETS-domain transcription factor family
Sharrocks, A. D. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35099076 · Cited by 1,086 · see citing works
The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation
Plotnikov, A. N., Zehorai, E., Procaccia, S., & Seger, R. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.12.012 · Cited by 990 · see citing works
The MEK/ERK cascade: From signaling specificity to diverse functions
Shaul, Y. D., & Seger, R. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.10.005 · Cited by 934 · see citing works
Molecular interpretation of ERK signal duration by immediate early gene products
Murphy, L. O., Smith, S. W., Chen, R., Fingar, D. C., & Blenis, J. (2002) · Nature Cell Biology · doi:10.1038/ncb822 · Cited by 928 · see citing works
A conserved docking motif in MAP kinases common to substrates, activators and regulators
Tanoue, T., Adachi, M., Moriguchi, T., & Nishida, E. (2000) · Nature Cell Biology · doi:10.1038/35000065 · Cited by 816 · see citing works
Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
Junttila, M. R., Li, S., & Westermarck, J. (2008) · The FASEB Journal · doi:10.1096/fj.06-7859rev · Cited by 826 · see citing works
Dual specificity phosphatases: a gene family for control of MAP kinase function
Camps, M., NICHOLS, A., & Arkinstall, S. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.1.6 · Cited by 812 · see citing works
Chen, Z., Gibson, T. B., Robinson, F. L., Silvestro, L., Pearson, G. W., Xu, B.-E., Wright, A., Vanderbilt, C. A., & Cobb, M. H. (2001) · Chemical Reviews · doi:10.1021/cr000241p · Cited by 789 · see citing works
Protein–protein interactions define specificity in signal transductionPreprint
Pawson, T. J., & Nash, P. (2000) · Genes & Development · doi:10.1101/gad.14.9.1027 · Cited by 775 · see citing works
Rose, B. A., Force, T. L., & Wang, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00054.2009 · Cited by 720 · see citing works
Mapk signal specificity: The right place at the right time
Murphy, L. O., & Blenis, J. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.03.009 · Cited by 707 · see citing works
Frame, S., Cohen, P., & Biondi, R. M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00253-2 · Cited by 703 · see citing works
Regulation of RAF protein kinases in ERK signalling
Lavoie, H., & Therrien, M. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3979 · Cited by 683 · see citing works
Role of Nicotianamine in the Intracellular Delivery of Metals and Plant Reproductive Development
Takahashi, M., Terada, Y., Nakai, I., Nakanishi, H., Yoshimura, E., Mori, S., & Nishizawa, N. K. (2002) · The Plant Cell · doi:10.1105/tpc.010256 · Cited by 631 · see citing works
Integrating signals from RTKs to ERK/MAPK
Mckay, M., & Morrison, D. K. (2007) · Oncogene · doi:10.1038/sj.onc.1210394 · Cited by 616 · see citing works
Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin
Ding, Q., Xia, W., Liu, J.-C., Yang, J.-Y., Lee, D.-F., Xia, J., Bartholomeusz, G., Li, Y., Pan, Y., Li, Z., et al. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.06.009 · Cited by 597 · see citing works
Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases
Bogoyevitch, M. A., & Kobe, B. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00025-06 · Cited by 572 · see citing works
The c-jun kinase/stress-activated pathway: Regulation, function and role in human disease
Johnson, G. L., & Nakamura, K. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.12.009 · Cited by 505 · see citing works
MAP Kinase Cascades Regulate the Cold Response by Modulating ICE1 Protein Stability
Zhao, C., Wang, P., Si, T., Hsu, C., Wang, L., Zayed, O., Yu, Z., Zhu, Y., Dong, J., Tao, W. A., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.09.024 · Cited by 502 · see citing works
Cell Signaling and Stress ResponsesPreprint
Hotamışlıgil, G. S., & Davis, R. J. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a006072 · Cited by 496 · see citing works
Transcriptional regulation by the MAP kinase signaling cascades
Yang, S., Sharrocks, A. D., & Whitmarsh, A. J. (2003) · Gene · doi:10.1016/s0378-1119(03)00816-3 · Cited by 489 · see citing works
Docking domains and substrate-specificity determination for MAP kinases
Sharrocks, A. D., Yang, S.-H., & Galanis, A. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01627-3 · Cited by 442 · see citing works
New Insights into the Control of MAP Kinase Pathways
English, J. M., Pearson, G. W., Wilsbacher, J. L., Swantek, J. L., Karandikar, M. S., Xu, S., & Cobb, M. H. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4687 · Cited by 434 · see citing works
