Metabolic reprogramming: The driving force behind cancer drug resistance

The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism

Hoxhaj, G., & Manning, B. D. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0216-7 · Cited by 2,137 · see citing works

Mechanisms of Multidrug Resistance in Cancer Chemotherapy

Bukowski, K., Kciuk, M., & Kontek, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093233 · Cited by 1,770 · see citing works

Reprogramming of fatty acid metabolism in cancer

Koundouros, N., & Poulogiannis, G. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0650-z · Cited by 1,621 · see citing works

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

Mashouri, L., Yousefi, H., Aref, A., Ahadi, A., Molaei, F., & Alahari, S. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0991-5 · Cited by 1,345 · see citing works

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

Fong, M. Y., Zhou, W., Liu, L., Alontaga, A. Y., Chandra, M., Ashby, J., Chow, A., O’Connor, S. T. F., Li, S., Chin, A. R., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3094 · Cited by 1,118 · see citing works

Glutamine reliance in cell metabolism

Yoo, H. C., Yu, Y. C., Sung, Y., & Han, J. M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00504-8 · Cited by 1,021 · see citing works

Lipid metabolism and cancer

Bian, X., Liu, R. R., Meng, Y., Xing, D., Xu, D., & Lu, Z. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20201606 · Cited by 1,007 · see citing works

Revisiting the Warburg effect: historical dogma versus current understanding

Vaupel, P. W., & Multhoff, G. (2020) · The Journal of Physiology · doi:10.1113/jp278810 · Cited by 838 · see citing works

Lipid metabolism in cancer: New perspectives and emerging mechanisms

Broadfield, L. A., Pane, A. A., Talebi, A., Swinnen, J. V., & Fendt, S. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.04.013 · Cited by 765 · see citing works

The interaction between ferroptosis and lipid metabolism in cancer

Li, D., & Li, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00216-5 · Cited by 713 · see citing works

Seminars in Cell & Developmental Biology

Lee, H., & Kirkwood, A. (2011) · Cited by 692 · see citing works

miRNA-based biomarkers, therapies, and resistance in Cancer

He, B., Zhao, Z., Cai, Q., Zhang, Y., Zhang, P., Shi, S., Xie, H., Peng, X., Yin, W., Tao, Y., et al. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.47203 · Cited by 632 · see citing works

Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation

Schiliro, C., & Firestein, B. L. (2021) · Cells · doi:10.3390/cells10051056 · Cited by 631 · see citing works

Epithelial–mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis

Chen, T., You, Y., Jiang, H., & Wang, Z. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25797 · Cited by 557 · see citing works

Fatty acid oxidation: An emerging facet of metabolic transformation in cancer

Ma, Y., Temkin, S. M., Hawkridge, A. M., Guo, C., Wang, W., Wang, X., & Fang, X. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.08.006 · Cited by 541 · see citing works

Altered metabolism in cancer: insights into energy pathways and therapeutic targets

Tufail, M., Jiang, C.-H., & Li, N. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02119-3 · Cited by 534 · see citing works

Adipocyte and lipid metabolism in cancer drug resistance

Cao, Y. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127201 · Cited by 527 · see citing works

MYC as a target for cancer treatment

Duffy, M. J., O’Grady, S., Tang, M., & Crown, J. P. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2021.102154 · Cited by 524 · see citing works

Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target

Infantino, V., Santarsiero, A., Convertini, P., Todisco, S., & Iacobazzi, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115703 · Cited by 511 · see citing works

Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics

Jin, H.-R., Wang, J., Wang, Z., Xi, M., Xia, B., Deng, K., & Yang, J. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01498-2 · Cited by 509 · see citing works

New aspects of amino acid metabolism in cancer

Vettore, L. A., Westbrook, R. L., & Tennant, D. A. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0620-5 · Cited by 503 · see citing works

Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression

Yang, E., Wang, X., Gong, Z., Yu, M., Wu, H., & Zhang, D. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00359-5 · Cited by 502 · see citing works

Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies.

Phan, L. M., Yeung, S. J., & Lee, M. H. (2014) · Europe PMC (PubMed Central) · doi:10.7497/j.issn.2095-3941.2014.01.001 · Cited by 500 · see citing works

Therapeutic targeting of “undruggable” MYC

Llombart, V., & Mansour, M. R. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103756 · Cited by 483 · see citing works

ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer

Dong, S., Liang, S., Cheng, Z., Zhang, X., Luo, L., Li, L., Zhang, W., Li, S., Xu, Q., Zhong, M., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02229-6 · Cited by 466 · see citing works

Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity

Feng, Q., Liu, Z., Yu, X., Huang, T., Chen, J., Wang, J., Wilhelm, J., Li, S., Song, J., Li, W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32521-8 · Cited by 430 · see citing works

HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance

Nagao, A., Kobayashi, M., Koyasu, S., Chow, C. C. T., & Harada, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020238 · Cited by 411 · see citing works

Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming

Li, Z., Sun, C., & Qin, Z. (2021) · Theranostics · doi:10.7150/thno.62378 · Cited by 396 · see citing works

Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy

Yang, L., Chu, Z., Liu, M., Zou, Q., Li, J., Liu, Q., Wang, Y., Wang, T., Xiang, J., & Wang, B. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01453-1 · Cited by 363 · see citing works

Lactate-Lactylation Hands between Metabolic Reprogramming and Immunosuppression

Chen, L., Huang, L., Gu, Y. L., Cang, W., Sun, P., & Xiang, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911943 · Cited by 353 · see citing works

Metabolic Codependencies in the Tumor Microenvironment

Dey, P., Kimmelman, A. C., & DePinho, R. A. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1211 · Cited by 342 · see citing works

Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis

Lin, J., Hu, P., Wang, Y., Tan, Y., Yu, K., Liao, K. L., Wu, Q., Li, T., Qi, M., Lin, J., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00889-0 · Cited by 333 · see citing works

The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer

Jin, L., Chun, J., Pan, C., Kumar, A., Zhang, G., Ha, Y., Li, D., Alesi, G. N., Kang, Y., Zhou, L., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.11.025 · Cited by 329 · see citing works

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y.-F., et al. (2017) · Nature · doi:10.1038/nature22359 · Cited by 325 · see citing works

The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer

Fontana, F., Giannitti, G., Marchesi, S., & Limonta, P. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.89942 · Cited by 309 · see citing works

Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment

Tharp, K. M., Kersten, K., Maller, O., Timblin, G. A., Stashko, C., Canale, F. P., Menjivar, R. E., Hayward, M.-K., Berestjuk, I., ten Hoeve, J., et al. (2024) · Nature Cancer · doi:10.1038/s43018-024-00775-4 · Cited by 304 · see citing works

Biology of glucose metabolization in cancer cells

Fadaka, A. O., Ajiboye, B. O., Ojo, O. A., Adewale, O. B., Olayide, I., & Emuowhochere, R. (2017) · Journal of Oncological Sciences · doi:10.1016/j.jons.2017.06.002 · Cited by 301 · see citing works

Arginine reprograms metabolism in liver cancer via RBM39

Mossmann, D., Müller, C., Park, S., Ryback, B. M., Colombi, M., Ritter, N., Weißenberger, D., Dazert, E., Coto‐Llerena, M., Nuciforo, S., et al. (2023) · Cell · doi:10.1016/j.cell.2023.09.011 · Cited by 299 · see citing works

Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer

Becker, L. M., O’Connell, J. T., Vo, A. P., Cain, M. P., Tampe, D., Bizarro, L., Sugimoto, H., McGow, A. K., Asara, J. M., Lovisa, S., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107701 · Cited by 293 · see citing works

LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in <i>KRAS</i> -Mutant Lung Adenocarcinoma

Galan-Cobo, A., Sitthideatphaiboon, P., Qu, X., Poteete, A., Pisegna, M. A., Tong, P., Chen, P.-H., Boroughs, L. K., Rodriguez, M. L. M., Zhang, W., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3527 · Cited by 292 · see citing works

STAT proteins in cancer: orchestration of metabolism

Li, Y., Zhang, C., Martincuks, A., Herrmann, A., & Yu, H. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-022-00537-3 · Cited by 287 · see citing works

Metabolic reprogramming and therapeutic resistance in primary and metastatic breast cancer

Liu, S., Zhang, X., Wang, W., Li, X., Sun, X., Zhao, Y., Wang, Q., Li, Y., Hu, F., & Ren, H. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02165-x · Cited by 279 · see citing works

Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells

Tamada, M., Nagano, O., Tateyama, S., Ohmura, M., Yae, T., Ishimoto, T., Sugihara, E., Onishi, N., Yamamoto, T., Yanagawa, H., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3024 · Cited by 275 · see citing works

The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer

Jyotsana, N., Ta, K. T. L., & DelGiorno, K. E. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.858462 · Cited by 275 · see citing works

Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts

Zhang, C., Wang, X., Zhang, P., He, T.-C., Han, J.-H., Zhang, R., Lin, J., Fan, J., Lu, L., Zhu, W.-W., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04506-4 · Cited by 273 · see citing works

Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges

Ritterhoff, J., & Tian, R. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00887-x · Cited by 264 · see citing works

TGF-β signaling in the tumor metabolic microenvironment and targeted therapies

Shi, X., Yang, J., Deng, S., Xu, H., Wu, D., Zeng, Q., Wang, S., Hu, T., Wu, F., & Zhou, H. (2022) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-022-01349-6 · Cited by 262 · see citing works

Metabolic reprogramming in the tumor microenvironment of liver cancer

Lin, J., Rao, D., Zhang, M., & Gao, Q. (2024) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-024-01527-8 · Cited by 251 · see citing works

Multifaceted role of branched-chain amino acid metabolism in cancer

Peng, H., Wang, Y., & Luo, W. (2020) · Oncogene · doi:10.1038/s41388-020-01480-z · Cited by 244 · see citing works

Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity

Yan, Y., Huang, L., Liu, Y., Yi, M., Chu, Q., Jiao, D., & Wu, K. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01322-3 · Cited by 222 · see citing works

Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis

Wang, G., Qiu, M., Xing, X., Zhou, J., Yao, H., Li, M., Yin, R. H., Hou, Y., Li, Y., Pan, S., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abk2756 · Cited by 219 · see citing works

25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages

Xiao, J., Wang, S., Chen, L., Ding, X., Dang, Y., Han, M., Zheng, Y., Shen, H., Wu, S., Wang, M., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.021 · Cited by 207 · see citing works

METTL5 stabilizes c‐Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression

Xia, P., Zhang, H., Lu, H., Xu, K., Jiang, X. W., Jiang, Y., Gongye, X., Chen, Z., Liu, J., Chen, X., et al. (2023) · 癌症：英文版 · doi:10.1002/cac2.12403 · Cited by 200 · see citing works

Involvement of tumor immune microenvironment metabolic reprogramming in colorectal cancer progression, immune escape, and response to immunotherapy

Nicolini, A., & Ferrari, P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1353787 · Cited by 187 · see citing works

Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer

Einstein, J. M., Perelis, M., Chaim, I. A., Meena, J. K., Nussbacher, J. K., Tankka, A. T., Yee, B. A., Li, H., Madrigal, A. A., Neill, N. J., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.06.014 · Cited by 186 · see citing works

Acetyl-CoA regulates lipid metabolism and histone acetylation modification in cancer

He, W., Li, Q., & Li, X. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188837 · Cited by 175 · see citing works

miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect

SUN, Y., Zhao, X., Zhou, Y., & Hu, Y. (2012) · Oncology Reports · doi:10.3892/or.2012.1958 · Cited by 169 · see citing works

Impact of lactate on immune cell function in the tumor microenvironment: mechanisms and therapeutic perspectives

Gu, X.-Y., Yang, J., Lai, R., Zhou, Z., Tang, D., Hu, L., & Zhao, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1563303 · Cited by 162 · see citing works

Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches

Navarro, C., Ortega, Á., Santeliz, R., Garrido, B., Chacín, M., Galbán, N., Vera, I., Sanctis, J. B. D., & Bermúdez, V. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061303 · Cited by 152 · see citing works

Targeting glucose metabolism enzymes in cancer treatment: current and emerging strategies

Zhang, Y., Li, Q., Huang, Z., Li, B., Nice, E. C., Huang, C., Wei, L., & Zou, B. (2022) · Cancers · doi:10.3390/cancers14194568 · Cited by 144 · see citing works

The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer

Kim, J., Lee, H. M., Cai, F., Ko, B., Yang, C., Lieu, E. L., Muhammad, N., Rhyne, S., Li, K., Haloul, M., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00316-0 · Cited by 143 · see citing works

CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling

Gao, L., Xu, Z., Huang, Z., Tang, Y., Yang, D., Huang, J., He, L., Liu, M., Chen, Z., & Teng, Y. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01579-x · Cited by 140 · see citing works

Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc

Wang, J., Yang, Y., Shao, F., Meng, Y., Guo, D. S., He, J., & Lu, Z. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01037-4 · Cited by 137 · see citing works

The significant role of amino acid metabolic reprogramming in cancer

Liu, X., Ren, B., Ren, J., Gu, M., You, L., & Zhao, Y.-P. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01760-1 · Cited by 135 · see citing works

Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells

Sun, Y., Daemen, A., Hatzivassiliou, G., Arnott, D. P., WILSON, C. A., Zhuang, G., Gao, M., Liu, P. J., Boudreau, A., Johnson, L., et al. (2014) · Cancer & Metabolism · doi:10.1186/2049-3002-2-20 · Cited by 134 · see citing works

The metabolic flexibility of quiescent CSC: implications for chemotherapy resistance

Chen, K., Zhang, C., Ling, S., Wei, R., Wang, J., & Xu, X. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04116-6 · Cited by 133 · see citing works

Lipid metabolism in pancreatic cancer: emerging roles and potential targets

Yin, X., Xu, R., Song, J., Ruze, R., Chen, Y., Wang, C., & Xu, Q. (2022) · 癌症：英文版 · doi:10.1002/cac2.12360 · Cited by 132 · see citing works

The Function of the Mutant p53-R175H in Cancer

Chiang, Y.-T., Chien, Y., Lin, Y., Wu, H.-H., Lee, D., & Yu, Y. (2021) · Cancers · doi:10.3390/cancers13164088 · Cited by 119 · see citing works

Histone lactylation regulates cancer progression by reshaping the tumor microenvironment

Qu, J., Li, P., & Sun, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1284344 · Cited by 119 · see citing works

HIF-1α Mediates Functional Switching of TGF-Β Signaling by Regulating the PKM mRNA Splicing and Metabolic Reprogramming in Non-Small Cell Lung Cancer

Huang, Y., Chen, Z., Lu, T., Bi, G., Li, M., Liang, J., Hu, Z., Zheng, Y., Yin, J., Xi, J., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02188-y · Cited by 117 · see citing works

Metabolic Reprogramming in Anticancer Drug Resistance: A Focus on Amino Acids

Pranzini, E., Pardella, E., Paoli, P., Fendt, S., & Taddei, M. L. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.02.004 · Cited by 114 · see citing works

LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F1

Logotheti, S., Marquardt, S., Gupta, S. K., Richter, C., Edelhäuser, B. A. H., Engelmann, D., Brenmoehl, J., Söhnchen, C., Murr, N., Alpers, M., et al. (2020) · Theranostics · doi:10.7150/thno.44176 · Cited by 96 · see citing works

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

Wang, Y., Zhang, J., Ren, S., Sun, D., Huang, H., Wang, H., Jin, Y., Li, F., Zheng, C., Liu, Y., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.026 · Cited by 94 · see citing works

TRPM7 silencing modulates glucose metabolic reprogramming to inhibit the growth of ovarian cancer by enhancing AMPK activation to promote HIF-1α degradation

Chen, Y., Liu, L., Xia, L., Wu, N., Wang, Y., Li, H., Chen, X., Zhang, X., Liu, Z., Zhu, M., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02252-1 · Cited by 94 · see citing works

Cellular senescence and metabolic reprogramming: Unraveling the intricate crosstalk in the immunosuppressive tumor microenvironment

Zhang, F., Guo, J., Yu, S., Zheng, Y., Duan, M., Zhao, L., Wang, Y., Yang, Z., & Jiang, X. (2024) · 癌症：英文版 · doi:10.1002/cac2.12591 · Cited by 93 · see citing works

Mitochondrial oxidative phosphorylation in cutaneous melanoma

Kumar, P. R., Moore, J. A., Bowles, K. M., Rushworth, S. A., & Moncrieff, M. D. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01159-y · Cited by 92 · see citing works

Oxytosis/Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator Glutathione Peroxidase 4 (GPX4)

Dar, N. J., John, U., Bano, N., Khan, S., & Bhat, S. A. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03646-8 · Cited by 92 · see citing works

Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity

Zheng, Y., Yao, Y., Ge, T., Ge, S., Jia, R., Song, X., & Zhuang, A. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02845-4 · Cited by 86 · see citing works

MYC Rules: Leading Glutamine Metabolism toward a Distinct Cancer Cell Phenotype

Tambay, V., Raymond, V., & Bilodeau, M. (2021) · Cancers · doi:10.3390/cancers13174484 · Cited by 82 · see citing works

Dysregulated Amino Acid Sensing Drives Colorectal Cancer Growth and Metabolic Reprogramming Leading to Chemoresistance

Solanki, S. A., Sanchez, K., Ponnusamy, V., Kota, V., Bell, H. N., Cho, C., Kowalsky, A. H., Green, M., Lee, J. H., & Shah, Y. M. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.11.014 · Cited by 81 · see citing works

Regulation of Metabolic Activity by p53

Flöter, J., Kaymak, I., & Schulze, A. (2017) · Metabolites · doi:10.3390/metabo7020021 · Cited by 81 · see citing works

GDF15 Ameliorates Liver Fibrosis by Metabolic Reprogramming of Macrophages to Acquire Anti-Inflammatory Properties

Li, X., Huai, Q., Zhu, C., Zhang, X., Xu, W., Dai, H., & Wang, H. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.07.009 · Cited by 80 · see citing works

Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment

Tan, S., Yang, Y., Yang, W., Han, Y., Huang, L., Yang, R., Hu, Z., Tao, Y., Liu, L., Li, Y., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02634-z · Cited by 79 · see citing works

Lipid metabolism reprogramming of CD8+ T cell and therapeutic implications in cancer

Wang, R., Liu, Z., Fan, Z., & Zhan, H. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216267 · Cited by 79 · see citing works

Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells

Ullmann, P., Nurmik, M., Begaj, R., Haan, S., & Letellier, E. (2019) · Cells · doi:10.3390/cells8060528 · Cited by 77 · see citing works

LncRNA GLTC targets LDHA for succinylation and enzymatic activity to promote progression and radioiodine resistance in papillary thyroid cancer

Shi, L., Duan, R., Sun, Z., Jia, Q., Wu, W., Wang, F., Liu, J., Zhang, H., & Xue, X. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01157-6 · Cited by 77 · see citing works

