3D Culture Method for Alzheimer's Disease Modeling Reveals Interleukin-4 Rescues Aβ42-Induced Loss of Human Neural Stem Cell Plasticity

Papadimitriou, Christos, Celikkaya, Hilal, Cosacak, Mehmet I., Mashkaryan, Violeta, Bray, Laura, Bhattarai, Prabesh, Brandt, Kerstin, Hollak, Heike +12 more·2018·Developmental Cell

Cited by (144)

Items 101–144 of 144

  1. Comparison between dynamic versus static models and real-time monitoring of neuronal dysfunction in an amyloid-β induced neuronal toxic model on a chip platform
    Chu-Chun Liang, Po‐Yen Chen, Nien‐Che Liu, I‐Chi Lee · 2024 · Lab on a Chip
  2. Organelle perturbation in Alzheimer’s disease: do intracellular amyloid-ß and the fragmented Golgi mediate early intracellular neurotoxicity?
    Lou Fourrière, Paul A. Gleeson · 2025 · Frontiers in Cell and Developmental Biology
  3. Precision Culture Scaling to Establish High‐Throughput Vasculogenesis Models
    Nicholas R. Dennison, Maximilian Fusenig, Lisa Grönnert, Manfred F. Maitz, Maria Alejandra Ramirez Martinez, Manja Wobus, Uwe Freudenberg, Martin Bornhäuser, Jens Friedrichs, Peter D. Westenskow et al. · 2024 · Advanced Healthcare Materials
  4. Using Single-Cell RNA sequencing with Drosophila, Zebrafish, and mouse models for studying Alzheimer’s and Parkinson’s disease
    Frederik Lau, Rebecca Binacchi, Samuele Brugnara, Alba Cumplido-Mayoral, Serena Di Savino, Ihsanullah Khan, Angela Orso, Samuele Sartori, Paola Bellosta, Matthias Carl et al. · 2025 · Neuroscience
  5. Susceptibility of Ovine Bone Marrow-Derived Mesenchymal Stem Cell Spheroids to Scrapie Prion Infection
    Adelaida Hernaiz, Paula Cobeta, Belén Marín, Francisco José Vázquez, Juan José Badiola, P. Zaragoza, Rosa Bolea, Inmaculada Martín‐Burriel · 2023 · Animals
  6. A microphysiological system for parallelized morphological and electrophysiological read-out of 3D neuronal cell culture
    Peter D. Jones, Beatriz Molina-Martínez, Anita Niedworok, Paolo Cesare · 2024 · Lab on a Chip
  7. ABCA7‐dependent Neuropeptide‐Y signalling is a resilience mechanism required for synaptic integrity in Alzheimer’s disease
    Hüseyin Tayran, Elanur Yılmaz, Prabesh Bhattarai, Yuhao Min, Xue Wang, Yiyi Ma, Nastasia N. Nelson, Nada Kassara, Mehmet İlyas Coşacak, Rüya Merve Dogru et al. · 2024 · Alzheimer s & Dementia
  8. High‐Throughput 3D Glioblastoma Model in Glycosaminoglycan Hydrogels for Personalized Therapeutic Screening
    Rajvinder Kaur Trautmann, Nicholas R. Dennison, Kathleen McCortney, Solveig Klier, Mehmet İlyas Coşacak, Carsten Werner, Göktuğ Akyoldaş, Craig Horbinski, Uwe Freudenberg, Çağhan Kızıl · 2026 · Macromolecular Bioscience
  9. Research Progress on Neural Cell Culture Systems
    Ting Li, Xiaosong Qin, Qiang Ao · 2025 · Current Neuropharmacology
  10. Mimicking the neural stem cell niche: An engineer’s view of cell: material interactions
    Narges Yazdani, Rebecca Kuntz Willits · 2023 · Frontiers in Chemical Engineering
  11. Techniques for RNA extraction from cells cultured in starPEG–heparin hydrogels
    Anna Jaeschke, Nicholas R. Harvey, Mikhail V. Tsurkan, Carsten Werner, Lyn Robyn Griffiths, Larisa Margaret Haupt, Laura Jane Bray · 2021 · Open Biology
  12. Cutting-edge technologies in neural regeneration
    Chang-Ping Li, Yingying Wang, Ching-Wei Zhou, Chen‐Yun Ding, Peng Teng, Rui Nie, Shuguang Yang · 2025 · Cell Regeneration
  13. Effect and mechanism of mGluR6 on the biological function of rat embryonic neural stem cells
    Jing Zhang, Lu Zhang, Yani Chen, Haiyan Shi, Xiaoyong Huang, Yanfeng Wang, Yu Wang, Yameng Wei, Wanjuan Xue, Jiming Han · 2019 · Bioscience Biotechnology and Biochemistry
  14. Short-lived Niemann-Pick type C mice with accelerated brain aging as a novel model for Alzheimer’s disease research
