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Cited by 79Oral microbiology and periodontitis researchDental Health and Care UtilizationNutritional Studies and Diet

A high-fiber, low-fat diet improves periodontal disease markers in high-risk subjects: a pilot study

Kondo, Keiko, Ishikado, Atsushi, Morino, Katsutaro, Nishio, Yoshihiko, Ugi, Satoshi, Kajiwara, Sadae, Kurihara, Mika, Iwakawa, Hiromi +10 more·2014·Nutrition Research
DOI 10.1016/j.nutres.2014.06.001
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Abstract

Periodontal disease is related to aging, smoking habits, diabetes mellitus, and systemic inflammation. However, there remains limited evidence about causality from intervention studies. An effective diet for prevention of periodontal disease has not been well established. The current study was an intervention study examining the effects of a high-fiber, low-fat diet on periodontal disease markers in high-risk subjects. Forty-seven volunteers were interviewed for recruitment into the study. Twenty-one volunteers with a body mass index of at least 25.0 kg/m(2) or with impaired glucose tolerance were enrolled in the study. After a 2- to 3-week run-in period, subjects were provided with a test meal consisting of high fiber and low fat (30 kcal/kg of ideal body weight) 3 times a day for 8 weeks and followed by a regular diet for 24 weeks. Four hundred twenty-five teeth from 17 subjects were analyzed. Periodontal disease markers assessed as probing depth (2.28 vs 2.21 vs 2.13 mm; P < .0001), clinical attachment loss (6.11 vs 6.06 vs 5.98 mm; P < .0001), and bleeding on probing (16.2 vs 13.2 vs 14.6 %; P = .005) showed significant reductions after the test-meal period, and these improvements persisted until the follow-up period. Body weight (P < .0001), HbA1c (P < .0001), and high-sensitivity C-reactive protein (P = .038) levels showed improvement after the test-meal period; they returned to baseline levels after the follow-up period. In conclusion, treatment with a high-fiber, low-fat diet for 8 weeks effectively improved periodontal disease markers as well as metabolic profiles, at least in part, by effects other than the reduction of total energy intake.

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  • Consumption of whole grains and fruit has been shown to reduce periodontal disease progression and improve periodontal disease status among high-risk subjects.

    “Consumption of whole grains and fruit has also been shown to reduce periodontal disease progression and improve periodontal disease status among high‐risk subjects.”

    From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [275]

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Authors
Kondo, K., Ishikado, A., Morino, K., Nishio, Y., Ugi, S., Kajiwara, S., Kurihara, M., Iwakawa, H., Nakao, K., Uesaki, S., Shigeta, Y., Imanaka, H., Yoshizaki, T., Sekine, O., Makino, T., Maegawa, H., King, G. L., & Kashiwagi, A.
Affiliations
  • Shiga University of Medical Science (JP)
  • Kagoshima University (JP)
  • Sunstar Foundation (JP)
  • Sunstar (Japan) (JP)
  • Joslin Diabetes Center (US)
Corresponding author
Ishikado, Atsushi
ORCID
Venue
Nutrition Research
Publisher
Elsevier BV
Published
2014-06
Volume
34
Issue
6
Pages
491-498
ISSN
0271-5317 (ISSN-L)
DOI
10.1016/j.nutres.2014.06.001
OpenAlex
W2136008253
Cited by
79
References
38
Citations by year
2026: 8 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 7 · 2021: 10 · 2020: 4 · 2019: 2 · 2018: 10 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 1
FWCI
7.99
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Nutrition Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (24591350)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
periodontal disease, high-fiber diet, low-fat diet, probing depth, clinical attachment loss, bleeding on probing, impaired glucose tolerance, obesity, HbA1c, C-reactive protein, inflammation, dietary intervention, periodontal disease prevention
MeSH terms
Adult, Blood Glucose, Body Weight, C-Reactive Protein, Energy Intake, Dietary Carbohydrates, Dietary Fats, Dietary Fiber, Dietary Proteins, Feeding Behavior, Female, Humans, Insulin, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Periodontal Diseases, Pilot Projects, Triglycerides, Biomarkers, Body Mass Index, Glucose Intolerance, Diet, Fat-Restricted, Waist Circumference

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