MAP kinases and the control of nuclear events
Turjanski, A. G., Vaque, J. P., & Gutkind, J. S. (2007) · Oncogene · doi:10.1038/sj.onc.1210415 · Cited by 431 · see citing works
Zhang, K., Corsa, C. A. S., Ponik, S. M., Prior, J. L., Piwnica-Worms, D. R., Eliceiri, K. W., Keely, P. J., & Longmore, G. D. (2013) · Nature Cell Biology · doi:10.1038/ncb2743 · Cited by 393 · see citing works
MAP kinase pathways activated by stress: The p38 MAPK pathway
Obata, T., Brown, G. E., & Yaffe, M. B. (2000) · Critical Care Medicine · doi:10.1097/00003246-200004001-00008 · Cited by 355 · see citing works
A genetically encoded fluorescent sensor of ERK activity
Harvey, C. D., Ehrhardt, A. G., Cellurale, C., Zhong, H., Yasuda, R., Davis, R. J., & Svoboda, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804598105 · Cited by 347 · see citing works
Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions
BIONDI, R. M., & NEBREDA, A. R. (2003) · Biochemical Journal · doi:10.1042/bj20021641 · Cited by 334 · see citing works
Ets ternary complex transcription factors
Buchwalter, G., Gross, C., & Wasylyk, B. (2004) · Gene · doi:10.1016/j.gene.2003.09.028 · Cited by 336 · see citing works
Murphy, L. O., MacKeigan, J. P., & Blenis, J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.1.144-153.2004 · Cited by 332 · see citing works
Signaling by G-protein-coupled receptor (GPCR): Studies on the GnRH receptor
Naor, Z. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.07.001 · Cited by 322 · see citing works
Molecular recognitions in the MAP kinase cascades
Tanoue, T., & Nishida, E. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(02)00112-2 · Cited by 318 · see citing works
Wang, P., Du, Y., Li, Y., Ren, D., & Song, C. (2010) · The Plant Cell · doi:10.1105/tpc.109.072959 · Cited by 313 · see citing works
Targeting ERK1/2 protein-serine/threonine kinases in human cancers
Roskoski, R. J. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.01.039 · Cited by 309 · see citing works
Biondi, R. M., Cheung, P., Casamayor, A., Deák, M., Currie, R. A., & Alessi, D. R. (2000) · The EMBO Journal · doi:10.1093/emboj/19.5.979 · Cited by 301 · see citing works
Ory, S., Zhou, M., Conrads, T. P., Veenstra, T. D., & Morrison, D. K. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00535-9 · Cited by 296 · see citing works
Docking Motif Interactions in MAP Kinases Revealed by Hydrogen Exchange Mass Spectrometry
Lee, T., Hoofnagle, A. N., Kabuyama, Y., Stroud, J., Min, X., Goldsmith, E. J., Chen, L., Resing, K. A., & Ahn, N. G. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00161-3 · Cited by 282 · see citing works
The alphabet of intrinsic disorder
Theillet, F., Kalmár, L., Tompa, P., Han, K., Selenko, P., Dunker, A. K., Daughdrill, G. W., & Uversky, V. N. (2013) · Intrinsically Disordered Proteins · doi:10.4161/idp.24360 · Cited by 283 · see citing works
Nucleocytoplasmic shuttling of signal transducers
Xu, L., & Massagué, J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1331 · Cited by 272 · see citing works
Regulation of gene transcription by mitogen-activated protein kinase signaling pathways
Whitmarsh, A. J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.11.011 · Cited by 259 · see citing works
Autophagy proteins regulate ERK phosphorylation
Martínez-López, N., Athonvarangkul, D., Mishall, P. L., Sahu, S., & Singh, R. (2013) · Nature Communications · doi:10.1038/ncomms3799 · Cited by 249 · see citing works
Lee, J. T., & McCubrey, J. A. (2002) · Leukemia · doi:10.1038/sj.leu.2402460 · Cited by 249 · see citing works
Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors
Yang, S.-H., Galanis, A., & Sharrocks, A. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4028 · Cited by 244 · see citing works
PDE4 cAMP-specific phosphodiesterases
Houslay, M. D. (2001) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(01)69049-4 · Cited by 239 · see citing works
MacKenzie, S. J., Baillie, G. S., McPhee, I., Bolger, G. B., & Houslay, M. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.22.16609 · Cited by 237 · see citing works
Specificity Determinants of Substrate Recognition by the Protein Kinase DYRK1A
Himpel, S., Tegge, W. J., Frank, R., Leder, S., Joost, H., & Becker, W. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2431 · Cited by 235 · see citing works
Lawrence, M. C., Jivan, A., Shao, C., Duan, L., Goad, D. L., Zaganjor, E., Osborne, J. K., McGlynn, K., Stippec, S., Earnest, S. A., et al. (2008) · Cell Research · doi:10.1038/cr.2008.37 · Cited by 233 · see citing works
KSR: a MAPK scaffold of the Ras pathway?