Aberrant R-loop–mediated immune evasion, cellular communication, and metabolic reprogramming affect cancer progression: a single-cell analysis

Zhang, S., Liu, Y., Sun, Y., Liu, Q., Gu, Y. J., Huang, Y., Zeng, Z., Tang, F., & Ouyang, Y. (2024) · Molecular Cancer · doi:10.1186/s12943-023-01924-6 · Cited by 68 · see citing works

Loss of PTEN expression is associated with PI3K pathway-dependent metabolic reprogramming in hepatocellular carcinoma

Zhao, C., Wang, B., Liu, E., & Zhang, Z. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00622-w · Cited by 67 · see citing works

The Role of Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment

Huang, X., Zhang, F., Wang, X., & Liu, K. (2022) · Cancers · doi:10.3390/cancers14112756 · Cited by 66 · see citing works

Metabolic reprogramming of immune cells in pancreatic cancer progression

Xiang, H., Yang, R., Tu, J., Yan, X., Yang, S., Lv, L., Zhai, X., Zhu, Y., Dong, D., & Tao, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113992 · Cited by 64 · see citing works

Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression

Yang, D., Liu, H., Cai, Y., Lu, K., Zhong, X., Xing, S., Song, W., Zhang, Y., Ye, L., Zhu, X., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111691 · Cited by 62 · see citing works

The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy

Chen, J., Na, R., Xiao, C. W., Wang, X., Wang, Y., Yan, D., Song, G., Liu, X., Chen, J., Lu, H., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01815-4 · Cited by 61 · see citing works

Autophagy-Dependent Metabolic Reprogramming Sensitizes TSC2-Deficient Cells to the Antimetabolite 6-Aminonicotinamide

Parkhitko, A. A., Priolo, C., Coloff, J. L., Yun, J., Wu, J. J., Mizumura, K., Xu, W., Malinowska, I. A., Yu, J. J., Kwiatkowski, D. J., et al. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0258-t · Cited by 59 · see citing works

Regulation of Metabolic Plasticity in Cancer Stem Cells and Implications in Cancer Therapy

Papadaki, S., & Magklara, A. (2022) · Cancers · doi:10.3390/cancers14235912 · Cited by 59 · see citing works

Branched-chain amino acids catabolism and cancer progression: focus on therapeutic interventions

Xu, E., Ji, B., Jin, K., & Chen, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1220638 · Cited by 58 · see citing works

Transforming Growth Factor-β: An Agent of Change in the Tumor Microenvironment

Stuelten, C. H., & Zhang, Y. E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.764727 · Cited by 57 · see citing works

Targeting lipid metabolism in the treatment of ovarian cancer

Chaudhry, S., Thomas, S. N., & Simmons, G. E., Jr. (2022) · Oncotarget · doi:10.18632/oncotarget.28241 · Cited by 56 · see citing works

Targeting Glucose Metabolism in Cancer Cells as an Approach to Overcoming Drug Resistance

Cunha, A., Silva, P. M. A., Sarmento, B. F. C. C., & Queirós, O. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15112610 · Cited by 56 · see citing works

Acetyl-CoA metabolism as a therapeutic target for cancer

Chen, G., Bao, B., Cheng, Y., Tian, M., Song, J., Zheng, L., & Tong, Q. (2023) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2023.115741 · Cited by 54 · see citing works

The importance of Ras in drug resistance in cancer

Healy, F. M., Prior, I. A., & MacEwan, D. J. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15420 · Cited by 52 · see citing works

Amino Acid Degrading Enzymes and their Application in Cancer Therapy

Pokrovsky, V. S., Chepikova, O. E., Давыдов, Д. Ж., Zamyatnin, A. A., Lukashev, A. N., & Lukasheva, E. V. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666171006132729 · Cited by 50 · see citing works

HIF-1 mediated metabolic reprogramming in cancer: Mechanisms and therapeutic implications

Taneja, N., Chauhan, A., Kulshreshtha, R., & Singh, S. K. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122890 · Cited by 50 · see citing works

Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy

Kumar, R., Mishra, A., Gautam, P., Feroz, Z., Vijayaraghavalu, S., Likos, E., Shukla, G. C., & Kumar, M. (2022) · Cancers · doi:10.3390/cancers14215268 · Cited by 48 · see citing works

Glucose metabolic reprogramming and its therapeutic potential in obesity-associated endometrial cancer

Huang, P., Fan, X., Yu, H., Zhang, K., Li, H., Wang, Y., & Xue, F. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-022-03851-4 · Cited by 48 · see citing works

Metabolic reprogramming by tobacco-specific nitrosamines (TSNAs) in cancer

Sarlak, S., Lalou, C., Amoêdo, N. D., & Rossignol, R. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.09.001 · Cited by 47 · see citing works

Amino Acids in Cancer and Cachexia: An Integrated View

Ragni, M., Fornelli, C., Nisoli, E., & Penna, F. (2022) · Cancers · doi:10.3390/cancers14225691 · Cited by 47 · see citing works

Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms

Gu, D., Ye, M., Zhu, G., Bai, J., Chen, J., Yan, L., Yu, P., Lu, F., Hu, C., Zhong, Y., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04870-z · Cited by 47 · see citing works

Reprogramming of Lipid Metabolism Mediates Crosstalk, Remodeling, and Intervention of Microenvironment Components in Breast Cancer

Wang, J., Zhang, W.-F., Liu, C., Wang, L., Wu, J., Sun, C.-G., & Wu, Q.-B. (2024) · International Journal on Biological Sciences · doi:10.7150/ijbs.92125 · Cited by 47 · see citing works

Noncoding RNAs in Regulation of Cancer Metabolic Reprogramming

Yang, D., Sun, L., Li, Z., & Gao, P. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-1498-7_7 · Cited by 42 · see citing works

Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma

Xia, Y., Brown, Z. J., Huang, H., & Tsung, A. (2021) · Cancer Medicine · doi:10.1002/cam4.4177 · Cited by 41 · see citing works

Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets

Andersen, H. B., Ialchina, R., Pedersen, S. F., & Czaplińska, D. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10004-4 · Cited by 40 · see citing works

EGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association

Wang, Y., Shu, H., Liu, J., Jin, X., Wang, L., Qu, Y., Xia, M., Peng, P., Feng, Y., & Wei, M. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102340 · Cited by 40 · see citing works

