Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population

May combine two claims.

Insulin resistance leads to basal-fasting hyperinsulinemia, which may result in insensitivity of beta-cell secretion, leading to lower first-phase insulin secretion to rising postprandial glucose but a subsequent exaggerated compensatory second-phase insulin secretion, which might result in hypoglycemia.

“As indicated by several studies, insulin resistance leads to basal-fasting hyperinsulinemia, which may result in the insensitivity of beta-cell secretion. This insensitivity leads to a lower first-phase insulin secretion to the rising postprandial glucose but a subsequent exaggerated compensatory second-phase insulin secretion, which might result in hypoglycemia [2, 3].”

• cites [2] sourcePartly supported

  Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

  Experimental — accuracy not yet measured
• cites [3] sourceDisputed

  Split into 2 atoms — 0 confirmed, 0 partially supported, 2 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

  Checked by a reasoning model — may be wrong.

  Experimental — accuracy not yet measured

May combine two claims.

Compared to participants with normal glucose tolerance, participants with biochemical hypoglycemia had lower BMI and lower levels of fasting glucose, 30-minute OGTT glucose, and 2-hour OGTT glucose.

“Compared to participants with NGT, participants with biochemical hypoglycemia showed older age, lower BMI, and lower levels of fasting glucose, Glu30, and Glu120.”

• Also stated in: § Results · plain

  “Compared to participants with normal glucose tolerance (NGT), participants with biochemical hypoglycemia presented with a younger age, lower BMI, lower levels of fasting glucose, and lower levels of 30-minute and 2-hour OGTT glucose.”

May combine two claims.

Among 26,606 participants from the China National Diabetes and Metabolic Disorders Study, 141 were diagnosed with biochemical hypoglycemia on a 2-hour OGTT, giving a prevalence of 0.53%, and 26,465 had normal glucose tolerance.

“In total, 26,606 participants were included in this study analysis. Of these participants, 141 of them were diagnosed with biochemical hypoglycemia on a 2-hour OGTT with a prevalence 0.53%, and 26,465 of them were diagnosed with NGT.”

• Also stated in: § Results · plain

  “In total, 26,606 participants were included, and 141 participants were diagnosed with biochemical hypoglycemia on a 2-hour OGTT.”

May combine two claims.

Compared to participants with normal glucose tolerance, participants with biochemical hypoglycemia had higher secretion levels of insulin at 30 minutes (Ins30) but lower secretion levels of insulin at 120 minutes (Ins120).

“In terms of insulin secretion, participants with biochemical hypoglycemia showed higher secretion levels of Ins30 but lower secretion levels of Ins120.”

May combine two claims.

In a Chinese population, biochemical hypoglycemia on a 2-hour OGTT is associated with higher insulin sensitivity (lower insulin resistance) and higher β-cell function (insulin secretion).

“This study indicated that biochemical hypoglycemia might be associated with lower levels of insulin resistance but higher levels of β-cell function in a Chinese population.”

• Also stated in: § 4. Discussion · boosted

  “With the whole evaluation, we confirmed that in a Chinese population, biochemical postprandial hypoglycemia was associated with higher levels of both insulin sensitivity and insulin secretion.”

Probably not a substantial claim: may not pass S1 (asserted), S3 (load-bearing).

Vasan et al. suggested that biochemical hypoglycemia might be associated with insulin secretion rather than insulin resistance.

“Another recently published study suggested that biochemical hypoglycemia might be associated with insulin secretion rather than insulin resistance [7].”

• cites [7] sourceNot checked — no full text of the source

Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

Plasma glucose was measured by a hexokinase enzymatic method, and serum insulin was measured by radioimmunoassay with intra- and interassay coefficients of variation <5%.

“Plasma glucose was measured by applying a hexokinase enzymatic method, and serum immune reactive insulin was analyzed by applying radioimmunoassay (North Biotechnology Institute, Beijing, China; intra- and interassay coefficient of variation <5%).”

Classified as probably not a substantial claim.

Parekh et al. reported that biochemical hypoglycemia during an OGTT in the absence of diabetes or impaired glucose regulation was not associated with insulin resistance in a UK multiethnic population.

“However, Parekh et al. recently reported on an analysis from a United Kingdom population. This analysis indicated that biochemical hypoglycemia during an OGTT in the absence of diabetes or impaired glucose regulation (IGR) was not associated with insulin resistance [6].”

• cites [6] sourceNot checked — no full text of the source

Probably not a substantial claim: may not pass S3 (load-bearing).

Tamburrano et al. found that increased insulin sensitivity is a feature of idiopathic reactive hypoglycemia.

“On the contrary, Tamburrano et al. [11] performed a euglycemic hyperinsulinemic glucose clamp on 20 patients with symptoms suggesting reactive hypoglycemia, and the results suggested that increased insulin sensitivity represents a feature of idiopathic reactive hypoglycemia.”

• cites [11] sourceNot checked — no full text of the source

Probably not a substantial claim: may not pass S3 (load-bearing).

The study used surrogate indexes of insulin sensitivity and insulin secretion rather than clamp-derived gold standard indexes.

“First, we calculated different surrogate indexes of insulin sensitivity as well as insulin secretion, but it was well known that the gold standard should be represented by clamp-derived indexes. Unfortunately, in this large sample epidemiology study, the clamp test could not be made and these indexes could not be collected.”

Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

The study protocol was approved by the Institutional Review Board and Ethics Committee at each participating institution, and each participant provided written informed consent.

“The Institutional Review Board and Ethics Committee at each participating institution approved the study protocol. Each participant provided written informed consent.”