    Vikas Anil Gujjala, Morteza Abyadeh, Isaiah Klimek, Alexander Tyshkovskiy, Naci Oz, José Pedro Castro, Vadim N. Gladyshev, Jason C. Newton, Alaattin Kaya · 2025 · Neural Regeneration Research
  15. Interleukin-4 activates divergent cell-intrinsic signals to regulate retinal cell proliferation induced by classical growth factors
    Gustavo Mataruna da Silva, Camila Saggioro de Figueiredo, Amanda Cândida da Rocha Oliveira, Ícaro Raony, Raphael Amorim de Araújo Miranda, Eliezer de Mello Silva, Carla Valéria Vieira Guilarducci, Aline Araújo dos Santos, Elizabeth Giestal‐de‐Araujo · 2022 · Molecular and Cellular Neuroscience
  16. Control of Astrocyte Quiescence and Activation in a Synthetic Brain Hydrogel
    Sualyneth Galarza, Alfred J. Crosby, ChangHui Pak, Shelly R. Peyton · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  17. NCBP2-AS2 is a mitochondrial microprotein, regulates energy metabolism and neurogenesis, and is downregulated in Alzheimer’s disease
    Stanislava Dimitrova Popova, Prabesh Bhattarai, Elanur Yılmaz, Daniela Lascu, Juo-Han Kuo, Gizem Erdem, Başak Çoban, Jitka Michling, Mehmet İlyas Coşacak, Hüseyin Tayran et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  18. Unravelling the molecular network structure of biohybrid hydrogels
    Jana Sievers, Ron Dockhorn, Jens Friedrichs, Thomas Kurth, Peter Fratzl, Jens‐Uwe Sommer, Carsten Werner, Uwe Freudenberg · 2025 · Materials Today Bio
  19. ALUMINIUM AND FLUORINE IN DRINKING WATER AS RISK FACTORS FOR HUMAN HEALTH
    Fatma Özsel Özcan Araç, Ozan Aldemir · 2022 · GIDA / THE JOURNAL OF FOOD
  20. IL‐4/STAT6 axis observed to reverse proliferative defect in SCA3 patient‐derived neural progenitor cells
    Francis M. Chen, Huixian Li, Dittman Lai‐Shun Chung, Angel T. L. Mak, Fung Ping Leung, Ho Yin Edwin Chan, Wing Tak Wong · 2023 · Clinical and Experimental Pharmacology and Physiology
  21. Human Neural Stem Cell Expansion in Natural Polymer Scaffolds Under Chemically Defined Condition
    Fei‐Chien Chang, Matthew Michael James, Yang Zhou, Yoshiki Ando, Hadi M. Zareie, Jihui Yang, Miqin Zhang · 2024 · Advanced Biology
  22. A disease similarity approach identifies short-lived Niemann-Pick type C disease mice with accelerated brain aging as a novel mouse model for Alzheimer’s disease and aging research
    Vikas Anil Gujjala, Isaiah Klimek, Morteza Abyadeh, Alexander Tyshkovskiy, Naci Oz, José Pedro Castro, Vadim N. Gladyshev, Jason C. Newton, Alaattin Kaya · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  23. Recapitulation of plaque formation, tau pathology, and neurodegeneration in a human 3D matrix model of Alzheimer’s disease
    Matthias Hebisch, Viola Kamin, Giovanna Cenini, Antonia Piazzesi, Fabio Bertan, Beatrice Weykopf, Julia Schlee, Senthilvelrajan Kaniyappan, Kevin J. Washicosky, Doo Yeon Kim et al. · 2026 · Cell Reports Methods
  24. Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease
    Prabesh Bhattarai, Elanur Yılmaz, Elif Öykü Cakir, Hüseyin Tayran, Imdadul Haq, Dylan Murphy, Jonah Nadelmann Keller, Quentin Le Grand, Jacqueline Eschbach, Hilal Çelikkaya et al. · 2026 · Nature Aging
  25. Life inter vivos: modeling regeneration in the relation between bodies and biomaterials
    Gabriel G. Coren · 2020 · BioSocieties
  26. Negative cell cycle regulation by calcineurin is necessary for proper beta cell regeneration in zebrafish
    Laura Massoz, David Bergemann, Arnaud Lavergne, Célia Reynders, Caroline Désiront, Chiara Goossens, Lydie C. Flasse, Bernard Peers, Marianne L. Voz, Isabelle Manfroid · 2024 · eLife
  27. Negative cell cycle regulation by calcineurin is necessary for proper beta cell regeneration in zebrafish