Functional roles of lncRNA-TUG1 in hepatocellular carcinoma

Farzaneh, M., Ghasemian, M., Ghaedrahmati, F., Poodineh, J., Najafi, S., Masoodi, T., Kurniawan, D., Shahab Uddin, M. S., & Azizidoost, S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120974 · Cited by 40 · see citing works

Metabolic regulation by p53: Implications for cancer therapy

Koo, K. Y., Moon, K., He, S., & Lee, M.-S. (2025) · Molecules and Cells · doi:10.1016/j.mocell.2025.100198 · Cited by 40 · see citing works

Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines

Varshavi, D., Varshavi, D., McCarthy, N. J., Veselkov, K., Keun, H. C., & Everett, J. R. (2020) · Metabolomics · doi:10.1007/s11306-020-01674-2 · Cited by 39 · see citing works

Metabolic modulation of histone acetylation mediated by HMGCL activates the FOXM1/β-catenin pathway in glioblastoma

Sun, Y., Mu, G., Zhang, X., Wu, Y., Wang, S., Wang, X., Xue, Z., Wang, X., Liu, J., Li, W., et al. (2023) · Neuro-Oncology · doi:10.1093/neuonc/noad232 · Cited by 39 · see citing works

Decreased Efficacy of Doxorubicin Corresponds With Modifications in Lipid Metabolism Markers and Fatty Acid Profiles in Breast Tumors From Obese vs. Lean Mice

Mentoor, I., Nell, T. A., Emjedi, Z., van Jaarsveld, P. J., de Jager, L. J., & Engelbrecht, A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00306 · Cited by 38 · see citing works

Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?

Rossmeislová, L., Gojda, J., & Smolková, K. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10016-0 · Cited by 38 · see citing works

SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer

Ohara, Y., Tang, W., Liu, H., Yang, S., Dorsey, T. H., Cawley, H., Moreno, P., Chari, R., Guest, M., Azizian, A., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113434 · Cited by 38 · see citing works

Metabolic Reprogramming in Cancer: Role of HPV 16 Variants

Arizmendi-Izazaga, A., Navarro‐Tito, N., Jiménez‐Wences, H., Catalán, M. A. M., Martínez-Carrillo, D. N., Zacapala-Gómez, A. E., Olea‐Flores, M., Dircio-Maldonado, R., Torres‐Rojas, F. I., Soto-Flores, D. G., et al. (2021) · Pathogens · doi:10.3390/pathogens10030347 · Cited by 37 · see citing works

Environmentally relevant doses of endocrine disrupting chemicals affect male fertility by interfering with sertoli cell glucose metabolism in mice

Adegoke, E. O., Rahman, M. S., Amjad, S., Pang, W., Ryu, D., Park, Y.-J., & Pang, M.-G. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.139277 · Cited by 37 · see citing works

The role of noncoding RNAs in metabolic reprogramming of cancer cells

Safi, A., Saberiyan, M., Sanaei, M., Adelian, S., Asl, F. D., Zeinaly, M., Shamsi, M., & Ahmadi, R. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00447-8 · Cited by 36 · see citing works

Acetyl-CoA carboxylase 1 controls a lipid droplet–peroxisome axis and is a vulnerability of endocrine-resistant ER + breast cancer

Bacci, M., Lorito, N., Smiriglia, A., Subbiani, A., Bonechi, F., Comito, G., Morriset, L., Botty, R. E., Benelli, M., López-Velazco, J. I., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adf9874 · Cited by 36 · see citing works

c-Myc-driven Hepatocarcinogenesis

Moon, H., PARK, H., & Ro, S. W. (2021) · Anticancer Research · doi:10.21873/anticanres.15307 · Cited by 36 · see citing works

Branched-Chain Amino Acids and Risk of Breast Cancer

Zeleznik, O. A., Balasubramanian, R., Ren, Y., Tobias, D. K., ROSNER, B. A., Peng, C., Bever, A. M., Frueh, L., Jeanfavre, S., Ávila-Pacheco, J., et al. (2021) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkab059 · Cited by 34 · see citing works

Metabolic Flexibility Is a Determinant of Breast Cancer Heterogeneity and Progression

Fukano, M., Park, M., & Deblois, G. (2021) · Cancers · doi:10.3390/cancers13184699 · Cited by 34 · see citing works

Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc

Bakiri, L., Hasenfuss, S. C., Guío-Carrión, A., Thomsen, M. K., Hasselblatt, P., & Wagner, E. F. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2404188121 · Cited by 34 · see citing works

Metabolic reprogramming of the tumor microenvironment to enhance immunotherapy

Lim, S. A. (2024) · BMB Reports · doi:10.5483/bmbrep.2024-0031 · Cited by 33 · see citing works

Exosomal ACADM sensitizes gemcitabine-resistance through modulating fatty acid metabolism and ferroptosis in pancreatic cancer

Yang, Y., Gu, H., Zhang, K., Guo, Z., Wang, X., Wei, Q., Weng, L., Han, X., Lv, Y., Cao, M., et al. (2023) · BMC Cancer · doi:10.1186/s12885-023-11239-w · Cited by 31 · see citing works

PA‐MSHA inhibits the growth of doxorubicin‐resistant MCF‐7/ADR human breast cancer cells by downregulating Nrf2/p62

Wei, Y., Liu, D., Jin, X., Gao, P., Wang, Q., Zhang, J., & Zhang, N. (2016) · Cancer Medicine · doi:10.1002/cam4.938 · Cited by 30 · see citing works

Oncogenic K-ras Induces Mitochondrial OPA3 Expression to Promote Energy Metabolism in Pancreatic Cancer Cells

Meng, N., Glorieux, C., Zhang, Y., Liang, L., Zeng, P., Lu, W., & Huang, P. (2019) · Cancers · doi:10.3390/cancers12010065 · Cited by 30 · see citing works

Nutlin-3a induces KRAS mutant/p53 wild type lung cancer specific methuosis-like cell death that is dependent on GFPT2

Kim, D., Min, D., Kim, J., Kim, J. M., Seo, Y., Jung, B. H., Kwon, S., Ro, H., Lee, S., Sa, J. K., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02922-8 · Cited by 29 · see citing works

Identification of metabolic reprogramming-related genes as potential diagnostic biomarkers for diabetic nephropathy based on bioinformatics

Chen, H., Su, X., Li, N., Dang, C., & Luo, Z. (2024) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-024-01531-5 · Cited by 29 · see citing works

Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy

Liang, Y., Tan, Y., Chen, G., Fan, J., & Zhang, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910268 · Cited by 28 · see citing works

