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ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer’s disease through BDNF/NGFR signaling

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Alzheimer’s Disease: Current Perspectives and Advances in Physiological Modeling

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Cell models for Down syndrome-Alzheimer’s disease research

Wu, Y., West, N. R., Bhattacharyya, A., & Wiseman, F. K. (2022) · Neuronal Signaling · doi:10.1042/ns20210054 · Cited by 17 · see citing works

Modelling Alzheimer's disease using human brain organoids: current progress and challenges

Yanakiev, M., Soper, O., Berg, D. A., & Kang, E. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.40 · Cited by 16 · see citing works

Tackling neurodegeneration in vitro with omics: a path towards new targets and drugs

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Zebra-Fishing for Regenerative Awakening in Mammals

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Single‐cell transcriptomics analysis of cellular heterogeneity and immune mechanisms in neurodegenerative diseases

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Effects of Amyloid-β-Mimicking Peptide Hydrogel Matrix on Neuronal Progenitor Cell Phenotype for the in vitro Modeling of Alzheimer's Disease

Mathes, T. G., Monirizad, M., Ermis, M., de Barros, N. R., Rodriguez, M., Kraatz, H., Jucaud, V., Khademhosseini, A., & Falcone, N. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.05.020 · Cited by 15 · see citing works

Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism

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3D engineered tissue models for studying human-specific infectious viral diseases

Hwang, K. S., Seo, E. U., Choi, N., Kim, J., & Kim, H. N. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.09.010 · Cited by 13 · see citing works

Biomaterials-based strategies for in vitro neural models

Özgün, A., Lomboni, D. J., Arnott, H. G., Staines, W. A., Woulfe, J., & Variola, F. (2022) · Biomaterials Science · doi:10.1039/d1bm01361k · Cited by 13 · see citing works

Cytokine–Microglia Interactions in Neuroinflammation: Mechanisms, Disease Dynamics, and Therapeutic Strategies

Zhang, F., Yang, W., Sun, R., Duan, X., 杨云华, Wang, A., & Tian, Y. (2025) · Antioxidants and Redox Signaling · doi:10.1177/15230864251401591 · Cited by 13 · see citing works

APOE- ε4-induced Fibronectin at the blood-brain barrier is a conserved pathological mediator of disrupted astrocyte-endothelia interaction in Alzheimer’s diseasePreprint

Bhattarai, P., Yılmaz, E., Cakir, E. Ö., Yüceer, H., Lee, A., Ma, Y., Çelikkaya, H., Coşacak, M. İ., Haage, V. C., Wang, X., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.24.634732 · Cited by 12 · see citing works

Neural stem cells fate under neuroinflammatory conditions and oxidative stress response

Torrisi, F., Denaro, S., Ragonese, J., D’Aprile, S., Zappalà, A., & Parenti, R. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1736865 · Cited by 12 · see citing works

Long-term in vitro culture of 3D brain tissue model based on chitosan thermogel

Lisa, D. D., Muzzi, L., Lagazzo, A., Andolfi, A., Sergio Martinoia, A., & Pastorino, L. (2023) · Biofabrication · doi:10.1088/1758-5090/ad0979 · Cited by 10 · see citing works

Organoids derived from metastatic cancers: Present and future

Zheng, X., Zhang, X., & Yu, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30457 · Cited by 10 · see citing works

Approaches for studying neuroimmune interactions in Alzheimer’s disease

Lin, C., Tian, Y., Tanzi, R. E., & Jorfi, M. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.10.002 · Cited by 10 · see citing works

Preconditioning of Mesenchymal Stem Cells Enhances the Neuroprotective Effects of Their Conditioned Medium in an Alzheimer’s Disease In Vitro Model

Tolstova, T. V., Dotsenko, E., Luzgina, N. G., & Rusanov, A. L. (2024) · Biomedicines · doi:10.3390/biomedicines12102243 · Cited by 10 · see citing works

Cerebrospinal fluid HSP90AA1, HSPA4, and STUB1/CHIP levels in Alzheimer's disease, mild cognitive impairment, and frontotemporal dementia

Sordu, P., Alaylıoğlu, M., Samancı, B., Bulu, E., Güleç, Z. E. K., Bılgıç, B., Hanagasi, H. A., Gurvit, H. I., Ulutin, T., Dursun, E., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251329540 · Cited by 9 · see citing works

Three-Dimensional Biohybrid StarPEG–Heparin Hydrogel Cultures for Modeling Human Neuronal Development and Alzheimer’s Disease Pathology

Siddiqui, T., Çelikkaya, H., Atasavum, Z. T., Popova, S. D., Freudenberg, U., Werner, C., & Kızıl, Ç. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2655-9_8 · Cited by 9 · see citing works