    Laura Massoz, David Bergemann, Arnaud Lavergne, Célia Reynders, Caroline Désiront, Chiara Goossens, Lydie C. Flasse, Bernard Peers, Marianne L. Voz, Isabelle Manfroid · 2023 · eLife
  28. Negative cell cycle regulation by Calcineurin is necessary for proper beta cell regeneration in zebrafish
    Laura Massoz, David Bergemann, Arnaud Lavergne, Célia Reynders, Caroline Désiront, Chiara Goossens, Lydie C. Flasse, Bernard Peers, Marianne L. Voz, Isabelle Manfroid · 2024 · eLife
  29. 梨园戏《梁灏》渊源考述——兼与莆仙戏《梁灏》比较
    杨榕 · 2012 · 福建艺术
  30. Generation of Neurons and Their Integration in Pre-Existing Circuits in the Postnatal Brain: Signalling in Physiological and Regenerative Contexts
    Mira, Helena, Díez del Corral, Ruth, Morales, Aixa V. · 2020 · Frontiers research topics
  31. Accelerating drug development with 3D neural models
    Christine Evans-Pughe · 2023 · Nature
  32. Negative cell cycle regulation by Calcineurin is necessary for proper beta cell regeneration in zebrafish
    Laura Massoz, David Bergemann, Arnaud Lavergne, Célia Reynders, Caroline Désiront, Chiara Goossens, Lydie C. Flasse, Bernard Peers, Marianne L. Voz, Isabelle Manfroid · 2023 · eLife
  33. A novel patient-derived cellular platform for validating microglia-targeted therapeutics for Alzheimer’s disease
    Carla Cuní‐López, Romal Stewart, Satomi Okano, Garry L. Redlich, Mark W. Appleby, Anthony Robert White, Hazel Quek · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  34. IL-4 shaping glutamatergic synapse like structures for more mature iPSC derived neuron phenotypes
    David Zimmermann, Clemens L. Schöpf, Georg Kern, Theodora Kalpachidou, Maximilian Zeidler, Michaela Kress · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  35. Negative cell cycle regulation by Calcineurin is necessary for proper beta cell regeneration in zebrafish
    Laura Massoz, David Bergemann, Arnaud Lavergne, Célia Reynders, Caroline Désiront, Chiara Goossens, Lydie C. Flasse, Bernard Peers, Marianne L. Voz, Isabelle Manfroid · 2024 · eLife
  36. How Human Induced Pluripotent Stem Cells‐Derived Models can Advance our Understanding of Secretion Mechanisms in Physiological and Pathological Contexts?
    Lou Fourrière, Gaëlle Boncompain · 2025 · Biology of the Cell
  37. Additional file 1 of A 3D human co-culture to model neuron-astrocyte interactions in tauopathies
    Kevin Llewelyn Batenburg, Claudia Sestito, Paulien Cornelissen‐Steijger, van Weering, Jan R. T., Leo Price, Vivi Majella Heine, Wiep Scheper · 2024 · Figshare
  38. Additional file 2 of A 3D human co-culture to model neuron-astrocyte interactions in tauopathies
    Kevin Llewelyn Batenburg, Claudia Sestito, Paulien Cornelissen‐Steijger, van Weering, Jan R. T., Leo Price, Vivi Majella Heine, Wiep Scheper · 2024 · Figshare
  39. Studying the role of human Amyloid Precursor Protein (APP) during human cortical neurogenesis
    Khadijeh Shabani · 2021 · theses.fr (ABES)
  40. Use of nanoliposomes rich in omega-3 for the prevention of neurodegenerative diseases : bioavailability in vivo and in cortical neurons
    Elodie Passeri · 2021 · theses.fr (ABES)
  41. Hydrogels and cryogels as in vitro engineered 3D neurodegenerative models: scope and significance
    Ishaan Shah, Anuradha Vaidya, Yvonne Reinwald, Ruchi Mishra Tiwari · 2026 · Journal of Materials Science Materials in Medicine
  42. In Vitro Models of Neurodegenerative Diseases
    Amena Saleh, Esther B. E. Becker · 2026 · Contemporary clinical neuroscience
  43. IL-4 in Alzheimer’s Disease—Mechanisms and Therapeutic Potential
    Guangya Liu, Wenhua Li, Jiangmin Chen, Shuyu Xu, Xinyuan Liu, Zijie Wang, Qihui Yang, Anqi Xie, 杜艳军 · 2026 · Molecular Neurobiology
  44. BindingDB Entry 50016195: Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease.
    BindingDB · 2023 · UC San Diego