Morrison, D. K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.9.1609 · Cited by 233 · see citing works
Ouwens, D. M., de Ruiter, N. D., van der Zon, G. C. M., Carter, A. P., Schouten, J., van der Burgt, C., Kooistra, K., Bos, J. L., Maassen, J. A., & van Dam, H. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf361 · Cited by 227 · see citing works
Letourneux, C., Rocher, G., & Porteu, F. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600980 · Cited by 224 · see citing works
Elion, E. A. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.22.3967 · Cited by 226 · see citing works
Molecular determinants that mediate selective activation of p38 MAP kinase isoforms
Enslen, H., Brancho, D. M., & Davis, R. J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.6.1301 · Cited by 222 · see citing works
Mitogen-activated protein kinase pathways in redox signaling
Torrès, M. (2003) · Frontiers in bioscience · doi:10.2741/999 · Cited by 218 · see citing works
Ishibe, S., Joly, D., Zhu, X., & Cantley, L. G. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00406-4 · Cited by 218 · see citing works
Extracellular-Regulated Kinases: Signaling From Ras to ERK Substrates to Control Biological Outcomes
Eblen, S. T. (2018) · Advances in cancer research · doi:10.1016/bs.acr.2018.02.004 · Cited by 212 · see citing works
KSR is a scaffold required for activation of the ERK/MAPK module
Roy, F., Laberge, G., Douziech, M., Ferland-McCollough, D., & Therrien, M. (2002) · Genes & Development · doi:10.1101/gad.962902 · Cited by 217 · see citing works
Nuclear Signaling of Plant MAPKs
Bigeard, J., & Heribert Hirt, A. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00469 · Cited by 216 · see citing works
p38α MAPK pathway: A key factor in colorectal cancer therapy and chemoresistance
Grossi, V. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i29.9744 · Cited by 213 · see citing works
Guan, Y., Meng, X., Khanna, R., LaMontagne, E. D., Liu, Y., & Zhang, S. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004384 · Cited by 214 · see citing works
Mechanisms of MAPK signalling specificity
Bardwell, L. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340837 · Cited by 213 · see citing works
Hartsough, M. T., Morrison, D. K., Salerno, M., Palmieri, D., Ouatas, T., Mair, M., Patrick, J. B., & Steeg, P. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203115200 · Cited by 200 · see citing works
Houslay, M. D., & Kölch, W. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.4.659 · Cited by 201 · see citing works
Elk-1 a Transcription Factor with Multiple Facets in the Brain
Besnard, A., Galan-Rodriguez, B., Vanhoutte, P., & Caboche, J. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00035 · Cited by 195 · see citing works
Ras-Mediated Activation of the Raf Family KinasesPreprint
Terrell, E. M., & Morrison, D. K. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a033746 · Cited by 189 · see citing works
The MAP kinase Kpp2 regulates mating and pathogenic development in Ustilago maydis
Müller, P., Aichinger, C., Feldbrügge, M., & Kahmann, R. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01661.x · Cited by 194 · see citing works
An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors
Seidel, J. J., & Graves, B. J. (2002) · Genes & Development · doi:10.1101/gad.950902 · Cited by 182 · see citing works
Karpova, A., Mikhaylova, M., Bera, S., Bär, J., Reddy, P. P., Behnisch, T., Rankovic, V., Spilker, C., Bethge, P., Şahin, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.02.002 · Cited by 194 · see citing works
The love–hate relationship between Ras and NotchPreprint
Sundaram, M. V. (2005) · Genes & Development · doi:10.1101/gad.1330605 · Cited by 192 · see citing works
Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove
Garai, Á., Zeke, A., Gógl, G., Törő, I., Fördős, F., Blankenburg, H., Bárkai, T., Varga, J., Alexa, A., Emig, D., et al. (2012) · Science Signaling · doi:10.1126/scisignal.2003004 · Cited by 177 · see citing works
Dunn, C. A., Wiltshire, C. J., MacLaren, A., & Gillespie, D. A. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(01)00275-3 · Cited by 187 · see citing works
Fantz, D. A., Jacobs, D., Glossip, D., & Kornfeld, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102512200 · Cited by 183 · see citing works
Self-citationGuo, T., Lu, Z., Shan, J., Ye, W., Dong, N., & Lin, H. (2020) · The Plant Cell · doi:10.1105/tpc.20.00351 · Cited by 182 · see citing works
