Multi-center intervention study on glycohemoglobin (HbA1c) and serum, high-sensitivity CRP (hs-CRP) after local anti-infectious periodontal treatment in type 2 diabetic patients with periodontal disease
Abstract
The purpose of this study was to examine whether periodontal treatment incorporating topical antibiotic therapy affects on levels of glycohemoglobin (HbA1c) and serum high-sensitivity C-reactive protein (hs-CRP) in type 2 diabetic patients with periodontal disease, and to explore the relationship between CRP and glycemic control. The whole intervention group (n=32), which underwent anti-infectious periodontal treatment, showed only transient reduction in HbA1c levels without any change in hs-CRP, while the control group (n=17) did not show any changes in HbA1c or hs-CRP. Multiple regression analysis of all subjects revealed that BMI and change in hs-CRP correlated significantly with the reduction of HbA1c at 6 months after the periodontal treatment. Based on the results of multiple regression analysis, the intervention group was subdivided into two groups: those in which hs-CRP levels decreased (CRP-D group), and those in which hs-CRP levels unchanged or increased (CRP-N group) (n=16, respectively), and re-analysis was conducted based upon these subgroups. In the CRP-D subgroup, HbA1c was significantly reduced at the end of the study, but it did not decrease in the CRP-N subgroup. The decrease of HbA1c in the CRP-D subgroup following periodontal treatment was significantly greater than that in the CRP-N subgroup. BMI of each group remained unchanged in this study at the end of the study. Thus, the results suggested that periodontal treatment with topical antibiotics improves…
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Nesto, R. (2004) · Diabetic Medicine · doi:10.1111/j.1464-5491.2004.01296.x · Cited by 140 · see citing works
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Evidence-based practice guideline for the treatment for diabetes in Japan 2013
Tajima, N., Noda, M., Origasa, H., Noto, H., Yabe, D., Fujita, Y., Goto, A., Fujimoto, K., Sakamoto, M., & Haneda, M. (2015) · Diabetology International · doi:10.1007/s13340-015-0206-2 · Cited by 154 · see citing works
A high-fiber, low-fat diet improves periodontal disease markers in high-risk subjects: a pilot study
Kondo, K., Ishikado, A., Morino, K., Nishio, Y., Ugi, S., Kajiwara, S., Kurihara, M., Iwakawa, H., Nakao, K., Uesaki, S., et al. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.06.001 · Cited by 79 · see citing works
Luthra, S., Orlandi, M., Hussain, S. B., Leira, Y., Botelho, J., Machado, V., Mendes, J. J., Marletta, D., Harden, S., & D'Aiuto, F. (2023) · Journal of Clinical Periodontology · doi:10.1111/jcpe.13709 · Cited by 74 · see citing works
“…al., 2017, 2020; Zhou et al., 2017; D'Aiuto et al., 2018; Grubbs et al., 2020; Montero et al., 2020; Nguyen et al., 2021; Rapone et al., 2021), PPD (Katagiri et al., 2009; Offenbacher et al., 2009; Pinho Mde et al., 2009; Chen et al., 2012; Caúla et al., 2014; Kapellas et al., 2014; Geisinger et…”
Influential
- Authors
- Katagiri, S., Nitta, H., Nagasawa, T., Uchimura, I., Izumiyama, H., Inagaki, K., Kikuchi, T., Noguchi, T., Kanazawa, M., Matsuo, A., Chiba, H., Nakamura, N., Kanamura, N., Inoue, S., Ishikawa, I., & Izumi, Y.
- Affiliations
- Tokyo Medical and Dental University (JP)
- Junior College, Aichi Gakuin University (JP)
- Aichi Gakuin University (JP)
- Tokyo Medical University (JP)
- Kyoto Prefectural University of Medicine (JP)
- Kyoritsu Women's University (JP)
- Tokyo Women's Medical University (JP)
- ORCID
- Venue
- Diabetes Research and Clinical Practice
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 83
- Issue
- 3
- Pages
- 308-315
- ISSN
- 0168-8227 (ISSN-L)
- OpenAlex
- W2144645658
- Cited by
- 111
- References
- 1
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2023: 1 · 2022: 11 · 2021: 14 · 2020: 1 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 10 · 2012: 8
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Research and Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sumitomo Foundation
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- type 2 diabetes, periodontal disease, periodontal treatment, topical antibiotics, glycohemoglobin, HbA1c, high-sensitivity C-reactive protein, glycemic control, insulin resistance, body mass index, inflammation
- MeSH terms
- Adult, Aged, Anti-Infective Agents, C-Reactive Protein, Dentition, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Male, Middle Aged, Periodontal Diseases, Treatment Outcome
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