Higher S-adenosylhomocysteine and lower ratio of S-adenosylmethionine to S-adenosylhomocysteine were more closely associated with increased risk of subclinical atherosclerosis than homocysteine

Xiao, J., You, Y., Chen, X., Tang, Y., Chen, Y., Liu, Q., Liu, Z., & Ling, W. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.918698 · Cited by 28 · see citing works

The Metabolism Reprogramming of microRNA Let-7-Mediated Glycolysis Contributes to Autophagy and Tumor Progression

Li, C., & Liao, C.-C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010113 · Cited by 27 · see citing works

Regulation of Metabolic Reprogramming by Long Non-Coding RNAs in Cancer

Sellitto, A., Pecoraro, G., Giurato, G., Nassa, G., Rizzo, F. M., Saggese, P., Martinez, C. A., Scafoglio, C., & Tarallo, R. (2021) · Cancers · doi:10.3390/cancers13143485 · Cited by 26 · see citing works

Ultrasensitive and label free electrochemical immunosensor for detection of ROR1 as an oncofetal biomarker using gold nanoparticles assisted LDH/rGO nanocomposite

Abolhasan, R., Khalilzadeh, B., Yousefi, H., Samemaleki, S., Chakari-Khiavi, F., Ghorbani, F., Pourakbari, R., Kamrani, A., Khataee, A., Rad, T. S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94380-5 · Cited by 26 · see citing works

MicroRNA-Mediated Metabolic Shaping of the Tumor Microenvironment

Virga, F., Quirico, L., Cucinelli, S., Mazzone, M., Taverna, D., & Orso, F. (2021) · Cancers · doi:10.3390/cancers13010127 · Cited by 25 · see citing works

Comprehensive analysis of the amino acid metabolism-related gene signature for prognosis, tumor immune microenvironment, and candidate drugs in hepatocellular carcinoma

Li, Y., Mo, H., Jia, S., Wang, J., Ma, Y., Liu, X., & Tu, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1066773 · Cited by 25 · see citing works

Targeting glutamine metabolism enhances responses to platinum-based chemotherapy in triple-negative breast cancers (TNBC)

Hong, J., Shen, Y., Hsu, C., Huang, P., Tomaszewski, A., Gabrielson, E. W., Shih, I., Gaillard, S. L., & Wang, T. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.02.009 · Cited by 24 · see citing works

Alone and Together: Current Approaches to Targeting Glutaminase Enzymes As Part of Anti-Cancer Therapies

Nguyen, T. T., Katt, W. P., & Cerione, R. A. (2022) · Future Drug Discovery · doi:10.4155/fdd-2022-0011 · Cited by 23 · see citing works

Amino acid metabolism regulated by lncRNAs: the propellant behind cancer metabolic reprogramming

Hu, Q., Li, Y., Li, D., Yuan, Y., Wang, K., Lü, Y., Cheng, Z., & Han, T. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01116-1 · Cited by 23 · see citing works

Research progress of circRNA in malignant tumour metabolic reprogramming

Geng, Y., Wang, M., Wu, Z., Jia, J., Yang, T., & Yu, L. (2023) · RNA Biology · doi:10.1080/15476286.2023.2247877 · Cited by 22 · see citing works

Tumor Glucose and Fatty Acid Metabolism in the Context of Anthracycline and Taxane-Based (Neo)Adjuvant Chemotherapy in Breast Carcinomas

Tõkés, A., Vári-Kakas, S., Kulka, J., & Törőcsik, B. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.850401 · Cited by 21 · see citing works

Exploiting the Metabolic Consequences of PTEN Loss and Akt/Hexokinase 2 Hyperactivation in Prostate Cancer: A New Role for δ-Tocotrienol

Fontana, F., Anselmi, M., & Limonta, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095269 · Cited by 21 · see citing works

PTEN ‐knockout regulates metabolic rewiring and epigenetic reprogramming in prostate cancer and chemoprevention by triterpenoid ursolic acid

Wang, L., Wang, C., Sarwar, M. S., Chou, P. J., Wang, Y., Su, X., & Kong, A. T. (2022) · The FASEB Journal · doi:10.1096/fj.202201195r · Cited by 20 · see citing works

Omega-3 Fatty Acid Treatment Combined with Chemotherapy to Prevent Toxicity, Drug Resistance, and Metastasis in Cancer

Soni, S., Torvund, M., & Mandal, C. C. (2021) · Current Drug Targets · doi:10.2174/1389450122666210901121935 · Cited by 20 · see citing works

Targeting lipid metabolism in cancer: neuroblastoma

Agostini, M., Melino, G., Habeb, B. F., Calandria, J. M., & Bazan, N. G. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10040-8 · Cited by 19 · see citing works

CEMIP promotes small cell lung cancer proliferation by activation of glutamine metabolism via FBXW7/c-Myc-dependent axis

Mo, X., Shen, X., Mo, X., Yu, F., Tan, W., Deng, Z., He, J., Luo, Z., Chen, Z., & Yang, J. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115446 · Cited by 19 · see citing works

miR-10b-5p promotes tumor growth by regulating cell metabolism in liver cancer via targeting SLC38A2

Xia, M.-Z., Chen, J., Hu, Y., Qu, B., Bu, Q., & Shen, H. (2024) · Cancer Biology & Therapy · doi:10.1080/15384047.2024.2315651 · Cited by 19 · see citing works

The role of lipid metabolism in cancer radioresistance

An, D., Zhai, D., Wan, C., & Yang, K. (2023) · Clinical & Translational Oncology · doi:10.1007/s12094-023-03134-4 · Cited by 18 · see citing works

Connexins and Glucose Metabolism in Cancer

Jones, J. C., & Bodenstine, T. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710172 · Cited by 17 · see citing works

Resensitizing Paclitaxel-Resistant Ovarian Cancer via Targeting Lipid Metabolism Key Enzymes CPT1A, SCD and FASN

Ma, Q., Liu, Z., WANG, T., PengFei, Z., Liu, M., Wang, Y.-F., Zhao, W., Yuan, Y., & Li, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216503 · Cited by 17 · see citing works

LncRNA SOX9-AS1 triggers a transcriptional program involved in lipid metabolic reprogramming, cell migration and invasion in triple-negative breast cancer