Harris, I. S., Zhang, S., Treskov, I., Kovács, A. D., Weinheimer, C. J., & Muslin, A. J. (2004) · Circulation · doi:10.1161/01.cir.0000138190.50127.6a · Cited by 177 · see citing works
Self-citationBardwell, A. J., Flatauer, L. J., Matsukuma, K. E., Thorner, J. W., & Bardwell, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010271200 · Cited by 177 · see citing works
Regulation of WNK1 by an Autoinhibitory Domain and Autophosphorylation
Xu, B.-E., Min, X., Stippec, S., Lee, B., Goldsmith, E. J., & Cobb, M. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207917200 · Cited by 176 · see citing works
Substrate and Docking Interactions in Serine/Threonine Protein Kinases
Goldsmith, E. J., Akella, R., Min, X., Zhou, T., & Humphreys, J. M. (2007) · Chemical Reviews · doi:10.1021/cr068221w · Cited by 143 · see citing works
A Novel MAPK Phosphatase MKP-7 Acts Preferentially on JNK/SAPK and p38α and β MAPKs
Tanoue, T., Yamamoto, T., Maeda, R., & Nishida, E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101981200 · Cited by 165 · see citing works
Reményi, A., Good, M. C., Bhattacharyya, R. P., & Lim, W. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.030 · Cited by 154 · see citing works
Signaling dynamics of the KSR1 scaffold complex
McKay, M. M., Ritt, D. A., & Morrison, D. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901590106 · Cited by 163 · see citing works
Sundaram, M. V. (2006) · WormBook · doi:10.1895/wormbook.1.80.1 · Cited by 163 · see citing works
Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions
Courcelles, M., Frémin, C., Voisin, L., Lemieux, S., Meloche, S., & Thibault, P. (2013) · Molecular Systems Biology · doi:10.1038/msb.2013.25 · Cited by 158 · see citing works
Casar, B., Pinto, A., & Crespo, P. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.07.024 · Cited by 152 · see citing works
Porter, C. M., Havens, M. A., & Clipstone, N. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3543 · Cited by 151 · see citing works
de la Cova, C., Townley, R. A., Regot, S., & Greenwald, I. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.07.014 · Cited by 148 · see citing works
Sheridan, D. L., Kong, Y., Parker, S. A., Dalby, K. N., & Turk, B. E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801074200 · Cited by 147 · see citing works
Theodosiou, A. M., Smith, A., Gillieron, C., Arkinstall, S., & Ashworth, A. (1999) · Oncogene · doi:10.1038/sj.onc.1203185 · Cited by 145 · see citing works
Identification of a Motif in the Carboxyl Terminus of β-Arrestin2 Responsible for Activation of JNK3
Miller, W. E., McDonald, P. H., Cai, S. F., Field, M. E., Davis, R. J., & Lefkowitz, R. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102264200 · Cited by 145 · see citing works
Biliverdin reductase isozymes in metabolism
O’Brien, L., Hosick, P. A., John, K., Stec, D. E., & Hinds, T. D. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.02.001 · Cited by 142 · see citing works
Yang, S., Vickers, E., Brehm, A., Kouzarides, T., & Sharrocks, A. D. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.8.2802-2814.2001 · Cited by 142 · see citing works
KSR and CNK: two scaffolds regulating RAS-mediated RAF activation
Clapéron, A., & Therrien, M. (2007) · Oncogene · doi:10.1038/sj.onc.1210408 · Cited by 141 · see citing works
ERK2 enters the nucleus by a carrier-independent mechanism
Whitehurst, A. W., Wilsbacher, J. L., You, Y., Luby‐Phelps, K., Moore, M. S., & Cobb, M. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112495999 · Cited by 139 · see citing works
- Authors
- Jacobs, D., Glossip, D., Xing, H., Muslin, A. J., & Kornfeld, K.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-01-15
- Volume
- 13
- Issue
- 2
- Pages
- 163-175
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W4239714346
- Cited by
- 439
- References
- 49
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 4 · 2023: 9 · 2022: 16 · 2021: 12 · 2020: 13 · 2019: 7 · 2018: 13 · 2017: 13 · 2016: 16 · 2015: 15 · 2014: 10 · 2013: 13 · 2012: 15
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- Funders
- Burroughs Wellcome Fund
- Foundation for Barnes-Jewish Hospital
- Edward Mallinckrodt, Jr. Foundation
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- ERK MAP kinase, docking site, D-box, substrate specificity, JNK MAP kinase, phosphorylation, peptide inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review