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Lipid metabolism in cancer: New perspectives and emerging mechanisms
Open accessAbstract
Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell death, and seed in secondary organs. An increased focus on cancer lipid metabolism has unveiled a number of mechanisms that promote tumor growth and survival, many of which are independent of classical cellular bioenergetics. These mechanisms include modulation of ferroptotic-mediated cell death, support during tumor metastasis, and interactions with the cells of the tumor microenvironment. As such, targeting lipid metabolism for anti-cancer therapies is attractive, with recent work on small-molecule inhibitors identifying compounds to target lipid metabolism. Here, we discuss these topics and identify open questions.
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Metabolic reprogramming: The driving force behind cancer drug resistance
El-Sehrawy, A. A. M. A., Hsu, C.-Y., Alkhathami, A. G., Chandra, M., Basunduwah, T. S., Malathi, H., Senapati, J. N., Gautam, A., Kadhem, M., & Yasin, H. A. (2025) · Seminars in Oncology · doi:10.1016/j.seminoncol.2025.152392 · Cited by 11
Metadata
- Authors
- Broadfield, L. A., Pane, A. A., Talebi, A., Swinnen, J. V., & Fendt, S.-M.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 56
- Issue
- 10
- Pages
- 1363-1393
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W3157598024
- Cited by
- 758
- References
- 241
- FWCI
- 33.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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