Cisneros-Villanueva, M., Fonseca-Montaño, M. A., Ríos-Romero, M., López‐Camarillo, C., Jiménez‐Morales, S., Langley, E., Rosette-Rueda, A. S., Cedro‐Tanda, A., Hernández‐Sotelo, D., & Hidalgo‐Miranda, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-51947-2 · Cited by 17 · see citing works

LncRNAs in tumor metabolic reprogramming and tumor microenvironment remodeling

Jiao, J., Zhao, Y., Li, Q., Jin, S., & Liu, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1467151 · Cited by 17 · see citing works

Non-metabolic functions of Pyruvate kinase M2: PKM2 in tumorigenesis and therapy resistance

İlhan, M. (2022) · Neoplasma · doi:10.4149/neo_2022_220119n77 · Cited by 16 · see citing works

miRNA-21, which disrupts metabolic reprogramming to facilitate CD4+ T cell polarization toward the Th2 phenotype, accelerates arsenite-induced hepatic fibrosis

Sun, J., Wu, M., Wang, L., Wang, P., Xiao, T., Wang, S., & Liu, Q. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114321 · Cited by 16 · see citing works

Long Noncoding RNAs and Circular RNAs in the Metabolic Reprogramming of Lung Cancer: Functions, Mechanisms, and Clinical Potential

Zhou, Y., Zhan, Y., Jiang, W., Liu, H., & Wei, S. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4802338 · Cited by 15 · see citing works

Multi-omics analyses of glucose metabolic reprogramming in colorectal cancer

Huang, M., Wu, Y., Cheng, L., Fu, L., Yan, H., Ru, H., Mo, X., Yan, L., & Su, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1179699 · Cited by 15 · see citing works

p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cells

Hassin, O., Sernik, M., Seligman, A., Vogel, F. C. E., Wellenstein, M. D., Smollich, J., Halperin, C., Pirona, A. C., Toledano, L. N., Caballero, C. D., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2311460120 · Cited by 14 · see citing works

Circular RNA: The main regulator of energy metabolic reprogramming in cancer cells

Zhang, L. (2019) · Thoracic Cancer · doi:10.1111/1759-7714.13251 · Cited by 13 · see citing works

Metabolic reprogramming in colon cancer reversed by DHTS through regulating PTEN/AKT/HIF1α mediated signal pathway

Wang, L., Yu, Z., Ren, S., Song, J., Wang, J., & Du, G. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.07.017 · Cited by 13 · see citing works

Guideline Recommendations for Empirical Antimicrobial Therapy: An Appraisal of Research Evidence for Clinical Decision-Making in Ethiopia

Arega, B., Agunie, A., Minda, A., Mersha, A., Sitotaw, A., Weldeyohhans, G., Teshome, A., Adane, K., & Mengistu, G. (2020) · Infectious Diseases and Therapy · doi:10.1007/s40121-020-00308-3 · Cited by 11 · see citing works

Increasing cisplatin exposure promotes small-cell lung cancer transformation after a shift from glucose metabolism to fatty acid metabolism

Zhao, Q., Liu, W.-J., Wang, J., Li, H., Lv, J.-L., Wang, Y., & Wang, C. (2025) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-025-06164-3 · Cited by 11 · see citing works

ETS1 drives EGF-induced glycolytic shift and metastasis of epithelial ovarian cancer cells

Chatterjee, P., Ghosh, D., Chowdhury, S., & Roy, S. S. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2024.119805 · Cited by 10 · see citing works

GNA15 induces drug resistance in B cell acute lymphoblastic leukemia by promoting fatty acid oxidation via activation of the AMPK pathway

Luo, J., Pan, S., Luo, J., Wang, L., Yin, J., Zhao, H., Su, R., Liao, M., Liu, L., & Zhang, J. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05198-4 · Cited by 10 · see citing works

Therapeutic Metabolic Reprograming Using microRNAs: From Cancer to HIV Infection

Gibson, M. S., Noronha-Estima, C., & Gama‐Carvalho, M. (2022) · Genes · doi:10.3390/genes13020273 · Cited by 9 · see citing works

Application of Metabolic Reprogramming to Cancer Imaging and Diagnosis

Yang, Y., Li, C., Cai, H.-Y., Lin, B.-S., Kim, C., & Chang, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415831 · Cited by 9 · see citing works

Recent advances microRNAs and metabolic reprogramming in colorectal cancer research

Xiong, B., Huang, Q.-Y., Zheng, H., Lin, S., & Xu, J. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1165862 · Cited by 9 · see citing works

microRNA-143 interferes the EGFR-stimulated glucose metabolism to re-sensitize 5-FU resistant colon cancer cells via targeting hexokinase 2

Chen, W., Chen, Y., & Hui, T. (2022) · Journal of Chemotherapy · doi:10.1080/1120009x.2022.2157617 · Cited by 9 · see citing works

Oxygen and metabolic reprogramming in the tumor microenvironment influences metastasis homing

Bisht, V. S., Giri, K., Kumar, D., & Ambatipudi, K. (2021) · Cancer Biology & Therapy · doi:10.1080/15384047.2021.1992233 · Cited by 8 · see citing works

Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy

Zhang, J., Bai, J., Chen, G., Wang, J., Cheng, Y., Zhao, J., & Xiong, H. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1184626 · Cited by 8 · see citing works

Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1

Lin, Y., Li, L., Yuan, B., Luo, F., Zhang, X., Yang, Y., Luo, S., Lin, J., Ye, T., Zhang, Y., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02034-5 · Cited by 8 · see citing works

Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review)

Nor, W., Kwong, S. C., Fuzi, A. A. M., Said, N. A. B. M., Jamil, A. H. A., Lee, Y. Y., Lee, S. C., Lim, Y. A. L., & Chung, I. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5487 · Cited by 8 · see citing works

Role of the circular RNAs/microRNA/messenger RNA axis in renal cell carcinoma: From gene regulation to metabolism and immunity

Xu, Z., Dong, Y., Cui, K., Hu, B., Lu, Y., Liu, X., Shahzad, A., Zhang, J., Duan, Q., Bai, Z., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112183 · Cited by 8 · see citing works

Engineering circular RNA for molecular and metabolic reprogramming

Sharma, N. K., Dwivedi, P., Bhushan, R., Maurya, P. K., Kumar, A., & Dakal, T. C. (2024) · Functional & Integrative Genomics · doi:10.1007/s10142-024-01394-z · Cited by 8 · see citing works

Forkhead box M1 mediates metabolic reprogramming in human colorectal cancer cells

Li, P.-C., Dai, S.-Y., Lin, Y., Chang, Y.-T., Liu, C.-C., Wang, I., & Lee, M. (2024) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00032.2024 · Cited by 7 · see citing works

Roles of microRNAs in metabolic reprogramming of breast cancer

Feng, F., Yu, Q., & Zhang, F. (2022) · Journal of the Pakistan Medical Association · doi:10.47391/jpma.1132 · Cited by 6 · see citing works

Metabolic Reprogramming of Myeloid-derived Suppressor Cells in the Tumor Microenvironment.