Patient-derived iPSCs, a reliable in vitro model for the investigation of Alzheimer’s disease

Asiamah, E. A., Guo, R., Kong, D., Feng, B., He, J., Zhang, W., Liu, X., Du, X., Ma, Z., Liu, B., et al. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0065 · Cited by 9 · see citing works

Tuning the network charge of biohybrid hydrogel matrices to modulate the release of SDF-1

Kühn, S., Freyse, J., Atallah, P., Rademann, J., Freudenberg, U., & Werner, C. (2021) · Biological Chemistry · doi:10.1515/hsz-2021-0175 · Cited by 8 · see citing works

Poly(2‐alkyl‐2‐oxazoline)‐Heparin Hydrogels—Expanding the Physicochemical Parameter Space of Biohybrid Materials

Hahn, D., Sonntag, J. M., Lück, S., Maitz, M. F., Freudenberg, U., Jordan, R., & Werner, C. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101327 · Cited by 8 · see citing works

Microgels With Electrostatically Controlled Molecular Affinity to Direct Morphogenesis

Kühn, S., Magno, V., Zimmermann, R., Limasale, Y. D. P., Atallah, P., Stoppa, A., Männel, M. J., Thiele, J., Friedrichs, J., Freudenberg, U., et al. (2024) · Advanced Materials · doi:10.1002/adma.202409731 · Cited by 8 · see citing works

Screening neuroprotective compounds in herpes-induced Alzheimer's disease cell and 3D tissue models

Silveira, I. A., Mullis, A. S., Cairns, D. M., Shevzov-Zebrun, A., Whalen, J., Galuppo, A., Walsh, K. G., & Kaplan, D. L. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.05.002 · Cited by 8 · see citing works

Mechanisms linking cerebrovascular dysfunction and tauopathy: Adding a layer of epiregulatory complexity

Kim, Y. A., Mellén, M., Kızıl, Ç., & Santa‐María, I. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16280 · Cited by 9 · see citing works

Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging

Erbaba, B., Burhan, Ö. P., Şerifoğlu, N., Muratoğlu, B., Kahveci, F., Adams, M. M., & Arslan-Ergül, A. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.04.017 · Cited by 8 · see citing works

Potential of Nano-Engineered Stem Cells in the Treatment of Multiple Sclerosis: A Comprehensive Review

Ghosh, S., Bhatti, G. K., Sharma, P., Kandimalla, R., Mastana, S., & Bhatti, J. S. (2023) · Cellular and molecular neurobiology · doi:10.1007/s10571-023-01434-5 · Cited by 5 · see citing works

The NLRP3-P2X7 Axis and Cytokine Crosstalk in Alzheimer's Disease: Mechanisms, Implications, and Therapeutic Opportunities

Kurmi, S., Doshi, G., & Parab, S. B. (2025) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273377780250505115039 · Cited by 7 · see citing works

Dissecting the immune response of CD4+ T cells in Alzheimer’s disease

Kostić, M. S., Živković, N., Cvetanović, A., Bašić, J., & Stojanović, I. R. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0090 · Cited by 8 · see citing works

Three-Dimensional Human Neural Stem Cell Models to Mimic Heparan Sulfate Proteoglycans and the Neural Niche

Peall, I. W., Okolicsanyi, R. K., Griffiths, L. R., & Haupt, L. M. (2021) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0041-1724117 · Cited by 7 · see citing works

How an increase in the copy number of HSV-1 during latency can cause Alzheimer’s disease: the viral and cellular dynamics according to the microcompetition model

Polansky, H., & Goral, B. (2021) · Journal of NeuroVirology · doi:10.1007/s13365-021-01012-9 · Cited by 8 · see citing works

Identification of a novel mechanism controlling neural stem cell plasticity in Alzheimer's disease model of adult zebrafish using single cell transcriptomics

Kızıl, Ç. (2019) · DZNE Pub

Human neural stem cells alleviate Alzheimer-like pathology in a mouse model

Lee, I.-S., Jung, K., Kim, I., Lee, H.-J., Kim, M., Yun, S., Hwang, K., Shin, J. E., & Park, K. I. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0035-6 · Cited by 169 · see citing works

Single-cell transcriptomics analyses of neural stem cell heterogeneity and contextual plasticity in a zebrafish brain model of amyloid toxicity

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Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer’s disease

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Instructive starPEG-Heparin biohybrid 3D cultures for modeling human neural stem cell plasticity, neurogenesis, and neurodegenerationPreprint

Papadimitriou, C., Coşacak, M. İ., Mashkaryan, V., Çelikkaya, H., Bray, L. J., Bhattarai, P., Hollak, H., Chen, X., He, S., Antos, C. L., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/225243 · Cited by 4 · see citing works