Clinical characteristics of people experiencing biochemical hypoglycaemia during an oral glucose tolerance test: Cross-sectional analyses from a UK multi-ethnic population
Abstract
Aims People who experience biochemical hypoglycaemia during an oral glucose tolerance test (OGTT) may be insulin resistant, but this has not been investigated robustly, therefore we examined this in a population-based multi-ethnic UK study. Methods Cross-sectional data from 6478 diabetes-free participants (849 with fasting insulin data available) who had an OGTT in the ADDITION-Leicester screening study (2005-2009) were analysed. People with biochemical hypoglycaemia (2-h glucose Results 359 participants (5.5%) had biochemical hypoglycaemia, 1079 (16.7%) IGR and 5040 (77.8%) NGT. Biochemical hypoglycaemia was associated with younger age (P Conclusions Biochemical hypoglycaemia during an OGTT in the absence of diabetes or IGR was not associated with insulin resistance, but instead appeared to be associated with more favourable glycaemic risk profiles than IGR and NGT. Thus, clinicians may not need to intervene due to biochemical hypoglycaemia on a 2-h OGTT.
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Parekh et al. reported that biochemical hypoglycemia during an OGTT in the absence of diabetes or impaired glucose regulation was not associated with insulin resistance in a UK multiethnic population.
“However, Parekh et al. recently reported on an analysis from a United Kingdom population. This analysis indicated that biochemical hypoglycemia during an OGTT in the absence of diabetes or impaired glucose regulation (IGR) was not associated with insulin resistance [6].”
From Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population (2017) · cites this paper as [6]
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References 20 · Cited by 16
- Authors
- Parekh, S., Bodicoat, D. H., Brady, E., Webb, D., Mani, H., Mostafa, S., Levy, M. J., Khunti, K., & Davies, M. J.
- Affiliations
- University of Leicester (GB)
- University Hospitals of Leicester NHS Trust (GB)
- Venue
- Diabetes Research and Clinical Practice
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 104
- Issue
- 3
- Pages
- 427-434
- ISSN
- 0168-8227 (ISSN-L)
- OpenAlex
- W1975819360
- Cited by
- 16
- References
- 20
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2014: 1
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Research and Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Hospitals of Leicester NHS Trust
- National Institute for Health and Care Research (CL-2013-11-001)
- Diabetes UK
- Loughborough University
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- oral glucose tolerance test, insulin resistance, prediabetes, insulin sensitivity, HDL cholesterol, body mass index, triglycerides, HbA1c, fasting blood glucose, ethnic differences
- MeSH terms
- Adult, Aged, Blood Glucose, Cross-Sectional Studies, Diabetes Mellitus, Fasting, Female, Glucose Tolerance Test, United Kingdom, Humans, Hyperinsulinism, Hypoglycemia, Insulin, Insulin Resistance, Male, Middle Aged, Body Mass Index, Glucose Intolerance
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