Liu, L., Huo, S., Liu, J., Li, Q., & Wang, J. (2021) · PubMed · Cited by 4 · see citing works

Moxibustion enables protective effects on rheumatoid arthritis-induced myocardial injury transforming growth factor beta1 signaling and metabolic reprogramming.

Wang, M., Zhu, Y., Zhao, H., & Zhao, H. (2023) · PubMed Central · doi:10.19852/j.cnki.jtcm.20230802.005 · Cited by 3 · see citing works

The role of circular RNAs in glucose metabolic reprogramming: impact on cancer progression and therapeutic implications in breast cancer

Liang, Y., & Yang, Q. (2025) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2024.93 · Cited by 3 · see citing works

An amino acid metabolism-based seventeen-gene signature correlates with the clinical outcome and immune features in pancreatic cancer

Hao, J., Zhou, C., Wang, Z., Ma, Z., Wu, Z., Lv, Y., & Wu, R. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1084275 · Cited by 2 · see citing works

LKB1/ AMPK / TSC2 signaling pathway alterations in non-small-cell-lung-carcinoma

Egaña, A., & de Lecuona, I. (2014) · TDX (Tesis Doctorals en Xarxa) · Cited by 1 · see citing works

Investigating the effects of diet-induced obesity on acute Doxorubicin-induced cardiotoxicity in a tumour-bearing model

Bock, B. A. (2019) · SUNScholar (Stellenbosch University) · Cited by 1 · see citing works

Regulated cell death in cancer: Mechanisms, crosstalk, and opportunities for therapy

Meng, Y., Chen, Q., Zhou, Z., & Li, M. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.218077 · Cited by 34 · see citing works

Role of autophagy in tumorigenesis and drug resistance: molecular mechanisms and therapeutic targets

Zhu, J., Lv, L., Yan, Y., Wang, S., Lu, X. Y., Ma, X., Sun, X., Qin, Y., Wu, H.-M., yu, G., et al. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00430-7 · Cited by 14 · see citing works

The toxic effects of doxorubicin and trastuzumab on cardiac metabolic reprogramming are associated with impaired mitochondrial dynamics balance

Thonusin, C., Maneechote, C., Chattipakorn, S. C., & Chattipakorn, N. (2025) · Food and Chemical Toxicology · doi:10.1016/j.fct.2025.115895 · Cited by 2 · see citing works

The Immune Biology of the Adrenal Gland Microenvironment and Its Role in Metastatic Progression

Liu, N. M., Sholevar, C. J., Karimzadeh, M., Uppuluri, J., Dongen, C. V., Graves, C. E., Campbell, M. J., Zamora, A. E., Judge, S. J., & Canter, R. J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031153 · Cited by 2 · see citing works

Metabolic rewiring of the tumor microenvironment: therapeutic intervention of multi-pathway adaptations to impede cancer metastasis

Kaushik, K., Singh, H., Jha, K., Singh, R. P., & Kaur, N. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1792455 · Cited by 2 · see citing works

Rewiring tumor metabolism: heterogeneity, oncometabolites, and adaptive plasticity

Yang, J., Zhou, C. C., Kumar, S. V., Shay, C., & Teng, Y. (2026) · Experimental Hematology and Oncology · doi:10.1186/s40164-026-00795-z · Cited by 2 · see citing works

Primary cell cultures versus immortalized cell lines: critical comparative insights into biological fidelity and translational applications

Suali, L., Chia, Y., Rustin, C., Lem, F. F., Ching, X. J., Mansur, M. A. B., Henry, Z. A., Chan, M. K. S., Wong, M. B. F., & Pan, S. Y. (2026) · Biotechnic &amp; Histochemistry · doi:10.1080/10520295.2026.2714776 · Cited by 1 · see citing works

ETV4 enhances glycolysis to suppress NK-cell cytotoxicity in the immune microenvironment of colon cancer

Zhang, Z., Wang, P., Chen, Y., Wang, J., Yang, W., Ou, W., Huang, X., Wei, Y., Zhao, X., & Wu, X. (2026) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2026.130978 · Cited by 1 · see citing works

Lipid-based nanocarriers for oral delivery of natural anticancer bioactive compounds: A comprehensive review on mechanisms and approaches

Dima, C. V., Assadpour, E., Nechifor, A., & Jafari, S. M. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.115825

Characterization of acquired capecitabine resistance in MKN-45 gastric cancer cells reveals preserved apoptotic sensitivity

Mohseni, H. S., Tavajohi, S., Kebriaeezadeh, A., Ghahremani, M. H., & Ostad, S. N. (2026) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-026-00653-7

Disulfidptosis: Current View of Understanding the Novel Pattern of Regulatory Cell Death

Xing, K., 李晓卿, Li, T., Dong, S., Zhu, H., Yan, M., Yu, S., & He, H. (2026) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2026.107059

The metabolic escape: how tumor metabolic reprogramming drives drug resistance

Chen, Y., Wu, Z., Si, W., & Liu, X. (2026) · PeerJ · doi:10.7717/peerj.21400

Metabolic Reprogramming: A Crucial Contributor to Anticancer Drug Resistance

Zhu, Y., Yan, W., Tong, L., Yang, J., Ge, S., Fan, J., Jia, R., & Wen, X. (2025) · MedComm · doi:10.1002/mco2.70358 · Cited by 28 · see citing works

Cancer Drug Resistance and Metabolic Reprogramming

Jan, S., Fatima, K., Wani, A., Malik, F. A., & Khan, S. U. (2024) · Springer eBooks · doi:10.1007/978-981-97-1666-1_6 · Cited by 3 · see citing works

Therapeutic strategies targeting metabolic characteristics of cancer cells

Bai, R., Meng, Y., & Cui, J. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104037 · Cited by 22 · see citing works

Relationship between metabolic reprogramming and drug resistance in breast cancer

Lv, L., Yang, S., Zhu, Y., Zhai, X., Li, S., Tao, X., & Dong, D. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.942064 · Cited by 38 · see citing works